Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor RXR | 0.004 | 0.0214 | 0.0214 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0214 | 0.0214 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0075 | 0.1079 | 0.1782 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0075 | 0.1079 | 0.1079 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0848 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0257 | 0.5548 | 0.7478 |
Schistosoma mansoni | thyroid hormone receptor | 0.0332 | 0.7382 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0257 | 0.5548 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0332 | 0.7382 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0035 | 0.011 | 0.011 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0075 | 0.1079 | 0.1079 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0065 | 0.0848 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0075 | 0.1079 | 0.1333 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0175 | 0.3547 | 0.632 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0075 | 0.1079 | 0.1079 |
Echinococcus multilocularis | Protein lozenge | 0.0055 | 0.0594 | 0.0665 |
Schistosoma mansoni | nuclear hormone receptor | 0.0075 | 0.1079 | 0.1333 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0041 | 0.0242 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0075 | 0.1079 | 0.1782 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0214 | 0.0214 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.004 | 0.0214 | 0.0143 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0075 | 0.1079 | 0.1333 |
Echinococcus granulosus | FTZ F1 alpha | 0.0075 | 0.1079 | 0.1782 |
Brugia malayi | conserved hypotetical protein | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0075 | 0.1079 | 0.1782 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0242 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0075 | 0.1079 | 0.1079 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0075 | 0.1079 | 0.1333 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0214 | 0.0214 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0075 | 0.1079 | 0.1079 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0332 | 0.7382 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0075 | 0.1079 | 0.1079 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0075 | 0.1079 | 0.1333 |
Brugia malayi | bZIP transcription factor family protein | 0.0086 | 0.1347 | 0.1347 |
Brugia malayi | hypothetical protein | 0.004 | 0.0214 | 0.0214 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0242 | 0.2858 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0136 | 0.2578 | 0.3394 |
Echinococcus multilocularis | jun protein | 0.0086 | 0.1347 | 0.1701 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Brugia malayi | steroid hormone receptor | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0214 | 0.0214 |
Schistosoma mansoni | coup transcription factor | 0.0075 | 0.1079 | 0.1333 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Schistosoma mansoni | jun-related protein | 0.007 | 0.0954 | 0.1159 |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0035 | 0.011 | 0.011 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0075 | 0.1079 | 0.1333 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0954 | 0.1159 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0175 | 0.3547 | 0.4726 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0075 | 0.1079 | 0.098 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0075 | 0.1079 | 0.1079 |
Echinococcus multilocularis | dna polymerase kappa | 0.0041 | 0.0242 | 0.0181 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0075 | 0.1079 | 0.1079 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0075 | 0.1079 | 0.1333 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0075 | 0.1079 | 0.1333 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0075 | 0.1079 | 0.1333 |
Brugia malayi | nuclear receptor NHR-88 | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0035 | 0.011 | 0.011 |
Echinococcus granulosus | jun protein | 0.0086 | 0.1347 | 0.2275 |
Brugia malayi | nuclear receptor NHR-88 | 0.0035 | 0.011 | 0.011 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0075 | 0.1079 | 0.1333 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0075 | 0.1079 | 0.1079 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.004 | 0.0214 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0075 | 0.1079 | 0.1079 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0034 | 0.0082 | 0.0969 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.004 | 0.0214 | 0.0214 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0257 | 0.5548 | 0.7478 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0242 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0075 | 0.1079 | 0.1333 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.0848 | 0.1014 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0041 | 0.0242 | 0.5 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | DR-78 | 0.0035 | 0.011 | 0.011 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0035 | 0.011 | 0.011 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0075 | 0.1079 | 0.098 |
Onchocerca volvulus | 0.0067 | 0.0896 | 0.0794 | |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0065 | 0.0848 | 0.0848 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0086 | 0.1347 | 0.1701 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.129 | 0.129 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0075 | 0.1079 | 0.1079 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0075 | 0.1079 | 0.1782 |
Brugia malayi | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.004 | 0.0214 | 0.0214 |
Onchocerca volvulus | 0.0075 | 0.1079 | 0.098 | |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0075 | 0.1079 | 0.1079 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.004 | 0.0214 | 0.0191 |
Brugia malayi | nuclear hormone receptor | 0.0075 | 0.1079 | 0.1079 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0242 | 0.2858 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0035 | 0.011 | 0.011 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0065 | 0.0848 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0896 | 0.0896 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.0848 | 0.1357 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Loa Loa (eye worm) | runx1 | 0.0055 | 0.0594 | 0.0594 |
Echinococcus granulosus | dna polymerase kappa | 0.0041 | 0.0242 | 0.0243 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0075 | 0.1079 | 0.1079 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0075 | 0.1079 | 0.1333 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0075 | 0.1079 | 0.098 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.004 | 0.0214 | 0.0214 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0848 | 1 |
Onchocerca volvulus | 0.0439 | 1 | 1 | |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0075 | 0.1079 | 0.1333 |
Brugia malayi | ecdysteroid receptor | 0.0075 | 0.1079 | 0.1079 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0038 | 0.0173 | 0.0086 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0075 | 0.1079 | 0.1079 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0075 | 0.1079 | 0.1333 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0075 | 0.1079 | 0.1333 |
Schistosoma mansoni | lozenge | 0.0055 | 0.0594 | 0.0665 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0214 | 0.0214 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0075 | 0.1079 | 0.1782 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.0848 | 0.1014 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0075 | 0.1079 | 0.1333 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0075 | 0.1079 | 0.1079 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1079 | 0.1079 |
Brugia malayi | nuclear receptor RXR | 0.0035 | 0.011 | 0.011 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0242 | 0.2858 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0038 | 0.0173 | 0.0115 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0848 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.004 | 0.0214 | 0.0143 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0086 | 0.1347 | 0.2275 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0075 | 0.1079 | 0.1782 |
Brugia malayi | hypothetical protein | 0.0035 | 0.011 | 0.011 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0075 | 0.1079 | 0.1333 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0035 | 0.011 | 0.011 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0075 | 0.1079 | 0.1079 |
Trypanosoma brucei | unspecified product | 0.0034 | 0.0082 | 0.0969 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0075 | 0.1079 | 0.1782 |
Brugia malayi | tailless protein | 0.0035 | 0.011 | 0.011 |
Brugia malayi | ecdysone receptor | 0.0035 | 0.011 | 0.011 |
Brugia malayi | hypothetical protein | 0.004 | 0.0214 | 0.0214 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.