Detailed information for compound 783956

Basic information

Technical information
  • TDR Targets ID: 783956
  • Name: 4-(4-methoxyphenyl)-N-[(4-nitrophenyl)methyli deneamino]butanamide
  • MW: 341.361 | Formula: C18H19N3O4
  • H donors: 1 H acceptors: 3 LogP: 3.22 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CCCC(=O)N/N=C/c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C18H19N3O4/c1-25-17-11-7-14(8-12-17)3-2-4-18(22)20-19-13-15-5-9-16(10-6-15)21(23)24/h5-13H,2-4H2,1H3,(H,20,22)/b19-13+
  • InChiKey: QSRAKLMGQJGKEM-CPNJWEJPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-methoxyphenyl)-N-[(4-nitrophenyl)methyleneamino]butanamide
  • 4-(4-methoxyphenyl)-N-[(4-nitrobenzylidene)amino]butyramide
  • A0652/0030304

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0062 0.0061
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0117 0.0957
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0372 0.069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0011
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0136 0.1223
Giardia lamblia Aldose reductase 0.0387 0.2763 0.5
Brugia malayi beta-NAC-like protein 0.0035 0.0196 0.0708
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0703
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0011 0.0011
Leishmania major hypothetical protein, conserved 0.0034 0.0184 0.0496
Entamoeba histolytica alcohol dehydrogenase, putative 0.0112 0.0755 0.218
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0196 0.0003
Trichomonas vaginalis aldo-keto reductase, putative 0.0387 0.2763 1
Onchocerca volvulus 0.0387 0.2763 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0195 0.0194
Brugia malayi CXXC zinc finger family protein 0.0028 0.0144 0.0522
Echinococcus multilocularis aldo keto reductase 0.0387 0.2763 0.2763
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0011 0.0039
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0011
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0516 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0372 0.069
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.005 0.0049
Loa Loa (eye worm) oxidoreductase 0.0387 0.2763 1
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.005 0.0049
Schistosoma mansoni pol-related 0.0387 0.2763 0.2755
Onchocerca volvulus 0.0387 0.2763 1
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0184 0.0665
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0011 0.0042
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0516 0.0505
Leishmania major prostaglandin f synthase, putative 0.0387 0.2763 1
Onchocerca volvulus 0.0112 0.0755 0.2703
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0195 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0011 0.0042
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0196 0.0003
Trichomonas vaginalis aldo-keto reductase, putative 0.0387 0.2763 1
Brugia malayi jmjC domain containing protein 0.006 0.0373 0.1351
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0196 0.0705
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0387 0.2763 0.2763
Trichomonas vaginalis aldo-keto reductase, putative 0.0387 0.2763 1
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.3254 0.3253
Plasmodium falciparum aldo-keto reductase, putative 0.0112 0.0755 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0516 0.1718
Onchocerca volvulus 0.0387 0.2763 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0117 0.0957
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0516 0.1718
Plasmodium falciparum aldehyde reductase, putative 0.0112 0.0755 1
Brugia malayi beta-lactamase 0.0035 0.0195 0.0705
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0184 0.0184
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0011 0.0011
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0387 0.2763 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0195 0.0184
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0184 0.0184
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0606 0.0605
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0606 0.2191
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.005 0.0178
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0184 0.0496
Echinococcus multilocularis geminin 0.0172 0.1192 0.1191
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0387 0.2763 0.2763
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0387 0.2763 0.2763
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0011 0.0039
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0039
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0039
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0011 0.0011
Entamoeba histolytica alcohol dehydrogenase, putative 0.0112 0.0755 0.218
Brugia malayi steroid hormone receptor 0.001 0.0011 0.0042
Trichomonas vaginalis aldo-keto reductase, putative 0.0112 0.0755 0.2182
Schistosoma mansoni transcription factor btf3 0.0035 0.0196 0.0184
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0387 0.2763 1
Echinococcus granulosus hypothetical protein 0.0387 0.2763 0.2763
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0039
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0184 0.1907
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0011
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0112 0.0755 0.26
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0316 0.0473
Schistosoma mansoni aldo-keto reductase 0.0387 0.2763 0.2755
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0372 0.069
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0011
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0196 0.2065
Echinococcus granulosus phd:f box containing protein 0.0016 0.005 0.0049
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0011 0.0039
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0516 0.0515
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0703
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0294 0.1064
Leishmania major aldo-keto reductase-like protein 0.0387 0.2763 1
Echinococcus granulosus aldo keto reductase 0.0387 0.2763 0.2763
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0387 0.2763 1
Brugia malayi nuclear hormone receptor 0.001 0.0011 0.0042
Trichomonas vaginalis aldo-keto reductase, putative 0.0387 0.2763 1
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0184 0.0496
Onchocerca volvulus 0.0035 0.0195 0.0666
Loa Loa (eye worm) oxidoreductase 0.0387 0.2763 1
Schistosoma mansoni microtubule-associated protein tau 0.1377 1 1
Echinococcus multilocularis aldo keto reductase 0.0387 0.2763 0.2763
Leishmania major hypothetical protein, conserved 0.0035 0.0195 0.0534
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0606 0.0595
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0195 0.0184
Trichomonas vaginalis aldo/keto reductase, putative 0.0387 0.2763 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0112 0.0755 0.2731
Brugia malayi NADH-dependent xylose reductase 0.0112 0.0755 0.2734
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0018 0.0017
Trichomonas vaginalis aldo-keto reductase, putative 0.0387 0.2763 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0039
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0011 0.0042
Mycobacterium tuberculosis Probable oxidoreductase 0.0387 0.2763 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0387 0.2763 0.2763
Trichomonas vaginalis aldo/keto reductase, putative 0.0387 0.2763 1
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0184 0.0496
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0011 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0011
Onchocerca volvulus 0.0035 0.0195 0.0666
Onchocerca volvulus 0.0035 0.0195 0.0666
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0011 0.0042
Brugia malayi hypothetical protein 0.0025 0.0117 0.0425
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.005 0.0038
Brugia malayi Probable ClpP-like protease 0.0079 0.0516 0.1867
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0039
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0703
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0011 0.0042
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0516 0.6607
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0516 0.5
Echinococcus granulosus dnaJ subfamily B 0.0404 0.2892 0.2892
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0011 0.0042
Echinococcus multilocularis aldehyde reductase 0.0275 0.1945 0.1944
Brugia malayi jmjC domain containing protein 0.0016 0.005 0.0181
Brugia malayi beta-lactamase family protein 0.0035 0.0195 0.0705
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0516 0.125
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0178
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0039
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0316 0.0316
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0196 0.0537
Echinococcus multilocularis cpg binding protein 0.003 0.0156 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0195 0.0534
Entamoeba histolytica aldose reductase, putative 0.0387 0.2763 1
Onchocerca volvulus 0.0387 0.2763 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0387 0.2763 0.2763
Echinococcus granulosus survival motor neuron protein 1 0.024 0.1689 0.1688
Entamoeba histolytica aldose reductase, putative 0.0387 0.2763 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0387 0.2763 1
Schistosoma mansoni jumonji domain containing protein 0.0016 0.005 0.0038
Brugia malayi jmjC domain containing protein 0.0016 0.005 0.0181
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0178
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0387 0.2763 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0112 0.0755 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0362 0.0361
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0387 0.2763 1
Schistosoma mansoni aldo-keto reductase 0.0387 0.2763 0.2755
Echinococcus granulosus geminin 0.0172 0.1192 0.1191
Mycobacterium leprae Probable lipase LipE 0.0035 0.0195 0.0223
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0606 0.0595
Schistosoma mansoni hypothetical protein 0.0172 0.1192 0.1182
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0196 0.0537
Schistosoma mansoni potassium channel beta 0.0112 0.0755 0.0745
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0387 0.2763 0.2763
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.005 0.0049
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0144 0.0519
Mycobacterium ulcerans hypothetical protein 0.0112 0.0755 0.2182
Brugia malayi jmjC domain containing protein 0.0016 0.005 0.0181
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0011
Mycobacterium leprae Conserved hypothetical protein 0.0275 0.1945 0.6883
Echinococcus multilocularis voltage gated potassium channel subunit 0.0112 0.0755 0.0755
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.1689 0.1688
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0117 0.0249
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0516 0.6607
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0373 0.0362
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0387 0.2763 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0387 0.2763 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0387 0.2763 0.2763
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0196 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0377 0.0366
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0373 0.1349
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0387 0.2763 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0195 0.0223
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0703
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0387 0.2763 0.2763
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0703
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0606 0.0595
Echinococcus granulosus neuropeptide s receptor 0.0454 0.3254 0.3253
Trypanosoma brucei prostaglandin f synthase 0.0387 0.2763 1
Brugia malayi beta-lactamase family protein 0.0035 0.0195 0.0705
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0011 0.0039
Echinococcus multilocularis transcription factor btf3 0.0035 0.0196 0.0195
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0011
Trichomonas vaginalis aldo-keto reductase, putative 0.0387 0.2763 1
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0362 0.035
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.005 0.0178
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0373 0.0373
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.033 0.1031
Schistosoma mansoni survival motor neuron protein 0.0049 0.0294 0.0283
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.3254 0.3253
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0112 0.0755 0.2734
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0372 0.069
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0011 0.0042
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0372 0.0361
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0362 0.0361
Onchocerca volvulus 0.0387 0.2763 1
Echinococcus granulosus aldehyde reductase 0.0275 0.1945 0.1944
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0039
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.005 0.0049
Onchocerca volvulus 0.0387 0.2763 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0011 0.0011
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0184 0.0496
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0195 0.0534
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0755 0.2182
Toxoplasma gondii aldo-keto reductase 0.0112 0.0755 0.26
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0387 0.2763 0.2763
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0387 0.2763 0.2763
Trypanosoma cruzi aldo/keto reductase, putative 0.0112 0.0755 0.26
Plasmodium vivax aldehyde reductase, putative 0.0112 0.0755 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0039
Trichomonas vaginalis aldo-keto reductase, putative 0.0387 0.2763 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0011 0.0042
Loa Loa (eye worm) oxidoreductase 0.0387 0.2763 1
Schistosoma mansoni protein phosphatase 2C 0.0016 0.005 0.0038
Echinococcus multilocularis aldo keto reductase 0.0387 0.2763 0.2763
Loa Loa (eye worm) hypothetical protein 0.0387 0.2763 1
Mycobacterium leprae Possible oxidoreductase 0.0112 0.0755 0.2357
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.005 0.0038
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0011 0.0042
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0372 0.0371
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0136 0.1223
Trichomonas vaginalis aldo-keto reductase, putative 0.0112 0.0755 0.2182
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0387 0.2763 0.2763
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0387 0.2763 0.2763
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0018 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0606 0.0605
Schistosoma mansoni hypothetical protein 0.0049 0.0294 0.0283
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0387 0.2763 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0117 0.0249
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0316 0.0686
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0062 0.0061
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0196 0.0537
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0011 0.0042
Brugia malayi jmjC domain containing protein 0.0058 0.0362 0.1308
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0387 0.2763 0.2763
Trichomonas vaginalis aldo-keto reductase, putative 0.0112 0.0755 0.2182
Echinococcus granulosus cpg binding protein 0.003 0.0156 0.0155
Schistosoma mansoni hypothetical protein 0.0011 0.0018 0.0006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0606 0.2193
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0178
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0606 0.0605
Onchocerca volvulus 0.0049 0.0294 0.1026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0011 0.0039
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0112 0.0755 0.0755
Schistosoma mansoni cpg binding protein 0.003 0.0156 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0011 0.0042
Trichomonas vaginalis aldo-keto reductase, putative 0.0387 0.2763 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0703
Echinococcus multilocularis microtubule associated protein 2 0.1377 1 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0112 0.0755 0.2182
Schistosoma mansoni cpg binding protein 0.0028 0.0144 0.0133
Brugia malayi ecdysteroid receptor 0.001 0.0011 0.0042
Brugia malayi Augmenter of liver regeneration 0.0034 0.0184 0.0668
Loa Loa (eye worm) beta-lactamase 0.0035 0.0195 0.0703
Trichomonas vaginalis aldo-keto reductase, putative 0.0387 0.2763 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0011 0.0039
Giardia lamblia Aldose reductase 0.0387 0.2763 0.5
Trypanosoma brucei aldo/keto reductase, putative 0.0112 0.0755 0.26
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0112 0.0755 0.26
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0112 0.0755 0.26
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0011 0.0039
Brugia malayi jmjC domain containing protein 0.0016 0.005 0.0181
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0195 0.0194
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0184 0.1907
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0606 0.0605
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0387 0.2763 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1587 0.5419
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0316 0.0316
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0184 0.0496
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0516 0.125
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.005 0.0178
Trypanosoma brucei aldo-keto reductase, putative 0.0387 0.2763 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0373 0.0362
Leishmania major basic transcription factor 3a, putative 0.0035 0.0196 0.0537
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.2892 0.2892
Trichomonas vaginalis aldo-keto reductase, putative 0.0387 0.2763 1
Echinococcus multilocularis aldo keto reductase 0.0387 0.2763 0.2763
Schistosoma mansoni phd/f-box containing protein 0.0016 0.005 0.0038
Brugia malayi hypothetical protein 0.0016 0.0053 0.0193
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0372 0.1188
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0516 0.1446
Echinococcus granulosus aldo keto reductase 0.0387 0.2763 0.2763
Toxoplasma gondii ABC1 family protein 0.0035 0.0195 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.0079 0.0516 0.1865
Schistosoma mansoni cpg binding protein 0.003 0.0156 0.0145
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0011
Loa Loa (eye worm) oxidoreductase 0.0387 0.2763 1
Schistosoma mansoni hypothetical protein 0.0404 0.2892 0.2884
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0387 0.2763 0.2763
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0316 0.0473
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0195 0.2055
Trypanosoma cruzi aldo-keto reductase 0.0387 0.2763 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0387 0.2763 1
Echinococcus multilocularis phd:f box containing protein 0.0016 0.005 0.0049
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0372 0.1188
Brugia malayi nuclear receptor NHR-88 0.001 0.0011 0.0042
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0196 0.2065
Entamoeba histolytica aldose reductase, putative 0.0387 0.2763 1
Echinococcus granulosus voltage gated potassium channel subunit 0.0112 0.0755 0.0755
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.0025 0.0117 0.0422
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0387 0.2763 0.2763
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0196 0.0537
Echinococcus granulosus aldo keto reductase 0.0387 0.2763 0.2763
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0011 0.0011
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.005 0.0049
Trichomonas vaginalis aldo/keto reductase, putative 0.0387 0.2763 1
Mycobacterium tuberculosis Conserved protein 0.0112 0.0755 0.2182
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0011 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0117 0.0249
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0387 0.2763 0.2763
Toxoplasma gondii aldose reductase, putative 0.0387 0.2763 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0117 0.0249
Brugia malayi hypothetical protein 0.024 0.1689 0.6111
Loa Loa (eye worm) oxidoreductase 0.0387 0.2763 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0117 0.0957
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0011 0.0039
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0387 0.2763 0.2763
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0184 0.0496
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.3254 0.3253
Echinococcus granulosus transcription factor btf3 0.0035 0.0196 0.0195
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0195 0.0705
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0387 0.2763 0.2763
Echinococcus granulosus FTZ F1 alpha 0.001 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.024 0.1689 0.6109
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0516 0.0515
Onchocerca volvulus 0.0028 0.0144 0.0482
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0387 0.2763 0.2763
Toxoplasma gondii hypothetical protein 0.0027 0.0136 0.0318
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0195 0.0703
Mycobacterium ulcerans oxidoreductase 0.0387 0.2763 1
Schistosoma mansoni hypothetical protein 0.0172 0.1192 0.1182
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0011 0.0042
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0516 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0387 0.2763 0.2763
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0516 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0362 0.0361
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0372 0.0371
Trypanosoma cruzi aldo/keto reductase, putative 0.0387 0.2763 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0011 0.0042
Leishmania major hypothetical protein, conserved 0.0025 0.0117 0.0249
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.005 0.0049
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0372 0.0361

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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