Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.007 | 0.2957 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1014 | 0.3429 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0187 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.2957 | 0.2957 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.1014 | 0.3429 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.2957 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2957 | 0.2957 |
Brugia malayi | RNA binding protein | 0.007 | 0.2957 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.2061 | 0.697 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2957 | 0.2957 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.2957 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.2061 | 0.697 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.2061 | 0.697 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.2957 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.2957 | 0.2957 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.2957 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1014 | 0.1014 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2957 | 0.2957 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2061 | 0.697 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2957 | 0.2957 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2957 | 0.2957 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.