Detailed information for compound 784793

Basic information

Technical information
  • TDR Targets ID: 784793
  • Name: 2-(2-bromo-4-nitrophenoxy)-N-[1-(4-chlorophen yl)ethylideneamino]acetamide
  • MW: 426.649 | Formula: C16H13BrClN3O4
  • H donors: 1 H acceptors: 3 LogP: 4.24 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COc1ccc(cc1Br)[N+](=O)[O-])N/N=C(/c1ccc(cc1)Cl)\C
  • InChi: 1S/C16H13BrClN3O4/c1-10(11-2-4-12(18)5-3-11)19-20-16(22)9-25-15-7-6-13(21(23)24)8-14(15)17/h2-8H,9H2,1H3,(H,20,22)/b19-10+
  • InChiKey: ZBAPQUQNCNHRCP-VXLYETTFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-bromo-4-nitro-phenoxy)-N-[1-(4-chlorophenyl)ethylideneamino]acetamide
  • 2-(2-bromo-4-nitro-phenoxy)-N-[1-(4-chlorophenyl)ethylideneamino]ethanamide
  • A0662/0030776

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.0911 0.123
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0059 0.1077 0.3105
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0376 0.0099
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.1874 0.223
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.2499 0.4303
Brugia malayi polk-prov protein 0.0081 0.158 0.158
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0345 0.008
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0026 0.0345 0.0135
Schistosoma mansoni high-affinity choline transporter 0.0343 0.7536 0.9374
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0026 0.0343 0.0303
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0606 0.0567
Echinococcus granulosus MAM 0.0017 0.0134 0.0093
Trypanosoma cruzi trypanothione reductase, putative 0.0026 0.0345 0.008
Echinococcus granulosus snurportin 1 0.0365 0.8032 0.8024
Schistosoma mansoni hypothetical protein 0.0167 0.3544 0.4337
Loa Loa (eye worm) hypothetical protein 0.0034 0.0523 0.0523
Onchocerca volvulus 0.0038 0.0606 0.3288
Brugia malayi RNA binding protein 0.0062 0.1158 0.1158
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.4166 0.7529
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0575 0.0536
Trypanosoma cruzi DNA polymerase eta, putative 0.0251 0.5442 1
Plasmodium falciparum importin beta, putative 0.0034 0.0523 0.3541
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0911 0.1181
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0134
Leishmania major DNA damage repair protein, putative 0.0051 0.0911 0.123
Echinococcus granulosus geminin 0.0167 0.3544 0.3517
Schistosoma mansoni sodium/solute symporter 0.0038 0.0606 0.063
Loa Loa (eye worm) hypothetical protein 0.0251 0.5442 0.5442
Loa Loa (eye worm) hypothetical protein 0.0343 0.7536 0.7536
Onchocerca volvulus 0.0017 0.0134 0.0179
Trypanosoma brucei unspecified product 0.0114 0.2333 0.3982
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0784 0.0746
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0173 0.3683 0.8858
Loa Loa (eye worm) hypothetical protein 0.0025 0.0304 0.0304
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0784 0.0784
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0304 0.0264
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0784 0.0746
Echinococcus multilocularis muscleblind protein 0.0452 1 1
Brugia malayi TAR-binding protein 0.0062 0.1158 0.1158
Echinococcus granulosus solute carrier family 5 0.0038 0.0606 0.0567
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0026 0.0345 0.0269
Leishmania major DNA polymerase kappa, putative 0.0051 0.0911 0.123
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0656 0.0618
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0784 0.0855
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0132 0.0032
Plasmodium falciparum glutathione reductase 0.0076 0.1473 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0357 0.0315
Schistosoma mansoni terminal deoxycytidyl transferase 0.0165 0.3497 0.4277
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0173 0.3663 0.6555
Onchocerca volvulus 0.0027 0.0357 0.1645
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0165 0.3497 0.4277
Plasmodium vivax JmjC domain containing protein 0.0025 0.0304 0.2048
Trypanosoma brucei hypothetical protein, conserved 0.0215 0.4627 0.8423
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0345 0.008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.121 0.1393
Plasmodium vivax glutathione reductase, putative 0.0076 0.1473 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.4166 0.7529
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.4166 0.7529
Brugia malayi glutathione reductase 0.0076 0.1473 0.1473
Brugia malayi Inositol-1 0.0036 0.0575 0.0575
Loa Loa (eye worm) hypothetical protein 0.0081 0.158 0.158
Echinococcus multilocularis cpg binding protein 0.0032 0.0476 0.0437
Entamoeba histolytica deoxycytidyl transferase, putative 0.0165 0.3497 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0318 0.2147
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0357 0.0357
Brugia malayi jmjC domain containing protein 0.0025 0.0304 0.0304
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1158 0.1158
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0026 0.0345 0.2329
Mycobacterium tuberculosis Probable reductase 0.0173 0.3683 0.8858
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0304 0.0304
Onchocerca volvulus 0.0017 0.0134 0.0179
Echinococcus multilocularis geminin 0.0167 0.3544 0.3517
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.158 0.2525
Brugia malayi Bromodomain containing protein 0.0029 0.04 0.04
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0784 0.0855
Plasmodium falciparum thioredoxin reductase 0.0026 0.0345 0.2329
Echinococcus granulosus thioredoxin glutathione reductase 0.0077 0.1496 0.146
Trypanosoma cruzi DNA polymerase kappa, putative 0.0195 0.4166 0.7516
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0784 0.0784
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0345 0.008
Schistosoma mansoni importin beta-1 0.0034 0.0523 0.0526
Schistosoma mansoni lamin 0.0027 0.0357 0.0315
Echinococcus granulosus jumonji domain containing protein 0.004 0.0656 0.0618
Schistosoma mansoni hypothetical protein 0.0017 0.0134 0.0034
Loa Loa (eye worm) hypothetical protein 0.0029 0.04 0.04
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0606 0.1281
Echinococcus multilocularis dna polymerase eta 0.0251 0.5442 0.5423
Onchocerca volvulus 0.003 0.0437 0.2174
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0304 0.0055
Echinococcus multilocularis peregrin 0.0029 0.04 0.0361
Plasmodium falciparum thioredoxin reductase 0.0076 0.1473 1
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0575 0.0536
Echinococcus granulosus muscleblind protein 0.0452 1 1
Leishmania major GTP-binding protein, putative 0.0025 0.0318 0.0083
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0107
Brugia malayi glutaminase DH11.1 0.0324 0.7105 0.7105
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0026 0.0345 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.04 0.2706
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0345 0.2324
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.1626 0.1591
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0606 0.0567
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1158 0.1158
Toxoplasma gondii NADPH-glutathione reductase 0.0026 0.0345 0.0269
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1158 0.1327
Loa Loa (eye worm) hypothetical protein 0.0026 0.0345 0.0345
Brugia malayi PHD-finger family protein 0.0029 0.04 0.04
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0437 0.0437
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0575 0.0391
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0026 0.0345 0.0135
Mycobacterium ulcerans hypothetical protein 0.0025 0.0309 0.0049
Leishmania major trypanothione reductase 0.0076 0.1473 0.2317
Loa Loa (eye worm) hypothetical protein 0.0083 0.1626 0.1626
Trypanosoma cruzi hypothetical protein, conserved 0.0215 0.4627 0.8414
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1158 0.1327
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0134
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0026 0.0345 0.2329
Trichomonas vaginalis glutaminase, putative 0.0324 0.7105 1
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0606 0.0567
Schistosoma mansoni hypothetical protein 0.0017 0.0134 0.0034
Trypanosoma brucei DNA damage repair protein, putative 0.0051 0.0911 0.123
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0575 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.2499 0.4303
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.003
Echinococcus multilocularis lamin dm0 0.0027 0.0357 0.0317
Echinococcus granulosus dnaJ subfamily C 6 0.0061 0.113 0.1093
Leishmania major hypothetical protein, conserved 0.0025 0.0304 0.0055
Brugia malayi CXXC zinc finger family protein 0.003 0.0437 0.0437
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0304 0.0304
Mycobacterium ulcerans glutaminase 0.0324 0.7105 1
Brugia malayi jmjC domain containing protein 0.0094 0.1874 0.1874
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0606 0.0606
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1158 0.1327
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0318 0.0278
Entamoeba histolytica hypothetical protein 0.0036 0.0553 0.0862
Trypanosoma brucei DNA polymerase IV, putative 0.0195 0.4166 0.7529
Schistosoma mansoni hypothetical protein 0.0061 0.113 0.1291
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.0911 0.2461
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0345 0.0135
Echinococcus multilocularis musashi 0.0027 0.0357 0.0317
Mycobacterium tuberculosis Probable oxidoreductase 0.0193 0.4122 1
Leishmania major DNA polymerase eta, putative 0.0251 0.5442 1
Echinococcus multilocularis snurportin 1 0.0365 0.8032 0.8024
Brugia malayi Protein kinase domain containing protein 0.0017 0.0134 0.0134
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0173 0.3683 0.8858
Brugia malayi hypothetical protein 0.0017 0.0134 0.0134
Schistosoma mansoni inositol monophosphatase 0.0036 0.0575 0.0591
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0606 0.0567
Schistosoma mansoni hypothetical protein 0.0167 0.3544 0.4337
Schistosoma mansoni hypothetical protein 0.0365 0.8032 1
Brugia malayi ImpB/MucB/SamB family protein 0.0165 0.3497 0.3497
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0304 0.0264
Plasmodium falciparum phd finger protein, putative 0.0029 0.04 0.2706
Loa Loa (eye worm) DOMON domain-containing protein 0.0016 0.0107 0.0107
Schistosoma mansoni DNA polymerase IV / kappa 0.0051 0.0911 0.1015
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.4166 0.7529
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0575 0.0391
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0318 0.2147
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0304 0.2048
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0376 0.0099
Brugia malayi Thioredoxin reductase 0.0076 0.1473 0.1473
Echinococcus multilocularis dna polymerase kappa 0.0195 0.4166 0.4141
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0575 0.0579
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0309 0.0049
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.0911 0.123
Echinococcus granulosus dna polymerase eta 0.0251 0.5442 0.5423
Echinococcus multilocularis lamin 0.0027 0.0357 0.0317
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0304 0.0264
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.04 0.0484
Schistosoma mansoni ran 0.0025 0.0318 0.0267
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0318 0.0083
Loa Loa (eye worm) TK/ALK protein kinase 0.0017 0.0134 0.0134
Loa Loa (eye worm) glutathione reductase 0.0076 0.1473 0.1473
Leishmania major hypothetical protein, conserved 0.0215 0.4627 0.8423
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0.0345 0.0102
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0074 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.4166 0.7529
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0345 0.008
Schistosoma mansoni inositol monophosphatase 0.0036 0.0575 0.0591
Loa Loa (eye worm) hypothetical protein 0.0452 1 1
Schistosoma mansoni cpg binding protein 0.0032 0.0476 0.0466
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0137 0.2857 1
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0309 0.001
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0345 0.2324
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0376 0.0099
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0151 0.3184 0.3155
Brugia malayi RNA, U transporter 1 0.0097 0.1954 0.1954
Leishmania major importin beta-1 subunit, putative 0.0028 0.0376 0.0195
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0304 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.4166 0.7529
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0173 0.3683 0.8858
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1054 0.3016
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0304 0.0264
Echinococcus multilocularis lysine specific demethylase 5A 0.0092 0.1835 0.1801
Brugia malayi jmjC domain containing protein 0.0151 0.3184 0.3184
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0553 0.0514
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.04 0.0361
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0195 0.4166 0.5675
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1158 0.1122
Giardia lamblia PHD finger protein 15 0.0029 0.04 0.0245
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0318 0.0318
Trypanosoma brucei unspecified product 0.0114 0.2333 0.3982
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0.0345 0.0102
Echinococcus granulosus dna polymerase kappa 0.0195 0.4166 0.4141
Schistosoma mansoni hypothetical protein 0.0036 0.0553 0.0564
Echinococcus granulosus lamin 0.0027 0.0357 0.0317
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0276 0.1856
Mycobacterium ulcerans hypothetical protein 0.0051 0.0911 0.093
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.04 0.04
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0026 0.0345 0.0345
Mycobacterium tuberculosis Probable dehydrogenase 0.0173 0.3683 0.8858
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0784 0.0855
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0784 0.0746
Brugia malayi DnaJ domain containing protein 0.0061 0.113 0.113
Trichomonas vaginalis ran, putative 0.0025 0.0318 0.0014
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0165 0.3497 0.3497
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0318 0.0166
Loa Loa (eye worm) hypothetical protein 0.0038 0.0606 0.0606
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0606 0.0567
Trypanosoma cruzi hypothetical protein, conserved 0.0215 0.4627 0.8414
Brugia malayi jmjC domain containing protein 0.0025 0.0304 0.0304
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.04 0.0371
Trypanosoma cruzi DNA damage repair protein, putative 0.0051 0.0911 0.1181
Onchocerca volvulus 0.0027 0.0357 0.1645
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0376 0.0141
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1096 0.1096
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0304 0.0264
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0026 0.0345 0.0181
Brugia malayi SEA domain containing protein 0.0016 0.0107 0.0107
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0151 0.3184 0.3155
Brugia malayi jmjC domain containing protein 0.0025 0.0304 0.0304
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.04 0.0484
Brugia malayi hypothetical protein 0.0036 0.0553 0.0553
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0193 0.4122 1
Brugia malayi ImpB/MucB/SamB family protein 0.0251 0.5442 0.5442
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0575 0.0438
Schistosoma mansoni cpg binding protein 0.0032 0.0476 0.0466
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.1626 0.1626
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0309 0.0049
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0304 0.0249
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.1626 0.1917
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0193 0.4122 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0304 0.011
Trypanosoma brucei DNA damage repair protein, putative 0.0051 0.0911 0.123
Schistosoma mansoni hypothetical protein 0.0029 0.04 0.0371
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0345 0.0135
Giardia lamblia DINP protein human, muc B family 0.0173 0.3663 1
Brugia malayi Muscle positioning protein 4 0.0016 0.0107 0.0107
Trypanosoma cruzi DNA polymerase kappa, putative 0.0195 0.4166 0.7516
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0357 0.0357
Schistosoma mansoni glutaminase 0.0324 0.7105 0.883
Loa Loa (eye worm) hypothetical protein 0.0027 0.0357 0.0357
Plasmodium vivax DNA repair protein REV1, putative 0.0051 0.0911 0.6178
Trypanosoma brucei DNA polymerase IV, putative 0.0187 0.4 0.7208
Entamoeba histolytica hypothetical protein 0.0028 0.0376 0.0313
Loa Loa (eye worm) hypothetical protein 0.0065 0.1213 0.1213
Echinococcus multilocularis dnaJ subfamily C 6 0.0061 0.113 0.1093
Loa Loa (eye worm) glutaminase 2 0.0324 0.7105 0.7105
Echinococcus multilocularis muscleblind protein 1 0.0452 1 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0195 0.4166 0.5675
Echinococcus granulosus high affinity choline transporter 1 0.0343 0.7536 0.7526
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0553 0.0514
Trypanosoma brucei chrX additional, unordered contigs 0.0051 0.0911 0.123
Entamoeba histolytica hypothetical protein 0.0036 0.0553 0.0862
Plasmodium falciparum glutathione reductase 0.0026 0.0345 0.2329
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0318 0.0318
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0019 0.0186 0.0186
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0575 0.0391
Echinococcus granulosus tar DNA binding protein 0.0062 0.1158 0.1122
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0318 0.0028
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1158 0.1158
Schistosoma mansoni cpg binding protein 0.003 0.0437 0.0417
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0575 0.1159
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0173 0.3663 0.8805
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0026 0.0345 0.0305
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0304 0.011
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0488 0.0552
Loa Loa (eye worm) hypothetical protein 0.0025 0.0304 0.0304
Echinococcus multilocularis solute carrier family 5 0.0038 0.0606 0.0567
Trypanosoma brucei trypanothione reductase 0.0076 0.1473 0.2317
Loa Loa (eye worm) DnaJ domain-containing protein 0.0061 0.113 0.113
Trichomonas vaginalis glutathione reductase, putative 0.0026 0.0345 0.0053
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0309 0.0087
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0304 0.0249
Mycobacterium tuberculosis Conserved protein 0.0025 0.0309 0.0087
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0345 0.008
Leishmania major DNA polymerase kappa, putative 0.0173 0.3663 0.6555
Leishmania major DNA polymerase eta, putative 0.0137 0.2857 0.4995
Echinococcus granulosus lysine specific demethylase 5A 0.0094 0.1874 0.184
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0488 0.0552
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0026 0.0345 0.0135
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0076 0.1473 0.3112
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0026 0.0345 0.2329
Brugia malayi Importin beta-1 subunit 0.0034 0.0523 0.0523
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0304 0.0264
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0304 0.0249
Trypanosoma cruzi DNA polymerase kappa, putative 0.0195 0.4166 0.7516
Mycobacterium ulcerans DNA polymerase IV 0.0195 0.4166 0.5696
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0523 0.0479
Toxoplasma gondii thioredoxin reductase 0.0076 0.1473 0.4638
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0309 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.158 0.2525
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0171 0.0171
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0357 0.0357
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0345 0.008
Plasmodium vivax importin-beta 2, putative 0.0034 0.0523 0.3541
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0026 0.0345 0.2329
Plasmodium falciparum DNA repair protein REV1, putative 0.0051 0.0911 0.6178
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.4166 0.7529
Schistosoma mansoni inositol transporter 0.0038 0.0606 0.063
Echinococcus granulosus cpg binding protein 0.0032 0.0476 0.0437
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0309 0.001
Loa Loa (eye worm) glutaminase 0.0324 0.7105 0.7105
Giardia lamblia NADH oxidase lateral transfer candidate 0.0026 0.0345 0.008
Brugia malayi jmjC domain containing protein 0.0025 0.0304 0.0304
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0165 0.3497 0.347
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.4166 0.7529
Loa Loa (eye worm) hypothetical protein 0.0013 0.0041 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0173 0.3663 0.6555
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0309 0.0065
Schistosoma mansoni inositol transporter 0.0038 0.0606 0.063
Entamoeba histolytica hypothetical protein 0.0036 0.0553 0.0862
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1158 0.1327
Entamoeba histolytica hypothetical protein 0.0036 0.0553 0.0862
Loa Loa (eye worm) hypothetical protein 0.0452 1 1
Trypanosoma brucei unspecified product 0.0187 0.4 0.7208
Schistosoma mansoni jumonji domain containing protein 0.0132 0.2744 0.3327
Loa Loa (eye worm) inositol-1 0.0036 0.0575 0.0575
Entamoeba histolytica Ran family GTPase 0.0025 0.0318 0.0133
Echinococcus granulosus phd:f box containing protein 0.0025 0.0304 0.0264
Loa Loa (eye worm) hypothetical protein 0.0017 0.0134 0.0134
Trypanosoma cruzi DNA polymerase kappa, putative 0.0195 0.4166 0.7516
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0173 0.3683 0.8858
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0345 0.008
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0026 0.0343 0.0303
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0026 0.0345 0.0301
Trypanosoma brucei DNA polymerase eta, putative 0.0251 0.5442 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0.0345 0.0102
Loa Loa (eye worm) thioredoxin reductase 0.0076 0.1473 0.1473
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.1626 0.1591
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0575 0.0527
Echinococcus multilocularis high affinity choline transporter 1 0.0343 0.7536 0.7526
Loa Loa (eye worm) RNA binding protein 0.0062 0.1158 0.1158
Giardia lamblia DNA damage repair protein 0.0051 0.0911 0.1772
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0074 0.0074
Echinococcus granulosus intermediate filament protein 0.0027 0.0357 0.0317
Onchocerca volvulus Alhambra homolog 0.0029 0.04 0.1934
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0309 0.0269
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0523 0.0484
Loa Loa (eye worm) hypothetical protein 0.0016 0.0107 0.0107
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0553 0.0564
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0026 0.0345 0.0135
Mycobacterium ulcerans hypothetical protein 0.0025 0.0309 0.0049
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0276 0.1856
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0309 0.0269
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0523 0.096
Echinococcus multilocularis MAM 0.0017 0.0134 0.0093
Schistosoma mansoni DNA polymerase eta 0.0251 0.5442 0.6732
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0606 0.0567
Treponema pallidum NADH oxidase 0.0026 0.0345 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0345 0.0135
Trichomonas vaginalis protein kinase inhibitor, putative 0.0061 0.113 0.1207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0345 0.008
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0606 0.0567
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.2499 0.4303
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0318 0.0278
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0365 0.8032 0.8032
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0911 0.1181
Trypanosoma cruzi DNA damage repair protein, putative 0.0051 0.0911 0.1181
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0304 0.0264
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0575 0.0929
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0345 0.0135
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.003
Echinococcus granulosus lamin dm0 0.0027 0.0357 0.0317
Brugia malayi intermediate filament protein 0.0027 0.0357 0.0357
Brugia malayi GH02984p 0.0343 0.7536 0.7536
Trypanosoma brucei DNA polymerase IV, putative 0.0195 0.4166 0.7529
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.1874 0.223
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.3497 0.8373
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0173 0.3683 0.8858
Trypanosoma brucei DNA polymerase kappa, putative 0.0195 0.4166 0.7529
Echinococcus granulosus importin subunit beta 1 0.0034 0.0523 0.0484
Schistosoma mansoni ran 0.0025 0.0318 0.0267
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0304 0.0249
Echinococcus granulosus peregrin 0.0029 0.04 0.0361
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0523 0.0479
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0019 0.0186 0.0186
Mycobacterium ulcerans DNA polymerase IV 0.0195 0.4166 0.5696
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0193 0.4122 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0784 0.0746
Trypanosoma cruzi trypanothione reductase, putative 0.0076 0.1473 0.2275
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0026 0.0345 0.0305
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0165 0.3497 0.347
Echinococcus multilocularis thioredoxin glutathione reductase 0.0077 0.1496 0.146
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.04 0.0361
Schistosoma mansoni lamin 0.0027 0.0357 0.0315
Trypanosoma cruzi DNA polymerase eta, putative 0.0137 0.2857 0.4968
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0304 0.0249
Plasmodium vivax thioredoxin reductase, putative 0.0076 0.1473 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0575 0.0527
Onchocerca volvulus 0.0083 0.1626 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0318 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1158 0.1327
Trichomonas vaginalis mercuric reductase, putative 0.0026 0.0345 0.0053
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.1874 0.1874
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0575 0.0579

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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