Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2636 | 0.9606 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.2744 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0105 | 0.699 | 0.8837 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.2636 | 0.338 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2636 | 0.9606 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0578 | 0.0742 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0578 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.2744 | 0.3519 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0016 | 0.0578 | 0.2108 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.2744 | 0.2985 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.2744 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0.0578 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2636 | 0.2636 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0578 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.2744 | 0.3519 |
Brugia malayi | glutathione reductase | 0.0046 | 0.2744 | 0.3519 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.2744 | 0.3519 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.2636 | 0.338 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2636 | 0.2636 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.2744 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0016 | 0.0578 | 0.0578 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.2744 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0016 | 0.0578 | 0.2108 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0016 | 0.0578 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0117 | 0.7834 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.2744 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.2744 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.2744 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0105 | 0.699 | 0.8837 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2636 | 0.9606 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.2744 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2636 | 0.9606 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0016 | 0.0578 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0016 | 0.0578 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0105 | 0.699 | 0.8837 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0016 | 0.0578 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0117 | 0.7834 | 1 |
Leishmania major | trypanothione reductase | 0.0046 | 0.2744 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0105 | 0.699 | 0.8837 |
Treponema pallidum | NADH oxidase | 0.0016 | 0.0578 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2636 | 0.2636 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0012 | 0.0274 | 0.0351 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.2744 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.7798 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0016 | 0.0578 | 0.5 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0012 | 0.0274 | 0.0351 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0117 | 0.7834 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0105 | 0.699 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0117 | 0.7834 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0016 | 0.0578 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.7798 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0105 | 0.699 | 0.8837 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.7798 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.