Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | pantothenate kinase, putative | 0.0087 | 0.4887 | 1 |
Schistosoma mansoni | pantothenate kinase | 0.0087 | 0.4887 | 0.5739 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0314 | 0.0314 |
Toxoplasma gondii | pantothenate kinase | 0.0037 | 0.1682 | 0.0181 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0314 | 0.0314 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0314 | 0.0314 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0014 | 0.022 | 0.0399 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1623 | 0.3007 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.1384 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0314 | 0.0314 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0314 | 0.0369 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.1623 | 0.5 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0037 | 0.1704 | 0.1704 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.1704 | 0.3181 |
Loa Loa (eye worm) | RNA binding protein | 0.0123 | 0.7191 | 0.7191 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0037 | 0.1704 | 0.3181 |
Loa Loa (eye worm) | TAR-binding protein | 0.0123 | 0.7191 | 0.7191 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.7151 | 0.7151 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.2422 | 0.2422 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.7151 | 0.7151 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.0087 | 0.4887 | 1 |
Trypanosoma brucei | pantothenate kinase subunit, putative | 0.0087 | 0.4887 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.1623 | 0.3007 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.1623 | 0.1623 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0167 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.1623 | 0.1906 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0314 | 0.0369 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0087 | 0.4887 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1446 | 0.1446 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1446 | 0.1446 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.7191 | 0.8445 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.2422 | 0.2422 |
Trypanosoma brucei | glucosidase, putative | 0.0037 | 0.1704 | 0.3181 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0037 | 0.1704 | 0.3181 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0314 | 0.0369 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0314 | 0.0314 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.1623 | 0.3007 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.1704 | 0.3181 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1623 | 0.3007 |
Plasmodium falciparum | pantothenate kinase 1, putative | 0.0087 | 0.4887 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0014 | 0.022 | 0.022 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.7151 | 0.7151 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.1384 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.022 | 0.022 |
Schistosoma mansoni | alpha glucosidase | 0.0037 | 0.1704 | 0.2002 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0037 | 0.1704 | 0.3181 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0167 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0123 | 0.7191 | 0.7191 |
Schistosoma mansoni | alpha-glucosidase | 0.0144 | 0.8515 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.7191 | 0.8445 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0123 | 0.7191 | 0.7191 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0087 | 0.4887 | 1 |
Giardia lamblia | Pantothenate kinase 4 | 0.0087 | 0.4887 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0123 | 0.7191 | 0.7191 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.1623 | 0.1906 |
Leishmania major | pantothenate kinase subunit, putative | 0.0087 | 0.4887 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1446 | 0.1699 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0047 | 0.2356 | 0.2356 |
Onchocerca volvulus | 0.0096 | 0.5505 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2422 | 0.2422 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.1704 | 0.3181 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.2422 | 0.2422 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.1623 | 0.3007 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0037 | 0.1704 | 0.1704 |
Loa Loa (eye worm) | pantothenate kinase | 0.0087 | 0.4887 | 0.4887 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0314 | 0.0314 |
Echinococcus multilocularis | pantothenate kinase 4 | 0.0087 | 0.4887 | 0.4887 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.1704 | 0.3181 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.1704 | 0.3181 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.1623 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0047 | 0.2356 | 0.2356 |
Entamoeba histolytica | pantothenate kinase 1, putative | 0.0087 | 0.4887 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0123 | 0.7191 | 0.7191 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.1623 | 0.1623 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0087 | 0.4887 | 1 |
Brugia malayi | pantothenate kinase family protein | 0.0087 | 0.4887 | 0.4887 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.1704 | 0.3181 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.1704 | 0.3181 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.7191 | 0.8445 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.7191 | 0.8445 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.7191 | 0.8445 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0087 | 0.4887 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1623 | 0.3007 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1623 | 0.3007 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0037 | 0.1704 | 0.1704 |
Brugia malayi | RNA binding protein | 0.0123 | 0.7191 | 0.7191 |
Plasmodium vivax | pantothenate kinase, putative | 0.0087 | 0.4887 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.1623 | 0.3007 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0314 | 0.0369 |
Echinococcus granulosus | pantothenate kinase 4 | 0.0087 | 0.4887 | 0.4887 |
Onchocerca volvulus | Fumble homolog | 0.0087 | 0.4887 | 0.8878 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.1704 | 0.3181 |
Brugia malayi | TAR-binding protein | 0.0123 | 0.7191 | 0.7191 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0314 | 0.0314 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0167 | 1 | 1 |
Schistosoma mansoni | pantothenate kinase | 0.0087 | 0.4887 | 0.5739 |
Brugia malayi | Inositol-1 | 0.0036 | 0.1623 | 0.1623 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.1704 | 0.3181 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0314 | 0.0314 |
Toxoplasma gondii | fumble protein | 0.0087 | 0.4887 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0037 | 0.1704 | 0.0249 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.1623 | 0.1623 |
Schistosoma mansoni | alpha-glucosidase | 0.0144 | 0.8515 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0314 | 0.0314 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0037 | 0.1704 | 0.1704 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0.2543 | 0.4979 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.1704 | 0.3181 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0314 | 0.0314 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.0087 | 0.4887 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.1704 | 0.3181 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.