Detailed information for compound 784433

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 423.501 | Formula: C25H29NO5
  • H donors: 2 H acceptors: 4 LogP: 5.3 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCN1C(c2ccc(c(c2)OC)O)C(=C(C1=O)O)C(=O)c1ccc(cc1)C
  • InChi: 1S/C25H29NO5/c1-4-5-6-7-14-26-22(18-12-13-19(27)20(15-18)31-3)21(24(29)25(26)30)23(28)17-10-8-16(2)9-11-17/h8-13,15,22,27,29H,4-7,14H2,1-3H3
  • InChiKey: RNZCVRXFHPCWIC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0156 0.1745
Loa Loa (eye worm) inositol-1 0.004 0.0603 0.0878
Schistosoma mansoni alpha-glucosidase 0.0139 0.2898 0.4126
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0519 0.3754
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0109 0.021
Loa Loa (eye worm) hypothetical protein 0.0148 0.3094 0.4505
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0894 0.0794
Brugia malayi hypothetical protein 0.0053 0.091 0.1326
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.2433 0.5717
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0109 0.1215
Brugia malayi glutathione reductase 0.0052 0.0894 0.1301
Loa Loa (eye worm) hypothetical protein 0.0053 0.091 0.1326
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0109 0.1215
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0053 0.091 0.1186
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0053 0.091 0.0811
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0156 0.0048
Entamoeba histolytica hypothetical protein 0.0073 0.1381 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0769 0.0667
Echinococcus granulosus GPCR family 2 0.0047 0.0769 0.0667
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0109 0.1215
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0382 0.0276
Plasmodium vivax hypothetical protein, conserved 0.0053 0.091 0.2128
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0603 0.1312
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0109 0.1215
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0894 0.2175
Schistosoma mansoni hypothetical protein 0.0047 0.0769 0.0976
Brugia malayi hypothetical protein 0.0073 0.1381 0.2011
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0156 0.0239
Loa Loa (eye worm) solute carrier family 6 member 4 0.0311 0.6869 1
Onchocerca volvulus 0.0237 0.5163 0.7517
Treponema pallidum sodium- and chloride- dependent transporter 0.0311 0.6869 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0356 0.025
Brugia malayi Inositol-1 0.004 0.0603 0.0878
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.2726 0.3969
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0285 0.0469
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0603 0.6746
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0109 0.0115
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0053 0.091 0.1186
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0053 0.091 0.2219
Loa Loa (eye worm) hypothetical protein 0.0101 0.2018 0.2938
Echinococcus granulosus serotonin transporter 0.0311 0.6869 0.6834
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0519 0.0414
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.2726 0.3969
Echinococcus multilocularis sodium and chloride dependent glycine 0.0053 0.091 0.0811
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0109 0.1215
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0156 0.0239
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.2433 0.6215
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0603 0.4365
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0109 0.021
Toxoplasma gondii hypothetical protein 0.0053 0.091 0.2219
Onchocerca volvulus 0.003 0.0382 0.0556
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0182 0.3876 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.3416 0.4974
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0382 0.0404
Loa Loa (eye worm) hypothetical protein 0.003 0.0382 0.0556
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0519 0.1004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0109 0.1215
Echinococcus multilocularis sodium and chloride dependent glycine 0.0053 0.091 0.0811
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0053 0.091 0.1326
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0109 0.0158
Echinococcus multilocularis GPCR, family 2 0.0047 0.0769 0.0667
Loa Loa (eye worm) hypothetical protein 0.0053 0.091 0.1326
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0156 0.0227
Loa Loa (eye worm) glutathione reductase 0.0052 0.0894 0.1301
Toxoplasma gondii exonuclease III APE 0.002 0.0156 0.0239
Plasmodium vivax amine transporter, putative 0.0053 0.091 0.2128
Mycobacterium tuberculosis Probable reductase 0.0119 0.2433 0.6215
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.2018 0.2938
Trypanosoma brucei glucosidase, putative 0.0036 0.0519 0.5802
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0894 0.2084
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0053 0.091 0.1186
Echinococcus multilocularis serotonin transporter 0.0311 0.6869 0.6834
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.2739 0.7017
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0109 0.0115
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0156 0.007
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0053 0.091 0.2128
Schistosoma mansoni sodium-dependent amino acid transporter 0.0053 0.091 0.1186
Schistosoma mansoni hypothetical protein 0.0073 0.1381 0.1883
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0156 0.1745
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.2739 0.6625
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0769 0.0667
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0382 0.0404
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0519 0.1004
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0285 0.0469
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0053 0.091 0.0811
Schistosoma mansoni sodium/chloride dependent transporter 0.0311 0.6869 1
Schistosoma mansoni inositol monophosphatase 0.004 0.0603 0.0731
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0603 0.6746
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0156 0.0126
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0603 0.1168
Brugia malayi hypothetical protein 0.0017 0.0075 0.0109
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0156 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0109 0.1215
Trichomonas vaginalis hypothetical protein 0.0182 0.3876 0.7507
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.3094 0.4505
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0053 0.091 0.1186
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0311 0.6869 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0285 0.0416
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0769 0.1119
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0182 0.3876 1
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0894 0.1301
Toxoplasma gondii hypothetical protein 0.0053 0.091 0.2219
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0285 0.0469
Loa Loa (eye worm) hypothetical protein 0.0053 0.091 0.1326
Onchocerca volvulus 0.0093 0.1846 0.2688
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0156 0.0302
Echinococcus multilocularis neuropeptide s receptor 0.0447 1 1
Onchocerca volvulus 0.0053 0.091 0.1326
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0109 0.0115
Trichomonas vaginalis set domain proteins, putative 0.0237 0.5163 1
Brugia malayi MH2 domain containing protein 0.0132 0.2726 0.3969
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.1381 0.1883
Plasmodium vivax SET domain protein, putative 0.003 0.0382 0.0725
Brugia malayi hypothetical protein 0.0026 0.0285 0.0416
Schistosoma mansoni hypothetical protein 0.0047 0.0769 0.0976
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0109 0.1215
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0156 0.0227
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.4499 0.655
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0382 0.0831
Toxoplasma gondii thioredoxin reductase 0.0052 0.0894 0.2175
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0053 0.091 0.2219
Plasmodium falciparum thioredoxin reductase 0.0052 0.0894 0.2084
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.3416 0.3344
Brugia malayi Pre-SET motif family protein 0.0209 0.4499 0.655
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0109 0.1215
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0109 0.1215
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0109 0.1215
Echinococcus multilocularis neuropeptide receptor A26 0.0447 1 1
Plasmodium falciparum transporter, putative 0.0053 0.091 0.2128
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0285 0.3193
Loa Loa (eye worm) hypothetical protein 0.0047 0.0769 0.1119
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0109 0.0115
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0053 0.091 0.2219
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0382 0.0276
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0769 0.1119
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.3416 0.3344
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0519 0.0414
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0053 0.091 0.1326
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0519 0.5802
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0508 0.1162
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0182 0.3876 1
Leishmania major oxidoreductase-like protein 0.0016 0.0065 0.0725
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0156 1
Entamoeba histolytica hypothetical protein 0.0073 0.1381 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0053 0.091 0.1186
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0769 0.0667
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0519 0.1004
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0053 0.091 0.1326
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0109 0.0115
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0182 0.3876 1
Plasmodium falciparum glutathione reductase 0.0052 0.0894 0.2084
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0894 1
Plasmodium vivax glutathione reductase, putative 0.0052 0.0894 0.2084
Loa Loa (eye worm) hypothetical protein 0.0053 0.091 0.1326
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.1381 0.1287
Loa Loa (eye worm) hypothetical protein 0.0053 0.091 0.1326
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0053 0.091 0.0811
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.3094 0.4505
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0894 0.0794
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.3416 0.3344
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0156 0.1745
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0053 0.091 0.1326
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0109 0.1215
Schistosoma mansoni sodium/chloride dependent transporter 0.0053 0.091 0.1186
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0519 0.1004
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0519 0.1004
Echinococcus granulosus neuropeptide receptor A26 0.0447 1 1
Leishmania major trypanothione reductase 0.0052 0.0894 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0519 0.1004
Echinococcus granulosus sodium and chloride dependent glycine 0.0053 0.091 0.0811
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0519 0.1004
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0519 0.5802
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0519 0.3754
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0382 0.0404
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0053 0.091 0.1186
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0156 0.0048
Loa Loa (eye worm) hypothetical protein 0.0311 0.6869 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0382 0.0276
Schistosoma mansoni hypothetical protein 0.0047 0.0769 0.0976
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.2433 0.6215
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0285 0.0579
Loa Loa (eye worm) hypothetical protein 0.0311 0.6869 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0382 0.0404
Schistosoma mansoni inositol monophosphatase 0.004 0.0603 0.0731
Brugia malayi Pre-SET motif family protein 0.003 0.0382 0.0556
Schistosoma mansoni sodium/chloride dependent transporter 0.0053 0.091 0.1186
Plasmodium falciparum enoyl-acyl carrier reductase 0.0182 0.3876 1
Loa Loa (eye worm) serotonin transporter b 0.0311 0.6869 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0603 0.1168
Schistosoma mansoni ap endonuclease 0.002 0.0156 0.007
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0182 0.3876 1
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0603 0.05
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0603 0.1412
Onchocerca volvulus 0.0016 0.0065 0.0094
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0053 0.091 0.0811
Plasmodium falciparum amino acid transporter, putative 0.0053 0.091 0.2128
Loa Loa (eye worm) hypothetical protein 0.0053 0.091 0.1326
Entamoeba histolytica hypothetical protein 0.0073 0.1381 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0519 0.1191
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0519 0.5802
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0109 0.1215
Schistosoma mansoni hypothetical protein 0.0047 0.0769 0.0976
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0053 0.091 0.1186
Schistosoma mansoni alpha glucosidase 0.0036 0.0519 0.0606
Leishmania major hypothetical protein, conserved 0.0026 0.0285 0.3193
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0109 0.1215
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0603 0.1168
Onchocerca volvulus 0.0053 0.091 0.1326
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0053 0.091 0.0811
Echinococcus granulosus sodium and chloride dependent glycine 0.0053 0.091 0.0811
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.3094 0.4505
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0156 0.0302
Schistosoma mansoni alpha-glucosidase 0.0139 0.2898 0.4126
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0769 0.0667
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0109 0.1215
Schistosoma mansoni ap endonuclease 0.002 0.0156 0.007
Loa Loa (eye worm) norepinephrine transporter 0.0311 0.6869 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0109 0.0115
Onchocerca volvulus 0.0053 0.091 0.1326
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0053 0.091 0.0811
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.2739 0.7017
Entamoeba histolytica hypothetical protein 0.0073 0.1381 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0016 0.0065 0.0725
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0053 0.091 0.0811
Leishmania major pteridine reductase 1 0.0016 0.0065 0.0725
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.2433 0.6215
Trypanosoma brucei trypanothione reductase 0.0052 0.0894 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.3416 0.4974
Trypanosoma brucei oxidoreductase-like protein 0.0016 0.0065 0.0725
Brugia malayi Thioredoxin reductase 0.0052 0.0894 0.1301
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.2739 0.7017
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0285 0.3193
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.2433 0.6215
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0156 0.1129
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0182 0.3876 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0519 0.1004
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0519 0.1004
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0053 0.091 0.1186
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0311 0.6869 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.1381 0.1287
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0156 0.0126
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0603 0.6746
Loa Loa (eye worm) hypothetical protein 0.0053 0.091 0.1326
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0109 0.1215
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.2433 0.6215
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0603 0.1412
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0603 0.05
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0285 0.3193
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0182 0.3876 1
Onchocerca volvulus 0.0311 0.6869 1
Schistosoma mansoni hypothetical protein 0.0101 0.2018 0.2824
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0053 0.091 0.1326
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0519 0.0755
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0156 0.1745
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0519 0.0755
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0053 0.091 0.1326
Loa Loa (eye worm) hypothetical protein 0.0311 0.6869 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0769 0.1119
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0603 0.6746
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0109 0.1215

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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