Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0019 | 0.0029 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0019 | 0.0029 |
Brugia malayi | CHE-14 protein | 0.0045 | 0.2322 | 0.2322 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.1873 | 0.1873 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.001 | 0 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0158 | 1 | 1 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3834 | 0.5936 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3834 | 0.5936 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0019 | 0.0019 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0019 | 0.0019 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1873 | 0.2949 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0019 | 0.0029 |
Echinococcus multilocularis | protein patched | 0.0045 | 0.2322 | 0.2322 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0019 | 0.0029 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0105 | 0.6459 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0019 | 0.0029 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.2322 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.3834 | 0.3834 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0045 | 0.2322 | 0.2322 |
Schistosoma mansoni | patched 1 | 0.0045 | 0.2322 | 0.3595 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.1873 | 0.2899 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0019 | 0.0019 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.001 | 0 | 0.5 |
Giardia lamblia | Replication factor C, subunit 1 | 0.001 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0019 | 0.0029 |
Echinococcus granulosus | expressed conserved protein | 0.0098 | 0.5922 | 0.5922 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0019 | 0.0029 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.3834 | 0.3834 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0045 | 0.2322 | 0.2322 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.1873 | 0.1873 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1873 | 0.2899 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2213 | 0.3426 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.3834 | 0.3834 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0019 | 0.0019 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0019 | 0.0029 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0019 | 0.0019 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1873 | 0.2949 |
Echinococcus multilocularis | muscleblind protein | 0.0158 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0019 | 0.0019 |
Chlamydia trachomatis | DNA ligase | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3834 | 0.5936 |
Echinococcus multilocularis | protein dispatched 1 | 0.0051 | 0.275 | 0.275 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.3834 | 0.3834 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2322 | 0.2322 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0019 | 0.0029 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0019 | 0.0029 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0019 | 0.0019 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.0019 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3834 | 0.5936 |
Onchocerca volvulus | 0.0011 | 0.0019 | 1 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0104 | 0.635 | 0.635 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0104 | 0.635 | 0.635 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0148 | 0.9378 | 0.9378 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0148 | 0.9378 | 0.9378 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3834 | 0.5936 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0019 | 0.0019 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0 | 0.5 |
Toxoplasma gondii | ATPase, AAA family protein | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0019 | 0.0019 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1873 | 0.2949 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.635 | 0.635 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2213 | 0.3426 |
Treponema pallidum | DNA ligase (lig) | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2213 | 0.3426 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.3834 | 0.3834 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.0019 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0019 | 0.0019 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1873 | 0.2949 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0019 | 0.0019 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.3834 | 0.3834 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.3004 | 0.3004 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0045 | 0.2322 | 0.2322 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | RNA binding protein | 0.0067 | 0.3834 | 0.3834 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 1 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0104 | 0.635 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0019 | 0.0029 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0019 | 0.0029 |
Echinococcus multilocularis | expressed conserved protein | 0.0098 | 0.5922 | 0.5922 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0104 | 0.635 | 0.635 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.3834 | 0.3834 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.001 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.0019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0045 | 0.2322 | 0.2322 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2213 | 0.3426 |
Brugia malayi | hypothetical protein | 0.0038 | 0.1873 | 0.1873 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0019 | 0.0029 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0158 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.