Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.1873 | 0.2899 |
Echinococcus multilocularis | expressed conserved protein | 0.0098 | 0.5922 | 0.5922 |
Brugia malayi | RNA binding protein | 0.0067 | 0.3834 | 0.3834 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0019 | 0.0029 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0019 | 0.0029 |
Toxoplasma gondii | ATPase, AAA family protein | 0.001 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2213 | 0.3426 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1873 | 0.2949 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0019 | 0.0029 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.0019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3834 | 0.5936 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0019 | 0.0019 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | CHE-14 protein | 0.0045 | 0.2322 | 0.2322 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0104 | 0.635 | 0.635 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.001 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0019 | 0.0019 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1873 | 0.2949 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0019 | 0.0019 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1873 | 0.2949 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0105 | 0.6459 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.3834 | 0.3834 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Echinococcus multilocularis | protein patched | 0.0045 | 0.2322 | 0.2322 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.2322 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.1873 | 0.1873 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0148 | 0.9378 | 0.9378 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2213 | 0.3426 |
Treponema pallidum | DNA ligase (lig) | 0.001 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0019 | 0.0029 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.3834 | 0.3834 |
Echinococcus multilocularis | protein dispatched 1 | 0.0051 | 0.275 | 0.275 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.0019 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0019 | 0.0029 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.3834 | 0.3834 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0019 | 0.0019 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0019 | 0.0019 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.3834 | 0.3834 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0019 | 0.0019 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0045 | 0.2322 | 0.2322 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0019 | 0.0029 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.3834 | 0.3834 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0019 | 0.0019 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.001 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2213 | 0.3426 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0019 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2322 | 0.2322 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1873 | 0.2899 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0148 | 0.9378 | 0.9378 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0019 | 0.0019 |
Chlamydia trachomatis | DNA ligase | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0045 | 0.2322 | 0.2322 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | patched 1 | 0.0045 | 0.2322 | 0.3595 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0019 | 0.0019 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0158 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0019 | 0.0029 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.1873 | 0.1873 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0019 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.635 | 0.635 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | hypothetical protein | 0.0038 | 0.1873 | 0.1873 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.0019 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1873 | 0.2949 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0045 | 0.2322 | 0.2322 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3834 | 0.5936 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0019 | 0.0019 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0104 | 0.635 | 1 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3834 | 0.5936 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3834 | 0.5936 |
Echinococcus multilocularis | muscleblind protein | 0.0158 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0019 | 0.0019 |
Giardia lamblia | Replication factor C, subunit 1 | 0.001 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.3834 | 0.3834 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0019 | 0.0029 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.3834 | 0.3834 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.3004 | 0.3004 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2213 | 0.3426 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0104 | 0.635 | 0.635 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0019 | 0.0029 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.0011 | 0.0019 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0045 | 0.2322 | 0.2322 |
Echinococcus granulosus | expressed conserved protein | 0.0098 | 0.5922 | 0.5922 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0104 | 0.635 | 0.635 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3834 | 0.5936 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0019 | 0.0019 |
Echinococcus granulosus | muscleblind protein | 0.0158 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0019 | 0.0019 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0019 | 0.0029 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0019 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0019 | 0.0019 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0019 | 0.0019 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.001 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.