Detailed information for compound 784756

Basic information

Technical information
  • TDR Targets ID: 784756
  • Name: A0671/0031251
  • MW: 357.404 | Formula: C19H23N3O4
  • H donors: 2 H acceptors: 1 LogP: 3.16 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C=NNC(=O)CNc2ccc(cc2)C)cc(c1OC)OC
  • InChi: 1S/C19H23N3O4/c1-13-5-7-15(8-6-13)20-12-18(23)22-21-11-14-9-16(24-2)19(26-4)17(10-14)25-3/h5-11,20H,12H2,1-4H3,(H,22,23)/b21-11+
  • InChiKey: VNYMPTFYYACPND-SRZZPIQSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis DNA polymerase eta, putative 0.0195 0.279 0.6351
Schistosoma mansoni hypothetical protein 0.0341 0.4959 0.4954
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0138 0.0118
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0138 0.0128
Schistosoma mansoni apoferritin-2 0.0009 0.0032 0.0022
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0055 0.0022
Entamoeba histolytica hypothetical protein 0.0026 0.029 0.0171
Schistosoma mansoni ran 0.0024 0.0254 0.0245
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0055 0.0045
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0055 0.0045
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.029 0.0658
Brugia malayi ImpB/MucB/SamB family protein 0.0163 0.2324 0.2617
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.279 0.7076
Trypanosoma brucei unspecified product 0.0113 0.1573 0.399
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1288 0.3098
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0379 0.0962
Brugia malayi hypothetical protein 0.0016 0.0141 0.0122
Trypanosoma cruzi DNA damage repair protein, putative 0.0051 0.0656 0.1458
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0138 0.0128
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0095 0.007
Toxoplasma gondii thioredoxin reductase 0.0037 0.0453 0.1638
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0095 0.0145
Echinococcus multilocularis cpg binding protein 0.003 0.0348 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0055 0.0024
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0048 0.0617 0.2393
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0048 0.0617 1
Echinococcus granulosus muscleblind protein 0.06 0.8784 0.8783
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0055 0.0024
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.1288 0.1279
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0055 0.0024
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1288 0.3098
Echinococcus multilocularis MAM 0.0016 0.0141 0.0131
Loa Loa (eye worm) hypothetical protein 0.0016 0.0141 0.012
Brugia malayi DnaJ domain containing protein 0.0063 0.0835 0.0916
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.1153 0.8896
Schistosoma mansoni lamin 0.0029 0.0332 0.0322
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0095 0.0215
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.0656 0.1664
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0022
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.1153 0.4679
Onchocerca volvulus 0.0029 0.0332 0.1163
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0801 0.0792
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0567 0.0558
Leishmania major DNA polymerase kappa, putative 0.0171 0.244 0.6092
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0171 0.2435 0.2745
Loa Loa (eye worm) TK/ALK protein kinase 0.0016 0.0141 0.012
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.1292 0.5255
Brugia malayi jmjC domain containing protein 0.0059 0.0777 0.0849
Trypanosoma brucei polo-like protein kinase 0.0093 0.1288 0.3265
Schistosoma mansoni intermediate filament proteins 0.0029 0.0332 0.0322
Schistosoma mansoni microtubule-associated protein tau 0.0682 1 1
Onchocerca volvulus 0.0171 0.2435 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0324 0.0332
Echinococcus multilocularis ferritin 0.0009 0.0032 0.0022
Schistosoma mansoni coup transcription factor 0.001 0.0055 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0055 0.0022
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.1292 0.5255
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0055 0.0024
Schistosoma mansoni hypothetical protein 0.0015 0.0124 0.0114
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0055 0.0045
Loa Loa (eye worm) glutaminase 2 0.0303 0.4393 0.4981
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0254 0.0245
Echinococcus granulosus lamin dm0 0.0029 0.0332 0.0322
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.0656 0.1664
Leishmania major trypanothione reductase 0.0037 0.0453 0.0928
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0163 0.2324 0.2616
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0055 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.279 0.7076
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0035 0.0026
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0112 0.0102
Echinococcus multilocularis lamin 0.0029 0.0332 0.0322
Schistosoma mansoni ferritin 0.0009 0.0032 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0055 0.0024
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.029 0.0505
Loa Loa (eye worm) hypothetical protein 0.0016 0.0138 0.0118
Schistosoma mansoni ferritin 0.0009 0.0032 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0138 0.0118
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0617 0.4644
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0055 0.0022
Trypanosoma cruzi DNA polymerase eta, putative 0.0273 0.3943 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0254 0.0413
Brugia malayi nuclear hormone receptor 0.001 0.0055 0.0024
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0055 0.0045
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0055 0.0045
Onchocerca volvulus 0.0015 0.0124 0.029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0101
Echinococcus granulosus expressed protein 0.0009 0.0032 0.0022
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0095 0.0242
Trypanosoma cruzi DNA polymerase eta, putative 0.016 0.2276 0.5667
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.279 0.7076
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.0656 0.2572
Echinococcus granulosus cpg binding protein 0.003 0.0348 0.0339
Mycobacterium ulcerans glutaminase 0.0303 0.4393 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.1153 0.4679
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0134 0.0113
Brugia malayi jmjC domain containing protein 0.006 0.0801 0.0877
Loa Loa (eye worm) hypothetical protein 0.0273 0.3943 0.4467
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0055 0.0024
Schistosoma mansoni nuclear hormone receptor 0.001 0.0055 0.0045
Onchocerca volvulus 0.0015 0.0124 0.029
Echinococcus granulosus MAM 0.0016 0.0141 0.0131
Leishmania major GTP-binding protein, putative 0.0024 0.0254 0.0413
Brugia malayi RNA, U transporter 1 0.0091 0.1252 0.1392
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.1288 0.1279
Leishmania major DNA polymerase eta, putative 0.016 0.2276 0.5667
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0095 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0055 0.0022
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.2324 0.9521
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0332 0.0339
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0254 0.2833
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0055 0.0022
Leishmania major DNA damage repair protein, putative 0.0051 0.0656 0.1458
Giardia lamblia DNA damage repair protein 0.0051 0.0656 0.2393
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0656 0.1458
Loa Loa (eye worm) DnaJ domain-containing protein 0.0063 0.0835 0.0914
Plasmodium vivax importin-beta 2, putative 0.0032 0.0379 0.506
Trichomonas vaginalis ran, putative 0.0024 0.0254 0.0577
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0055 0.0045
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0055 0.0024
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0095 0.0242
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0095 0.0086
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0138 0.0128
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0453 0.6369
Echinococcus multilocularis dna polymerase kappa 0.0195 0.279 0.2783
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0048 0.0617 0.1342
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0095 0.0305
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.029 0.0658
Mycobacterium ulcerans DNA polymerase IV 0.0195 0.279 0.6325
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0055 0.0045
Schistosoma mansoni thyroid hormone receptor 0.001 0.0055 0.0045
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0254 0.0645
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0087
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0794 0.0784
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0055 0.0022
Schistosoma mansoni hypothetical protein 0.0063 0.0835 0.0826
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.0045 0.0013
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0055 0.0045
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0801 0.0875
Leishmania major importin beta-1 subunit, putative 0.0026 0.029 0.0505
Trypanosoma brucei DNA polymerase IV, putative 0.0187 0.2675 0.6782
Loa Loa (eye worm) hypothetical protein 0.0171 0.2435 0.2743
Echinococcus multilocularis musashi 0.0029 0.0332 0.0322
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1288 0.293
Schistosoma mansoni ferritin 0.0009 0.0032 0.0022
Brugia malayi jmjC domain containing protein 0.0016 0.0138 0.0119
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0055 0.0045
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0112 0.0102
Entamoeba histolytica hypothetical protein 0.0048 0.0617 0.1754
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0055 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0055 0.0024
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0095 0.0242
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.1153 0.4679
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0254 0.025
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0379 0.1302
Brugia malayi ImpB/MucB/SamB family protein 0.0273 0.3943 0.4468
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.279 0.7076
Plasmodium falciparum importin beta, putative 0.0032 0.0379 0.506
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0379 0.0962
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0055 0.0024
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0138 0.0128
Loa Loa (eye worm) hypothetical protein 0.0016 0.0138 0.0118
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0567 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0055 0.0024
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0138 0.0128
Trypanosoma brucei DNA damage repair protein, putative 0.0051 0.0656 0.1664
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0777 0.0768
Giardia lamblia DINP protein human, muc B family 0.0171 0.244 1
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0138 0.0128
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0332 0.0341
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0055 0.0045
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0055 0.0045
Brugia malayi SEA domain containing protein 0.0015 0.0124 0.0103
Echinococcus granulosus lamin 0.0029 0.0332 0.0322
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0341 0.4959 0.5628
Trypanosoma brucei DNA polymerase IV, putative 0.0195 0.279 0.7076
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0048 0.0617 1
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0379 0.037
Echinococcus multilocularis muscleblind protein 0.06 0.8784 0.8783
Brugia malayi glutaminase DH11.1 0.0303 0.4393 0.4982
Toxoplasma gondii ImpB/MucB/SamB family protein 0.016 0.2276 1
Loa Loa (eye worm) DOMON domain-containing protein 0.0015 0.0124 0.0101
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0254 0.2833
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0048 0.0617 0.1342
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0055 0.0045
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0171 0.244 0.6092
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.1153 0.4679
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0138 0.0128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0567 0.0558
Loa Loa (eye worm) glutaminase 0.0303 0.4393 0.4981
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0138 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.279 0.7076
Schistosoma mansoni apoferritin-2 0.0009 0.0032 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0055 0.0045
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.1288 0.4993
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0095 0.0086
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0254 0.0413
Loa Loa (eye worm) hypothetical protein 0.06 0.8784 1
Brugia malayi intermediate filament protein 0.0029 0.0332 0.0341
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0035 0.0026
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0163 0.2324 0.2316
Trypanosoma brucei DNA polymerase IV, putative 0.0195 0.279 0.7076
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0055 0.0045
Schistosoma mansoni hypothetical protein 0.0016 0.0141 0.0131
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.1288 0.3098
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1288 0.293
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0138 0.0196
Onchocerca volvulus 0.0016 0.0141 0.036
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0095 0.1081
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0171 0.2435 0.2428
Schistosoma mansoni ferritin light chain 0.0009 0.0032 0.0022
Leishmania major hypothetical protein, conserved 0.0016 0.0138 0.0111
Trypanosoma cruzi DNA polymerase kappa, putative 0.0195 0.279 0.7003
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0777 0.0768
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0055 0.0045
Treponema pallidum NADH oxidase 0.0013 0.0095 0.1081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0055 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0567 0.0558
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0163 0.2324 0.2316
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0095 0.0242
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0138 0.0351
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.059 0.1341
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0022
Echinococcus granulosus phd:f box containing protein 0.0016 0.0138 0.0128
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.1292 1
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0656 0.1458
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0055 0.0045
Loa Loa (eye worm) glutathione reductase 0.0037 0.0453 0.0477
Loa Loa (eye worm) hypothetical protein 0.0016 0.0141 0.012
Schistosoma mansoni importin beta-1 0.0032 0.0379 0.037
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.1153 0.4679
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.1288 0.1433
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0055 0.0045
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0048 0.0617 1
Onchocerca volvulus 0.0028 0.0324 0.1132
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.0045 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.279 0.7076
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.1288 0.5179
Onchocerca volvulus 0.0015 0.0124 0.029
Echinococcus granulosus FTZ F1 alpha 0.001 0.0055 0.0045
Brugia malayi jmjC domain containing protein 0.0016 0.0138 0.0119
Trypanosoma cruzi DNA damage repair protein, putative 0.0051 0.0656 0.1458
Mycobacterium ulcerans DNA polymerase IV 0.0195 0.279 0.6325
Loa Loa (eye worm) hypothetical protein 0.0016 0.0141 0.012
Schistosoma mansoni kinase 0.0047 0.0608 0.0599
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0048 0.0617 0.2463
Trypanosoma brucei unspecified product 0.0187 0.2675 0.6782
Echinococcus multilocularis lamin dm0 0.0029 0.0332 0.0322
Brugia malayi nuclear receptor NHR-88 0.001 0.0055 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0022
Brugia malayi Muscleblind-like protein 0.06 0.8784 1
Echinococcus granulosus dna polymerase eta 0.0273 0.3943 0.3937
Trypanosoma brucei DNA polymerase kappa, putative 0.0171 0.244 0.6186
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0138 0.0128
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0138 0.0128
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1288 0.293
Echinococcus multilocularis expressed protein 0.0009 0.0032 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0567 0.0558
Schistosoma mansoni lamin 0.0029 0.0332 0.0322
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0022
Schistosoma mansoni DNA polymerase IV / kappa 0.0051 0.0656 0.0647
Plasmodium falciparum thioredoxin reductase 0.0037 0.0453 0.6369
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1288 0.293
Schistosoma mansoni glutaminase 0.0303 0.4393 0.4387
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0022
Schistosoma mansoni ran 0.0024 0.0254 0.0245
Trypanosoma brucei DNA damage repair protein, putative 0.0051 0.0656 0.1664
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0055 0.0045
Onchocerca volvulus 0.0029 0.0332 0.1163
Echinococcus multilocularis dnaJ subfamily C 6 0.0063 0.0835 0.0826
Echinococcus granulosus dna polymerase kappa 0.0195 0.279 0.2783
Brugia malayi Protein kinase domain containing protein 0.0016 0.0141 0.0122
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0055 0.0024
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0055 0.0045
Echinococcus multilocularis L aminoadipate semialdehyde 0.0171 0.2435 0.2428
Loa Loa (eye worm) hypothetical protein 0.0029 0.0332 0.0339
Brugia malayi ecdysteroid receptor 0.001 0.0055 0.0024
Brugia malayi jmjC domain containing protein 0.0016 0.0138 0.0119
Leishmania major DNA polymerase eta, putative 0.0273 0.3943 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0567 0.0558
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0055 0.0045
Echinococcus multilocularis snurportin 1 0.0341 0.4959 0.4954
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.1689 0.4283
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0453 0.1782
Echinococcus granulosus intermediate filament protein 0.0029 0.0332 0.0322
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0171 0.244 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0022
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0048 0.0617 0.2393
Echinococcus granulosus ferritin 0.0009 0.0032 0.0022
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0162 0.0152
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0055 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1288 0.293
Brugia malayi Thioredoxin reductase 0.0037 0.0453 0.0479
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.279 0.7076
Trichomonas vaginalis protein kinase inhibitor, putative 0.0063 0.0835 0.19
Trypanosoma cruzi DNA polymerase kappa, putative 0.0195 0.279 0.7003
Schistosoma mansoni thyroid hormone receptor 0.001 0.0055 0.0045
Schistosoma mansoni hypothetical protein 0.0016 0.0141 0.0131
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0453 0.0928
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.046 0.045
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0138 0.0118
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0324 0.033
Loa Loa (eye worm) hypothetical protein 0.0013 0.0104 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.1689 0.4283
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0055 0.0045
Schistosoma mansoni terminal deoxycytidyl transferase 0.0163 0.2324 0.2316
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0055 0.0045
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0101
Plasmodium vivax DNA repair protein REV1, putative 0.0051 0.0656 1
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0134 0.0115
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0567 0.0609
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0138 0.0118
Brugia malayi polk-prov protein 0.0082 0.1123 0.1245
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0055 0.0045
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0138 0.0764
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0332 0.0339
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0254 0.0245
Brugia malayi Importin beta-1 subunit 0.0032 0.0379 0.0395
Echinococcus multilocularis dna polymerase eta 0.0273 0.3943 0.3937
Onchocerca volvulus 0.0015 0.0124 0.029
Schistosoma mansoni ferritin light chain 0.0009 0.0032 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0022
Mycobacterium ulcerans hypothetical protein 0.0051 0.0656 0.1431
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0195 0.279 0.6351
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1123 0.2848
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0801 0.0792
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0254 0.0252
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0095 0.1081
Trypanosoma brucei DNA polymerase eta, putative 0.0273 0.3943 1
Schistosoma mansoni ferritin 0.0009 0.0032 0.0022
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0055 0.0045
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0138 0.0196
Echinococcus multilocularis microtubule associated protein 2 0.0682 1 1
Schistosoma mansoni cpg binding protein 0.003 0.0348 0.0339
Echinococcus granulosus dnaJ subfamily C 6 0.0063 0.0835 0.0826
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0055 0.0024
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0254 0.0729
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0162 0.0152
Onchocerca volvulus 0.0015 0.0124 0.029
Plasmodium falciparum DNA repair protein REV1, putative 0.0051 0.0656 1
Trypanosoma brucei chrX additional, unordered contigs 0.0051 0.0656 0.1664
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0138 0.0111
Brugia malayi glutathione reductase 0.0037 0.0453 0.0479
Mycobacterium tuberculosis Probable reductase 0.0084 0.1153 0.4679
Loa Loa (eye worm) hypothetical protein 0.0013 0.0104 0.0078
Schistosoma mansoni cpg binding protein 0.003 0.0348 0.0339
Echinococcus granulosus L aminoadipate semialdehyde 0.0171 0.2435 0.2428
Echinococcus granulosus importin subunit beta 1 0.0032 0.0379 0.037
Leishmania major DNA polymerase kappa, putative 0.0051 0.0656 0.1458
Loa Loa (eye worm) hypothetical protein 0.06 0.8784 1
Schistosoma mansoni cpg binding protein 0.0028 0.0324 0.0315
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.1689 0.4283
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0095 0.0145
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0055 0.0022
Trypanosoma brucei trypanothione reductase 0.0037 0.0453 0.1148
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0095 0.0086
Trichomonas vaginalis glutaminase, putative 0.0303 0.4393 1
Echinococcus granulosus snurportin 1 0.0341 0.4959 0.4954
Trypanosoma cruzi DNA polymerase kappa, putative 0.0195 0.279 0.7003
Loa Loa (eye worm) hypothetical protein 0.0032 0.0379 0.0393
Trypanosoma brucei unspecified product 0.0113 0.1573 0.399
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0048 0.0617 0.9304
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0032 0.0043
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0048 0.0617 0.9304
Schistosoma mansoni DNA polymerase eta 0.0273 0.3943 0.3937
Trichomonas vaginalis importin beta-1, putative 0.0026 0.029 0.0658
Onchocerca volvulus 0.0016 0.0141 0.036
Leishmania major phosphopantetheinyl transferase-like protein 0.0048 0.0617 0.1356
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0617 0.1566
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0138 0.0128
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0095 0.0215
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1288 0.293
Loa Loa (eye worm) hypothetical protein 0.0082 0.1123 0.1243
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.1288 0.1279
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0801 0.0792
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0777 0.0768
Trypanosoma cruzi DNA polymerase kappa, putative 0.0195 0.279 0.7003
Brugia malayi Muscle positioning protein 4 0.0015 0.0124 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0055 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1288 0.293
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0163 0.2324 0.2316
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.1288 0.1431
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0138 0.0128
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0059 0.0772 0.3103
Brugia malayi jmjC domain containing protein 0.0016 0.0138 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0055 0.0024
Plasmodium vivax JmjC domain containing protein 0.0016 0.0138 0.0764
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0055 0.0024
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.1292 0.5255
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0007 0.0012 0.0002
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0254 0.0678
Loa Loa (eye worm) hypothetical protein 0.0028 0.0324 0.033
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1123 0.2848
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0777 0.0768
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.279 0.7076
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.279 0.7076
Echinococcus multilocularis muscleblind protein 1 0.06 0.8784 0.8783
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0567 0.0558
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0699 0.2767
Brugia malayi steroid hormone receptor 0.001 0.0055 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0567 0.0558
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0453 0.0477
Entamoeba histolytica deoxycytidyl transferase, putative 0.0163 0.2324 1
Giardia lamblia Kinase, PLK 0.0093 0.1288 0.5086
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0032 0.0043
Trichomonas vaginalis ferritin, putative 0.0009 0.0032 0.0071
Plasmodium falciparum glutathione reductase 0.0037 0.0453 0.6369
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.059 0.1341
Plasmodium vivax glutathione reductase, putative 0.0037 0.0453 0.6369
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0138 0.0111
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.046 0.045

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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