Detailed information for compound 784998

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 490.347 | Formula: C22H24BrN3O5
  • H donors: 2 H acceptors: 3 LogP: 3.71 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)NC(=O)CC(=NNC(=O)COc1ccc(cc1Br)C)C
  • InChi: 1S/C22H24BrN3O5/c1-4-30-22(29)16-6-8-17(9-7-16)24-20(27)12-15(3)25-26-21(28)13-31-19-10-5-14(2)11-18(19)23/h5-11H,4,12-13H2,1-3H3,(H,24,27)(H,26,28)/b25-15+
  • InChiKey: PVTANXKBWBTKAU-MFKUBSTISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0448 0.1693
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0074 0.0773 0.458
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0118 0.0095
Echinococcus multilocularis cpg binding protein 0.006 0.0593 0.0571
Toxoplasma gondii NADPH-glutathione reductase 0.0074 0.0773 0.2803
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0146 0.0123
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0029 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0773 0.2803
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0074 0.0773 0.2803
Echinococcus granulosus sulfide:quinone oxidoreductase 0.002 0.0086 0.0063
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0575 0.2197
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0031 0.0033
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0074 0.0773 0.0751
Echinococcus multilocularis transient receptor potential gamma protein 0.0094 0.1026 0.1005
Echinococcus granulosus peregrin 0.0032 0.024 0.0217
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1006 0.0986
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0086 0.0253
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.002 0.0086 0.0252
Trichomonas vaginalis glutathione reductase, putative 0.0074 0.0773 0.2263
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0074 0.0773 0.2803
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0992 0.0971
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.002 0.0086 0.0063
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1585 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1585 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3414 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0073 0.005
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0029 0.0006
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0147 0.0246
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3414 1
Trypanosoma cruzi trypanothione reductase, putative 0.0074 0.0773 0.2803
Chlamydia trachomatis glutamine binding protein 0.0038 0.0312 0.3285
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0038 0.0312 0.0678
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0195 0.0444
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0029 0.0006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0376 0.1101
Onchocerca volvulus 0.0031 0.023 0.0523
Trichomonas vaginalis glutamate synthase, putative 0.002 0.0086 0.0253
Plasmodium vivax glutathione reductase, putative 0.0214 0.2534 1
Brugia malayi hypothetical protein 0.0025 0.0147 0.0492
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.002 0.0086 0.0063
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.002 0.0086 0.0253
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0031 0.0008
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0038 0.0312 0.1505
Echinococcus granulosus nmda type glutamate receptor 0.0052 0.0497 0.0475
Giardia lamblia PHD finger protein 15 0.0028 0.0195 0.0326
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3414 1
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0624 0.0602
Loa Loa (eye worm) thioredoxin reductase 0.0214 0.2534 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0074 0.0773 0.2803
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.1666 0.6543
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0074 0.0773 0.458
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0147 0.0246
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0074 0.0773 0.2985
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1006 0.0986
Schistosoma mansoni hypothetical protein 0.0808 1 1
Echinococcus multilocularis glutamate receptor 2 0.0022 0.0118 0.0095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0992 0.0971
Brugia malayi MH2 domain containing protein 0.012 0.1344 0.526
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0147 0.0246
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0376 0.1183
Plasmodium vivax SET domain protein, putative 0.0031 0.023 0.0588
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0074 0.0773 1
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.002 0.0086 0.0063
Loa Loa (eye worm) glutathione reductase 0.0214 0.2534 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0086 0.0252
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.1666 0.1647
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.023 0.0208
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0311 0.0288
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0073 0.005
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0074 0.0773 0.2803
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0086 0.0252
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1344 0.526
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0624 0.0602
Echinococcus multilocularis glutamate synthase 0.002 0.0086 0.0063
Echinococcus granulosus geminin 0.0165 0.1911 0.1892
Schistosoma mansoni cpg binding protein 0.006 0.0593 0.0571
Brugia malayi glutamate synthase 0.002 0.0086 0.0252
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0074 0.0773 0.458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0773 0.2803
Treponema pallidum NADH oxidase 0.0074 0.0773 0.2063
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0195 0.0444
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0335 0.0312
Schistosoma mansoni transient receptor potential channel 0.0062 0.0624 0.0602
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0086 0.0063
Leishmania major hypothetical protein, conserved 0.0025 0.0147 0.0246
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0992 0.3858
Echinococcus multilocularis nmda type glutamate receptor 0.0052 0.0497 0.0475
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0086 0.0253
Loa Loa (eye worm) hypothetical protein 0.0049 0.045 0.1699
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0118 0.0095
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.3414 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.1615 0.1596
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0195 0.0172
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0311 0.1145
Brugia malayi Thioredoxin reductase 0.0214 0.2534 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3414 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0147 0.0246
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0376 0.1101
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0552 0.2105
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0992 0.3858
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.002 0.0086 0.0252
Schistosoma mansoni hypothetical protein 0.0015 0.0031 0.0008
Schistosoma mansoni hypothetical protein 0.0015 0.0031 0.0008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0255 0.0924
Onchocerca volvulus 0.0239 0.2841 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.1666 0.1647
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0086 0.0253
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0038 0.0312 0.0921
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.0986 0.0965
Brugia malayi jmjC domain containing protein 0.0093 0.1006 0.3915
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0074 0.0773 0.2803
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0074 0.0773 0.2803
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.002 0.0086 0.0063
Plasmodium vivax thioredoxin reductase, putative 0.0214 0.2534 1
Brugia malayi PHD-finger family protein 0.0028 0.0195 0.0685
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0086 0.0253
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0074 0.0773 0.458
Schistosoma mansoni transient receptor potential channel 4 0.0094 0.1026 0.1005
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0118 0.0095
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0335 0.0312
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.027 0.0248
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0073 0.0199
Loa Loa (eye worm) hypothetical protein 0.002 0.0086 0.0252
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.002 0.0086 0.0063
Brugia malayi Pre-SET motif family protein 0.021 0.2479 0.9778
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0195 0.0172
Schistosoma mansoni hypothetical protein 0.0028 0.0195 0.0172
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0376 0.1183
Trichomonas vaginalis mercuric reductase, putative 0.0074 0.0773 0.2263
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.023 0.0208
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0992 0.0971
Loa Loa (eye worm) hypothetical protein 0.0032 0.024 0.0865
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0031 0.0008
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.028 0.0257
Echinococcus granulosus glutamate synthase 0.002 0.0086 0.0063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0773 0.2803
Echinococcus granulosus glutamate receptor 2 0.0022 0.0118 0.0095
Schistosoma mansoni hypothetical protein 0.0165 0.1911 0.1892
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0376 0.1183
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0086 0.0253
Loa Loa (eye worm) acetyltransferase 0.0145 0.1666 0.6543
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0086 0.0253
Plasmodium falciparum phd finger protein, putative 0.0028 0.0195 0.0444
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0331 0.0736
Mycobacterium tuberculosis Probable oxidoreductase 0.0074 0.0773 0.2803
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0074 0.0773 0.2803
Schistosoma mansoni glutamate synthase 0.002 0.0086 0.0063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0773 0.2803
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0992 0.0971
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1585 0.6121
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0074 0.0773 0.2803
Schistosoma mansoni hypothetical protein 0.002 0.0086 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3414 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0022 0.0118 0.0095
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0074 0.0773 0.2803
Schistosoma mansoni glutamate synthase 0.002 0.0086 0.0063
Echinococcus multilocularis GPCR, family 2 0.0015 0.0031 0.0008
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.1249 0.4748
Leishmania major trypanothione reductase 0.0214 0.2534 1
Schistosoma mansoni cpg binding protein 0.006 0.0593 0.0571
Loa Loa (eye worm) programmed cell death 8 0.002 0.0086 0.0252
Plasmodium falciparum glutathione reductase 0.0214 0.2534 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0029 0.0006
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.028 0.0257
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0624 0.0602
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.1366 0.1346
Schistosoma mansoni sulfide quinone reductase 0.002 0.0086 0.0063
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0147 0.0246
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0118 0.0095
Echinococcus granulosus transient receptor potential gamma protein 0.0094 0.1026 0.1005
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0038 0.0312 0.3285
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0074 0.0773 0.2803
Trichomonas vaginalis apoptosis inducing factor, putative 0.002 0.0086 0.0253
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.023 0.0588
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3414 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0074 0.0773 0.0751
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0992 0.0971
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0147 0.0246
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.3414 1
Brugia malayi glutathione reductase 0.0214 0.2534 1
Brugia malayi hypothetical protein 0.0016 0.0037 0.0057
Loa Loa (eye worm) hypothetical protein 0.0094 0.1026 0.3992
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0331 0.1
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1344 0.526
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0031 0.0033
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0038 0.0312 0.0678
Loa Loa (eye worm) hypothetical protein 0.0025 0.0147 0.0492
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0074 0.0773 0.2803
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.023 0.0208
Trichomonas vaginalis set domain proteins, putative 0.0239 0.2841 0.8323
Loa Loa (eye worm) hypothetical protein 0.0048 0.0448 0.1693
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0376 0.0354
Schistosoma mansoni disulfide oxidoreductase 0.002 0.0086 0.0063
Schistosoma mansoni hypothetical protein 0.0015 0.0031 0.0008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0773 0.2803
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0147 0.0246
Brugia malayi Transient-receptor-potential like protein 0.0035 0.028 0.1023
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0195 0.0172
Echinococcus multilocularis thioredoxin glutathione reductase 0.0214 0.2534 0.2517
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0074 0.0773 0.2803
Schistosoma mansoni transient receptor potential channel 0.0062 0.0624 0.0602
Echinococcus granulosus thioredoxin glutathione reductase 0.0214 0.2534 0.2517
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0055 0.0525 0.1997
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0033
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0022 0.0118 0.0095
Trichomonas vaginalis glutamate synthase, putative 0.002 0.0086 0.0253
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0448 0.1693
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0086 0.0253
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.023 0.0208
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0074 0.0773 0.2803
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0055 0.0525 0.1997
Trypanosoma cruzi trypanothione reductase, putative 0.0214 0.2534 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.002 0.0086 0.0253
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0086 0.0063
Echinococcus multilocularis dnaJ subfamily B 0.0808 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0624 0.0602
Onchocerca volvulus Alhambra homolog 0.0028 0.0195 0.0394
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0086 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.023 0.0208
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.023 0.0208
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0214 0.2534 1
Schistosoma mansoni glutamate synthase 0.002 0.0086 0.0063
Schistosoma mansoni sulfide quinone reductase 0.002 0.0086 0.0063
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0118 0.0095
Brugia malayi Bromodomain containing protein 0.0032 0.024 0.0863
Echinococcus multilocularis geminin 0.0165 0.1911 0.1892
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0074 0.0773 0.2803
Schistosoma mansoni hypothetical protein 0.0033 0.0255 0.0233
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0074 0.0773 0.0751
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0086 0.0253
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0992 0.0971
Giardia lamblia NADH oxidase lateral transfer candidate 0.0074 0.0773 0.2063
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0052 0.0497 0.0475
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0766 0.0745
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0031 0.0008
Loa Loa (eye worm) hypothetical protein 0.0059 0.0584 0.2234
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2479 0.9778
Schistosoma mansoni hypothetical protein 0.0165 0.1911 0.1892
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.002 0.0086 0.0063
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0074 0.0773 0.2803
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0118 0.0095
Trypanosoma brucei trypanothione reductase 0.0214 0.2534 1
Echinococcus granulosus cpg binding protein 0.006 0.0593 0.0571
Schistosoma mansoni cpg binding protein 0.0057 0.0552 0.053
Onchocerca volvulus 0.0057 0.0552 0.169
Schistosoma mansoni hypothetical protein 0.0015 0.0031 0.0008
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0074 0.0773 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0992 0.0971
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0031 0.0008
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0074 0.0773 0.2803
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.023 0.0208
Loa Loa (eye worm) hypothetical protein 0.0035 0.028 0.1023
Echinococcus granulosus GPCR family 2 0.0015 0.0031 0.0008
Brugia malayi Pre-SET motif family protein 0.0031 0.023 0.0826
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0201 0.0178
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0255 0.0924
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.0986 0.0965
Loa Loa (eye worm) hypothetical protein 0.0031 0.023 0.0826
Brugia malayi CXXC zinc finger family protein 0.0057 0.0552 0.2105
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3414 1
Echinococcus multilocularis peregrin 0.0032 0.024 0.0217
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0773 0.2803
Loa Loa (eye worm) hypothetical protein 0.0028 0.0195 0.0685
Plasmodium falciparum thioredoxin reductase 0.0074 0.0773 0.2803
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0311 0.0288
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3414 1
Plasmodium falciparum thioredoxin reductase 0.0214 0.2534 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0311 0.0288
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0086 0.0063
Toxoplasma gondii thioredoxin reductase 0.0214 0.2534 1
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0187 0.0652
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0448 0.1693
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.3414 1
Plasmodium falciparum glutathione reductase 0.0074 0.0773 0.2803
Schistosoma mansoni glutamate receptor NMDA 0.0022 0.0118 0.0095
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0195 0.0685
Schistosoma mansoni transient receptor potential channel 0.0094 0.1026 0.1005
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.3414 1
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0195 0.0444
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0031 0.0033
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0074 0.0773 0.2803
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0074 0.0773 0.2803
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0074 0.0773 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.002 0.0086 0.0063
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0331 0.0736
Brugia malayi jmjC domain containing protein 0.0038 0.0311 0.1145

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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