TDR Targets

Basic information

Technical information

TDR Targets ID: 784848
Name: N,N'-bis(4-nitrophenyl)benzene-1,3-dicarboxam ide
MW: 406.348 | Formula: C20H14N4O6
H donors: 2 H acceptors: 6 LogP: 3.25 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cccc(c1)C(=O)Nc1ccc(cc1)[N+](=O)[O-])Nc1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C20H14N4O6/c25-19(21-15-4-8-17(9-5-15)23(27)28)13-2-1-3-14(12-13)20(26)22-16-6-10-18(11-7-16)24(29)30/h1-12H,(H,21,25)(H,22,26)
InChiKey: DJBDRLMLMAGJBF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N,N'-bis(4-nitrophenyl)isophthalamide
ZINC04402376
Oprea1_867033
EU-0084238
A0713/0033278

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Rrm3p helicase	0.0169	0.5427	1
Onchocerca volvulus		0.0035	0.0849	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0293	0.0293
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0849	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0849	0.1157
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0849	0.1157
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0303	1	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0849	0.1157
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0849	0.0849
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0432	0.0143
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.1184	0.2552
Trichomonas vaginalis	esterase, putative	0.0035	0.0849	0.0966
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1675	0.1675
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.3636	0.3636
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0615	0.0615
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0849	0.1157
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.1675	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1184	0.1184
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0848	0.0848
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0432	0.0795
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0849	0.1157
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0359	0.0359
Schistosoma mansoni	ran	0.0021	0.0359	0.0359
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.3636	0.3636
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0849	0.1564
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0849	0.0849
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0849	0.0966
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0615	0.1133
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0169	0.5427	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.4639	0.4639
Brugia malayi	beta-lactamase family protein	0.0035	0.0849	0.183
Trichomonas vaginalis	conserved hypothetical protein	0.0169	0.5427	1
Brugia malayi	RNA, U transporter 1	0.0081	0.2403	0.5181
Entamoeba histolytica	hypothetical protein	0.0035	0.0848	0.0965
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1184	0.1184
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1675	0.1675
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1184	0.1184
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0849	0.0966
Echinococcus granulosus	muscleblind protein	0.0146	0.4639	0.4639
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0849	0.0849
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0849	0.1157
Entamoeba histolytica	hypothetical protein, conserved	0.0169	0.5427	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1675	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.1675	0.1675
Trypanosoma brucei	cytochrome P450, putative	0.0019	0.0293	0.054
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0169	0.5427	1
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0849	1
Schistosoma mansoni	importin beta-1	0.0028	0.0615	0.0615
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0849	0.183
Brugia malayi	beta-lactamase	0.0035	0.0849	0.183
Onchocerca volvulus		0.0035	0.0849	0.5
Echinococcus multilocularis	snurportin 1	0.0303	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1184	0.1184
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.1675	0.2284
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0293	0.0631
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0848	0.0848
Brugia malayi	hypothetical protein	0.0035	0.0848	0.1828
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0225	0.7335	1
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0849	0.0849
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0169	0.5427	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0638	0.0638
Leishmania major	hypothetical protein, conserved	0.0035	0.0849	0.1564
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0019	0.0293	0.1749
Schistosoma mansoni	hypothetical protein	0.0303	1	1
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0359	0.0661
Schistosoma mansoni	hypothetical protein	0.0169	0.5427	0.5427
Brugia malayi	Importin beta-1 subunit	0.0028	0.0615	0.1326
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0849	0.0849
Onchocerca volvulus		0.0035	0.0849	0.5
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0638	0.1375
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0849	0.1157
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1184	0.1184
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0849	0.1157
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1675	1
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0169	0.5427	0.5427
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0293	0.0631
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0359	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0849	0.0849
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0849	0.0849
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0293	0.054
Brugia malayi	Muscleblind-like protein	0.0146	0.4639	1
Leishmania major	GTP-binding protein, putative	0.0021	0.0359	0.0661
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0849	0.0849
Entamoeba histolytica	hypothetical protein	0.0035	0.0848	0.0965
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.1675	0.1675
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0293	0.054
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0849	0.1157
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0849	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0848	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0146	0.4639	0.4639
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0849	0.5067
Plasmodium falciparum	importin beta, putative	0.0028	0.0615	1
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0169	0.5427	0.5427
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0615	0.1133
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0615	0.0615
Entamoeba histolytica	hypothetical protein	0.0023	0.0432	0.0143
Schistosoma mansoni	hypothetical protein	0.0035	0.0848	0.0848
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0169	0.5427	1
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0615	0.5228
Toxoplasma gondii	ABC1 family protein	0.0035	0.0849	0.5067
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0293	0.0293
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0849	0.5067
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1675	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0848	0.0965
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0849	0.0966
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0849	0.0849
Loa Loa (eye worm)	CYP4Cod1	0.0019	0.0293	0.0293
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0849	0.0849
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0615	0.0615
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0432	0.0143
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0432	0.0795
Schistosoma mansoni	ran	0.0021	0.0359	0.0359
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.4639	0.4639
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1184	0.1184
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0359	0.0661
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0849	0.0849
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1184	0.1184
Mycobacterium ulcerans	lipase LipD	0.0035	0.0849	0.5067
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0848	0.0848
Leishmania major	cytochrome p450-like protein	0.0019	0.0293	0.054
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0849	0.1157
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0169	0.5427	1
Brugia malayi	beta-lactamase family protein	0.0035	0.0849	0.183
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0359	0.0774
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0169	0.5427	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0849	0.5067
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0169	0.5427	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0849	0.0966
Brugia malayi	MH2 domain containing protein	0.0117	0.3636	0.7838
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0169	0.5427	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0849	0.1564
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0432	0.0143
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0359	0.0661
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.1675	0.3087
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0849	0.0849
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0615	0.3672
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0849	0.5067
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0849	0.0966
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0849	0.1564
Echinococcus multilocularis	muscleblind protein	0.0146	0.4639	0.4639
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.1184	0.1184
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0359	0.0359
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0359	0.2143

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 784848