Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.0242 | 0.0322 |
Echinococcus granulosus | peregrin | 0.0031 | 0.0174 | 0.0372 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0439 | 0.0752 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.0512 | 0.1096 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0025 | 0.0103 | 0.002 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0053 | 0.0439 | 0.0415 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0282 | 0.0604 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.0592 | 0.1268 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0307 | 0.0657 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0592 | 0.1268 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0592 | 0.1268 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1474 | 0.3155 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0292 | 0.3353 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.1298 | 0.2777 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0029 | 0.0145 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0103 | 0.0221 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0292 | 0.3353 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0255 | 0.0546 |
Mycobacterium ulcerans | thymidylate synthase | 0.0111 | 0.1147 | 0.202 |
Schistosoma mansoni | jumonji domain containing protein | 0.0075 | 0.0706 | 0.1511 |
Echinococcus granulosus | dihydrofolate reductase | 0.04 | 0.4673 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.1928 | 0.4125 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0255 | 0.0468 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0242 | 0.0517 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.026 | 0.2962 | 0.6339 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0407 | 0.0682 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0025 | 0.0103 | 0.0103 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0255 | 0.0352 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.0592 | 0.1088 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0255 | 0.0352 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0284 | 0.0608 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.2962 | 0.8879 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0592 | 0.1268 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.0555 | 0.1187 |
Echinococcus granulosus | geminin | 0.0175 | 0.1928 | 0.4125 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.0242 | 0.0517 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0171 | 0.1873 | 0.5307 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.2962 | 0.8879 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0025 | 0.0103 | 0.0221 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0213 | 0.026 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0025 | 0.0103 | 0.0221 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.04 | 0.4673 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0255 | 0.0546 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0255 | 0.0546 |
Schistosoma mansoni | choline o-acyltransferase | 0.0025 | 0.0103 | 0.0221 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0171 | 0.1873 | 0.5307 |
Schistosoma mansoni | choline o-acyltransferase | 0.0025 | 0.0103 | 0.0221 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0171 | 0.1873 | 0.5307 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3304 | 1 |
Onchocerca volvulus | 0.0038 | 0.0255 | 0.0428 | |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0242 | 0.0517 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.026 | 0.2962 | 0.6263 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0255 | 0.0546 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0145 | 0.0111 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0037 | 0.0242 | 0.0517 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3304 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0141 | 0.1509 | 0.2838 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.2962 | 0.8879 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0171 | 0.1873 | 0.5307 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3304 | 1 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0255 | 0.0352 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.0592 | 0.1268 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0292 | 0.3353 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.0592 | 0.1268 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0255 | 0.0546 |
Onchocerca volvulus | Alhambra homolog | 0.0029 | 0.0145 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0255 | 0.0546 |
Onchocerca volvulus | 0.0038 | 0.0255 | 0.0428 | |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0141 | 0.1509 | 0.2838 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0255 | 0.0468 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0025 | 0.0103 | 0.0221 |
Brugia malayi | jmjC domain containing protein | 0.0094 | 0.0941 | 0.185 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0255 | 0.0343 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0111 | 0.1147 | 0.202 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0288 | 0.3304 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.0518 | 0.1108 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.1985 | 0.5674 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.1985 | 0.5674 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0053 | 0.0439 | 0.1032 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.003 | 0.0065 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.0696 | 0.1313 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0138 | 0.1474 | 0.3155 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0407 | 0.0682 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0025 | 0.0103 | 0.0103 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0043 | 0.0092 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0066 | 0.0066 |
Brugia malayi | Dihydrofolate reductase | 0.04 | 0.4673 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.003 | 0.0065 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0592 | 0.1268 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0439 | 0.0601 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0255 | 0.0468 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0138 | 0.1474 | 0.4219 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.1928 | 0.4125 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0025 | 0.0103 | 0.0221 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.1298 | 0.2628 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0288 | 0.3304 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3304 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.0145 | 0.0311 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0007 | 0.0016 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 0.0941 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0407 | 0.087 |
Echinococcus multilocularis | peregrin | 0.0031 | 0.0174 | 0.0174 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3304 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0213 | 0.0456 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0255 | 0.0352 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0282 | 0.0282 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0138 | 0.1474 | 0.1474 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0255 | 0.0546 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.2962 | 0.8879 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3304 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0255 | 0.0546 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.0592 | 0.0592 |
Echinococcus granulosus | choline O acetyltransferase | 0.0025 | 0.0103 | 0.0221 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 0.0941 | 0.2015 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0145 | 0.0311 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.0512 | 0.0512 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0111 | 0.1147 | 0.2456 |
Onchocerca volvulus | 0.0111 | 0.1147 | 0.2938 | |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.3657 | 0.7826 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0227 | 0.0485 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0138 | 0.1474 | 0.4219 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.003 | 0.003 |
Brugia malayi | RNA binding protein | 0.0065 | 0.0592 | 0.1088 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0111 | 0.1147 | 0.202 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0395 | 0.0846 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3304 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0407 | 0.087 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0255 | 0.0343 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0066 | 0.0141 |
Onchocerca volvulus | 0.0038 | 0.0255 | 0.0428 | |
Brugia malayi | dihydrofolate reductase family protein | 0.04 | 0.4673 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.04 | 0.4673 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.04 | 0.4673 | 0.4673 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.04 | 0.4673 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0255 | 0.0468 |
Echinococcus multilocularis | thymidylate synthase | 0.0111 | 0.1147 | 0.1147 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.0592 | 0.1268 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0025 | 0.0103 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0145 | 0.0311 |
Trypanosoma brucei | pteridine reductase 1 | 0.0201 | 0.2241 | 0.6578 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0219 | 0.0219 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0029 | 0.0145 | 0.0145 |
Onchocerca volvulus | 0.0317 | 0.3657 | 1 | |
Brugia malayi | Choline O-acetyltransferase | 0.0025 | 0.0103 | 0.002 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0171 | 0.1873 | 0.5307 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0288 | 0.3304 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0141 | 0.1509 | 0.2838 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0255 | 0.0546 |
Brugia malayi | thymidylate synthase | 0.0111 | 0.1147 | 0.23 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0292 | 0.3353 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0066 | 0.0141 |
Echinococcus multilocularis | geminin | 0.0175 | 0.1928 | 0.1928 |
Loa Loa (eye worm) | thymidylate synthase | 0.0111 | 0.1147 | 0.2456 |
Echinococcus granulosus | thymidylate synthase | 0.0111 | 0.1147 | 0.2456 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0644 | 0.1379 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0043 | 0.0092 |
Brugia malayi | Bromodomain containing protein | 0.0031 | 0.0174 | 0.0173 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0138 | 0.1474 | 0.3014 |
Brugia malayi | Choline O-acetyltransferase | 0.0025 | 0.0103 | 0.002 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3304 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0241 | 0.2735 | 0.5612 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0256 | 0.0548 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.1298 | 0.2777 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0292 | 0.3353 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0227 | 0.0227 |
Brugia malayi | hypothetical protein | 0.0317 | 0.3657 | 0.7781 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0255 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0255 | 0.0546 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0292 | 0.3353 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.04 | 0.4673 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0592 | 0.1268 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0288 | 0.3304 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0213 | 0.0456 |
Chlamydia trachomatis | dihydrofolate reductase | 0.04 | 0.4673 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.0592 | 0.1088 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0138 | 0.1474 | 0.4219 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.2962 | 0.8879 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.04 | 0.4673 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0171 | 0.1873 | 0.498 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0255 | 0.0351 |
Leishmania major | pteridine reductase 1 | 0.0203 | 0.2273 | 0.6678 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.2962 | 0.8879 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0171 | 0.1873 | 0.5307 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0171 | 0.1873 | 0.5307 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0029 | 0.0145 | 0.0311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.