TDR Targets

Basic information

Technical information

TDR Targets ID: 782523
Name: methyl 3-(2-methoxyethyl)-2,4-dioxo-1H-quinaz oline-7-carboxylate
MW: 278.261 | Formula: C13H14N2O5
H donors: 1 H acceptors: 3 LogP: 0.33 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COCCn1c(=O)[nH]c2c(c1=O)ccc(c2)C(=O)OC
InChi: 1S/C13H14N2O5/c1-19-6-5-15-11(16)9-4-3-8(12(17)20-2)7-10(9)14-13(15)18/h3-4,7H,5-6H2,1-2H3,(H,14,18)
InChiKey: RKESOTWRXCDIJS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(2-methoxyethyl)-2,4-dioxo-1H-quinazoline-7-carboxylic acid methyl ester
2,4-diketo-3-(2-methoxyethyl)-1H-quinazoline-7-carboxylic acid methyl ester
MLS000086792
SMR000022820
methyl 3-(2-methoxyethyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate
ChemDiv3_007786
IDI1_025696
EU-0056430

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	huntingtin	Starlite/ChEMBL	No references
Homo sapiens	hydroxyprostaglandin dehydrogenase 15-(NAD)	Starlite/ChEMBL	No references
Homo sapiens	hydroxysteroid (17-beta) dehydrogenase 10	Starlite/ChEMBL	No references
Homo sapiens	polymerase (DNA directed) iota	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Leishmania braziliensis	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Leishmania mexicana	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	Get druggable targets OG5_129031	All targets in OG5_129031
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	Get druggable targets OG5_129031	All targets in OG5_129031
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	Get druggable targets OG5_129031	All targets in OG5_129031
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Cryptosporidium parvum	scully CG7113-PA, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Brugia malayi	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	Get druggable targets OG5_129031	All targets in OG5_129031
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	Get druggable targets OG5_129031	All targets in OG5_129031
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Schistosoma japonicum	ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania donovani	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Cryptosporidium hominis	scully CG7113-PA	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania infantum	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	Get druggable targets OG5_129031	All targets in OG5_129031
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	Get druggable targets OG5_129031	All targets in OG5_129031

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	hydroxysteroid (17-beta) dehydrogenase 10	252 aa	251 aa	24.7 %
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxyprostaglandin dehydrogenase 15-(NAD)	266 aa	216 aa	22.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0009	0.0027	0.0027
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0009	0.0027	0.0027
Brugia malayi	CXXC zinc finger family protein	0.0035	0.036	0.036
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0211	0.0211
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0009	0.0027	0.0027
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0046	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0027	0.0027
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0023	0.0211	0.4337
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0027	0.0027
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0211	0.0211
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0027	0.0027
Leishmania major	DNA polymerase eta, putative	0.0023	0.0211	0.0211
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0475	0.0475
Loa Loa (eye worm)	dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0475	0.0449
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0211	0.0211
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0009	0.0027	0.0027
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0475	0.0475
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0475	0.0475
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.077	1	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0009	0.0027	0.0027
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0475	0.0475
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0023	0.0211	1
Toxoplasma gondii	oxidoreductase, putative	0.0009	0.0027	0.0027
Toxoplasma gondii	carbonyl reductase 1, putative	0.0009	0.0027	0.0027
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0475	0.0449
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0475	0.0449
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Leishmania major	short chain dehydrogenase/reductase, putative	0.0009	0.0027	0.0027
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0009	0.0027	0.0027
Leishmania major	hypothetical protein, conserved	0.0009	0.0027	0.0027
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0009	0.0027	0.0027
Mycobacterium ulcerans	short-chain dehydrogenase	0.0009	0.0027	0.0027
Leishmania major	hypothetical protein, conserved	0.0009	0.0027	0.0027
Giardia lamblia	Reductase, putative	0.0009	0.0027	0.1303
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.077	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0211	0.0211
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0027	0.0027
Echinococcus multilocularis	steroid dehydrogenase	0.0009	0.0027	0.0009
Echinococcus multilocularis	oxidoreductase	0.0009	0.0027	0.0009
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Leishmania major	quinonoid dihydropteridine reductase	0.0009	0.0027	0.0027
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	dehydrogenase	0.0009	0.0027	0.0027
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0009	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0027	0.0027
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0009	0.0027	0.0027
Echinococcus granulosus	oxidoreductase	0.0009	0.0027	0.0009
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0074	0.0875	0.0875
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0027	0.0027
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0027	0.0413
Leishmania major	quinonoid dihydropteridine reductase	0.0009	0.0027	0.0027
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0009	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0475	0.0475
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0475	0.0449
Trypanosoma brucei	unspecified product	0.0016	0.0116	0.0116
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.077	1	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0009	0.0027	0.0027
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0211	0.0211
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0074	0.0875	0.0875
Schistosoma mansoni	DNA polymerase eta	0.0023	0.0211	0.0211
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0211	0.0211
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0027	0.0027
Loa Loa (eye worm)	dihydrofolate reductase	0.077	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0475	1
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Brugia malayi	Dehydrogenases, short chain protein 30	0.0009	0.0027	0.0027
Leishmania major	short chain dehydrogenase/reductase, putative	0.0009	0.0027	0.0027
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0475	0.0458
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0009	0.0027	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1845	0.1845
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Plasmodium vivax	hypothetical protein, conserved	0.0009	0.0027	0.0027
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0475	0.0475
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0475	0.0475
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0009	0.0027	0.0027
Echinococcus multilocularis	retinol dehydrogenase 11	0.0009	0.0027	0.0009
Mycobacterium ulcerans	short-chain dehydrogenase	0.0009	0.0027	0.0027
Plasmodium falciparum	steroid dehydrogenase, putative	0.0009	0.0027	0.0027
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Echinococcus granulosus	carbonyl reductase 1	0.0009	0.0027	0.0009
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0475	0.0475
Mycobacterium ulcerans	short-chain dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0009	0.0027	0.0027
Echinococcus granulosus	hypothetical protein	0.0009	0.0027	0.0009
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0475	0.0475
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0211	0.0211
Leishmania major	dehydrogenase-like protein	0.0009	0.0027	0.0027
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0009	0.0027	0.0027
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0027	0.0027
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0211	0.0211
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0475	0.0449
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0211	0.0211
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0027	0.0027
Echinococcus granulosus	steroid dehydrogenase	0.0009	0.0027	0.0009
Echinococcus granulosus	carbonyl reductase 1	0.0009	0.0027	0.0009
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0211	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0009	0.0027	0.0027
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0027	0.0413
Schistosoma mansoni	cpg binding protein	0.0035	0.036	0.036
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0475	0.0449
Leishmania major	hypothetical protein, conserved	0.0009	0.0027	0.0027
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0.0027	0.0027
Onchocerca volvulus		0.0043	0.0475	0.2464
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0027	0.0027
Trypanosoma brucei	unspecified product	0.0016	0.0116	0.0116
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0009	0.0027	0.0027
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0116	0.0116
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0009	0.0027	0.0009
Echinococcus multilocularis	dna polymerase eta	0.0023	0.0211	0.0193
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0009	0.0027	0.0413
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0009	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0027	0.0027
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0027	0.0027
Echinococcus multilocularis	carbonyl reductase 1	0.0009	0.0027	0.0009
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0211	0.0211
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0475	0.0449
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0009	0.0027	0.0027
Echinococcus granulosus	retinol dehydrogenase 11	0.0009	0.0027	0.0009
Leishmania major	oxidoreductase-like protein	0.0009	0.0027	0.0027
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0027	0.0027
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0009	0.0027	0.0027
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0475	0.0475
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0009	0.0027	0.0413
Chlamydia trachomatis	dihydrofolate reductase	0.077	1	0.5
Schistosoma mansoni	dihydrofolate reductase	0.077	1	1
Brugia malayi	hypothetical protein	0.0148	0.1845	0.1845
Mycobacterium ulcerans	oxidoreductase	0.0009	0.0027	0.0027
Leishmania major	short chain dehydrogenase, putative	0.0009	0.0027	0.0027
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0009	0.0027	0.0027
Echinococcus multilocularis	carbonyl reductase 1	0.0009	0.0027	0.0009
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0475	0.0449
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0475	0.0449
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Echinococcus granulosus	dna polymerase eta	0.0023	0.0211	0.0193
Leishmania major	3-keto-dihydrosphingosine reductase	0.0009	0.0027	0.0027
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0009	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0027	0.0027
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.3548	0.353
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0475	0.0475
Schistosoma mansoni	carbonyl reductase	0.0009	0.0027	0.0027
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.036	0.036
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0009	0.0027	0.0027
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0475	0.0475
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0009	0.0027	0.0027
Echinococcus multilocularis	retinol dehydrogenase 13	0.0009	0.0027	0.0009
Echinococcus granulosus	carbonyl reductase 1	0.0009	0.0027	0.0009
Leishmania major	hypothetical protein, conserved	0.0009	0.0027	0.0027
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	dehydrogenase/reductase	0.0009	0.0027	0.0027
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0211	0.0211
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0009	0.0027	0.0009
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0074	0.0875	0.0875
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0065	0.0752	0.0752
Mycobacterium ulcerans	ketoacyl reductase	0.0009	0.0027	0.0027
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0.0027	0.0027
Echinococcus multilocularis	retinol dehydrogenase 11	0.0009	0.0027	0.0009
Brugia malayi	Retinol dehydrogenase 12	0.0009	0.0027	0.0027
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0027	0.0027
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0475	1
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0027	0.0027
Echinococcus multilocularis	carbonyl reductase 1	0.0009	0.0027	0.0009
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0027	0.0027
Leishmania major	pteridine reductase 1	0.0009	0.0027	0.0027
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0027	0.0413
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0009	0.0027	0.0027
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0027	0.0027
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0475	0.0475
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0027	0.0027
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0027	0.0027
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0027	0.0027
Onchocerca volvulus		0.0035	0.036	0.1829
Trypanosoma brucei	unspecified product	0.0023	0.0211	0.0211
Schistosoma mansoni	carbonyl reductase	0.0009	0.0027	0.0027
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0211	0.0193
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0009	0.0027	0.0027
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0027	0.0027
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0475	0.0475
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0046	0.0028
Brugia malayi	beta-lactamase family protein	0.0043	0.0475	0.0475
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0009	0.0027	0.0027
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Brugia malayi	Dihydrofolate reductase	0.077	1	1
Loa Loa (eye worm)	oxidoreductase	0.0009	0.0027	0.0027
Plasmodium vivax	steroid dehydrogenase, putative	0.0009	0.0027	0.0027
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0211	0.0211
Leishmania major	quinonoid dihydropteridine reductase	0.0009	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0027	0.0027
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0211	0.0211
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0475	1
Brugia malayi	dehydrogenases, short chain protein 9	0.0009	0.0027	0.0027
Brugia malayi	beta-lactamase family protein	0.0043	0.0475	0.0475
Echinococcus granulosus	cpg binding protein	0.0037	0.0386	0.0368
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Leishmania major	quinonoid dihydropteridine reductase	0.0009	0.0027	0.0027
Toxoplasma gondii	ABC1 family protein	0.0043	0.0475	0.0475
Echinococcus granulosus	WW domain containing oxidoreductase	0.0009	0.0027	0.0009
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0027	0.0027
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0009	0.0027	0.0027
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.087	0.087
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.0027	0.0027
Trypanosoma cruzi	DNA polymerase eta, putative	0.0023	0.0211	0.0211
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0475	1
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0211	0.0211
Brugia malayi	hypothetical protein	0.0009	0.0027	0.0027
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0009	0.0027	0.1303
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	lipase LipD	0.0043	0.0475	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0027	0.0027
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Echinococcus granulosus	hypothetical protein	0.0009	0.0027	0.0009
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0074	0.0875	0.0875
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0027	0.0413
Echinococcus multilocularis	transient receptor potential cation channel	0.0009	0.0027	0.0009
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0.0027	0.0027
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.077	1	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0475	0.0449
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0027	0.0027
Trichomonas vaginalis	esterase, putative	0.0043	0.0475	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0.0027	0.0027
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0009	0.0027	0.0009
Schistosoma mansoni	cpg binding protein	0.0037	0.0386	0.0386
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0027	0.0027
Echinococcus granulosus	carbonyl reductase 1	0.0009	0.0027	0.0009
Echinococcus multilocularis	conserved hypothetical protein	0.0009	0.0027	0.0009
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0475	0.0475
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0009	0.0027	0.0027
Toxoplasma gondii	oxidoreductase, putative	0.0009	0.0027	0.0027
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0009	0.0027	0.0027
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0009	0.0027	0.0027
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.077	1	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1845	0.1845
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0018	0.0018
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Brugia malayi	beta-lactamase	0.0043	0.0475	0.0475
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0211	0.0193
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0009	0.0027	0.0009
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0027	0.0027
Echinococcus granulosus	dihydrofolate reductase	0.077	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0211	0.0211
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0027	0.0027
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0009	0.0027	0.0027
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0009	0.0027	0.0027
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0027	0.0413
Leishmania major	hypothetical protein, conserved	0.0009	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0027	0.0027
Brugia malayi	Dehydrogenases, short chain protein 2	0.0009	0.0027	0.0027
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0009	0.0027	0.0027
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0.0027	0.0027
Onchocerca volvulus	Huntingtin homolog	0.0148	0.1845	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0211	0.0211
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0211	0.0211
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0767	0.0767
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0211	0.0211
Onchocerca volvulus	Huntingtin homolog	0.0148	0.1845	1
Echinococcus granulosus	retinol dehydrogenase 11	0.0009	0.0027	0.0009
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0009	0.0027	0.0027
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0211	0.0211
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.077	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0027	0.0027
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0027	0.0027
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0027	0.0027
Brugia malayi	hypothetical protein	0.0009	0.0027	0.0027
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0044	0.0044
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0009	0.0027	0.0027
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	ketoacyl reductase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0211	0.0211
Leishmania major	short chain dehydrogenase, putative	0.0009	0.0027	0.0027
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0009	0.0027	0.0027
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0211	0.0211
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0027	0.0413
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0475	0.0475
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0211	0.0184
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0.0027	0.0027
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0009	0.0027	0.5
Schistosoma mansoni	retinal dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0074	0.0875	0.0858
Leishmania major	quinonoid dihydropteridine reductase	0.0009	0.0027	0.0027
Brugia malayi	dehydrogenases, short chain protein 2	0.0009	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0027	0.0027
Onchocerca volvulus		0.0043	0.0475	0.2464
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0009	0.0027	0.0027
Onchocerca volvulus		0.0043	0.0475	0.2464
Schistosoma mansoni	carbonyl reductase	0.0009	0.0027	0.0027
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0116	0.0116
Leishmania major	quinonoid dihydropteridine reductase	0.0009	0.0027	0.0027
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0009	0.0027	0.0009
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0211	0.0211
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0009	0.0027	0.0027
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0009	0.0027	0.0027
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0074	0.0875	0.085
Giardia lamblia	Short-chain dehydrogenase, putative	0.0009	0.0027	0.1303
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0211	0.0193
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0211	0.0211
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0211	0.0211
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0009	0.0027	0.0027
Schistosoma mansoni	cpg binding protein	0.0037	0.0386	0.0386
Brugia malayi	oxidoreductase	0.0009	0.0027	0.0027
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0475	1
Echinococcus multilocularis	cpg binding protein	0.0037	0.0386	0.0368
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0027	0.0027
Leishmania major	hypothetical protein, conserved	0.0043	0.0475	0.0475
Giardia lamblia	Hypothetical protein	0.0009	0.0027	0.1303
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0211	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0475	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0475	0.0475
Loa Loa (eye worm)	dehydrogenase	0.0009	0.0027	0.0027
Trypanosoma brucei	DNA polymerase eta, putative	0.0023	0.0211	0.0211
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Echinococcus multilocularis	steroid dehydrogenase	0.0009	0.0027	0.0009
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0027	0.0413
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0475	0.0449
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0009	0.0027	0.0027
Echinococcus multilocularis	dihydrofolate reductase	0.077	1	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0211	0.0184
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0027	0.0027
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0211	0.0211
Mycobacterium ulcerans	oxidoreductase	0.0009	0.0027	0.0027
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0009	0.0027	0.0413
Trypanosoma brucei	oxidoreductase-like protein	0.0009	0.0027	0.0027
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	short-chain dehydrogenase	0.0009	0.0027	0.0027
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0046	0.0046
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0475	0.0449
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0.0027	0.0027
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.077	1	1
Mycobacterium ulcerans	ketoacyl reductase	0.0009	0.0027	0.0027
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0475	0.0475
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.077	1	1
Leishmania major	short chain dehydrogenase-like protein	0.0009	0.0027	0.0027
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.0027	0.0027
Leishmania major	quinonoid dihydropteridine reductase	0.0009	0.0027	0.0027
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0.0027	0.0027
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0475	0.0458
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0.0027	0.0027
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.0027	0.0413
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.077	1	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0074	0.0875	0.0875
Echinococcus multilocularis	carbonyl reductase 1	0.0009	0.0027	0.0009
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0074	0.0875	0.0858
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0009	0.0027	0.0027
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0027	0.0027
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0009	0.0027	0.0413
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0009	0.0027	0.0027
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0211	0.0211
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0211	0.0211
Trichomonas vaginalis	DNA polymerase eta, putative	0.0023	0.0211	0.4337
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0009	0.0027	0.0009

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.5623 um	PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ]	ChEMBL.	No reference
Potency (functional)	= 1.4125 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))]	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	= 17.7828 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ]	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1444201
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 782523