Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0032 | 0.0313 | 0.0055 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0313 | 0.0055 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0032 | 0.0313 | 0.0055 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.021 | 0.6906 | 0.8837 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0.0498 | 0.083 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0313 | 0.0055 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0233 | 0.7773 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0037 | 0.0498 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.021 | 0.6906 | 0.8837 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0037 | 0.0498 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0032 | 0.0313 | 0.0055 |
Schistosoma mansoni | rotamase | 0.0032 | 0.0329 | 0.0016 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0037 | 0.0498 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0313 | 0.0055 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0037 | 0.0498 | 0.083 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0037 | 0.0498 | 0.0881 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0233 | 0.7773 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0092 | 0.254 | 1 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0032 | 0.0313 | 0.0055 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0313 | 0.0055 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0037 | 0.0498 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0032 | 0.0313 | 0.063 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0037 | 0.0498 | 0.0881 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0037 | 0.0498 | 0.0765 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0032 | 0.0313 | 0.1234 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0.0498 | 0.083 |
Toxoplasma gondii | exonuclease III APE | 0.0037 | 0.0498 | 0.0881 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0092 | 0.254 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0092 | 0.254 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0037 | 0.0498 | 1 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0032 | 0.0329 | 0.1296 |
Echinococcus multilocularis | expressed protein | 0.0032 | 0.0329 | 0.0071 |
Plasmodium vivax | glutathione reductase, putative | 0.0092 | 0.254 | 1 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0032 | 0.0313 | 0.0055 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0233 | 0.7773 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0092 | 0.254 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.0329 | 0.1429 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.021 | 0.6906 | 0.8837 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0032 | 0.0313 | 0.0055 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0032 | 0.0313 | 0.0055 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0032 | 0.0313 | 0.0055 |
Leishmania major | trypanothione reductase | 0.0092 | 0.254 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0092 | 0.254 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0313 | 0.0055 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0032 | 0.0313 | 0.0055 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.021 | 0.6906 | 0.8837 |
Plasmodium falciparum | thioredoxin reductase | 0.0092 | 0.254 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0092 | 0.254 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0037 | 0.0498 | 0.0191 |
Trichomonas vaginalis | rotamase, putative | 0.0032 | 0.0329 | 0.1429 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0037 | 0.0498 | 0.083 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0313 | 0.0055 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0313 | 0.0055 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0313 | 0.0055 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0233 | 0.7773 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.021 | 0.6906 | 0.8837 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0032 | 0.0313 | 0.063 |
Echinococcus granulosus | expressed protein | 0.0032 | 0.0329 | 0.0071 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0092 | 0.254 | 0.2985 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0037 | 0.0498 | 0.1961 |
Brugia malayi | Thioredoxin reductase | 0.0092 | 0.254 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0092 | 0.254 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0032 | 0.0313 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0032 | 0.0313 | 0.0055 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0032 | 0.0313 | 0.0055 |
Schistosoma mansoni | ap endonuclease | 0.0037 | 0.0498 | 0.0191 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0037 | 0.0498 | 0.0881 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0037 | 0.0498 | 0.0881 |
Brugia malayi | glutathione reductase | 0.0092 | 0.254 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0037 | 0.0498 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0092 | 0.254 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.021 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0037 | 0.0498 | 0.0248 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0037 | 0.0498 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0092 | 0.254 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.