Detailed information for compound 784143

Basic information

Technical information
  • TDR Targets ID: 784143
  • Name: N-(4-ethoxyphenyl)-N'-[(3-ethoxy-4-propoxyphe nyl)methylideneamino]oxamide
  • MW: 413.467 | Formula: C22H27N3O5
  • H donors: 2 H acceptors: 2 LogP: 3.98 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1ccc(cc1OCC)C=NNC(=O)C(=O)Nc1ccc(cc1)OCC
  • InChi: 1S/C22H27N3O5/c1-4-13-30-19-12-7-16(14-20(19)29-6-3)15-23-25-22(27)21(26)24-17-8-10-18(11-9-17)28-5-2/h7-12,14-15H,4-6,13H2,1-3H3,(H,24,26)(H,25,27)/b23-15+
  • InChiKey: OJWUHMLYFTZOEB-HZHRSRAPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-ethoxyphenyl)-N'-[(3-ethoxy-4-propoxy-phenyl)methyleneamino]oxamide
  • N-(4-ethoxyphenyl)-N'-[(3-ethoxy-4-propoxyphenyl)methyleneamino]oxamide
  • N-(4-ethoxyphenyl)-N'-[(3-ethoxy-4-propoxy-benzylidene)amino]oxamide
  • N-(4-ethoxyphenyl)-N'-[(3-ethoxy-4-propoxy-phenyl)methylideneamino]ethanediamide
  • A0637/0029591

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0013 0.0013
Brugia malayi jmjC domain containing protein 0.0016 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Giardia lamblia Isoprenylcysteine carboxyl methyltransferase 0.7163 1 0.5
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0055 0.0055
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0024 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0029 0.0029
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0036 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0036 0.0028
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0008 0.0008
Onchocerca volvulus 0.0049 0.0055 0.1745
Brugia malayi intermediate filament protein 0.0027 0.0024 0.0024
Onchocerca volvulus 0.0056 0.0065 0.2049
Echinococcus granulosus lamin 0.0027 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.7163 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0007 0.0007
Echinococcus granulosus protein S isoprenylcysteine O methyltransferase 0.7163 1 1
Mycobacterium ulcerans hypothetical protein 0.3127 0.4358 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0036 0.0036
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.007 0.007
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.007 0.007
Schistosoma mansoni lamin 0.0027 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0024 0.0024
Loa Loa (eye worm) protein-S isoprenylcysteine O-methyltransferase 0.7163 1 1
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.7163 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0008 0.0008
Brugia malayi Pre-SET motif family protein 0.0207 0.0275 0.0275
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0012 0.0012
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0036 0.0036
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0004 0.0004
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0008 0.0008
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0008 0.0008
Brugia malayi Pre-SET motif family protein 0.0031 0.0029 0.0029
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0008 0.0008
Onchocerca volvulus 0.0036 0.0036 0.1149
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0004
Echinococcus granulosus dnaJ subfamily B 0.0802 0.1106 0.1106
Plasmodium vivax protein-S-isoprenylcysteine O-methyltransferase, putative 0.7163 1 1
Trypanosoma brucei prenyl protein specific carboxyl methyltransferase 0.7163 1 1
Schistosoma mansoni cpg binding protein 0.0059 0.0069 0.0069
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0075 0.0075
Plasmodium vivax SET domain protein, putative 0.0031 0.0029 0.002
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0006 0.0006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0029 0.0029
Schistosoma mansoni cpg binding protein 0.0056 0.0065 0.0065
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.7163 1 1
Echinococcus multilocularis 0.7163 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0802 0.1106 0.1106
Echinococcus granulosus intermediate filament protein 0.0027 0.0024 0.0024
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0036 0.0028
Trichomonas vaginalis set domain proteins, putative 0.0235 0.0315 0.0311
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0008 0.0008
Schistosoma mansoni intermediate filament proteins 0.0027 0.0024 0.0024
Echinococcus multilocularis dnaJ subfamily B 0.0802 0.1106 0.1106
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0036 0.0032
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0008 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0036 0.0032
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0075 0.0075
Brugia malayi jmjC domain containing protein 0.0061 0.007 0.007
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0029 0.0029
Onchocerca volvulus 0.0031 0.0029 0.0916
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0004 0.0004
Brugia malayi jmjC domain containing protein 0.0016 0.0008 0.0008
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0136 0.0128
Schistosoma mansoni protein-s-isoprenylcysteine o-methyltransferase 0.7163 1 1
Onchocerca volvulus 0.0036 0.0036 0.1149
Leishmania major hypothetical protein, conserved 0.0036 0.0036 0.0028
Onchocerca volvulus 0.0036 0.0036 0.1149
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0029 0.002
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0008 0.0008
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0055 0.0055
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0008 0.0008
Leishmania major prenyl protein specific carboxyl methyltransferase, putative 0.7163 1 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0029 0.0029
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.3127 0.4358 1
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.7163 1 0.5
Echinococcus multilocularis tumor protein p63 0.0338 0.0458 0.0458
Schistosoma mansoni hypothetical protein 0.0174 0.023 0.023
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0007 0.0007
Plasmodium falciparum protein-S-isoprenylcysteine O-methyltransferase, putative 0.7163 1 1
Echinococcus granulosus tumor protein p63 0.0338 0.0458 0.0458
Echinococcus multilocularis lamin 0.0027 0.0024 0.0024
Brugia malayi jmjC domain containing protein 0.0016 0.0008 0.0008
Onchocerca volvulus 0.0027 0.0024 0.0748
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.7163 1 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0036 0.0032
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0036 0.0028
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.0307 0.0627
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0029 0.0029
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0174 0.023 0.023
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.081 0.1119 0.1119
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0006 0.0006
Onchocerca volvulus 0.0027 0.0024 0.0748
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0023
Brugia malayi beta-lactamase 0.0036 0.0036 0.0036
Mycobacterium leprae Probable lipase LipE 0.0036 0.0036 0.5
Brugia malayi beta-lactamase family protein 0.0036 0.0036 0.0036
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0024 0.0024
Brugia malayi jmjC domain containing protein 0.0064 0.0075 0.0075
Brugia malayi CXXC zinc finger family protein 0.0056 0.0065 0.0065
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0036 0.0036
Schistosoma mansoni jumonji domain containing protein 0.0061 0.007 0.007
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0008 0.0008
Echinococcus multilocularis cpg binding protein 0.0059 0.0069 0.0069
Echinococcus multilocularis lamin dm0 0.0027 0.0024 0.0024
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0007 0.0007
Echinococcus granulosus lamin dm0 0.0027 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0008
Echinococcus granulosus cpg binding protein 0.0059 0.0069 0.0069
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0036 0.5
Onchocerca volvulus 0.0235 0.0315 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0012 0.0012
Loa Loa (eye worm) beta-lactamase 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0007 0.0007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.0154 0.0154
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0008 0.0008
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0075 0.0075
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0008 0.0008
Brugia malayi jmjC domain containing protein 0.0016 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0036 0.0036
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0008
Schistosoma mansoni cpg binding protein 0.0059 0.0069 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0036 0.0028
Toxoplasma gondii ABC1 family protein 0.0036 0.0036 0.0028
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0013 0.0013
Trichomonas vaginalis esterase, putative 0.0036 0.0036 0.0032
Echinococcus granulosus phd:f box containing protein 0.0016 0.0008 0.0008
Echinococcus granulosus geminin 0.0174 0.023 0.023
Echinococcus multilocularis geminin 0.0174 0.023 0.023
Echinococcus multilocularis musashi 0.0027 0.0024 0.0024
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0075 0.0075
Toxoplasma gondii isoprenylcysteine carboxyl methyltransferase (icmt) family protein 0.7163 1 1
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.7163 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0036 0.0032
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0008 0.0008
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.7163 1 1
Brugia malayi beta-lactamase family protein 0.0036 0.0036 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0029 0.0029
Schistosoma mansoni lamin 0.0027 0.0024 0.0024
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0026 0.0026
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0012 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0036 0.0032
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0008 0.0008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0029 0.0029

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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