Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0015 | 0.0088 | 0.0088 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0015 | 0.0088 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0016 | 0.0016 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0265 | 0.3359 | 0.508 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0514 | 0.6612 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0514 | 0.6612 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0015 | 0.0088 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Echinococcus granulosus | protein kinase C gamma type | 0.0265 | 0.3359 | 0.508 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0015 | 0.0088 | 0.0133 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0514 | 0.6612 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0508 | 0.6538 | 0.9887 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0015 | 0.0088 | 0.0088 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0015 | 0.0088 | 0.0133 |
Schistosoma mansoni | nAChR subunit | 0.0015 | 0.0088 | 0.0133 |
Onchocerca volvulus | 0.0015 | 0.0088 | 1 | |
Echinococcus multilocularis | serine threonine protein kinase | 0.0265 | 0.3359 | 0.508 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0514 | 0.6612 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0773 | 1 | 1 |
Echinococcus granulosus | nAChR subunit | 0.0015 | 0.0088 | 0.0133 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.0064 | 0.0064 |
Trichomonas vaginalis | AGC family protein kinase | 0.0265 | 0.3359 | 0.0111 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0015 | 0.0088 | 0.0088 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0265 | 0.3359 | 0.508 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0265 | 0.3359 | 0.508 |
Brugia malayi | protein kinase C II. | 0.0265 | 0.3359 | 0.3359 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Entamoeba histolytica | protein kinase, putative | 0.0773 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0773 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0773 | 1 | 1 |
Toxoplasma gondii | AGC kinase | 0.0773 | 1 | 0.5 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0514 | 0.6612 | 0.6612 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0015 | 0.0088 | 0.0133 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.0064 | 0.0064 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0015 | 0.0088 | 0.0088 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0015 | 0.0088 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Brugia malayi | Protein kinase domain containing protein | 0.0265 | 0.3359 | 0.3359 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0015 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0265 | 0.3359 | 0.508 |
Schistosoma mansoni | nAChR subunit | 0.0015 | 0.0088 | 0.0133 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0773 | 1 | 1 |
Onchocerca volvulus | 0.0015 | 0.0088 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.0265 | 0.3359 | 0.3359 |
Loa Loa (eye worm) | ACC-1 protein | 0.0015 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0015 | 0.0088 | 0.0133 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0015 | 0.0088 | 0.0133 |
Entamoeba histolytica | protein kinase, putative | 0.0265 | 0.3359 | 0.3359 |
Echinococcus multilocularis | protein kinase c iota type | 0.0265 | 0.3359 | 0.508 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0514 | 0.6612 | 1 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0015 | 0.0088 | 0.0133 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0265 | 0.3359 | 0.508 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0265 | 0.3359 | 0.508 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0265 | 0.3359 | 0.508 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0265 | 0.3359 | 0.508 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0015 | 0.0088 | 0.0133 |
Leishmania major | cytochrome p450-like protein | 0.0013 | 0.0064 | 0.5 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0514 | 0.6612 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0265 | 0.3359 | 0.508 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0265 | 0.3359 | 0.508 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0514 | 0.6612 | 0.6612 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0064 | 0.0064 |
Onchocerca volvulus | 0.0015 | 0.0088 | 1 | |
Brugia malayi | Cation transporter family protein | 0.0015 | 0.0088 | 0.0088 |
Trichomonas vaginalis | AGC family protein kinase | 0.0265 | 0.3359 | 0.0111 |
Echinococcus granulosus | nervana 2 | 0.0508 | 0.6538 | 0.9887 |
Trichomonas vaginalis | AGC family protein kinase | 0.0773 | 1 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0015 | 0.0088 | 0.0088 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0514 | 0.6612 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0773 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0015 | 0.0088 | 0.0133 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0773 | 1 | 1 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0015 | 0.0088 | 0.0088 |
Brugia malayi | Cation transporter family protein | 0.0015 | 0.0088 | 0.0088 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0773 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0265 | 0.3359 | 0.3359 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0015 | 0.0088 | 0.0133 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0514 | 0.6612 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0015 | 0.0088 | 0.0133 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0265 | 0.3359 | 0.3359 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0015 | 0.0088 | 0.0088 |
Echinococcus granulosus | nervana 2 | 0.0508 | 0.6538 | 0.9887 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.3359 | 0.3359 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0265 | 0.3359 | 0.3359 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0015 | 0.0088 | 0.0133 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0265 | 0.3359 | 0.508 |
Trichomonas vaginalis | AGC family protein kinase | 0.0773 | 1 | 1 |
Onchocerca volvulus | 0.0015 | 0.0088 | 1 | |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0015 | 0.0088 | 0.0088 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0015 | 0.0088 | 0.0133 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0015 | 0.0088 | 0.0133 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0015 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | LGC-31 protein | 0.0015 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Schistosoma mansoni | nAChR subunit | 0.0015 | 0.0088 | 0.0133 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0015 | 0.0088 | 0.0088 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0015 | 0.0088 | 0.0133 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0265 | 0.3359 | 0.3359 |
Schistosoma mansoni | nAChR subunit | 0.0015 | 0.0088 | 0.0133 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0015 | 0.0088 | 0.0133 |
Echinococcus multilocularis | nervana 2 | 0.0508 | 0.6538 | 0.9887 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0015 | 0.0088 | 0.0088 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0265 | 0.3359 | 0.508 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0265 | 0.3359 | 0.508 |
Brugia malayi | Protein kinase domain containing protein | 0.0773 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0265 | 0.3359 | 0.508 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0015 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0514 | 0.6612 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0265 | 0.3359 | 0.508 |
Giardia lamblia | Kinase, AGC PKA | 0.0514 | 0.6612 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.0265 | 0.3359 | 0.508 |
Schistosoma mansoni | nAChR subunit | 0.0015 | 0.0088 | 0.0133 |
Trichomonas vaginalis | AGC family protein kinase | 0.0265 | 0.3359 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0015 | 0.0088 | 0.0088 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0015 | 0.0088 | 0.0133 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0015 | 0.0088 | 0.0088 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0015 | 0.0088 | 0.0088 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0015 | 0.0088 | 0.0088 |
Onchocerca volvulus | 0.0015 | 0.0088 | 1 | |
Schistosoma mansoni | nAChR subunit | 0.0015 | 0.0088 | 0.0133 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0508 | 0.6538 | 0.9887 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0015 | 0.0088 | 0.0088 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0265 | 0.3359 | 0.508 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Entamoeba histolytica | protein kinase, putative | 0.0773 | 1 | 1 |
Onchocerca volvulus | 0.0015 | 0.0088 | 1 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0015 | 0.0088 | 0.0088 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0508 | 0.6538 | 0.9887 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0015 | 0.0088 | 0.0088 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0015 | 0.0088 | 0.0133 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0015 | 0.0088 | 0.0133 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0514 | 0.6612 | 1 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0015 | 0.0088 | 0.0133 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0015 | 0.0088 | 0.0088 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0015 | 0.0088 | 0.0133 |
Trypanosoma cruzi | Protein kinase B | 0.0514 | 0.6612 | 1 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0015 | 0.0088 | 0.0133 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0508 | 0.6538 | 0.9887 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0265 | 0.3359 | 0.3359 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0015 | 0.0088 | 0.0133 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0015 | 0.0088 | 0.0133 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0015 | 0.0088 | 0.0133 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0015 | 0.0088 | 0.0133 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0015 | 0.0088 | 0.0133 |
Schistosoma mansoni | nAChR subunit | 0.0015 | 0.0088 | 0.0133 |
Trichomonas vaginalis | AGC family protein kinase | 0.0265 | 0.3359 | 0.0111 |
Trichomonas vaginalis | AGC family protein kinase | 0.0773 | 1 | 1 |
Entamoeba histolytica | protein kinase 2, putative | 0.0514 | 0.6612 | 0.6612 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Onchocerca volvulus | Putative nachr subunit | 0.0015 | 0.0088 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0265 | 0.3359 | 0.508 |
Echinococcus multilocularis | nervana 2 | 0.0508 | 0.6538 | 0.9887 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0265 | 0.3359 | 0.3359 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0265 | 0.3359 | 0.508 |
Echinococcus granulosus | NDR protein kinase | 0.0265 | 0.3359 | 0.508 |
Brugia malayi | Cation transporter family protein | 0.0015 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Brugia malayi | Hr1 repeat family protein | 0.0265 | 0.3359 | 0.3359 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0015 | 0.0088 | 0.0133 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0514 | 0.6612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Schistosoma mansoni | serine/threonine kinase | 0.0265 | 0.3359 | 0.508 |
Trichomonas vaginalis | AGC family protein kinase | 0.0773 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0088 | 0.0088 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0015 | 0.0088 | 0.0088 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0015 | 0.0088 | 0.0133 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0265 | 0.3359 | 0.508 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0265 | 0.3359 | 0.508 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0015 | 0.0088 | 0.0088 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0013 | 0.0064 | 0.5 |
Loa Loa (eye worm) | ACC-1 protein | 0.0015 | 0.0088 | 0.0088 |
Echinococcus multilocularis | nAChR subunit | 0.0015 | 0.0088 | 0.0133 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0064 | 0.0064 |
Schistosoma mansoni | atypical protein kinase C | 0.0265 | 0.3359 | 0.508 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0265 | 0.3359 | 0.508 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.