Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D3 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Homo sapiens | sigma non-opioid intracellular receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | amine GPCR | Dopamine D3 receptor | 446 aa | 420 aa | 31.4 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine D2 receptor | 444 aa | 440 aa | 30.0 % |
Schistosoma mansoni | biogenic amine (dopamine) receptor | Dopamine D2 receptor | 444 aa | 494 aa | 26.3 % |
Onchocerca volvulus | Dopamine D3 receptor | 446 aa | 462 aa | 26.0 % | |
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Dopamine D3 receptor | 446 aa | 489 aa | 22.9 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D3 receptor | 446 aa | 463 aa | 29.8 % |
Echinococcus multilocularis | serotonin receptor | Dopamine D2 receptor | 444 aa | 428 aa | 31.3 % |
Echinococcus multilocularis | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 465 aa | 21.5 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Dopamine D2 receptor | 444 aa | 429 aa | 31.7 % |
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D3 receptor | 446 aa | 501 aa | 28.5 % |
Echinococcus multilocularis | alpha 1A adrenergic receptor | Dopamine D3 receptor | 446 aa | 473 aa | 21.6 % |
Onchocerca volvulus | Dopamine D3 receptor | 446 aa | 434 aa | 19.4 % | |
Echinococcus granulosus | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 457 aa | 21.0 % |
Echinococcus granulosus | alpha 1A adrenergic receptor | Dopamine D3 receptor | 446 aa | 460 aa | 21.1 % |
Loa Loa (eye worm) | hypothetical protein | Dopamine D3 receptor | 446 aa | 425 aa | 21.4 % |
Schistosoma mansoni | biogenic amine receptor | Dopamine D3 receptor | 446 aa | 455 aa | 28.6 % |
Echinococcus multilocularis | biogenic amine (5HT) receptor | Dopamine D3 receptor | 446 aa | 499 aa | 30.9 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D3 receptor | 446 aa | 426 aa | 28.6 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Dopamine D2 receptor | 444 aa | 386 aa | 19.7 % |
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D3 receptor | 446 aa | 478 aa | 22.8 % |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Dopamine D2 receptor | 444 aa | 487 aa | 23.8 % |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | Dopamine D3 receptor | 446 aa | 463 aa | 25.5 % |
Loa Loa (eye worm) | TYRA-2 protein | Dopamine D3 receptor | 446 aa | 494 aa | 24.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 0.78 | 1 |
Onchocerca volvulus | 0.0038 | 0.022 | 0.5 | |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0078 | 0.0972 | 0.1363 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.0409 | 0.713 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 0.78 | 1 |
Echinococcus multilocularis | expressed protein | 0.0371 | 0.6431 | 0.902 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0082 | 0.1042 | 0.119 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 0.78 | 1 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0038 | 0.022 | 0.0308 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0563 | 1 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0445 | 0.78 | 1 |
Echinococcus granulosus | expressed protein | 0.0371 | 0.6431 | 0.8989 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0078 | 0.0972 | 0.1088 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0105 | 0.1462 | 0.1798 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0105 | 0.1462 | 0.2051 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0082 | 0.1042 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.3747 | 0.4653 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0563 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0.022 | 0.5 | |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0038 | 0.022 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0563 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.009 | 0.118 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.78 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0563 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0563 | 1 | 0.5 |
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | 0.0409 | 0.713 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0563 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0563 | 1 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0563 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 30 nM | Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]-IABN the radioligand. | ChEMBL. | 11356115 |
Ki (binding) | = 30 nM | Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]-IABN the radioligand. | ChEMBL. | 11356115 |
Ki (binding) | = 31 nM | Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand. | ChEMBL. | 11356115 |
Ki (binding) | = 31 nM | Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand. | ChEMBL. | 11356115 |
Ki (binding) | = 35 nM | Binding affinity for sigma-2 receptor measured on rat liver membranes using [3H]-DTG as radioligand in the presence of (+)-pentazocine | ChEMBL. | 11356115 |
Ki (binding) | = 157 nM | Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand. | ChEMBL. | 11356115 |
Ki (binding) | = 157 nM | Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand. | ChEMBL. | 11356115 |
Ratio (binding) | = 5 | Dopamine D2/D3 ratio of the compound | ChEMBL. | 11356115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.