TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 425.476 | Formula: C22H20FN3O3S
H donors: 0 H acceptors: 2 LogP: 3.56 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: N#CC1=C2SCN(CN2C(=O)CC1c1ccc(cc1)F)c1ccc(cc1OC)OC
InChi: 1S/C22H20FN3O3S/c1-28-16-7-8-19(20(9-16)29-2)25-12-26-21(27)10-17(14-3-5-15(23)6-4-14)18(11-24)22(26)30-13-25/h3-9,17H,10,12-13H2,1-2H3
InChiKey: MQIKPIJWPHQHAN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0041	0.0359	1
Leishmania major	cathepsin L-like protease	0.0036	0.0301	0.0524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0301	0.1228
Echinococcus granulosus	thymidylate synthase	0.0342	0.4192	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0301	0.1228
Onchocerca volvulus	Pyruvate kinase homolog	0.0035	0.0279	0.0324
Echinococcus granulosus	beta LACTamase domain containing family member	0.0073	0.0765	0.1825
Mycobacterium ulcerans	lipase LipD	0.0073	0.0765	0.1654
Brugia malayi	thymidylate synthase	0.0342	0.4192	1
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0342	0.4192	1
Echinococcus granulosus	cathepsin L	0.0019	0.0076	0.0181
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0301	0.1228
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0765	0.1699
Mycobacterium leprae	Probable lipase LipE	0.0073	0.0765	0.1243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0301	0.1228
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0301	0.1228
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0175	0.0417
Trypanosoma brucei	pyruvate kinase 1	0.0035	0.0279	0.0492
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0035	0.0279	0.0492
Loa Loa (eye worm)	thymidylate synthase	0.0342	0.4192	1
Giardia lamblia	Pyruvate kinase	0.0035	0.0279	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0139	0.1606	0.3717
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0342	0.4192	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0765	0.376
Onchocerca volvulus		0.0036	0.0301	0.038
Mycobacterium tuberculosis	Hypothetical protein	0.0163	0.1909	0.3208
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0076	0.003
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0036	0.0301	0.0718
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0035	0.0279	0.0492
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0036	0.0301	0.0718
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0301	0.1228
Echinococcus multilocularis	lamin dm0	0.0027	0.0175	0.0175
Echinococcus multilocularis	musashi	0.0027	0.0175	0.0175
Entamoeba histolytica	hypothetical protein	0.0041	0.0359	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0036	0.0301	0.0547
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0765	0.1825
Leishmania major	cathepsin L-like protease	0.0036	0.0301	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0145	0.0346
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0301	0.1228
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0301	0.1228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0036	0.0301	0.1228
Echinococcus multilocularis	pyruvate kinase	0.0035	0.0279	0.0279
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0301	0.1228
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0301	0.0678
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0086	0.1038
Echinococcus granulosus	intermediate filament protein	0.0027	0.0175	0.0417
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0175	0.0417
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0342	0.4192	1
Echinococcus multilocularis	geminin	0.0172	0.2023	0.2023
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0073	0.0765	0.1195
Plasmodium vivax	pyruvate kinase, putative	0.0035	0.0279	0.0521
Leishmania major	pyruvate kinase	0.0035	0.0279	0.0469
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0342	0.4192	1
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0301	0.7942
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0279	0.0665
Onchocerca volvulus		0.0036	0.0301	0.038
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0036	0.0301	0.0575
Brugia malayi	cathepsin L-like precursor	0.0024	0.0148	0.0311
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.0765	0.376
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0148	0.0311
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0076	0.003
Loa Loa (eye worm)	MH2 domain-containing protein	0.0124	0.1418	0.3383
Plasmodium vivax	vivapain-1	0.0019	0.0076	0.003
Loa Loa (eye worm)	pyruvate kinase	0.0035	0.0279	0.0665
Echinococcus granulosus	cathepsin l1	0.0036	0.0301	0.0718
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0024	0.0148	0.0311
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0301	0.0678
Schistosoma mansoni	hypothetical protein	0.0041	0.0359	0.0717
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0139	0.1606	0.3717
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0086	0.0054
Plasmodium falciparum	pyruvate kinase	0.0035	0.0279	0.0521
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0175	0.0269
Echinococcus multilocularis	lamin	0.0027	0.0175	0.0175
Mycobacterium tuberculosis	Probable lipase LipD	0.0073	0.0765	0.1195
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0301	0.1228
Echinococcus multilocularis	cathepsin L cysteine protease	0.0036	0.0301	0.0301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0301	0.1228
Leishmania major	cysteine peptidase A (CPA)	0.0036	0.0301	0.0524
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0086	0.0024
Loa Loa (eye worm)	transcription factor SMAD2	0.0124	0.1418	0.3383
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0035	0.0279	0.0339
Schistosoma mansoni	lamin	0.0027	0.0175	0.0269
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0175	0.0417
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0073	0.0765	0.0765
Echinococcus granulosus	geminin	0.0172	0.2023	0.4826
Brugia malayi	hypothetical protein	0.0041	0.0359	0.0818
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.0765	0.376
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0036	0.0301	0.0301
Toxoplasma gondii	pyruvate kinase PyK1	0.0035	0.0279	0.0521
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0301	0.0575
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0036	0.0301	0.1228
Schistosoma mansoni	ap endonuclease	0.002	0.0086	0.0054
Onchocerca volvulus	Cathepsin F homolog	0.0036	0.0301	0.038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0301	0.1228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0301	0.1228
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0765	0.1825
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0139	0.1606	0.3717
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0073	0.0765	0.1195
Echinococcus multilocularis	cathepsin L cysteine protease	0.0036	0.0301	0.0301
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0139	0.1606	0.3717
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0086	0.0205
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0086	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0139	0.1606	0.3717
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0765	0.1195
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0036	0.0301	0.0575
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0342	0.4192	0.7228
Echinococcus granulosus	cathepsin l1	0.0024	0.0148	0.0352
Loa Loa (eye worm)	pyruvate kinase	0.0035	0.0279	0.0665
Plasmodium vivax	vivapain-2	0.0036	0.0301	0.0575
Schistosoma mansoni	pyruvate kinase	0.0035	0.0279	0.0521
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0139	0.1606	0.3717
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0301	0.1228
Leishmania major	cathepsin L-like protease	0.0139	0.1606	0.3702
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0342	0.4192	1
Trypanosoma brucei	pyruvate kinase 1, putative	0.0035	0.0279	0.0492
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0301	0.1228
Loa Loa (eye worm)	ctsf protein	0.0036	0.0301	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0765	0.1825
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0301	0.1228
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0073	0.0765	0.1654
Onchocerca volvulus	Pyruvate kinase homolog	0.0035	0.0279	0.0324
Echinococcus multilocularis	pyruvate kinase	0.0018	0.0064	0.0064
Mycobacterium tuberculosis	Probable lipase LipE	0.0073	0.0765	0.1195
Leishmania major	cathepsin L-like protease	0.0036	0.0301	0.0524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0301	0.1228
Mycobacterium ulcerans	beta-lactamase	0.0073	0.0765	0.1654
Leishmania major	cathepsin L-like protease	0.0139	0.1606	0.3702
Leishmania major	hypothetical protein, conserved	0.0073	0.0765	0.1654
Entamoeba histolytica	hypothetical protein	0.0041	0.0359	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0301	0.1228
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0163	0.1909	0.4453
Trichomonas vaginalis	esterase, putative	0.0073	0.0765	0.376
Leishmania major	pyruvate kinase	0.0035	0.0279	0.0469
Echinococcus multilocularis	cysteine protease	0.0036	0.0301	0.0301
Echinococcus multilocularis	pyruvate kinase	0.0018	0.0064	0.0064
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0086	0.0205
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0086	0.0086
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0076	0.0139
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0086	0.0054
Onchocerca volvulus		0.0036	0.0301	0.038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0148	0.0391
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0076	0.003
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0466	0.5766	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0169	0.0402
Loa Loa (eye worm)	cysteine protease	0.0036	0.0301	0.0718
Mycobacterium ulcerans	esterase/lipase LipP	0.0073	0.0765	0.1654
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0139	0.1606	0.3717
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0018	0.0043
Chlamydia trachomatis	pyruvate kinase	0.0035	0.0279	0.5
Onchocerca volvulus		0.0027	0.0175	0.0067
Plasmodium vivax	vivapain-2	0.0036	0.0301	0.0575
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0765	0.1195
Echinococcus granulosus	pyruvate kinase	0.0035	0.0279	0.0665
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0301	0.1228
Trichomonas vaginalis	pyruvate kinase, putative	0.0035	0.0279	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0148	0.0352
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0301	0.1228
Schistosoma mansoni	hypothetical protein	0.0172	0.2023	0.4746
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0148	0.0352
Brugia malayi	beta-lactamase family protein	0.0073	0.0765	0.179
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0301	0.0678
Brugia malayi	intermediate filament protein	0.0027	0.0175	0.0376
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0139	0.1606	0.3717
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0301	0.0718
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0035	0.0279	0.0625
Onchocerca volvulus	Pyruvate kinase homolog	0.0035	0.0279	0.0324
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0301	0.1228
Trypanosoma cruzi	cruzipain precursor, putative	0.0139	0.1606	0.3717
Loa Loa (eye worm)	beta-lactamase	0.0073	0.0765	0.1825
Trichomonas vaginalis	pyruvate kinase, putative	0.0035	0.0279	0.1106
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0086	0.0024
Mycobacterium tuberculosis	Probable hydrolase	0.0073	0.0765	0.1195
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0036	0.0301	0.0301
Echinococcus multilocularis	pyruvate kinase	0.0018	0.0064	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0163	0.1909	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0359	0.0359
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0301	0.7942
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0301	0.0678
Loa Loa (eye worm)	pyruvate kinase-PB	0.0024	0.0145	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0301	0.0718
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0765	0.1674
Schistosoma mansoni	hypothetical protein	0.0172	0.2023	0.4746
Loa Loa (eye worm)	pyruvate kinase	0.0035	0.0279	0.0665
Echinococcus granulosus	pyruvate kinase	0.0035	0.0279	0.0665
Mycobacterium tuberculosis	Probable esterase LipL	0.0073	0.0765	0.1195
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0076	0.0139
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0765	0.376
Brugia malayi	beta-lactamase family protein	0.0073	0.0765	0.179
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0765	0.1825
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0139	0.1606	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0765	0.1825
Trypanosoma cruzi	major cysteine proteinase, putative	0.0109	0.1227	0.2797
Schistosoma mansoni	ap endonuclease	0.002	0.0086	0.0054
Plasmodium vivax	unspecified product	0.0019	0.0076	0.003
Schistosoma mansoni	cathepsin F (C01 family)	0.0024	0.0148	0.0203
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0086	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0148	0.0352
Onchocerca volvulus		0.0342	0.4192	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0765	0.1699
Onchocerca volvulus	Cathepsin L homolog	0.0036	0.0301	0.038
Echinococcus multilocularis	pyruvate kinase	0.0027	0.0186	0.0186
Onchocerca volvulus		0.0036	0.0301	0.038
Onchocerca volvulus		0.0036	0.0301	0.038
Onchocerca volvulus		0.0073	0.0765	0.1527
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0301	0.7942
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0139	0.1606	0.3717
Plasmodium vivax	hypothetical protein, conserved	0.0073	0.0765	0.1699
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0301	0.0678
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0148	0.0311
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0342	0.4192	1
Onchocerca volvulus		0.0036	0.0301	0.038
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0086	0.0054
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0175	0.0376
Toxoplasma gondii	exonuclease III APE	0.002	0.0086	0.0054
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0086	0.0024
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0086	0.0351
Plasmodium vivax	vivapain-3	0.0019	0.0076	0.003
Leishmania major	cathepsin L-like protease	0.0036	0.0301	0.0524
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0127	0.1452	0.3344
Echinococcus multilocularis	cysteine protease	0.0036	0.0301	0.0301
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0073	0.0765	0.1195
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0139	0.1606	0.3717
Onchocerca volvulus	Cathepsin L homolog	0.0036	0.0301	0.038
Schistosoma mansoni	pyruvate kinase	0.0035	0.0279	0.0521
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0148	0.0391
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0073	0.0765	0.179
Echinococcus multilocularis	cathepsin L	0.0019	0.0076	0.0076
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0036	0.0301	0.0575
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0086	0.0054
Echinococcus granulosus	pyruvate kinase	0.0018	0.0064	0.0152
Onchocerca volvulus		0.0073	0.0765	0.1527
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0036	0.0301	0.0718
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0139	0.1606	0.3717
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0342	0.4192	1
Echinococcus granulosus	lamin dm0	0.0027	0.0175	0.0417
Leishmania major	cathepsin L-like protease	0.0139	0.1606	0.3702
Entamoeba histolytica	pyruvate kinase, putative	0.0024	0.0145	0.2434
Trypanosoma brucei	hypothetical protein, conserved	0.0073	0.0765	0.1674
Echinococcus multilocularis	thymidylate synthase	0.0342	0.4192	0.4192
Onchocerca volvulus		0.0073	0.0765	0.1527
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0301	0.1228
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0765	0.1674
Toxoplasma gondii	cathepsin CPL	0.0036	0.0301	0.0575
Mycobacterium ulcerans	pyruvate kinase	0.0035	0.0279	0.0469
Mycobacterium ulcerans	thymidylate synthase	0.0342	0.4192	1
Mycobacterium ulcerans	hypothetical protein	0.0073	0.0765	0.1654
Echinococcus multilocularis	pyruvate kinase	0.0035	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0163	0.1909	0.453
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0765	0.1195
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0139	0.1606	0.3717
Leishmania major	cathepsin L-like protease	0.0036	0.0301	0.0524
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0359	0.0858
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0301	0.0575
Echinococcus granulosus	lamin	0.0027	0.0175	0.0417
Mycobacterium leprae	conserved hypothetical protein	0.0073	0.0765	0.1243
Brugia malayi	MH2 domain containing protein	0.0124	0.1418	0.3355
Echinococcus granulosus	pyruvate kinase	0.0018	0.0064	0.0152
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0148	0.2527
Loa Loa (eye worm)	fibroinase	0.0036	0.0301	0.0718
Schistosoma mansoni	lamin	0.0027	0.0175	0.0269
Trypanosoma cruzi	cysteine peptidase, putative	0.0139	0.1606	0.3717
Toxoplasma gondii	ABC1 family protein	0.0073	0.0765	0.1699
Echinococcus granulosus	cathepsin L cysteine protease	0.0019	0.0076	0.0181
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0301	0.0678
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0765	0.376
Brugia malayi	beta-lactamase	0.0073	0.0765	0.179
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0035	0.0279	0.0625
Echinococcus granulosus	pyruvate kinase	0.0018	0.0064	0.0152
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0086	0.0163
Entamoeba histolytica	hypothetical protein	0.0041	0.0359	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0765	0.1825
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0301	0.0678
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0359	0.0717
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0301	0.1228
Onchocerca volvulus		0.0036	0.0301	0.038
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0019	0.0076	0.003
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0073	0.0765	0.1825
Echinococcus granulosus	cysteine protease	0.0019	0.0076	0.0181
Onchocerca volvulus		0.0027	0.0175	0.0067
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0342	0.4192	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 783917