Detailed information for compound 782546

Basic information

Technical information
  • TDR Targets ID: 782546
  • Name: N-[4-(propylcarbamoyl)phenyl]oxolane-2-carbox amide
  • MW: 276.331 | Formula: C15H20N2O3
  • H donors: 2 H acceptors: 2 LogP: 1.68 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNC(=O)c1ccc(cc1)NC(=O)C1CCCO1
  • InChi: 1S/C15H20N2O3/c1-2-9-16-14(18)11-5-7-12(8-6-11)17-15(19)13-4-3-10-20-13/h5-8,13H,2-4,9-10H2,1H3,(H,16,18)(H,17,19)
  • InChiKey: BVZPSFHIKRXZDJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-(propylcarbamoyl)phenyl]tetrahydrofuran-2-carboxamide
  • N-[4-(oxo-propylaminomethyl)phenyl]-2-tetrahydrofurancarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0283 0.0818
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0283 0.0818
Trypanosoma brucei unspecified product 0.0015 0.0018 0.0021
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0283 0.0277
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0133 0.0126
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0296 0.029
Onchocerca volvulus 0.0099 0.1023 0.2348
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0018 0.0021
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0097 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0296 0.0953
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0444 0.0457
Echinococcus multilocularis epidermal growth factor receptor 0.0818 0.9587 0.9587
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0283 0.0968
Loa Loa (eye worm) hypothetical protein 0.0161 0.1761 0.1837
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0296 0.0297
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0062
Brugia malayi beta-lactamase family protein 0.0037 0.0283 0.0283
Schistosoma mansoni hypothetical protein 0.007 0.0677 0.0691
Echinococcus multilocularis GPCR, family 2 0.0032 0.0229 0.0223
Echinococcus multilocularis dihydrofolate reductase 0.0265 0.2995 0.2991
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0265 0.2995 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0051 0.0447 0.0441
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0133 0.0249
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0068 0.0092
Schistosoma mansoni alpha-glucosidase 0.0147 0.16 0.1655
Loa Loa (eye worm) hypothetical protein 0.0021 0.0097 0.0101
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0133 0.031
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.1884 0.1955
Schistosoma mansoni alpha-glucosidase 0.0147 0.16 0.1655
Loa Loa (eye worm) hypothetical protein 0.0123 0.1309 0.1366
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0444 0.0448
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0133 0.0249
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0444 0.0438
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0584 0.1788
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0019 0.0071 0.0065
Echinococcus granulosus dihydrofolate reductase 0.0265 0.2995 0.312
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0097 0.0285
Echinococcus granulosus dna polymerase kappa 0.0021 0.0097 0.0095
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0755 0.0787
Brugia malayi Bromodomain containing protein 0.0064 0.0601 0.0616
Loa Loa (eye worm) MH2 domain-containing protein 0.0101 0.105 0.1095
Mycobacterium ulcerans hypothetical protein 0.0024 0.0133 0.0249
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0296 0.0863
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0296 0.1016
Echinococcus granulosus intermediate filament protein 0.0028 0.0181 0.0182
Trypanosoma brucei unspecified product 0.0015 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0376 0.4321 0.4507
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0296 0.1016
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0229 0.0239
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0265 0.2995 1
Echinococcus multilocularis microtubule associated protein 2 0.0585 0.6819 0.6817
Trypanosoma brucei glucosidase, putative 0.0038 0.0296 0.0953
Brugia malayi hypothetical protein 0.0159 0.1736 0.1801
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0283 0.0968
Mycobacterium tuberculosis Conserved protein 0.0037 0.0283 0.0818
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0097 0.0285
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0018 0.0021
Echinococcus granulosus epidermal growth factor receptor 0.0439 0.5078 0.5294
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0097 0.0285
Trichomonas vaginalis set domain proteins, putative 0.0249 0.281 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0283 0.0295
Loa Loa (eye worm) hypothetical protein 0.0033 0.0231 0.0241
Echinococcus multilocularis survival motor neuron protein 1 0.0746 0.8737 0.8736
Loa Loa (eye worm) hypothetical protein 0.0159 0.1736 0.1811
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0283 0.0968
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0389 0.04
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0444 0.0438
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0133 0.0405
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0097 0.0285
Brugia malayi RNA binding protein 0.0076 0.0755 0.0776
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0283 0.0818
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0097 0.0285
Brugia malayi Pre-SET motif family protein 0.0031 0.0217 0.0214
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0389 0.0391
Brugia malayi isocitrate dehydrogenase 0.0017 0.0041 0.0031
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0014 0.0016 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0217 0.0211
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0097 0.0304
Loa Loa (eye worm) hypothetical protein 0.0037 0.0283 0.0295
Echinococcus granulosus epidermal growth factor receptor 0.0818 0.9587 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0584 0.0604
Brugia malayi intermediate filament protein 0.0028 0.0181 0.0177
Onchocerca volvulus 0.0031 0.0217 0.0476
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0097 0.0285
Schistosoma mansoni tyrosine kinase 0.0435 0.5023 0.5232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0444 0.0448
Loa Loa (eye worm) dihydrofolate reductase 0.0265 0.2995 0.3124
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0584 0.0594
Loa Loa (eye worm) hypothetical protein 0.007 0.0677 0.0706
Schistosoma mansoni tyrosine kinase 0.0435 0.5023 0.5232
Mycobacterium tuberculosis Conserved protein 0.0037 0.0283 0.0818
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0024 0.0013
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0097 0.0089
Schistosoma mansoni hypothetical protein 0.0032 0.0229 0.0223
Mycobacterium ulcerans beta-lactamase 0.0037 0.0283 0.0761
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0133 0.0249
Schistosoma mansoni ap endonuclease 0.0019 0.0068 0.0055
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0181 0.0177
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0677 0.0694
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0294 0.0291
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0097 0.0285
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0444 0.0448
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0041 0.0035
Echinococcus granulosus muscleblind protein 0.0161 0.1761 0.1832
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0097 0.0189
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0062
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.1884 0.1879
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.0266
Onchocerca volvulus 0.0028 0.0181 0.0393
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0097 0.0285
Echinococcus multilocularis lamin dm0 0.0028 0.0181 0.0175
Brugia malayi dihydrofolate reductase family protein 0.0265 0.2995 0.3116
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0041 0.0035
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0283 0.0818
Leishmania major hypothetical protein, conserved 0.0037 0.0283 0.0908
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0584 0.1919
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0265 0.2995 1
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0283 0.0818
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0097 0.0285
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0203 0.0206
Onchocerca volvulus Huntingtin homolog 0.0123 0.1309 0.3012
Entamoeba histolytica hypothetical protein 0.0038 0.0294 0.9923
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0018 0.0021
Brugia malayi beta-lactamase 0.0037 0.0283 0.0283
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0041 0.0035
Echinococcus multilocularis geminin 0.0178 0.1966 0.1961
Onchocerca volvulus 0.0159 0.1736 0.4001
Loa Loa (eye worm) hypothetical protein 0.0746 0.8737 0.9113
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0283 0.0818
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0296 0.0309
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0068 0.0065
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0133 0.0249
Chlamydia trachomatis dihydrofolate reductase 0.0265 0.2995 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0068 0.0092
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0068 0.003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0283 0.0295
Echinococcus multilocularis X box binding protein 1 0.0244 0.2756 0.2751
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0283 0.0289
Onchocerca volvulus 0.0028 0.0181 0.0393
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0068 0.0202
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0584 0.1788
Schistosoma mansoni tyrosine kinase 0.0261 0.2957 0.3073
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0217 0.0211
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0048 0.0022
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0041 0.0043
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0296 0.0302
Schistosoma mansoni lozenge 0.0047 0.0405 0.0407
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0283 0.0968
Schistosoma mansoni tyrosine kinase 0.0439 0.5078 0.529
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0755 0.0772
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0041 0.0098
Schistosoma mansoni alpha glucosidase 0.0038 0.0296 0.0293
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0283 0.0524
Loa Loa (eye worm) transcription factor SMAD2 0.0101 0.105 0.1095
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0133 0.0249
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.2651 0.8836
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0133 0.031
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0041 0.0035
Brugia malayi hypothetical protein 0.0376 0.4321 0.45
Echinococcus granulosus survival motor neuron protein 1 0.0746 0.8737 0.9113
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0283 0.0279
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0097 0.299
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0294 0.0288
Loa Loa (eye worm) hypothetical protein 0.0024 0.0133 0.0138
Echinococcus multilocularis 0.0253 0.2859 0.2855
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0296 0.1016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0048 0.0022
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.003 0.0206 0.0209
Schistosoma mansoni dihydrofolate reductase 0.0265 0.2995 0.3113
Loa Loa (eye worm) hypothetical protein 0.0046 0.0389 0.0406
Brugia malayi Dihydrofolate reductase 0.0265 0.2995 0.3116
Loa Loa (eye worm) hypothetical protein 0.0036 0.0274 0.0286
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0755 0.0776
Leishmania major DNA polymerase kappa, putative 0.0021 0.0097 0.0285
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0097 0.0089
Brugia malayi hypothetical protein 0.0123 0.1309 0.1355
Echinococcus granulosus tar DNA binding protein 0.0076 0.0755 0.0781
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0296 0.1016
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0283 0.0818
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0181 0.0189
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0283 0.0968
Schistosoma mansoni hypothetical protein 0.0152 0.1657 0.1715
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0041 0.0098
Entamoeba histolytica hypothetical protein 0.0038 0.0294 0.9923
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0181 0.0189
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0133 0.0126
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0041 0.0098
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0296 0.0953
Schistosoma mansoni hypothetical protein 0.0038 0.0294 0.0291
Trypanosoma brucei unspecified product 0.0021 0.0097 0.0285
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.1884 0.196
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0051 0.0447 0.046
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0041 0.0027
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0265 0.2995 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0062
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0097 0.0095
Onchocerca volvulus 0.0249 0.281 0.6494
Schistosoma mansoni DNA polymerase eta 0.0021 0.0097 0.0085
Loa Loa (eye worm) hypothetical protein 0.0024 0.0133 0.0138
Echinococcus multilocularis lamin 0.0028 0.0181 0.0175
Echinococcus multilocularis musashi 0.0028 0.0181 0.0175
Loa Loa (eye worm) hypothetical protein 0.0123 0.1309 0.1366
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0048 0.0022
Echinococcus granulosus insulin receptor 0.0261 0.2957 0.308
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.1884 0.1965
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0755 0.0772
Echinococcus granulosus lamin dm0 0.0028 0.0181 0.0182
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0229 0.0227
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0097 0.0091
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.1063 0.1108
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0041 0.0036
Trichomonas vaginalis esterase, putative 0.0037 0.0283 0.0968
Schistosoma mansoni tyrosine kinase 0.0818 0.9587 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0261 0.2957 0.3084
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Schistosoma mansoni tyrosine kinase 0.0439 0.5078 0.529
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0133 0.0249
Brugia malayi hypothetical protein 0.0038 0.0294 0.0294
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0133 0.4251
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0755 0.0772
Schistosoma mansoni hypothetical protein 0.0018 0.0052 0.0038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.245 0.2556
Loa Loa (eye worm) hypothetical protein 0.0161 0.1761 0.1837
Entamoeba histolytica hypothetical protein 0.0038 0.0294 0.9923
Plasmodium vivax SET domain protein, putative 0.0031 0.0217 0.0596
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0097 0.0091
Loa Loa (eye worm) hypothetical protein 0.0037 0.0283 0.0295
Brugia malayi Furin-like cysteine rich region family protein 0.0818 0.9587 1
Schistosoma mansoni tyrosine kinase 0.0435 0.5023 0.5232
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0296 0.1016
Toxoplasma gondii ABC1 family protein 0.0037 0.0283 0.0818
Echinococcus granulosus microtubule associated protein 2 0.0585 0.6819 0.7111
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0261 0.2957 0.2952
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0041 0.0098
Mycobacterium ulcerans lipase LipD 0.0037 0.0283 0.0761
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0097 0.0285
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0068 0.5
Schistosoma mansoni lamin 0.0028 0.0181 0.0173
Echinococcus granulosus geminin 0.0178 0.1966 0.2045
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0296 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0444 0.0457
Schistosoma mansoni lamin 0.0028 0.0181 0.0173
Echinococcus granulosus fetal alzheimer antigen falz 0.0019 0.0071 0.0068
Echinococcus granulosus lamin 0.0028 0.0181 0.0182
Loa Loa (eye worm) hypothetical protein 0.0028 0.0181 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0296 0.0953
Onchocerca volvulus 0.0037 0.0283 0.0629
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0283 0.0818
Schistosoma mansoni ap endonuclease 0.0019 0.0068 0.0055
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0265 0.2995 1
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0283 0.0761
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0265 0.2995 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0068 0.0059
Brugia malayi TAR-binding protein 0.0076 0.0755 0.0776
Schistosoma mansoni hypothetical protein 0.0032 0.0229 0.0223
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0097 0.0285
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0097 0.0285
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0294 0.03
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0068 0.1986
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0283 0.0761
Schistosoma mansoni hypothetical protein 0.0244 0.2756 0.2863
Echinococcus granulosus methyl CpG binding domain protein 2 0.0014 0.0016 0.001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.003 0.0206 0.02
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0068 0.0092
Onchocerca volvulus Huntingtin homolog 0.0123 0.1309 0.3012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0584 0.1788
Schistosoma mansoni tyrosine kinase 0.0261 0.2957 0.3073
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0229 0.0223
Echinococcus granulosus zinc finger protein 0.0017 0.0041 0.0036
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0584 0.0594
Giardia lamblia DINP protein human, muc B family 0.0021 0.0097 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0097 0.0285
Schistosoma mansoni bromodomain containing protein 0.0054 0.0483 0.0488
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0265 0.2995 1
Brugia malayi Bromodomain containing protein 0.0032 0.023 0.0228
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0068 0.0202
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0059 0.0062
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0296 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0265 0.2995 1
Onchocerca volvulus 0.0037 0.0283 0.0629
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0229 0.0233
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0097 0.0127
Loa Loa (eye worm) hypothetical protein 0.0024 0.0133 0.0138
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0097 0.0285
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0068 0.0189
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0041 0.0035
Echinococcus granulosus GPCR family 2 0.0032 0.0229 0.0233
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0097 0.0127
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0584 0.0579
Entamoeba histolytica hypothetical protein 0.0038 0.0294 0.9923
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0283 0.0908
Loa Loa (eye worm) runx1 0.0047 0.0405 0.0422
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0217 0.0211
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0041 0.0031
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0444 0.0463
Schistosoma mansoni hypothetical protein 0.0178 0.1966 0.2037
Mycobacterium leprae Probable lipase LipE 0.0037 0.0283 0.0524
Echinococcus multilocularis dna polymerase eta 0.0021 0.0097 0.0091
Echinococcus multilocularis muscleblind protein 0.0161 0.1761 0.1756
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.1063 0.1097
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0068 0.0071
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0133 0.0405
Loa Loa (eye worm) RNA binding protein 0.0076 0.0755 0.0787
Schistosoma mansoni hypothetical protein 0.0032 0.0229 0.0223
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0068 0.0062
Toxoplasma gondii exonuclease III APE 0.0019 0.0068 0.0092
Leishmania major DNA polymerase eta, putative 0.0021 0.0097 0.0285
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0755 0.0772
Loa Loa (eye worm) hypothetical protein 0.0376 0.4321 0.4507
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0097 0.0285
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0584 0.1839
Loa Loa (eye worm) beta-lactamase 0.0037 0.0283 0.0295
Echinococcus multilocularis epidermal growth factor receptor 0.0439 0.5078 0.5075
Echinococcus multilocularis Protein lozenge 0.0047 0.0405 0.0399
Brugia malayi Muscleblind-like protein 0.0161 0.1761 0.1827
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0097 0.0085
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0265 0.2995 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0097 0.0285
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0097 0.0285
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0068 0.0189
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0041 0.0098
Onchocerca volvulus 0.0376 0.4321 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0024 0.0025
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0068 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0229 0.0233
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0028 0.0175 0.0182
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0133 0.4251
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0296 0.1016
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0097 0.0304
Schistosoma mansoni hypothetical protein 0.0032 0.0229 0.0223
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0097 0.0285
Brugia malayi beta-lactamase family protein 0.0037 0.0283 0.0283
Mycobacterium tuberculosis Conserved protein 0.0037 0.0283 0.0818
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0283 0.0279
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0389 0.0384
Echinococcus multilocularis insulin receptor 0.0261 0.2957 0.2952
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.1884 0.1879
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0048 0.0022
Loa Loa (eye worm) PHD-finger family protein 0.0018 0.0052 0.0054
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0439 0.5078 0.5294
Loa Loa (eye worm) hypothetical protein 0.0032 0.0229 0.0239
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0068 0.0189
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0152 0.1657 0.1718
Brugia malayi PHD-finger family protein 0.0021 0.0095 0.0087
Loa Loa (eye worm) bromodomain containing protein 0.0015 0.0022 0.0023
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0059 0.0062
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0062
Loa Loa (eye worm) TK/EGFR protein kinase 0.0818 0.9587 1
Schistosoma mansoni hypothetical protein 0.0178 0.1966 0.2037
Loa Loa (eye worm) hypothetical protein 0.0037 0.0283 0.0295
Loa Loa (eye worm) hypothetical protein 0.0037 0.0283 0.0295
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.1063 0.1097
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0133 0.0405
Schistosoma mansoni survival motor neuron protein 0.0152 0.1657 0.1715
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0444 0.0452
Brugia malayi Pre-SET motif family protein 0.0219 0.245 0.2546
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0283 0.0908
Echinococcus granulosus X box binding protein 1 0.0244 0.2756 0.287
Mycobacterium ulcerans hypothetical protein 0.0037 0.0283 0.0761
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0755 0.0787
Echinococcus multilocularis zinc finger protein 0.0017 0.0041 0.0035
Loa Loa (eye worm) hypothetical protein 0.006 0.0558 0.0582
Echinococcus granulosus dna polymerase eta 0.0021 0.0097 0.0095
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0283 0.0283
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0755 0.0749
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0389 0.0391
Schistosoma mansoni intermediate filament proteins 0.0028 0.0181 0.0173
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0584 0.1839
Loa Loa (eye worm) hypothetical protein 0.0102 0.1063 0.1108
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0019 0.0071 0.0058
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0133 0.4251
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0296 0.1016
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0296 0.1016
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0097 0.0101
Brugia malayi MH2 domain containing protein 0.0101 0.105 0.1084
Brugia malayi hypothetical protein 0.0746 0.8737 0.9112
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0068 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0097 0.0285
Loa Loa (eye worm) hypothetical protein 0.0037 0.0283 0.0295
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0097 0.0285
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0097 0.0189
Onchocerca volvulus 0.0037 0.0283 0.0629
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0296 0.1016
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0283 0.0908
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0133 0.0249
Echinococcus multilocularis muscleblind protein 1 0.0161 0.1761 0.1756
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0261 0.2957 0.308
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0229 0.0227
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0062
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0059 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0755 0.0772
Onchocerca volvulus 0.0152 0.1657 0.3819
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0229 0.0223
Schistosoma mansoni zinc finger protein 0.0017 0.0041 0.0027
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0217 0.0596
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0133 0.0126
Onchocerca volvulus 0.0024 0.0133 0.028
Schistosoma mansoni microtubule-associated protein tau 0.0585 0.6819 0.7108
Brugia malayi Protein kinase domain containing protein 0.0261 0.2957 0.3076

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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