Detailed information for compound 784805

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 484.349 | Formula: C21H22BrN7O2
  • H donors: 3 H acceptors: 4 LogP: 4.58 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Nc1nc(N/N=C/c2cc(Br)ccc2O)nc(n1)N1CCOCC1
  • InChi: 1S/C21H22BrN7O2/c1-14-2-5-17(6-3-14)24-19-25-20(27-21(26-19)29-8-10-31-11-9-29)28-23-13-15-12-16(22)4-7-18(15)30/h2-7,12-13,30H,8-11H2,1H3,(H2,24,25,26,27,28)/b23-13+
  • InChiKey: UAXUHOZBRADGKB-YDZHTSKRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.014 0.0005
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.005 0.0461 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.005 0.0461 0.1298
Leishmania major DNA polymerase eta, putative 0.0281 0.3444 1
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0313 0.0378
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0182 0.02
Onchocerca volvulus 0.0057 0.0558 0.2603
Echinococcus granulosus solute carrier family 5 0.0038 0.0313 0.0347
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0294 0.0468
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.014 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0867 0.2203
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0246 0.0204
Schistosoma mansoni hypothetical protein 0.0168 0.1992 0.2228
Leishmania major hypothetical protein, conserved 0.0025 0.014 0.0005
Loa Loa (eye worm) DOMON domain-containing protein 0.0015 0.0018 0.0023
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0313 0.0308
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0044 0.0384 0.0379
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0201 0.2417 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0287 0.3516 0.8881
Leishmania major phosphopantetheinyl transferase-like protein 0.005 0.0461 0.0975
Brugia malayi Thioredoxin reductase 0.0126 0.1442 0.1819
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.0384 0.074
Echinococcus multilocularis peregrin 0.0029 0.0196 0.0191
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.014 0.0005
Brugia malayi glutathione reductase 0.0126 0.1442 0.1819
Echinococcus granulosus dna polymerase kappa 0.0201 0.2417 0.2718
Brugia malayi jmjC domain containing protein 0.0025 0.014 0.0157
Brugia malayi DnaJ domain containing protein 0.0061 0.0613 0.076
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0295 0.0562
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0044 0.0384 0.1878
Onchocerca volvulus 0.0176 0.2092 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.2417 0.6894
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0295 0.0562
Brugia malayi GH02984p 0.0346 0.4274 0.5436
Schistosoma mansoni cpg binding protein 0.0057 0.0558 0.0609
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0294 0.0553
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.2417 0.6894
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0295 0.0113
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1062 0.3973
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.099 0.0985
Mycobacterium tuberculosis Probable oxidoreductase 0.0319 0.3928 1
Brugia malayi Muscleblind-like protein 0.0623 0.7846 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0061 0.0606 0.2664
Echinococcus granulosus dnaJ subfamily B 0.0399 0.4956 0.5579
Echinococcus multilocularis dna polymerase kappa 0.0201 0.2417 0.2413
Treponema pallidum 4'-phosphopantetheinyl transferase 0.005 0.0461 1
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0436 0.1188
Brugia malayi hypothetical protein 0.0036 0.0283 0.0339
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0169 0.0092
Loa Loa (eye worm) TK/ALK protein kinase 0.0016 0.0033 0.0042
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0044 0.0384 0.5377
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.1062 0.1334
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.1057 0.1347
Schistosoma mansoni phd/f-box containing protein 0.0025 0.014 0.0138
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0044 0.0384 0.5377
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0044 0.0384 0.0954
Trypanosoma brucei DNA polymerase IV, putative 0.0201 0.2417 0.6894
Echinococcus multilocularis lamin dm0 0.003 0.0205 0.02
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.014 0.0005
Schistosoma mansoni protein phosphatase 2C 0.0025 0.014 0.0138
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0044 0.0384 0.0413
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.005 0.0461 0.2472
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.1216 0.6137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.099 0.1109
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0294 0.0325
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0196 0.0325
Brugia malayi jmjC domain containing protein 0.0025 0.014 0.0157
Schistosoma mansoni hypothetical protein 0.0029 0.0196 0.0201
Brugia malayi intermediate filament protein 0.003 0.0205 0.0239
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0176 0.2092 0.2341
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0161 0.1893 1
Leishmania major trypanothione reductase 0.0126 0.1442 0.3942
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.0384 0.074
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0294 0.0289
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1062 0.3973
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0032 0.0235 0.0277
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0384 0.074
Brugia malayi hypothetical protein 0.0025 0.0139 0.0155
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0169 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0234 0.2833 0.8151
Trypanosoma cruzi DNA polymerase kappa, putative 0.0201 0.2417 0.6894
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0384 0.074
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.1062 0.1191
Brugia malayi PHD-finger family protein 0.0029 0.0196 0.0227
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.1382 0.154
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.005 0.0045
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0294 0.1188
Onchocerca volvulus 0.003 0.0205 0.0901
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0384 0.074
Schistosoma mansoni lamin 0.003 0.0205 0.0211
Schistosoma mansoni hypothetical protein 0.0061 0.0613 0.0671
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0054 0.052 0.2173
Leishmania major hypothetical protein, conserved 0.0234 0.2833 0.8151
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0044 0.0384 0.074
Echinococcus granulosus high affinity choline transporter 1 0.0346 0.4274 0.4809
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.014 0.0179
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0283 0.0278
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.014 0.0009
Entamoeba histolytica deoxycytidyl transferase, putative 0.0175 0.207 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.2417 0.6894
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0181 0.2156 0.5287
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.014 0.0152
Trypanosoma brucei hypothetical protein, conserved 0.0054 0.052 0.1154
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0436 0.1188
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.099 0.1096
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.0384 0.074
Echinococcus granulosus microtubule associated protein 2 0.0703 0.888 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.2417 0.6894
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0044 0.0384 0.0954
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0152 0.1786 0.1782
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.014 0.0138
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0027 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.014 0.0179
Trypanosoma cruzi hypothetical protein, conserved 0.0234 0.2833 0.8151
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0176 0.2092 0.265
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0196 0.0191
Brugia malayi Inositol-1 0.0037 0.0295 0.0355
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0283 0.0313
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0287 0.3516 0.8904
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0295 0.029
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.1062 0.1179
Plasmodium vivax thioredoxin reductase, putative 0.0126 0.1442 1
Loa Loa (eye worm) hypothetical protein 0.0346 0.4274 0.5447
Mycobacterium leprae conserved hypothetical protein 0.005 0.0461 0.0584
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1062 0.3973
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0867 0.2203
Loa Loa (eye worm) inositol-1 0.0037 0.0295 0.0377
Onchocerca volvulus 0.0038 0.0313 0.1424
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0044 0.0384 0.1395
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0196 0.0437
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0023
Treponema pallidum NADH oxidase 0.0044 0.0384 0.5377
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0032 0.0235 0.0277
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0196 0.0325
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0127 0.0123
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.014 0.0138
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0044 0.0384 0.0467
Loa Loa (eye worm) hypothetical protein 0.0016 0.0033 0.0042
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0287 0.3516 0.8904
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0205 0.0261
Trypanosoma brucei chrX additional, unordered contigs 0.0054 0.052 0.1154
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0294 0.0553
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.099 0.1261
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0294 0.0352
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.005 0.0461 0.1298
Schistosoma mansoni jumonji domain containing protein 0.0133 0.1535 0.1711
Echinococcus granulosus citrate lyase subunit beta protein 0.0027 0.0169 0.0185
Loa Loa (eye worm) hypothetical protein 0.0623 0.7846 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.066 0.0841
Brugia malayi polk-prov protein 0.0081 0.0867 0.1085
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.025
Schistosoma mansoni kinase 0.0049 0.0453 0.0491
Loa Loa (eye worm) intermediate filament protein 0.003 0.0205 0.0261
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0294 0.0553
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0294 0.0468
Schistosoma mansoni hypothetical protein 0.0399 0.4956 0.5572
Trypanosoma cruzi DNA polymerase kappa, putative 0.0201 0.2417 0.6894
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.1459 0.3994
Schistosoma mansoni terminal deoxycytidyl transferase 0.0175 0.207 0.2316
Trypanosoma brucei DNA polymerase kappa, putative 0.0181 0.2156 0.6105
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.0384 0.074
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.2417 0.6894
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.014 0.0135
Brugia malayi jmjC domain containing protein 0.0025 0.014 0.0157
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0342 0.0337
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0384 0.074
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.005 0.0051
Trichomonas vaginalis DNA polymerase eta, putative 0.0201 0.2417 1
Trypanosoma brucei DNA polymerase IV, putative 0.0201 0.2417 0.6894
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.052 0.1154
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.1057 0.1172
Mycobacterium tuberculosis Conserved hypothetical protein 0.0175 0.207 0.5058
Toxoplasma gondii exonuclease III APE 0.0037 0.0294 0.0882
Trypanosoma brucei unspecified product 0.012 0.1373 0.3734
Loa Loa (eye worm) hypothetical protein 0.0038 0.0313 0.0399
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0294 0.0468
Leishmania major DNA polymerase eta, putative 0.0161 0.1893 0.5309
Brugia malayi jmjC domain containing protein 0.0025 0.014 0.0157
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.1057 0.1172
Giardia lamblia NADH oxidase lateral transfer candidate 0.0044 0.0384 0.0958
Loa Loa (eye worm) glutathione reductase 0.0126 0.1442 0.1837
Schistosoma mansoni jumonji domain containing protein 0.0025 0.014 0.0138
Trypanosoma brucei polo-like protein kinase 0.0096 0.1062 0.2794
Echinococcus multilocularis lamin 0.003 0.0205 0.02
Trypanosoma cruzi trypanothione reductase, putative 0.0126 0.1442 0.3942
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0044 0.0384 0.1878
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.099 0.1241
Echinococcus multilocularis dnaJ subfamily C 6 0.0061 0.0613 0.0608
Schistosoma mansoni inositol transporter 0.0038 0.0313 0.0333
Echinococcus multilocularis thioredoxin glutathione reductase 0.0127 0.1455 0.1451
Trypanosoma brucei trypanothione reductase 0.0126 0.1442 0.3942
Brugia malayi jmjC domain containing protein 0.0152 0.1786 0.2259
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0205 0.0239
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0294 0.0058
Echinococcus multilocularis high affinity choline transporter 1 0.0346 0.4274 0.4271
Onchocerca volvulus 0.003 0.0205 0.0901
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0461 0.0975
Echinococcus granulosus MAM 0.0016 0.0033 0.0031
Schistosoma mansoni intermediate filament proteins 0.003 0.0205 0.0211
Loa Loa (eye worm) hypothetical protein 0.0176 0.2092 0.2667
Loa Loa (eye worm) hypothetical protein 0.0623 0.7846 1
Toxoplasma gondii NADPH-glutathione reductase 0.0044 0.0384 0.1395
Echinococcus multilocularis lysine specific demethylase 5A 0.0093 0.1015 0.101
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.005 0.0461 0.2472
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.2417 0.6894
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.005 0.0461 0.1836
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0287 0.3516 0.8904
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0044 0.0384 0.074
Trichomonas vaginalis protein kinase inhibitor, putative 0.0061 0.0613 0.1973
Echinococcus multilocularis MAM 0.0016 0.0033 0.0028
Echinococcus granulosus dnaJ subfamily C 6 0.0061 0.0613 0.0685
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.005 0.0461 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0175 0.207 0.2327
Mycobacterium tuberculosis Probable dehydrogenase 0.0287 0.3516 0.8904
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.4956 0.4954
Loa Loa (eye worm) hypothetical protein 0.0016 0.0033 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.1459 0.3994
Leishmania major DNA polymerase kappa, putative 0.0181 0.2156 0.6105
Plasmodium falciparum DNA repair protein REV1, putative 0.0054 0.052 0.2927
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0558 0.0711
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.014 0.0135
Plasmodium falciparum phd finger protein, putative 0.0029 0.0196 0.0437
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1062 0.3973
Echinococcus multilocularis microtubule associated protein 2 0.0703 0.888 0.8879
Mycobacterium ulcerans hypothetical protein 0.0054 0.052 0.1562
Giardia lamblia DNA damage repair protein 0.0054 0.052 0.1654
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0294 0.1188
Schistosoma mansoni cpg binding protein 0.006 0.06 0.0657
Leishmania major DNA polymerase kappa, putative 0.0054 0.052 0.1154
Brugia malayi Protein kinase domain containing protein 0.0016 0.0033 0.0019
Leishmania major DNA damage repair protein, putative 0.0054 0.052 0.1154
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1062 0.3973
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0294 0.0468
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0295 0.0474
Brugia malayi ImpB/MucB/SamB family protein 0.0175 0.207 0.2622
Trypanosoma brucei DNA polymerase IV, putative 0.0195 0.2331 0.6633
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0175 0.207 0.2639
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0169 0.0193
Brugia malayi ImpB/MucB/SamB family protein 0.0281 0.3444 0.4377
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0283 0.0299
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1062 0.2794
Giardia lamblia Kinase, PLK 0.0096 0.1062 0.4419
Schistosoma mansoni DNA polymerase eta 0.0281 0.3444 0.3866
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.1062 0.4359
Trypanosoma cruzi DNA polymerase eta, putative 0.0281 0.3444 1
Loa Loa (eye worm) thioredoxin reductase 0.0126 0.1442 0.1837
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0044 0.0384 0.1878
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0384 0.074
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0196 0.0215
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0175 0.207 0.2066
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0294 0.0331
Echinococcus multilocularis citrate lyase subunit beta protein 0.0027 0.0169 0.0164
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1062 0.3973
Schistosoma mansoni ap endonuclease 0.0037 0.0294 0.0311
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0181 0.2156 0.6105
Loa Loa (eye worm) hypothetical protein 0.0025 0.014 0.0179
Brugia malayi hypothetical protein 0.0016 0.0027 0.0011
Echinococcus multilocularis L aminoadipate semialdehyde 0.0176 0.2092 0.2088
Plasmodium falciparum thioredoxin reductase 0.0126 0.1442 1
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0313 0.0347
Brugia malayi CXXC zinc finger family protein 0.0057 0.0558 0.069
Schistosoma mansoni hypothetical protein 0.0036 0.0283 0.0299
Trypanosoma brucei unspecified product 0.012 0.1373 0.3734
Echinococcus multilocularis dna polymerase eta 0.0281 0.3444 0.344
Trypanosoma brucei DNA damage repair protein, putative 0.0054 0.052 0.1154
Echinococcus multilocularis musashi 0.003 0.0205 0.02
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0044 0.0384 0.074
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0295 0.0474
Trypanosoma cruzi DNA damage repair protein, putative 0.0054 0.052 0.1154
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0313 0.0347
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0027 0.0035
Mycobacterium tuberculosis Probable reductase 0.0287 0.3516 0.8904
Plasmodium vivax DNA repair protein REV1, putative 0.0054 0.052 0.2927
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0044 0.0384 0.1878
Onchocerca volvulus Alhambra homolog 0.0029 0.0196 0.0858
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0313 0.0308
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.1062 0.1354
Entamoeba histolytica hypothetical protein 0.005 0.0461 0.0995
Schistosoma mansoni microtubule-associated protein tau 0.0703 0.888 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.014 0.0179
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0007 0.0002
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0319 0.3928 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.0384 0.074
Schistosoma mansoni lamin 0.003 0.0205 0.0211
Plasmodium falciparum glutathione reductase 0.0126 0.1442 1
Echinococcus granulosus intermediate filament protein 0.003 0.0205 0.0225
Trypanosoma cruzi DNA damage repair protein, putative 0.0054 0.052 0.1154
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0295 0.0562
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.1062 0.5034
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1062 0.3973
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0295 0.0562
Echinococcus granulosus jumonji domain containing protein 0.004 0.0342 0.038
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0044 0.0384 0.057
Trichomonas vaginalis glutathione reductase, putative 0.0044 0.0384 0.0954
Schistosoma mansoni inositol monophosphatase 0.0037 0.0295 0.0313
Brugia malayi Bromodomain containing protein 0.0029 0.0196 0.0227
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.1062 0.1058
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0126 0.1442 0.3385
Loa Loa (eye worm) hypothetical protein 0.0281 0.3444 0.4389
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.1062 0.2794
Schistosoma mansoni hypothetical protein 0.0016 0.0033 0.0017
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0295 0.0327
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0319 0.3928 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.005 0.0461 0.1836
Loa Loa (eye worm) hypothetical protein 0.0016 0.0033 0.0042
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0593 0.0756
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0044 0.0384 0.0426
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0152 0.1786 0.2006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0295 0.0474
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.099 0.1109
Echinococcus granulosus phd:f box containing protein 0.0025 0.014 0.0152
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0044 0.0384 0.074
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.014 0.0152
Trypanosoma brucei DNA damage repair protein, putative 0.0054 0.052 0.1154
Plasmodium vivax glutathione reductase, putative 0.0126 0.1442 1
Schistosoma mansoni high-affinity choline transporter 0.0346 0.4274 0.4802
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1062 0.2794
Loa Loa (eye worm) hypothetical protein 0.0029 0.0198 0.0252
Plasmodium falciparum thioredoxin reductase 0.0044 0.0384 0.1878
Trypanosoma cruzi DNA polymerase kappa, putative 0.0201 0.2417 0.6894
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.099 0.1096
Schistosoma mansoni cpg binding protein 0.006 0.06 0.0657
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0295 0.0893
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0295 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.2417 0.6894
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0319 0.3928 1
Echinococcus multilocularis muscleblind protein 1 0.0623 0.7846 0.7845
Brugia malayi hypothetical protein 0.0016 0.0033 0.0019
Onchocerca volvulus 0.0016 0.0033 0.0071
Mycobacterium ulcerans DNA polymerase IV 0.0201 0.2417 1
Plasmodium falciparum glutathione reductase 0.0044 0.0384 0.1878
Schistosoma mansoni DNA polymerase IV / kappa 0.0054 0.052 0.0567
Echinococcus granulosus L aminoadipate semialdehyde 0.0176 0.2092 0.2352
Echinococcus multilocularis muscleblind protein 0.0623 0.7846 0.7845
Echinococcus granulosus geminin 0.0168 0.1992 0.2239
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0196 0.0201
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0313 0.0995
Onchocerca volvulus 0.0016 0.0033 0.0071
Loa Loa (eye worm) DnaJ domain-containing protein 0.0061 0.0613 0.0781
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.2417 0.6894
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0384 0.074
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.014 0.0013
Echinococcus multilocularis solute carrier family 5 0.0038 0.0313 0.0308
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0169 0.0092
Brugia malayi jmjC domain containing protein 0.0096 0.1057 0.1327
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.2417 0.6894
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0044 0.0384 0.0954
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0182 0.0177
Echinococcus multilocularis cpg binding protein 0.006 0.06 0.0595
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0287 0.3516 0.8904
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0295 0.0474
Echinococcus multilocularis phd:f box containing protein 0.0025 0.014 0.0135
Schistosoma mansoni sodium/solute symporter 0.0038 0.0313 0.0333
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0196 0.025
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.014 0.0135
Echinococcus granulosus lysine specific demethylase 5A 0.0096 0.1057 0.1185
Schistosoma mansoni hypothetical protein 0.0016 0.0033 0.0017
Trypanosoma brucei DNA polymerase eta, putative 0.0281 0.3444 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0007 0.0002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0294 0.0499
Mycobacterium ulcerans DNA polymerase IV 0.0201 0.2417 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0205 0.0261
Trichomonas vaginalis mercuric reductase, putative 0.0044 0.0384 0.0954
Echinococcus granulosus muscleblind protein 0.0623 0.7846 0.8835
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0384 0.074
Echinococcus granulosus lamin 0.003 0.0205 0.0225
Plasmodium vivax JmjC domain containing protein 0.0025 0.014 0.0013
Trypanosoma cruzi DNA polymerase eta, putative 0.0161 0.1893 0.5309
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0313 0.0347
Echinococcus multilocularis geminin 0.0168 0.1992 0.1988
Echinococcus granulosus thioredoxin glutathione reductase 0.0127 0.1455 0.1634
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0294 0.0374
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.014 0.0152
Trypanosoma cruzi DNA polymerase kappa, putative 0.0201 0.2417 0.6894
Giardia lamblia DINP protein human, muc B family 0.0181 0.2156 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0867 0.1105
Echinococcus granulosus peregrin 0.0029 0.0196 0.0215
Schistosoma mansoni hypothetical protein 0.0168 0.1992 0.2228
Toxoplasma gondii thioredoxin reductase 0.0126 0.1442 0.7425
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.005 0.0461 0.0776
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0313 0.0308
Schistosoma mansoni inositol transporter 0.0038 0.0313 0.0333
Trypanosoma brucei hypothetical protein, conserved 0.0234 0.2833 0.8151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.099 0.1096
Loa Loa (eye worm) hypothetical protein 0.0025 0.0139 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.1459 0.3994
Schistosoma mansoni ap endonuclease 0.0037 0.0294 0.0311
Echinococcus granulosus dna polymerase eta 0.0281 0.3444 0.3875
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.0384 0.074
Schistosoma mansoni inositol monophosphatase 0.0037 0.0295 0.0313
Loa Loa (eye worm) histone methyltransferase 0.0018 0.005 0.0064
Echinococcus granulosus cpg binding protein 0.006 0.06 0.067
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0313 0.0347
Echinococcus granulosus lamin dm0 0.003 0.0205 0.0225
Trypanosoma brucei unspecified product 0.0195 0.2331 0.6633
Trypanosoma brucei hypothetical protein, conserved 0.0054 0.052 0.1154
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.052 0.1154
Loa Loa (eye worm) hypothetical protein 0.0025 0.014 0.0179
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.099 0.0985
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0175 0.207 0.2316

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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