Detailed information for compound 783761

Basic information

Technical information
  • TDR Targets ID: 783761
  • Name: N-(2-ethylphenyl)-3-(2-oxo-1,3-benzothiazol-3 -yl)propanamide
  • MW: 326.413 | Formula: C18H18N2O2S
  • H donors: 1 H acceptors: 2 LogP: 3.46 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccccc1NC(=O)CCn1c(=O)sc2c1cccc2
  • InChi: 1S/C18H18N2O2S/c1-2-13-7-3-4-8-14(13)19-17(21)11-12-20-15-9-5-6-10-16(15)23-18(20)22/h3-10H,2,11-12H2,1H3,(H,19,21)
  • InChiKey: DXSZENFBRGUBRK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-ethylphenyl)-3-(2-keto-1,3-benzothiazol-3-yl)propionamide
  • ZINC00245991
  • IDI1_027597
  • T5456777
  • ChemDiv3_009687

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0078 0.3736 0.3703
Schistosoma mansoni tar DNA-binding protein 0.0123 0.7479 0.7465
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0078 0.3736 0.48
Brugia malayi Inositol-1 0.0036 0.0281 0.023
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Schistosoma mansoni inositol monophosphatase 0.0036 0.0281 0.023
Entamoeba histolytica pantothenate kinase 1, putative 0.0077 0.3653 0.6607
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0098 0.5385 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0047 0.1192 0.1145
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.1314 0.1268
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0078 0.3736 0.3703
Brugia malayi TAR-binding protein 0.0123 0.7479 0.7465
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Loa Loa (eye worm) GABA receptor subunit 0.0047 0.1192 0.1145
Echinococcus granulosus glycine receptor subunit beta 0.0078 0.3736 0.48
Schistosoma mansoni rotamase 0.01 0.558 0.5556
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0098 0.5385 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0078 0.3736 0.48
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0078 0.3736 0.48
Onchocerca volvulus 0.0153 1 1
Giardia lamblia Pantothenate kinase 4 0.0077 0.3653 0.5
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0078 0.3736 0.3703
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.01 0.558 0.5556
Onchocerca volvulus 0.0078 0.3736 0.2889
Schistosoma mansoni nAChR subunit 0.0078 0.3736 0.3703
Onchocerca volvulus 0.0153 1 1
Toxoplasma gondii fumble protein 0.0077 0.3653 0.6784
Brugia malayi Cation transporter family protein 0.0078 0.3736 0.3703
Echinococcus multilocularis nAChR subunit 0.0047 0.1192 0.1265
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0078 0.3736 0.48
Echinococcus granulosus glycine receptor subunit beta 0.0078 0.3736 0.48
Trichomonas vaginalis pantothenate kinase, putative 0.0077 0.3653 0.6364
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0078 0.3736 0.3703
Echinococcus granulosus glycine receptor subunit alpha 1 0.0078 0.3736 0.48
Plasmodium vivax pantothenate kinase, putative 0.0077 0.3653 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0078 0.3736 0.3703
Loa Loa (eye worm) hypothetical protein 0.0047 0.1192 0.1145
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0078 0.3736 0.48
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0078 0.3736 0.3703
Trichomonas vaginalis pantothenate kinase, putative 0.0077 0.3653 0.6364
Plasmodium falciparum pantothenate kinase 1, putative 0.0077 0.3653 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0078 0.3736 0.3703
Echinococcus granulosus glycine receptor subunit alpha 1 0.0078 0.3736 0.48
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0078 0.3736 0.3703
Echinococcus multilocularis expressed protein 0.01 0.558 0.7361
Trypanosoma brucei pantothenate kinase subunit, putative 0.0077 0.3653 0.6607
Schistosoma mansoni nAChR subunit 0.0078 0.3736 0.3703
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0078 0.3736 0.48
Entamoeba histolytica hypothetical protein 0.0047 0.1192 0.1784
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0078 0.3736 0.3703
Echinococcus granulosus expressed protein 0.01 0.558 0.7361
Schistosoma mansoni nAChR subunit 0.0078 0.3736 0.3703
Onchocerca volvulus Putative nachr subunit 0.0078 0.3736 0.2889
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0078 0.3736 0.48
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0078 0.3736 0.3703
Loa Loa (eye worm) hypothetical protein 0.0048 0.1314 0.1268
Echinococcus granulosus nAChR subunit 0.0078 0.3736 0.48
Loa Loa (eye worm) LGC-31 protein 0.0078 0.3736 0.3703
Loa Loa (eye worm) pantothenate kinase 0.0077 0.3653 0.362
Schistosoma mansoni tar DNA-binding protein 0.0123 0.7479 0.7465
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0078 0.3736 0.3703
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0047 0.1192 0.1145
Loa Loa (eye worm) hypothetical protein 0.0153 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0047 0.1192 0.1145
Loa Loa (eye worm) hypothetical protein 0.0047 0.1192 0.1145
Schistosoma mansoni tar DNA-binding protein 0.0123 0.7479 0.7465
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Trichomonas vaginalis conserved hypothetical protein 0.01 0.558 1
Onchocerca volvulus Fumble homolog 0.0077 0.3653 0.2795
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0098 0.5385 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0281 0.023
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0078 0.3736 0.3703
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.1192 0.1145
Loa Loa (eye worm) TAR-binding protein 0.0123 0.7479 0.7465
Schistosoma mansoni nAChR subunit 0.0078 0.3736 0.3703
Brugia malayi pantothenate kinase family protein 0.0077 0.3653 0.362
Loa Loa (eye worm) hypothetical protein 0.0047 0.1192 0.1145
Echinococcus multilocularis glycine receptor subunit beta 0.0078 0.3736 0.48
Onchocerca volvulus 0.0078 0.3736 0.2889
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.1314 0.1268
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0078 0.3736 0.48
Loa Loa (eye worm) hypothetical protein 0.0047 0.1192 0.1145
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0078 0.3736 0.48
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0047 0.1192 0.1145
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0982 0.1322
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0078 0.3736 0.48
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0078 0.3736 0.48
Loa Loa (eye worm) hypothetical protein 0.0047 0.1192 0.1145
Loa Loa (eye worm) RNA binding protein 0.0123 0.7479 0.7465
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0078 0.3736 0.3703
Trichomonas vaginalis rotamase, putative 0.01 0.558 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0098 0.5385 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0078 0.3736 0.48
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0153 1 1
Loa Loa (eye worm) ACC-1 protein 0.0078 0.3736 0.3703
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0078 0.3736 0.3703
Brugia malayi Cation transporter family protein 0.0078 0.3736 0.3703
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.1314 0.1268
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.01 0.558 0.5556
Loa Loa (eye worm) inositol-1 0.0036 0.0281 0.023
Trichomonas vaginalis pantothenate kinase, putative 0.0077 0.3653 0.6364
Loa Loa (eye worm) hypothetical protein 0.0123 0.7455 0.7442
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0078 0.3736 0.3703
Echinococcus granulosus pantothenate kinase 4 0.0077 0.3653 0.4685
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0078 0.3736 0.3703
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.1228 0.1182
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0078 0.3736 0.3703
Schistosoma mansoni nAChR subunit 0.0078 0.3736 0.3703
Loa Loa (eye worm) hypothetical protein 0.0153 1 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0281 0.5
Leishmania major pantothenate kinase subunit, putative 0.0077 0.3653 0.6607
Trichomonas vaginalis pantothenate kinase, putative 0.0077 0.3653 0.6364
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0078 0.3736 0.3703
Onchocerca volvulus 0.0153 1 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0078 0.3736 0.48
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0078 0.3736 0.3703
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0078 0.3736 0.3703
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0078 0.3736 0.3703
Schistosoma mansoni tar DNA-binding protein 0.0123 0.7479 0.7465
Echinococcus multilocularis tar DNA binding protein 0.0123 0.7479 1
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0077 0.3653 0.6607
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0047 0.1192 0.1145
Onchocerca volvulus 0.0078 0.3736 0.2889
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0078 0.3736 0.3703
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0077 0.3653 0.6607
Echinococcus multilocularis nAChR subunit 0.0078 0.3736 0.48
Schistosoma mansoni pantothenate kinase 0.0077 0.3653 0.362
Echinococcus granulosus glycine receptor subunit alpha 1 0.0078 0.3736 0.48
Echinococcus granulosus tar DNA binding protein 0.0123 0.7479 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0153 1 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0281 0.5
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0078 0.3736 0.48
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0281 0.0522
Schistosoma mansoni tar DNA-binding protein 0.0123 0.7479 0.7465
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0078 0.3736 0.3703
Loa Loa (eye worm) ACC-1 protein 0.0078 0.3736 0.3703
Schistosoma mansoni nAChR subunit 0.0078 0.3736 0.3703
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Brugia malayi excitatory GABA receptor EXP-1A 0.0078 0.3736 0.3703
Echinococcus granulosus nAChR subunit 0.0047 0.1192 0.1265
Schistosoma mansoni pantothenate kinase 0.0077 0.3653 0.362
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0078 0.3736 0.3703
Brugia malayi Cytochrome P450 family protein 0.0047 0.1228 0.1182
Toxoplasma gondii peptidylprolyl isomerase 0.0098 0.5385 1
Echinococcus multilocularis glycine receptor subunit beta 0.0078 0.3736 0.48
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0098 0.5385 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.1192 0.1145
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0078 0.3736 0.3703
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0047 0.1192 0.1145
Trichomonas vaginalis pantothenate kinase, putative 0.0077 0.3653 0.6364
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0078 0.3736 0.48
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.7479 0.7465
Loa Loa (eye worm) hypothetical protein 0.0047 0.1192 0.1145
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0078 0.3736 0.48
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0078 0.3736 0.3703
Schistosoma mansoni nAChR subunit 0.0078 0.3736 0.3703
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0078 0.3736 0.48
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Trichomonas vaginalis rotamase, putative 0.0098 0.5385 0.9633
Echinococcus multilocularis pantothenate kinase 4 0.0077 0.3653 0.4685
Loa Loa (eye worm) hypothetical protein 0.0047 0.1192 0.1145
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0078 0.3736 0.48
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.7479 0.7465
Brugia malayi RNA binding protein 0.0123 0.7479 0.7465
Loa Loa (eye worm) hypothetical protein 0.0078 0.3736 0.3703

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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