Detailed information for compound 785010

Basic information

Technical information
  • TDR Targets ID: 785010
  • Name: AG-205/36494011
  • MW: 324.331 | Formula: C18H16N2O4
  • H donors: 0 H acceptors: 4 LogP: 2.45 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C2C(C(=O)N1c1cc(ccc1C)[N+](=O)[O-])C1C3(C2C=C1)CC3
  • InChi: 1S/C18H16N2O4/c1-9-2-3-10(20(23)24)8-13(9)19-16(21)14-11-4-5-12(15(14)17(19)22)18(11)6-7-18/h2-5,8,11-12,14-15H,6-7H2,1H3
  • InChiKey: XTOIUIXMPLPZLM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • BIM-0026674.P001
  • Oprea1_268131
  • CBMicro_026614
  • A0983/0045966

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase eta, putative 0.0183 0.2522 0.6018
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0102 0.1344 0.1344
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0219 0.0398
Brugia malayi Bromodomain containing protein 0.0029 0.0269 0.0306
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0001 0.0001
Echinococcus granulosus intermediate filament protein 0.0029 0.0279 0.0279
Mycobacterium ulcerans glutaminase 0.0308 0.4359 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0095 0.1232 0.1232
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0269 0.1485
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.124 0.2751
Echinococcus multilocularis high affinity choline transporter 1 0.0341 0.484 0.484
Schistosoma mansoni inositol transporter 0.0038 0.0401 0.0401
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0056
Plasmodium falciparum DNA repair protein REV1, putative 0.0032 0.0314 0.5446
Schistosoma mansoni cpg binding protein 0.003 0.0295 0.0295
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0714 0.0814
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0219 0.0219
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.038 0.0793
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0065
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.038 0.0755
Schistosoma mansoni lamin 0.0029 0.0279 0.0279
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0219 0.0249
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0098
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0219 0.0398
Brugia malayi hypothetical protein 0.0035 0.0367 0.0418
Trichomonas vaginalis glutaminase, putative 0.0308 0.4359 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0056
Schistosoma mansoni importin beta-1 0.0033 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0341 0.484 0.5517
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.02 0.0353
Plasmodium falciparum phd finger protein, putative 0.0029 0.0269 0.4631
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0219 0.0219
Trypanosoma brucei DNA polymerase IV, putative 0.0102 0.1344 0.3143
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.2117 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.0086
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.1344 0.3143
Plasmodium vivax glutathione reductase, putative 0.0041 0.0442 0.7771
Trypanosoma brucei unspecified product 0.007 0.088 0.2012
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0401 0.0401
Schistosoma mansoni microtubule-associated protein tau 0.0694 1 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.038 0.038
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0103 0.1352 0.6286
Leishmania major DNA polymerase kappa, putative 0.0102 0.1344 0.3143
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0401 0.0401
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.02 0.0353
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0115 0.0132
Plasmodium falciparum glutathione reductase 0.0014 0.0055 0.0774
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1887 0.4469
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0112 0.1492 1
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0538 0.1121
Mycobacterium tuberculosis Probable reductase 0.0092 0.1201 0.5555
Trypanosoma brucei DNA polymerase IV, putative 0.0102 0.1344 0.3143
Echinococcus multilocularis peregrin 0.0029 0.0269 0.0269
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.124 0.2889
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0032 0.0314 0.1798
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0269 0.0269
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.1344 0.3143
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.02 0.3393
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.124 0.2889
Loa Loa (eye worm) inositol-1 0.0036 0.038 0.0434
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.008 0.0091
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.124 0.1413
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1167 0.1167
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0219 0.0219
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.038 0.637
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.1256 0.1256
Schistosoma mansoni hypothetical protein 0.0029 0.0269 0.0269
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0455 0.0976
Schistosoma mansoni cpg binding protein 0.0029 0.0271 0.0271
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.088 0.2012
Plasmodium falciparum thioredoxin reductase 0.0041 0.0442 0.7771
Echinococcus multilocularis musashi 0.0029 0.0279 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.1344 0.3143
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0219 0.0219
Echinococcus multilocularis muscleblind protein 0.061 0.8772 0.8772
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0742 0.0742
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0647 0.4116
Brugia malayi jmjC domain containing protein 0.0025 0.0219 0.0249
Loa Loa (eye worm) hypothetical protein 0.0038 0.0401 0.0457
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0243 0.0243
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0014 0.0055 0.0774
Schistosoma mansoni DNA polymerase IV / kappa 0.0032 0.0314 0.0314
Echinococcus granulosus cpg binding protein 0.003 0.0295 0.0295
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0347 0.4928 0.5617
Loa Loa (eye worm) hypothetical protein 0.0174 0.2394 0.2729
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.1256 0.1432
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.1344 0.3143
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0102 0.1344 0.1344
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.038 0.0793
Echinococcus granulosus L aminoadipate semialdehyde 0.0174 0.2394 0.2394
Schistosoma mansoni ran 0.0024 0.02 0.02
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0033 0.0326 0.0371
Entamoeba histolytica hypothetical protein 0.0035 0.0367 0.1455
Brugia malayi SEA domain containing protein 0.0015 0.0069 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.124 0.2751
Trichomonas vaginalis ran, putative 0.0024 0.02 0.0337
Leishmania major DNA polymerase eta, putative 0.0112 0.1492 0.3505
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0049 0.0566 0.1185
Echinococcus granulosus lamin 0.0029 0.0279 0.0279
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0326 0.066
Schistosoma mansoni terminal deoxycytidyl transferase 0.0102 0.1344 0.1344
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0055 0.0055
Onchocerca volvulus 0.0174 0.2394 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0279 0.0318
Schistosoma mansoni high-affinity choline transporter 0.0341 0.484 0.484
Onchocerca volvulus Alhambra homolog 0.0029 0.0269 0.1123
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0049 0.0566 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0314 0.0358
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0103 0.1352 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0092 0.1201 0.5555
Loa Loa (eye worm) hypothetical protein 0.0065 0.0801 0.0913
Brugia malayi Muscleblind-like protein 0.061 0.8772 1
Echinococcus multilocularis geminin 0.0332 0.4697 0.4697
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0401 0.0457
Schistosoma mansoni hypothetical protein 0.0347 0.4928 0.4928
Echinococcus multilocularis L aminoadipate semialdehyde 0.0174 0.2394 0.2394
Entamoeba histolytica hypothetical protein 0.0049 0.0566 0.3195
Schistosoma mansoni inositol transporter 0.0038 0.0401 0.0401
Schistosoma mansoni lamin 0.0029 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0025 0.0219 0.0249
Onchocerca volvulus 0.0015 0.0069 0.029
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.038 0.0793
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0442 0.1877
Leishmania major GTP-binding protein, putative 0.0024 0.02 0.0353
Toxoplasma gondii thioredoxin reductase 0.0041 0.0442 0.2693
Trypanosoma cruzi DNA polymerase eta, putative 0.0183 0.2522 0.6018
Plasmodium vivax DNA repair protein REV1, putative 0.0032 0.0314 0.5446
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0219 0.0219
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0049 0.0566 1
Leishmania major DNA damage repair protein, putative 0.0032 0.0314 0.063
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0314 0.063
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0219 0.0249
Loa Loa (eye worm) DnaJ domain-containing protein 0.0064 0.0785 0.0894
Loa Loa (eye worm) hypothetical protein 0.0029 0.0269 0.0306
Mycobacterium ulcerans hypothetical protein 0.0032 0.0314 0.06
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.02 0.0228
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0057 0.0057
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0102 0.1344 0.2994
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.038 0.0755
Schistosoma mansoni jumonji domain containing protein 0.0134 0.1815 0.1815
Brugia malayi glutaminase DH11.1 0.0308 0.4359 0.4969
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0401 0.0401
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.124 0.124
Entamoeba histolytica hypothetical protein 0.0035 0.0367 0.1455
Leishmania major hypothetical protein, conserved 0.0025 0.0219 0.0398
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.02 0.3393
Brugia malayi RNA, U transporter 1 0.0093 0.1203 0.1371
Echinococcus granulosus lamin dm0 0.0029 0.0279 0.0279
Schistosoma mansoni hypothetical protein 0.0035 0.0367 0.0367
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.02 0.0353
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0219 0.0219
Echinococcus granulosus dna polymerase eta 0.0183 0.2522 0.2522
Brugia malayi jmjC domain containing protein 0.0154 0.2096 0.239
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0367 0.0367
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.124 0.124
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0219 0.1137
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0001 0.0001
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.124 0.2889
Onchocerca volvulus 0.0015 0.0069 0.029
Trypanosoma cruzi DNA damage repair protein, putative 0.0032 0.0314 0.063
Leishmania major importin beta-1 subunit, putative 0.0026 0.0236 0.044
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.038 0.038
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0236 0.0419
Leishmania major phosphopantetheinyl transferase-like protein 0.0049 0.0566 0.1245
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0455 0.0976
Schistosoma mansoni DNA polymerase eta 0.0183 0.2522 0.2522
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1167 0.133
Echinococcus granulosus importin subunit beta 1 0.0033 0.0326 0.0326
Echinococcus granulosus MAM 0.0016 0.0086 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1167 0.1167
Schistosoma mansoni sodium/solute symporter 0.0038 0.0401 0.0401
Mycobacterium tuberculosis Probable oxidoreductase 0.0103 0.1352 0.6286
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0236 0.0419
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.02 0.0228
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.008 0.0091
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0367 0.0367
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0401 0.0401
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.124 0.1413
Trichomonas vaginalis protein kinase inhibitor, putative 0.0064 0.0785 0.1694
Brugia malayi intermediate filament protein 0.0029 0.0279 0.0318
Brugia malayi jmjC domain containing protein 0.0025 0.0219 0.0249
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.02 0.02
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0219 0.0219
Mycobacterium tuberculosis Conserved hypothetical protein 0.0102 0.1344 0.6248
Schistosoma mansoni intermediate filament proteins 0.0029 0.0279 0.0279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.1344 0.3143
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.1256 0.1256
Entamoeba histolytica hypothetical protein 0.0035 0.0367 0.1455
Echinococcus multilocularis lamin 0.0029 0.0279 0.0279
Loa Loa (eye worm) DOMON domain-containing protein 0.0015 0.0069 0.0079
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0103 0.1352 0.6286
Onchocerca volvulus 0.0038 0.0401 0.1673
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0442 0.0504
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.1344 0.3143
Echinococcus granulosus snurportin 1 0.0347 0.4928 0.4928
Trichomonas vaginalis DNA polymerase eta, putative 0.0102 0.1344 0.2994
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0219 0.0219
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0326 0.0326
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0055 0.0055
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0588 0.1299
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.038 0.0793
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1887 0.4469
Schistosoma mansoni ran 0.0024 0.02 0.02
Trypanosoma brucei DNA damage repair protein, putative 0.0032 0.0314 0.063
Echinococcus granulosus phd:f box containing protein 0.0025 0.0219 0.0219
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.124 0.5178
Mycobacterium ulcerans hypothetical protein 0.0155 0.2117 0.4791
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0025 0.0219 0.0249
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0049 0.0566 0.2474
Loa Loa (eye worm) glutaminase 2 0.0308 0.4359 0.4969
Echinococcus multilocularis cpg binding protein 0.003 0.0295 0.0295
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.02 0.1008
Onchocerca volvulus 0.0015 0.0069 0.029
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0401 0.2402
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0049 0.0566 0.3551
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0102 0.1344 0.3143
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0055 0.0063
Schistosoma mansoni cpg binding protein 0.003 0.0295 0.0295
Schistosoma mansoni hypothetical protein 0.0064 0.0785 0.0785
Onchocerca volvulus 0.0016 0.0086 0.0359
Plasmodium vivax importin-beta 2, putative 0.0033 0.0326 0.5664
Onchocerca volvulus 0.0016 0.0086 0.0359
Loa Loa (eye worm) glutathione reductase 0.0041 0.0442 0.0504
Brugia malayi GH02984p 0.0341 0.484 0.5517
Brugia malayi jmjC domain containing protein 0.0096 0.1256 0.1432
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1167 0.1167
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0219 0.0219
Echinococcus granulosus solute carrier family 5 0.0038 0.0401 0.0401
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0154 0.2096 0.2096
Echinococcus granulosus dnaJ subfamily C 6 0.0064 0.0785 0.0785
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0049 0.0566 1
Onchocerca volvulus 0.0029 0.0279 0.1164
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0314 0.063
Trypanosoma cruzi DNA polymerase eta, putative 0.0112 0.1492 0.3505
Schistosoma mansoni hypothetical protein 0.0332 0.4697 0.4697
Echinococcus granulosus muscleblind protein 0.061 0.8772 0.8772
Loa Loa (eye worm) hypothetical protein 0.0015 0.0069 0.0079
Brugia malayi DnaJ domain containing protein 0.0064 0.0785 0.0894
Brugia malayi jmjC domain containing protein 0.0025 0.0219 0.0249
Echinococcus granulosus lysine specific demethylase 5A 0.0096 0.1256 0.1256
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0102 0.1344 0.6248
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0401 0.0401
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0314 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.088 0.2012
Brugia malayi polk-prov protein 0.0032 0.0314 0.0358
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0174 0.2394 0.2729
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.1344 0.3143
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0269 0.0269
Brugia malayi ImpB/MucB/SamB family protein 0.0183 0.2522 0.2875
Schistosoma mansoni inositol monophosphatase 0.0036 0.038 0.038
Brugia malayi PHD-finger family protein 0.0011 0.0011 0.0013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0279 0.0318
Loa Loa (eye worm) TK/ALK protein kinase 0.0016 0.0086 0.0098
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0049 0.0566 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0314 0.1798
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0219 0.0398
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.1344 0.3143
Toxoplasma gondii hypothetical protein 0.0047 0.0544 0.3404
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0455 0.0976
Brugia malayi hypothetical protein 0.0016 0.0086 0.0098
Trypanosoma brucei unspecified product 0.007 0.088 0.2012
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.1344 0.3143
Trypanosoma brucei DNA damage repair protein, putative 0.0032 0.0314 0.063
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.02 0.1124
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0219 0.0219
Mycobacterium tuberculosis Probable dehydrogenase 0.0092 0.1201 0.5555
Loa Loa (eye worm) hypothetical protein 0.0015 0.0069 0.0079
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.4154 1
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0269 0.0306
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0057 0.0057
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0154 0.2096 0.2096
Entamoeba histolytica hypothetical protein 0.0026 0.0236 0.0311
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.038 0.1575
Loa Loa (eye worm) hypothetical protein 0.061 0.8772 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0367 0.0367
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.0086
Echinococcus granulosus dna polymerase kappa 0.0102 0.1344 0.1344
Giardia lamblia PHD finger protein 15 0.0029 0.0269 0.1655
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0314 0.063
Giardia lamblia DINP protein human, muc B family 0.0102 0.1344 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.1344 0.3143
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0325 0.1307
Brugia malayi Protein kinase domain containing protein 0.0016 0.0086 0.0098
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0174 0.2394 0.2394
Echinococcus multilocularis dna polymerase kappa 0.0102 0.1344 0.1344
Plasmodium falciparum thioredoxin reductase 0.0014 0.0055 0.0774
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.1344 0.3143
Mycobacterium ulcerans DNA polymerase IV 0.0102 0.1344 0.2994
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0455 0.0976
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0092 0.0092
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0049 0.0566 0.3551
Brugia malayi jmjC domain containing protein 0.0025 0.0219 0.0249
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0538 0.1121
Loa Loa (eye worm) hypothetical protein 0.061 0.8772 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0092 0.1201 0.5555
Brugia malayi glutathione reductase 0.0041 0.0442 0.0504
Mycobacterium leprae conserved hypothetical protein 0.0049 0.0566 0.2345
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0442 0.0944
Onchocerca volvulus 0.0029 0.0279 0.1164
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0014 0.0055 0.0774
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.045 0.045
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0092 0.1201 0.5555
Echinococcus multilocularis lamin dm0 0.0029 0.0279 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.1344 0.3143
Mycobacterium ulcerans DNA polymerase IV 0.0102 0.1344 0.2994
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0314 0.063
Trypanosoma brucei DNA polymerase IV, putative 0.0102 0.1344 0.3143
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0219 0.0249
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.4154 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0271 0.0309
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0092 0.1201 0.5555
Giardia lamblia Kinase, PLK 0.0095 0.124 0.9191
Loa Loa (eye worm) hypothetical protein 0.0183 0.2522 0.2875
Leishmania major DNA polymerase eta, putative 0.0183 0.2522 0.6018
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0092 0.1201 0.8532
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.038 0.0755
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.124 0.2751
Entamoeba histolytica hypothetical protein 0.0035 0.0367 0.1455
Entamoeba histolytica deoxycytidyl transferase, putative 0.0102 0.1344 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0219 0.1137
Onchocerca volvulus 0.0029 0.0271 0.1131
Plasmodium vivax JmjC domain containing protein 0.0025 0.0219 0.3728
Echinococcus multilocularis dnaJ subfamily C 6 0.0064 0.0785 0.0785
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0049 0.0566 0.1185
Trypanosoma cruzi DNA damage repair protein, putative 0.0032 0.0314 0.063
Trypanosoma brucei unspecified product 0.0102 0.1344 0.3143
Trypanosoma cruzi DNA polymerase kappa, putative 0.0102 0.1344 0.3143
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.124 0.2751
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0219 0.0219
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0271 0.0309
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0236 0.044
Echinococcus granulosus high affinity choline transporter 1 0.0341 0.484 0.484
Trypanosoma brucei trypanothione reductase 0.0041 0.0442 0.0944
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0243 0.0243
Brugia malayi Muscle positioning protein 4 0.0015 0.0069 0.0079
Echinococcus multilocularis muscleblind protein 1 0.061 0.8772 0.8772
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0102 0.1344 0.1532
Brugia malayi Inositol-1 0.0036 0.038 0.0434
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.088 0.2012
Plasmodium falciparum glutathione reductase 0.0041 0.0442 0.7771
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1887 0.4469
Echinococcus multilocularis solute carrier family 5 0.0038 0.0401 0.0401
Schistosoma mansoni glutaminase 0.0308 0.4359 0.4359
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0049 0.0566 1
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.038 0.038
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0014 0.0055 0.0774
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0566 0.1245
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.1344 0.3143
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0433 0.0433
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.4154 1
Echinococcus multilocularis snurportin 1 0.0347 0.4928 0.4928
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0326 0.1882
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0219 0.3728
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0401 0.0401
Trypanosoma brucei polo-like protein kinase 0.0095 0.124 0.2889
Echinococcus multilocularis microtubule associated protein 2 0.0694 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0314 0.063
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0014 0.0055 0.0774
Echinococcus multilocularis MAM 0.0016 0.0086 0.0086
Echinococcus granulosus geminin 0.0332 0.4697 0.4697
Plasmodium falciparum importin beta, putative 0.0033 0.0326 0.5664
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0236 0.0419
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0269 0.4631
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.124 0.2751
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0442 0.7771
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0279 0.0318
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1167 0.1167
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1167 0.133
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0269 0.1485
Brugia malayi Importin beta-1 subunit 0.0033 0.0326 0.0371
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0326 0.066
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.038 0.0755
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0309
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0219 0.0219
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.124 0.9089
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.124 0.2751
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1167 0.1167
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.4154 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0015 0.0069 0.0069
Brugia malayi PHD-finger family protein 0.0029 0.0269 0.0306
Schistosoma mansoni hypothetical protein 0.0332 0.4697 0.4697
Echinococcus granulosus jumonji domain containing protein 0.004 0.0433 0.0433
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1167 0.1167
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0279 0.0318
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0098
Brugia malayi ImpB/MucB/SamB family protein 0.0102 0.1344 0.1532
Onchocerca volvulus 0.0015 0.0069 0.029
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0102 0.1344 0.1344
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.124 0.2751
Trypanosoma brucei chrX additional, unordered contigs 0.0032 0.0314 0.063
Schistosoma mansoni kinase 0.0048 0.0556 0.0556
Echinococcus granulosus peregrin 0.0029 0.0269 0.0269
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.124 0.124
Echinococcus multilocularis dna polymerase eta 0.0183 0.2522 0.2522
Leishmania major trypanothione reductase 0.0041 0.0442 0.0944
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0269 0.0269
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.038 0.2262
Leishmania major DNA polymerase kappa, putative 0.0032 0.0314 0.063
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.045 0.045
Brugia malayi Thioredoxin reductase 0.0041 0.0442 0.0504
Loa Loa (eye worm) glutaminase 0.0308 0.4359 0.4969
Giardia lamblia DNA damage repair protein 0.0032 0.0314 0.2005
Onchocerca volvulus 0.0015 0.0069 0.029

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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