Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Saccharomyces cerevisiae | dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydrofolate reductase | 0.0676 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.0956 | 0.0956 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.0956 | 0.0956 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0676 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0676 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0676 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5777 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5777 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.0956 | 0.0956 |
Echinococcus granulosus | dihydrofolate reductase | 0.0676 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5777 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0676 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5777 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0676 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0421 | 0.5777 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0676 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.0956 | 0.0956 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0676 | 1 | 1 |
Onchocerca volvulus | 0.013 | 0.0956 | 0.5 | |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.0956 | 0.0956 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5777 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.6778 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 7.301 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 7.602 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.025 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 0.025 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 0.05 uM | Inhibitory activity against rat liver dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 0.05 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.05 uM | Inhibitory activity against rat liver dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 0.05 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.21 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 0.21 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.21 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. | ChEMBL. | 8627607 |
IC50 (binding) | = 0.21 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.25 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 0.25 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 6.6778 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 7.301 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 7.6021 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
Selectivity (binding) | = 0.24 | Ratio of inhibitory concentration of rat liver and Pneumocystis carinii DHFR. | ChEMBL. | 8627607 |
Selectivity (binding) | = 2 | Ratio of inhibitory concentration of rat liver and Toxoplasma gondii DHFR | ChEMBL. | 8627607 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.