Detailed information for compound 784383

Basic information

Technical information
  • TDR Targets ID: 784383
  • Name: 5-tert-butyl-2-methyl-N-(3-propoxyphenyl)fura n-3-carboxamide
  • MW: 315.407 | Formula: C19H25NO3
  • H donors: 1 H acceptors: 1 LogP: 4.79 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1cccc(c1)NC(=O)c1cc(oc1C)C(C)(C)C
  • InChi: 1S/C19H25NO3/c1-6-10-22-15-9-7-8-14(11-15)20-18(21)16-12-17(19(3,4)5)23-13(16)2/h7-9,11-12H,6,10H2,1-5H3,(H,20,21)
  • InChiKey: JPBQQPYANSOPNX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-tert-butyl-2-methyl-N-(3-propoxyphenyl)-3-furancarboxamide
  • 5-tert-butyl-2-methyl-N-(3-propoxyphenyl)-3-furamide
  • EU-0018821
  • A2150/0090312
  • Oprea1_233678
  • ZINC03670631

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis acetylcholinesterase 0.0268 0.2799 0.9115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0891 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0116 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0227 0.0693
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0056 0.0099
Brugia malayi PHD-finger family protein 0.0089 0.0731 0.2294
Plasmodium vivax SET domain protein, putative 0.003 0.0046 0.0154
Echinococcus multilocularis carboxylesterase 5A 0.0268 0.2799 0.9115
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0116 0.0116
Loa Loa (eye worm) acetylcholinesterase 1 0.0268 0.2799 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0044 0.0044
Echinococcus granulosus lysine specific demethylase 5A 0.0109 0.0968 0.3096
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.004 0.0522
Schistosoma mansoni jumonji/arid domain-containing protein 0.0109 0.0968 0.3373
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0891 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0484 0.1621
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0731 1
Onchocerca volvulus 0.0045 0.0227 0.0701
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0046 0.0066
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0046 0.0035
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0435 0.4734 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0116 0.029
Loa Loa (eye worm) hypothetical protein 0.0036 0.0116 0.029
Echinococcus multilocularis BC026374 protein (S09 family) 0.0045 0.0227 0.0632
Onchocerca volvulus 0.0052 0.0304 0.1038
Mycobacterium ulcerans carboxylesterase, LipT 0.0045 0.0227 0.0241
Trichomonas vaginalis set domain proteins, putative 0.023 0.2365 0.2365
Brugia malayi Pre-SET motif family protein 0.003 0.0046 0.0035
Loa Loa (eye worm) hypothetical protein 0.0036 0.0116 0.029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0116 0.029
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0046 0.0154
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.004 0.006
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0655 0.0655
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0227 0.0631
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0044 0.0044
Brugia malayi Carboxylesterase family protein 0.0268 0.2799 0.9115
Treponema pallidum fructose-bisphosphate aldolase 0.0891 1 0.5
Brugia malayi Pre-SET motif family protein 0.0202 0.2043 0.6619
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0046 0.0035
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0435 0.4734 1
Onchocerca volvulus 0.023 0.2365 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0045 0.0227 0.0241
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0116 1
Schistosoma mansoni chromobox protein 0.0136 0.1281 0.4506
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0227 0.0693
Onchocerca volvulus 0.0036 0.0116 0.0217
Onchocerca volvulus 0.0045 0.0227 0.0701
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0227 0.0693
Echinococcus granulosus carboxylesterase 5A 0.0268 0.2799 0.9117
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0588 0.0588
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0091 0.0751 0.259
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0076 0.0588 0.2271
Echinococcus granulosus L aminoadipate semialdehyde 0.0091 0.0751 0.2384
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0227 0.0693
Brugia malayi jmjC domain containing protein 0.0291 0.3068 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0116 0.029
Schistosoma mansoni cpg binding protein 0.0033 0.0086 0.0184
Echinococcus granulosus cpg binding protein 0.0033 0.0086 0.0198
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0116 0.0116
Trichomonas vaginalis chromobox protein, putative 0.0136 0.1281 0.1281
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0056 0.0068
Onchocerca volvulus Alhambra homolog 0.0089 0.0731 0.2894
Trichomonas vaginalis esterase, putative 0.0036 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0045 0.0227 0.0693
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0891 1 1
Brugia malayi beta-lactamase family protein 0.0036 0.0116 0.0264
Echinococcus granulosus peregrin 0.0089 0.0731 0.2318
Echinococcus multilocularis cpg binding protein 0.0033 0.0086 0.0168
Brugia malayi beta-lactamase 0.0036 0.0116 0.0264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0227 0.0693
Brugia malayi Carboxylesterase family protein 0.0045 0.0227 0.0632
Echinococcus multilocularis lysine specific demethylase 5A 0.0108 0.0947 0.3006
Brugia malayi PHD-finger family protein 0.0031 0.006 0.0082
Echinococcus multilocularis acetylcholinesterase 0.0268 0.2799 0.9115
Brugia malayi Carboxylesterase family protein 0.0045 0.0227 0.0632
Schistosoma mansoni cpg binding protein 0.0033 0.0086 0.0184
Plasmodium vivax hypothetical protein, conserved 0.0089 0.0731 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0402 0.5264
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.2334 0.4804
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0116 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0227 0.0693
Brugia malayi hypothetical protein 0.0045 0.0227 0.0632
Loa Loa (eye worm) hypothetical protein 0.0036 0.0116 0.029
Loa Loa (eye worm) hypothetical protein 0.0036 0.0116 0.029
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0039
Loa Loa (eye worm) hypothetical protein 0.0045 0.0227 0.0693
Loa Loa (eye worm) hypothetical protein 0.0091 0.0751 0.259
Schistosoma mansoni hypothetical protein 0.0089 0.0731 0.2517
Brugia malayi AF-10 protein 0.0029 0.004 0.0014
Brugia malayi Bromodomain containing protein 0.0089 0.0731 0.2294
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0045 0.0227 0.0241
Echinococcus granulosus BC026374 protein S09 family 0.0045 0.0227 0.0661
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0227 0.0693
Loa Loa (eye worm) carboxylesterase 0.0268 0.2799 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0046 0.0039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0116 0.029
Schistosoma mansoni jumonji domain containing protein 0.0231 0.2376 0.847
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0227 0.0661
Brugia malayi Heterochromatin protein 1 0.0136 0.1281 0.4107
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0066 0.0109
Brugia malayi Carboxylesterase family protein 0.0045 0.0227 0.0632
Loa Loa (eye worm) hypothetical protein 0.0045 0.0227 0.0693
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0044 0.0044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0227 0.0693
Onchocerca volvulus 0.0045 0.0227 0.0701
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0227 0.0631
Echinococcus granulosus para nitrobenzyl esterase 0.0045 0.0227 0.0661
Loa Loa (eye worm) hypothetical protein 0.0045 0.0227 0.0693
Trichomonas vaginalis chromobox protein, putative 0.0136 0.1281 0.1281
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.009
Loa Loa (eye worm) jmjC domain-containing protein 0.0184 0.1825 0.6473
Loa Loa (eye worm) hypothetical protein 0.0268 0.2799 1
Brugia malayi Carboxylesterase family protein 0.0045 0.0227 0.0632
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0044 0.0044
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0891 1 0.5
Schistosoma mansoni BC026374 protein (S09 family) 0.0045 0.0227 0.0693
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0268 0.2799 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0891 1 1
Brugia malayi jmjC domain containing protein 0.0109 0.0968 0.3074
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0116 0.0264
Echinococcus granulosus jumonji domain containing protein 0.0124 0.1133 0.364
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.0035 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.033 0.033
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0116 0.0264
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.0035 0.0031
Giardia lamblia Fructose-bisphosphate aldolase 0.0891 1 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0091 0.0751 0.236
Onchocerca volvulus 0.0045 0.0227 0.0701
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0031 0.0062 0.0377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0227 0.0631
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0291 0.3068 1
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0062 0.0377
Echinococcus granulosus phd:f box containing protein 0.0029 0.0035 0.0031
Onchocerca volvulus 0.0045 0.0227 0.0701
Echinococcus multilocularis chromobox protein 1 0.0136 0.1281 0.4107
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0116 0.029
Loa Loa (eye worm) PHD-finger family protein 0.0089 0.0731 0.2517
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0082 0.0655 0.2563
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.033 0.033
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0291 0.3068 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.004 0.006
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0116 1
Echinococcus granulosus acetylcholinesterase 0.0268 0.2799 0.9117
Echinococcus granulosus acetylcholinesterase 0.0268 0.2799 0.9117
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0116 0.0116
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0044 0.0044
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.004 0.0522
Loa Loa (eye worm) heterochromatin protein 1 0.0136 0.1281 0.4506
Loa Loa (eye worm) carboxylesterase 0.0045 0.0227 0.0693
Brugia malayi beta-lactamase family protein 0.0036 0.0116 0.0264
Loa Loa (eye worm) jmjC domain-containing protein 0.0109 0.0968 0.3373
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0006 0.0006
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0116 0.0295
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0435 0.4734 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0044 0.0044
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0045 0.0227 0.0661
Mycobacterium tuberculosis Carboxylesterase LipT 0.0045 0.0227 0.0241
Loa Loa (eye worm) hypothetical protein 0.0268 0.2799 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0227 0.0693
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0588 0.0588
Loa Loa (eye worm) hypothetical protein 0.0089 0.0731 0.2517
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0891 1 1
Schistosoma mansoni cpg binding protein 0.0031 0.0066 0.0109
Plasmodium falciparum phd finger protein, putative 0.0089 0.0731 1
Schistosoma mansoni hypothetical protein 0.0029 0.004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0152 0.1465 0.5171
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0091 0.0751 0.236
Echinococcus granulosus chromobox protein 1 0.0136 0.1281 0.4125
Echinococcus granulosus PHD finger protein rhinoceros 0.0089 0.0731 0.2318
Loa Loa (eye worm) carboxylesterase 0.0045 0.0227 0.0693
Echinococcus multilocularis chromobox protein 1 0.0136 0.1281 0.4107
Echinococcus multilocularis PHD finger protein rhinoceros 0.0089 0.0731 0.2294
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0045 0.0227 0.0632
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0089 0.0731 0.2517
Brugia malayi chromobox protein homolog 3 0.0076 0.0588 0.1822
Loa Loa (eye worm) hypothetical protein 0.006 0.0397 0.1308
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0044 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0891 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0891 1 1
Echinococcus granulosus chromobox protein 1 0.0136 0.1281 0.4125
Echinococcus multilocularis jumonji domain containing protein 0.0124 0.1133 0.362
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.0035 0.0031
Onchocerca volvulus 0.0036 0.0116 0.0217
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0227 0.0661
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0116 0.0116
Brugia malayi Carboxylesterase family protein 0.0268 0.2799 0.9115
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0052 0.0304 0.0972
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0891 1 1
Brugia malayi F/Y-rich N-terminus family protein 0.004 0.0162 0.0419
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0046 0.0039
Brugia malayi CXXC zinc finger family protein 0.0031 0.0066 0.01
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0731 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0045 0.0227 0.0693
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0006 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0142 0.0385
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0045 0.0227 0.0227
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0044 0.0044
Schistosoma mansoni gliotactin 0.0045 0.0227 0.0693
Leishmania major hypothetical protein, conserved 0.0036 0.0116 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0045 0.0227 0.0227
Onchocerca volvulus 0.006 0.0397 0.1441
Loa Loa (eye worm) beta-lactamase 0.0036 0.0116 0.029
Echinococcus multilocularis peregrin 0.0089 0.0731 0.2294
Echinococcus multilocularis para nitrobenzyl esterase 0.0045 0.0227 0.0632
Onchocerca volvulus 0.0036 0.0116 0.0217
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2043 0.7262
Loa Loa (eye worm) hypothetical protein 0.0045 0.0227 0.0693
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0655 0.0655
Schistosoma mansoni acetylcholinesterase 0.0045 0.0227 0.0693
Schistosoma mansoni chromobox protein 0.0136 0.1281 0.4506
Echinococcus granulosus neuroligin 0.0045 0.0227 0.0661
Onchocerca volvulus 0.0091 0.0751 0.2982
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0116 0.1152
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0046 0.0039
Schistosoma mansoni jumonji/arid domain-containing protein 0.0109 0.0968 0.3373
Echinococcus multilocularis neuroligin 0.0045 0.0227 0.0632
Loa Loa (eye worm) hypothetical protein 0.0076 0.0588 0.1999
Toxoplasma gondii ABC1 family protein 0.0036 0.0116 0.1152

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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