Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | intermediate filament protein | 0.0026 | 0.4349 | 0.4001 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.1892 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.4349 | 0.4263 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.1892 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.42 | 0.42 |
Onchocerca volvulus | 0.0026 | 0.4349 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.1892 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.1892 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.4349 | 0.5 | |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.1892 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0149 | 0.0149 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.1892 | 0.1892 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.1892 | 0.177 |
Schistosoma mansoni | lamin | 0.0026 | 0.4349 | 0.303 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.4349 | 0.4263 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.1892 | 0.1393 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.4349 | 0.4349 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.1892 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.4349 | 0.4263 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.1892 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.1892 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.1892 | 0.177 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.1892 | 0.5 |
Echinococcus multilocularis | lamin | 0.0026 | 0.4349 | 0.4263 |
Echinococcus granulosus | lamin | 0.0026 | 0.4349 | 0.4263 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.1892 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.4349 | 0.4349 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.058 | 0.058 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.1892 | 0.5 |
Schistosoma mansoni | lamin | 0.0026 | 0.4349 | 0.303 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.4349 | 0.4001 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.1892 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.1892 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.1892 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.4349 | 0.4349 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.4349 | 0.303 |
Echinococcus multilocularis | musashi | 0.0026 | 0.4349 | 0.4263 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.1892 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.