TDR Targets

Basic information

Technical information

TDR Targets ID: 784804
Name: N-[(3-hydroxyphenyl)methylideneamino]-2-[(3-m ethylphenyl)amino]acetamide
MW: 283.325 | Formula: C16H17N3O2
H donors: 3 H acceptors: 2 LogP: 2.89 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CNc1cccc(c1)C)N/N=C/c1cccc(c1)O
InChi: 1S/C16H17N3O2/c1-12-4-2-6-14(8-12)17-11-16(21)19-18-10-13-5-3-7-15(20)9-13/h2-10,17,20H,11H2,1H3,(H,19,21)/b18-10+
InChiKey: WSWTYXVHBCIIIE-VCHYOVAHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(3-hydroxyphenyl)methyleneamino]-2-[(3-methylphenyl)amino]acetamide
N-[(3-hydroxybenzylidene)amino]-2-[(3-methylphenyl)amino]acetamide
N-[(3-hydroxyphenyl)methylideneamino]-2-[(3-methylphenyl)amino]ethanamide
A0678/0031555

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0638	0.0638
Schistosoma mansoni	hypothetical protein	0.0023	0.0399	0.0399
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0455	0.0426
Giardia lamblia	Rrm3p helicase	0.0283	0.8695	1
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0283	0.8695	0.8695
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0844	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.1294	0.14
Echinococcus granulosus	importin subunit beta 1	0.003	0.0638	0.0638
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0088	0.0088
Brugia malayi	RNA, U transporter 1	0.0086	0.2422	0.6502
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0283	0.8695	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.1294	0.14
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0283	0.8695	1
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0283	0.8695	1
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0844	0.5065
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0088	0.0237
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0844	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0844	0.0555
Onchocerca volvulus		0.0037	0.0844	1
Brugia malayi	MH2 domain containing protein	0.0127	0.3725	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0844	0.0555
Brugia malayi	Importin beta-1 subunit	0.003	0.0638	0.1713
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0844	1
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0844	0.0878
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0844	0.0844
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0283	0.8695	1
Trichomonas vaginalis	conserved hypothetical protein	0.0283	0.8695	1
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0844	0.0844
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0324	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.1294	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0455	0.0087
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0283	0.8695	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0844	0.0844
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0844	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.0399	0.0399
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0088	0.0088
Toxoplasma gondii	ABC1 family protein	0.0037	0.0844	0.5065
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.1294	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.7168	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0088	0.0088
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0844	0.0878
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0844	0.0555
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0455	0.0087
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0844	0.5
Leishmania major	GTP-binding protein, putative	0.0022	0.0383	0.0342
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0844	0.0878
Schistosoma mansoni	hypothetical protein	0.0324	1	1
Leishmania major	hypothetical protein, conserved	0.0037	0.0844	0.0878
Loa Loa (eye worm)	hypothetical protein	0.003	0.0638	0.0638
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0844	0.0555
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0844	1
Brugia malayi	beta-lactamase	0.0037	0.0844	0.2266
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0638	0.0639
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.0399	0.0399
Leishmania major	hypothetical protein, conserved	0.0051	0.1294	0.14
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0383	0.0342
Brugia malayi	hypothetical protein	0.0051	0.1294	0.3473
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0383	0.0383
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0383	0.0342
Brugia malayi	hypothetical protein	0.0033	0.0718	0.1928
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.1294	0.14
Schistosoma mansoni	importin beta-1	0.003	0.0638	0.0638
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0455	0.0087
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.1294	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0844	0.0844
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0283	0.8695	1
Entamoeba histolytica	hypothetical protein	0.0025	0.0455	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0844	0.0844
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0283	0.8695	0.8695
Trichomonas vaginalis	esterase, putative	0.0037	0.0844	0.0555
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0638	0.0639
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0383	0.1027
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0844	0.0844
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0283	0.8695	1
Onchocerca volvulus		0.0037	0.0844	1
Echinococcus multilocularis	snurportin 1	0.0324	1	1
Mycobacterium ulcerans	lipase LipD	0.0037	0.0844	1
Plasmodium falciparum	importin beta, putative	0.003	0.0638	0.2804
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0844	0.0844
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0638	0.2804
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0844	0.0844
Brugia malayi	beta-lactamase family protein	0.0037	0.0844	0.2266
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0844	0.0844
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0844	0.0844
Loa Loa (eye worm)	MH2 domain-containing protein	0.0127	0.3725	0.3725
Onchocerca volvulus		0.0037	0.0844	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0455	0.0426
Loa Loa (eye worm)	transcription factor SMAD2	0.0127	0.3725	0.3725
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0844	0.0555
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0383	0.0383
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0844	0.2266
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0088	0.0237
Schistosoma mansoni	hypothetical protein	0.0283	0.8695	0.8695
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1294	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0844	0.0844
Schistosoma mansoni	ran	0.0022	0.0383	0.0383
Plasmodium vivax	importin-beta 2, putative	0.003	0.0638	0.2804
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0383	0.0383
Schistosoma mansoni	ran	0.0022	0.0383	0.0383
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.1294	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0383	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0844	0.0844
Entamoeba histolytica	hypothetical protein, conserved	0.0283	0.8695	1
Brugia malayi	beta-lactamase family protein	0.0037	0.0844	0.2266
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0283	0.8695	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 784804