Detailed information for compound 783859

Basic information

Technical information
  • TDR Targets ID: 783859
  • Name: 2-[4-(4-chlorophenyl)piperazine-1-carbonyl]-5 -methylthieno[3,2-c]quinolin-4-one
  • MW: 437.942 | Formula: C23H20ClN3O2S
  • H donors: 0 H acceptors: 2 LogP: 4.37 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)N1CCN(CC1)C(=O)c1cc2c(s1)c1ccccc1n(c2=O)C
  • InChi: 1S/C23H20ClN3O2S/c1-25-19-5-3-2-4-17(19)21-18(22(25)28)14-20(30-21)23(29)27-12-10-26(11-13-27)16-8-6-15(24)7-9-16/h2-9,14H,10-13H2,1H3
  • InChiKey: SJKLOGFJAMSKGM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-(4-chlorophenyl)piperazine-1-carbonyl]-5-methyl-thieno[3,2-c]quinolin-4-one
  • 2-[[4-(4-chlorophenyl)-1-piperazinyl]-oxomethyl]-5-methyl-4-thieno[3,2-c]quinolinone
  • 2-[4-(4-chlorophenyl)piperazin-1-yl]carbonyl-5-methyl-thieno[3,2-c]quinolin-4-one
  • C498-0650
  • NCGC00108718-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis epidermal growth factor receptor 0.0158 0.0835 0.0835
Schistosoma mansoni DNA topoisomerase II 0.0322 0.1803 0.1803
Brugia malayi Probable DNA topoisomerase II 0.0322 0.1803 0.1803
Onchocerca volvulus 0.0028 0.0074 0.0118
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0085 0.0085
Brugia malayi DNA mismatch repair protein MutL containing protein 0.0023 0.0044 0.0044
Mycobacterium ulcerans DNA gyrase subunit B 0.0322 0.1803 0.1862
Trypanosoma brucei heat shock protein, putative 0.1715 1 1
Echinococcus granulosus epidermal growth factor receptor 0.0158 0.0835 0.0835
Schistosoma mansoni regulator of G protein signaling 0.002 0.0025 0.0025
Toxoplasma gondii DNA mismatch repair protein, C-terminal domain-containing protein 0.0023 0.0044 0.004
Plasmodium vivax hypothetical protein, conserved 0.0322 0.1803 0.18
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0185 0.0185
Schistosoma mansoni axis inhibition protein axin 0.002 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0128 0.0128
Brugia malayi PXA domain containing protein 0.002 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0355 0.1996 0.1996
Trichomonas vaginalis heat shock protein, putative 0.073 0.4203 0.4203
Brugia malayi intermediate filament protein 0.0028 0.0074 0.0074
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0062 0.0062
Leishmania major heat shock protein 83-1 0.1715 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0091 0.0091
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0322 0.1803 0.2135
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0004 0.0004
Entamoeba histolytica DNA topoisomerase II, putative 0.0322 0.1803 0.1782
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0185 0.0185
Echinococcus multilocularis lamin 0.0028 0.0074 0.0074
Leishmania major heat shock protein, putative 0.0844 0.4877 0.4877
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0185 0.0185
Brugia malayi hypothetical protein 0.0026 0.0062 0.0062
Entamoeba histolytica heat shock protein 90, putative 0.1715 1 1
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0322 0.1803 0.1862
Leishmania major heat shock protein 83-1 0.1715 1 1
Echinococcus granulosus expressed protein 0.0392 0.2215 0.2215
Schistosoma mansoni tyrosine kinase 0.0083 0.0397 0.0397
Leishmania major mitochondrial DNA topoisomerase II 0.0322 0.1803 0.1803
Trypanosoma cruzi heat shock protein 90, putative 0.1393 0.8104 0.8104
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0055 0.0055
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0322 0.1803 0.18
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0025 0.0025
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0025 0.0025
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0322 0.1803 0.2184
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0322 0.1803 0.3676
Mycobacterium ulcerans two component regulator - sensor kinase 0.0322 0.1803 0.1862
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0025 0.0025
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0322 0.1803 0.2184
Brugia malayi ecdysteroid receptor 0.0019 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0087 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0113 0.0113
Treponema pallidum heat shock protein 90 0.1416 0.8241 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0016 0.0016
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0016 0.0016
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0025 0.0025
Leishmania major hypothetical protein, conserved 0.0322 0.1803 0.1803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0016 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0091 0.0091
Onchocerca volvulus 0.0051 0.0205 0.0389
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0128 0.0128
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.029 0.1616 0.1906
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0025 0.0025
Plasmodium falciparum DNA mismatch repair protein PMS1, putative 0.0023 0.0044 0.004
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0025 0.0025
Schistosoma mansoni DNA mismatch repair protein PMS2 0.0023 0.0044 0.0044
Trypanosoma brucei heat shock protein, putative 0.1715 1 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0322 0.1803 0.3676
Brugia malayi steroid hormone receptor 0.0019 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0016 0.0016
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Trichomonas vaginalis receptor histidine kinase, putative 0.0322 0.1803 0.1803
Trypanosoma brucei heat shock protein, putative 0.1715 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0004 0.0004
Echinococcus multilocularis insulin receptor 0.0051 0.0208 0.0208
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0055 0.0055
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.3405 0.3405
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0322 0.1803 0.1803
Onchocerca volvulus 0.0028 0.0074 0.0118
Trypanosoma cruzi heat shock protein 85, putative 0.1715 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0016
Echinococcus multilocularis DNA mismatch repair protein Mlh1 0.0023 0.0044 0.0044
Giardia lamblia Grp94/Hsp90 0.1416 0.8241 0.8234
Echinococcus granulosus GPCR family 2 0.0016 0.0004 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0016 0.0016
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0004 0.0004
Schistosoma mansoni microrchidia 2a 0.0023 0.0044 0.0044
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0322 0.1803 0.1803
Trypanosoma brucei DNA topoisomerase ii 0.0322 0.1803 0.1803
Schistosoma mansoni pyruvate dehydrogenase 0.0322 0.1803 0.1803
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0055 0.0055
Echinococcus multilocularis transfer RNA-Lys 0.0072 0.033 0.033
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0062
Trypanosoma brucei Heat shock protein 83, putative 0.1715 1 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0055 0.0055
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0185 0.0185
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0055 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0016 0.0016
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0016 0.0016
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0322 0.1803 0.2184
Trichomonas vaginalis heat shock protein, putative 0.1715 1 1
Echinococcus multilocularis endoplasmin 0.1416 0.8241 0.8241
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0016 0.0016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0213 0.0213
Leishmania major heat shock protein 83-1 0.1715 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0016 0.0016
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0128 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0025
Echinococcus granulosus heat shock protein 0.1715 1 1
Plasmodium vivax DNA mismatch repair protein PMS1, putative 0.0023 0.0044 0.004
Trypanosoma brucei heat shock protein, putative 0.1715 1 1
Echinococcus granulosus axis inhibition protein axin 0.002 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0025
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0322 0.1803 0.2184
Trypanosoma cruzi DNA topoisomerase II, putative 0.0322 0.1803 0.1803
Echinococcus granulosus DNA mismatch repair protein Mlh1 0.0023 0.0044 0.0044
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0025 0.0025
Schistosoma mansoni tyrosine kinase 0.0051 0.0208 0.0208
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0322 0.1803 0.1803
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0016 0.0016
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0322 0.1803 0.2145
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0025 0.0025
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0051 0.0208 0.0208
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0016 0.0016
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0038 0.0038
Echinococcus granulosus lamin dm0 0.0028 0.0074 0.0074
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0016 0.0016
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0594 0.3405 0.3388
Schistosoma mansoni heat shock protein 0.1715 1 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.1715 1 1
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0322 0.1803 0.1803
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0051 0.0208 0.0208
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0057 0.0057
Trichomonas vaginalis set domain proteins, putative 0.0249 0.1371 0.1371
Brugia malayi isocitrate dehydrogenase 0.0016 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0016 0.0016
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.1416 0.8241 1
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0322 0.1803 0.1803
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.3405 0.3405
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0016 0.0016
Leishmania major heat shock protein 83-1 0.1715 1 1
Plasmodium falciparum DNA topoisomerase 2 0.0322 0.1803 0.18
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0025 0.0025
Schistosoma mansoni endoplasmin 0.1715 1 1
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0322 0.1803 0.1862
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0322 0.1803 0.1803
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0322 0.1803 0.1803
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0185 0.0185
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0062 0.0058
Brugia malayi nuclear receptor NHR-88 0.0019 0.0016 0.0016
Mycobacterium leprae Probable two-component sensor kinase 0.0322 0.1803 0.2135
Trichomonas vaginalis heat shock protein, putative 0.1416 0.8241 0.8241
Giardia lamblia GTOR 0.0047 0.0185 0.0141
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0091 0.0091
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Schistosoma mansoni DNA mismatch repair protein MLH1 0.0023 0.0044 0.0044
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.1369 0.1369
Trypanosoma cruzi heat shock protein 85, putative 0.1715 1 1
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0322 0.1803 0.1803
Plasmodium falciparum DNA gyrase subunit B 0.0322 0.1803 0.18
Echinococcus multilocularis heat shock protein 90 0.1715 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0113 0.0113
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0055 0.0055
Trichomonas vaginalis heat shock protein, putative 0.1416 0.8241 0.8241
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0128 0.0128
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0185 0.0185
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0026 0.0062 0.0062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.3405 0.3405
Schistosoma mansoni tyrosine kinase 0.0085 0.0408 0.0408
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0116 0.0116
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0091 0.0091
Chlamydia trachomatis DNA gyrase subunit B 0.0322 0.1803 0.9221
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0025 0.0025
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0322 0.1803 0.18
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0004
Onchocerca volvulus 0.0025 0.0055 0.0081
Schistosoma mansoni tyrosine kinase 0.0085 0.0408 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0057 0.0057
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0185 0.016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0073 0.0073
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0322 0.1803 0.2145
Echinococcus granulosus epidermal growth factor receptor 0.0085 0.0408 0.0408
Toxoplasma gondii DNA topoisomerase 2, putative 0.0322 0.1803 0.18
Echinococcus granulosus MORC family CW type zinc finger protein 2B 0.0023 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0355 0.1996 0.1996
Schistosoma mansoni heat shock protein 0.1715 1 1
Schistosoma mansoni single-minded 0.0097 0.0479 0.0479
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.1416 0.8241 0.8241
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.1194 0.1194
Schistosoma mansoni regulator of G protein signaling 0.002 0.0025 0.0025
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0055 0.0055
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0091 0.0091
Schistosoma mansoni tyrosine kinase 0.0083 0.0397 0.0397
Entamoeba histolytica DNA mismatch repair protein PMS1, putative 0.0023 0.0044 0.0019
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0004
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0322 0.1803 0.1803
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0016 0.0016
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0322 0.1803 0.1862
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0322 0.1803 0.1803
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.029 0.1616 0.1957
Loa Loa (eye worm) hypothetical protein 0.0322 0.1803 0.1803
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0185 0.0185
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0205 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0071 0.0071
Echinococcus multilocularis epidermal growth factor receptor 0.0085 0.0408 0.0408
Trypanosoma cruzi heat shock protein 90, putative 0.1715 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0016 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0062 0.0058
Schistosoma mansoni Microrchidia 2a 0.0023 0.0044 0.0044
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0091 0.0091
Echinococcus multilocularis heat shock protein 0.1715 1 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0025
Schistosoma mansoni lamin 0.0028 0.0074 0.0074
Echinococcus granulosus heat shock protein 90 0.1715 1 1
Plasmodium vivax DNA gyrase subunit B, putative 0.0322 0.1803 0.18
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0025
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.3405 0.3405
Loa Loa (eye worm) heat shock protein 90 0.1715 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0185 0.0185
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0052 0.0213 0.0213
Brugia malayi PAS domain containing protein 0.0097 0.0479 0.0479
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0594 0.3405 0.3388
Brugia malayi Hsp90 protein 0.0844 0.4877 0.4877
Toxoplasma gondii heat shock protein HSP90 0.1715 1 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0158 0.0835 0.0835
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0055 0.0055
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0322 0.1803 0.1803
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0322 0.1803 0.1803
Onchocerca volvulus 0.0031 0.0091 0.0155
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0025 0.0025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0025
Echinococcus multilocularis microtubule associated protein 2 0.0725 0.4173 0.4173
Leishmania major heat shock protein 83-1 0.1715 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0062 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0016 0.0016
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0322 0.1803 0.2145
Loa Loa (eye worm) hypothetical protein 0.0322 0.1803 0.1803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0073 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0057 0.0057
Echinococcus granulosus insulin receptor 0.0051 0.0208 0.0208
Loa Loa (eye worm) RGS-3 protein 0.002 0.0025 0.0025
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0322 0.1803 0.1803
Echinococcus multilocularis lamin dm0 0.0028 0.0074 0.0074
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.3405 0.3405
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0057 0.0057
Mycobacterium ulcerans heat shock protein 90 0.1416 0.8241 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0025
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0016 0.0016
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0025 0.0025
Trichomonas vaginalis heat shock protein, putative 0.1052 0.6099 0.6099
Leishmania major heat shock protein 83-1 0.1715 1 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0322 0.1803 0.3676
Loa Loa (eye worm) endoplasmin 0.1715 1 1
Leishmania major heat shock protein 83-1 0.1715 1 1
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0322 0.1803 0.18
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0322 0.1803 0.1803
Trypanosoma cruzi heat shock protein 90, putative 0.0985 0.5704 0.5704
Brugia malayi hypothetical protein 0.002 0.0025 0.0025
Leishmania major heat shock protein 83-1 0.1715 1 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0322 0.1803 0.2184
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0016 0.0016
Trypanosoma cruzi Heat shock protein 83, putative 0.1715 1 1
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0025 0.0025
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0322 0.1803 0.2184
Brugia malayi hypothetical protein 0.002 0.0025 0.0025
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0025 0.0025
Giardia lamblia Fructose-bisphosphate aldolase 0.0594 0.3405 0.3376
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0322 0.1803 0.2135
Echinococcus granulosus endoplasmin 0.1416 0.8241 0.8241
Toxoplasma gondii heat shock protein 75, putative 0.0844 0.4877 0.4875
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0185 0.016
Trypanosoma cruzi heat shock protein, putative 0.0844 0.4877 0.4877
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0016 0.0016
Brugia malayi hypothetical protein 0.0248 0.1369 0.1369
Trypanosoma cruzi mismatch repair protein MLH1, putative 0.0023 0.0044 0.0044
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0016 0.0016
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0322 0.1803 0.1803
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0016 0.0016
Schistosoma mansoni lamin 0.0028 0.0074 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0016 0.0016
Leishmania major heat shock protein 83-1 0.1715 1 1
Leishmania major DNA topoisomerase ii 0.0322 0.1803 0.1803
Echinococcus multilocularis MORC family CW type zinc finger protein 2B 0.0023 0.0044 0.0044
Schistosoma mansoni microtubule-associated protein tau 0.0725 0.4173 0.4173
Leishmania major developmentally regulated phosphoprotein-like protein 0.0322 0.1803 0.1803
Schistosoma mansoni hypothetical protein 0.0036 0.0116 0.0116
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0023 0.0044 0.0044
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0025 0.0025
Schistosoma mansoni endoplasmin 0.1715 1 1
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0322 0.1803 0.2145
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0016 0.0016
Echinococcus granulosus geminin 0.0355 0.1996 0.1996
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0322 0.1803 0.1803
Schistosoma mansoni coup transcription factor 0.0019 0.0016 0.0016
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0025 0.0025
Trypanosoma brucei heat shock protein 90, putative 0.1715 1 1
Toxoplasma gondii corepressor complex CRC230 0.0023 0.0044 0.004
Brugia malayi Protein kinase domain containing protein 0.0051 0.0208 0.0208
Schistosoma mansoni tyrosine kinase 0.0158 0.0835 0.0835
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0185 0.0185
Leishmania major protein kinase, putative 0.0025 0.0055 0.0055
Plasmodium vivax DNA mismatch repair protein MLH, putative 0.0023 0.0044 0.004
Trichomonas vaginalis endoplasmin, putative 0.1052 0.6099 0.6099
Mycobacterium ulcerans putative regultory protein 0.0322 0.1803 0.1862
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0025 0.0025
Echinococcus multilocularis expressed protein 0.0392 0.2215 0.2215
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0062 0.0058
Brugia malayi bHLH-PAS transcription factor 0.0072 0.033 0.033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0113 0.0113
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0322 0.1803 0.18
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.3405 0.3405
Leishmania major heat shock protein 83-1 0.1715 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0025
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0025 0.0025
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0004 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0213 0.0213
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0074 0.0074
Onchocerca volvulus 0.0072 0.033 0.0646
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0326 0.1825 0.1825
Mycobacterium tuberculosis Possible two component sensor kinase 0.0322 0.1803 0.2184
Trypanosoma brucei heat shock protein, putative 0.1715 1 1
Trypanosoma brucei mismatch repair protein PMS1, putative 0.0023 0.0044 0.0044
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0322 0.1803 0.1803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0113 0.0113
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0213 0.0213
Plasmodium vivax SET domain protein, putative 0.0031 0.0091 0.0087
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0322 0.1803 0.2184
Loa Loa (eye worm) hypothetical protein 0.0036 0.0116 0.0116
Plasmodium falciparum heat shock protein 90 0.1715 1 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0322 0.1803 0.1803
Mycobacterium tuberculosis Probable two component sensor kinase 0.0322 0.1803 0.2184
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0128 0.0128
Trypanosoma cruzi DNA topoisomerase II, putative 0.0322 0.1803 0.1803
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0025 0.0025
Leishmania major heat shock protein 83-1 0.1715 1 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0185 0.0185
Plasmodium falciparum heat shock protein 90, putative 0.0753 0.434 0.4338
Trichomonas vaginalis mismatch repair protein Mlh2 (mutL homolog) 0.0023 0.0044 0.0044
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0185 0.0185
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0025 0.0025
Brugia malayi hypoxia-induced factor 1 0.0301 0.1676 0.1676
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0025 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.3405 0.3405
Brugia malayi heat shock protein 90 0.1715 1 1
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0322 0.1803 0.1803
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0055 0.0055
Brugia malayi nuclear hormone receptor 0.0019 0.0016 0.0016
Echinococcus multilocularis 0.0048 0.0192 0.0192
Brugia malayi hypothetical protein 0.0326 0.1825 0.1825
Plasmodium vivax endoplasmin, putative 0.1715 1 1
Brugia malayi kinase, mitochondrial precursor 0.0322 0.1803 0.1803
Echinococcus granulosus axis inhibition protein axin 0.002 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0248 0.1369 0.1369
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0004 0.0004
Trypanosoma brucei heat shock protein, putative 0.1715 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0062 0.0062
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0322 0.1803 0.1803
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0016 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0016 0.0016
Plasmodium falciparum endoplasmin, putative 0.1052 0.6099 0.6097
Schistosoma mansoni hypothetical protein 0.0023 0.0044 0.0044
Loa Loa (eye worm) hypoxia-induced factor 1 0.0301 0.1676 0.1676
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0004
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0322 0.1803 0.2145
Loa Loa (eye worm) heat shock protein 75 0.0844 0.4877 0.4877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0071 0.0071
Onchocerca volvulus 0.0249 0.1371 0.2788
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0085 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.0091
Toxoplasma gondii Hsp90 domain-containing protein 0.0753 0.434 0.4338
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0025 0.0025
Trypanosoma cruzi mismatch repair protein MLH1, putative 0.0023 0.0044 0.0044
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0649 0.3727 0.3727
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0185 0.0185
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0055 0.0055
Trypanosoma brucei heat shock protein, putative 0.1715 1 1
Echinococcus multilocularis heat shock protein 90 0.1393 0.8104 0.8104
Schistosoma mansoni survival motor neuron protein 0.0051 0.0205 0.0205
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0844 0.4877 0.4877
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0016 0.0016
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0025 0.0025
Schistosoma mansoni tyrosine kinase 0.0051 0.0208 0.0208
Trypanosoma brucei mismatch repair protein MLH1 0.0023 0.0044 0.0044
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0074 0.0074
Echinococcus multilocularis musashi 0.0028 0.0074 0.0074
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0055 0.0055
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0322 0.1803 0.1862
Schistosoma mansoni intermediate filament proteins 0.0028 0.0074 0.0074
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.1416 0.8241 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0016 0.0016
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0128 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0057 0.0057
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0016 0.0016
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0844 0.4877 0.4877
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0322 0.1803 0.2184
Giardia lamblia Pms1-like protein 0.0322 0.1803 0.1766
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0844 0.4877 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0113 0.0113
Echinococcus granulosus microtubule associated protein 2 0.0725 0.4173 0.4173
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0016 0.0016
Trichomonas vaginalis mismatch repair protein Mlh1B (mutL homolog) 0.0023 0.0044 0.0044
Brugia malayi Pre-SET motif family protein 0.0219 0.1194 0.1194
Trypanosoma brucei heat shock protein 84, putative 0.0844 0.4877 0.4877
Loa Loa (eye worm) TK/INSR protein kinase 0.0051 0.0208 0.0208
Leishmania major mismatch repair protein, putative 0.0023 0.0044 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0057 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0091 0.0091
Schistosoma mansoni tyrosine kinase 0.0083 0.0397 0.0397
Echinococcus granulosus lamin 0.0028 0.0074 0.0074
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0004
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0016
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0185 0.0185
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0051 0.0205 0.0205
Brugia malayi PXA domain containing protein 0.002 0.0025 0.0025
Chlamydia trachomatis DNA gyrase subunit B 0.0322 0.1803 0.9221
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0055 0.0055
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0025 0.0025
Leishmania major heat shock protein 83-1 0.1715 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0016 0.0016
Leishmania major heat shock protein 83-1 0.1715 1 1
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0322 0.1803 0.2184
Trichomonas vaginalis DNA topoisomerase II, putative 0.0322 0.1803 0.1803
Schistosoma mansoni hypothetical protein 0.0054 0.0227 0.0227
Trypanosoma cruzi heat shock protein 85, putative 0.1393 0.8104 0.8104
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0016 0.0016
Treponema pallidum fructose-bisphosphate aldolase 0.0594 0.3405 0.41
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0025
Leishmania major heat shock protein 83-1 0.1715 1 1
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0322 0.1803 0.2184
Trichomonas vaginalis mismatch repair protein Mlh3 (mutL homolog) 0.0023 0.0044 0.0044
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0004 0.0004
Trypanosoma cruzi heat shock protein 85, putative 0.1715 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0093 0.0093
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0025 0.0025
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0055 0.0055
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0016 0.0016
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0016
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.1393 0.8104 0.8104
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0753 0.434 0.4326
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0322 0.1803 0.1862
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0004
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0016 0.0016
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.1416 0.8241 1
Echinococcus granulosus single minded 2 0.0072 0.033 0.033
Leishmania major protein kinase, putative 0.0025 0.0055 0.0055
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0022 0.0022
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0322 0.1803 0.2184
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0347 0.1951 1
Loa Loa (eye worm) TOPoisomerase family member 0.0322 0.1803 0.1803
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0016 0.0016
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0071 0.0071
Brugia malayi Furin-like cysteine rich region family protein 0.0158 0.0835 0.0835
Plasmodium vivax heat shock protein 86, putative 0.1715 1 1
Trypanosoma brucei developmentally regulated phosphoprotein 0.0322 0.1803 0.1803
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0055
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0016 0.0016
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0055 0.0055
Entamoeba histolytica heat shock protein 90, putative 0.1715 1 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0091 0.0091
Echinococcus granulosus intermediate filament protein 0.0028 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0044
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0322 0.1803 0.1862
Plasmodium vivax heat shock protein, putative 0.0753 0.434 0.4338
Mycobacterium ulcerans two component sensor kinase MprB 0.0322 0.1803 0.1862
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0025 0.0025
Leishmania major heat shock protein 83-1 0.1715 1 1
Schistosoma mansoni axis inhibition protein axin 0.002 0.0025 0.0025
Schistosoma mansoni regulator of G protein signaling 0.002 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0057 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0016 0.0016
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0016 0.0016
Trichomonas vaginalis mismatch repair protein Pms1 (mutL homolog) 0.0023 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0055 0.0055
Schistosoma mansoni heat shock protein 0.0844 0.4877 0.4877
Leishmania major heat shock protein 83-1 0.1715 1 1
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.0055 0.0055
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0004 0.0004
Trypanosoma brucei heat shock protein 90, putative 0.1715 1 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0055 0.0055
Echinococcus granulosus heat shock protein 90 0.1393 0.8104 0.8104
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0091 0.0087
Plasmodium falciparum DNA mismatch repair protein MLH 0.0023 0.0044 0.004
Schistosoma mansoni aryl hydrocarbon receptor 0.0097 0.0479 0.0479
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0016 0.0016
Leishmania major mismatch repair protein PMS1, putative,mismatch repair protein 0.0023 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0055 0.0055
Toxoplasma gondii DNA mismatch repair protein, C-terminal domain-containing protein 0.0023 0.0044 0.004
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0016
Brugia malayi hypothetical protein 0.0017 0.0007 0.0007
Trypanosoma cruzi mismatch repair protein PMS1, putative 0.0023 0.0044 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0113 0.0113
Giardia lamblia Heat shock protein HSP 90-alpha 0.1393 0.8104 0.8096
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0322 0.1803 0.1803
Trypanosoma brucei heat shock protein, putative 0.1715 1 1
Trichomonas vaginalis sensor histidine kinase, putative 0.0322 0.1803 0.1803
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0016
Leishmania major heat shock protein 83-1 0.1715 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0016 0.0016
Entamoeba histolytica DNA mismatch repair protein MLH1, putative 0.0023 0.0044 0.0019
Brugia malayi DNA mismatch repair protein MutL containing protein 0.0023 0.0044 0.0044
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0004 0.0004
Trichomonas vaginalis heat shock protein, putative 0.1393 0.8104 0.8104
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0055 0.0055
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0322 0.1803 0.1862
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0128 0.0128
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0025 0.0025
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0113 0.011
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0322 0.1803 0.1862
Schistosoma mansoni regulator of G protein signaling 0.002 0.0025 0.0025
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0144 0.0144
Plasmodium falciparum heat shock protein 90, putative 0.0821 0.4739 0.4737
Echinococcus multilocularis geminin 0.0355 0.1996 0.1996
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.1369 0.1369
Plasmodium vivax DNA topoisomerase II, putative 0.0322 0.1803 0.18
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.029 0.1616 0.1625
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.3405 0.3405
Echinococcus multilocularis GPCR, family 2 0.0016 0.0004 0.0004
Toxoplasma gondii heat shock protein 90, putative 0.1715 1 1
Mycobacterium tuberculosis Conserved protein 0.0322 0.1803 0.2184
Mycobacterium leprae Probable two component sensor kinase MprB 0.0322 0.1803 0.2135
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0016 0.0016
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0128 0.0128
Plasmodium vivax heat shock protein 90, putative 0.0844 0.4877 0.4875
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0025 0.0025

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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