Detailed information for compound 785243

Basic information

Technical information
  • TDR Targets ID: 785243
  • Name: 2-(2,1,3-benzothiadiazol-7-ylsulfonyl-methyla mino)-N-(4-ethylphenyl)acetamide
  • MW: 390.48 | Formula: C17H18N4O3S2
  • H donors: 1 H acceptors: 5 LogP: 2.64 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)NC(=O)CN(S(=O)(=O)c1cccc2c1nsn2)C
  • InChi: 1S/C17H18N4O3S2/c1-3-12-7-9-13(10-8-12)18-16(22)11-21(2)26(23,24)15-6-4-5-14-17(15)20-25-19-14/h4-10H,3,11H2,1-2H3,(H,18,22)
  • InChiKey: QRYWEIXTQLBQAJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,1,3-benzothiadiazol-7-ylsulfonyl-methyl-amino)-N-(4-ethylphenyl)acetamide
  • N-(4-ethylphenyl)-2-(methyl-piazthiol-4-ylsulfonyl-amino)acetamide
  • 2-(2,1,3-benzothiadiazol-7-ylsulfonyl-methyl-amino)-N-(4-ethylphenyl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0153 0.023
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0169 0.0138
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0341 0.0253
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0259 0.011
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0169 0.0018
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0309 0.6904 0.6857
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0371 0.034
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.1229 0.1201
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.1243 0.1215
Echinococcus granulosus cpg binding protein 0.0065 0.1195 0.1167
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.6658 1
Echinococcus multilocularis snurportin 1 0.0323 0.7216 0.7207
Schistosoma mansoni ran 0.0022 0.0194 0.0043
Loa Loa (eye worm) hypothetical protein 0.0021 0.0169 0.0066
Schistosoma mansoni hypothetical protein 0.0442 1 1
Schistosoma mansoni hypothetical protein 0.0067 0.1243 0.1109
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0194 0.0099
Plasmodium falciparum phd finger protein, putative 0.003 0.0371 0.1424
Schistosoma mansoni ap endonuclease 0.002 0.0153 0.0002
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0194 0.0168
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0989 0.096
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0194 0.0247
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0169 0.0018
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0517 0.0487
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0169 0.0066
Echinococcus multilocularis GPCR, family 2 0.0067 0.1243 0.1215
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0169 0.0138
Schistosoma mansoni cpg binding protein 0.0065 0.1195 0.106
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0537 0.0807
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.6658 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.1243 0.149
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0537 0.0593
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0537 0.0807
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.6658 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0169 0.0066
Brugia malayi nuclear hormone receptor 0.0021 0.0169 0.0024
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0169 0.0138
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0247 0.0371
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.2727 0.2615
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0169 0.0018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0103 0.2077 0.2597
Onchocerca volvulus 0.0062 0.1113 0.538
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0169 0.0138
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0537 0.0807
Echinococcus granulosus GPCR family 2 0.0067 0.1243 0.1215
Entamoeba histolytica Ran family GTPase 0.0022 0.0194 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.6658 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0169 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0151 0.2772
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.1243 0.1215
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.1229 0.4436
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.1229 0.1094
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0169 0.0024
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0091 0.18 0.2704
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0091 0.18 0.6793
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0132 0.2756 0.2733
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0169 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0151 0.2772
Trichomonas vaginalis bromodomain-containing protein, putative 0.0091 0.18 0.2704
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0151 0.2772
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0169 0.0018
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.1229 1
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.6658 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.6658 1
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0248 0.0098
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.1229 0.1201
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0248 0.0129
Brugia malayi Bromodomain containing protein 0.0037 0.0548 0.0528
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0537 0.1584
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.2077 0.2052
Brugia malayi RNA binding protein 0.0342 0.7659 1
Echinococcus multilocularis cpg binding protein 0.0065 0.1195 0.1167
Echinococcus multilocularis peregrin 0.0037 0.0548 0.0518
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0151 0.012
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.1679 0.5
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0537 0.0807
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0537 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0169 0.0024
Schistosoma mansoni alpha glucosidase 0.0037 0.0537 0.0392
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0365 0.1285
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0989 0.096
Plasmodium falciparum importin beta, putative 0.003 0.038 0.1488
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0342 0.7659 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.2077 0.2052
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.0248 0.09
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0371 0.0897
Schistosoma mansoni thyroid hormone receptor 0.0153 0.3251 0.3147
Schistosoma mansoni tar DNA-binding protein 0.0342 0.7659 0.7624
Brugia malayi ecdysteroid receptor 0.0021 0.0169 0.0024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0169 0.0066
Giardia lamblia PHD finger protein 15 0.003 0.0371 0.0337
Plasmodium vivax hypothetical protein, conserved 0.003 0.0371 0.132
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.1956 0.193
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0599 0.0455
Loa Loa (eye worm) RNA binding protein 0.0342 0.7659 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.6658 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0309 0.6904 0.6894
Schistosoma mansoni transcription factor LCR-F1 0.004 0.062 0.0476
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0248 0.0098
Loa Loa (eye worm) hypothetical protein 0.0021 0.0169 0.0066
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0537 0.0507
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.062 0.0591
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0169 0.0024
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0086 0.1679 0.9267
Schistosoma mansoni hypothetical protein 0.0067 0.1243 0.1109
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0086 0.1679 0.4831
Echinococcus granulosus dna polymerase kappa 0.002 0.0151 0.012
Schistosoma mansoni hypothetical protein 0.0132 0.2756 0.2645
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0151 0.0227
Trypanosoma brucei glucosidase, putative 0.0037 0.0537 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0169 0.0024
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0537 0.0807
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0194 0.0066
Loa Loa (eye worm) hypothetical protein 0.0051 0.0868 0.0994
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.1956 0.193
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0537 0.0593
Leishmania major GTP-binding protein, putative 0.0022 0.0194 0.0397
Toxoplasma gondii hypothetical protein 0.003 0.0365 0.0873
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0599 0.057
Giardia lamblia Histone acetyltransferase GCN5 0.0083 0.1623 0.2262
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0086 0.1679 0.1653
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0151 0.0042
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0169 0.0018
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0086 0.1679 0.1653
Trichomonas vaginalis chaperonin, putative 0.0025 0.0248 0.0373
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.6658 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0212 0.4633 0.5969
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0194 0.0163
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0989 0.2292
Echinococcus granulosus tar DNA binding protein 0.0342 0.7659 0.7652
Loa Loa (eye worm) T-complex protein 1 0.0025 0.0248 0.0171
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0169 0.0024
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0086 0.1679 1
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.0248 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0169 0.0066
Brugia malayi RNA, U transporter 1 0.0086 0.1683 0.204
Toxoplasma gondii histone lysine methyltransferase SET1 0.0124 0.2578 1
Schistosoma mansoni hypothetical protein 0.0186 0.402 0.3928
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0091 0.18 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0169 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0169 0.0066
Brugia malayi steroid hormone receptor 0.0021 0.0169 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0169 0.0066
Schistosoma mansoni thyroid hormone receptor 0.0153 0.3251 0.3147
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0119 0.0088
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0153 0.0122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.6658 1
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.1229 0.1094
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.3564 0.3544
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.1229 0.3672
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0169 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0151 0.2772
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.038 0.7066
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.0248 0.2512
Echinococcus multilocularis thyroid hormone receptor alpha 0.0153 0.3251 0.3229
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0151 0.2772
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0153 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0169 0.0066
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.6658 1
Echinococcus granulosus dna polymerase eta 0.002 0.0151 0.012
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0537 0.0507
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0537 0.0807
Echinococcus multilocularis tar DNA binding protein 0.0342 0.7659 0.7652
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.2077 0.1956
Schistosoma mansoni alpha-glucosidase 0.0143 0.3022 0.2915
Echinococcus granulosus importin subunit beta 1 0.003 0.038 0.035
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0599 0.0637
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0091 0.18 0.6793
Schistosoma mansoni ran 0.0022 0.0194 0.0043
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0151 0.2772
Entamoeba histolytica hypothetical protein 0.004 0.062 0.0721
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.3564 0.4569
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0169 0.0138
Echinococcus granulosus peregrin 0.0037 0.0548 0.0518
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0153 0.0003
Echinococcus multilocularis importin subunit beta 1 0.003 0.038 0.035
Brugia malayi TAR-binding protein 0.0342 0.7659 1
Loa Loa (eye worm) acetyltransferase 0.0309 0.6904 0.8998
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0169 0.0138
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.3086 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0169 0.0066
Schistosoma mansoni peptidase Clp (S14 family) 0.0086 0.1679 0.1552
Loa Loa (eye worm) hypothetical protein 0.003 0.038 0.0346
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0537 0.0807
Schistosoma mansoni tar DNA-binding protein 0.0342 0.7659 0.7624
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.1679 0.5
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0537 0.0554
Schistosoma mansoni cpg binding protein 0.0062 0.1113 0.0977
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0643 0.0614
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0194 0.1109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0169 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0169 0.0024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0169 0.0066
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0248 0.0129
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0212 0.4633 0.5986
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0537 0.0514
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0599 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0151 0.2772
Echinococcus multilocularis dna polymerase kappa 0.002 0.0151 0.012
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.0248 0.0217
Brugia malayi Calcitonin receptor-like protein seb-1 0.0212 0.4633 0.5969
Brugia malayi Latrophilin receptor protein 2 0.0067 0.1243 0.1454
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0169 0.0024
Trypanosoma brucei unspecified product 0.002 0.0151 0.2772
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.1243 0.1215
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0248 0.0098
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.3564 0.4546
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.1229 0.3672
Schistosoma mansoni coup transcription factor 0.0021 0.0169 0.0018
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0153 0.0045
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0153 0.0122
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.0248 0.0621
Brugia malayi Probable ClpP-like protease 0.0086 0.1679 0.2036
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0169 0.0138
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0153 0.0057
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.1679 0.5208
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.2077 0.2052
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0169 0.0024
Plasmodium vivax importin-beta 2, putative 0.003 0.038 0.1379
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0132 0.2756 0.2733
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0194 0.0057
Schistosoma mansoni cpg binding protein 0.0065 0.1195 0.106
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.1112 0.1317
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.038 0.7066
Entamoeba histolytica hypothetical protein 0.004 0.062 0.0721
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.1229 0.3672
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0169 0.0024
Leishmania major importin beta-1 subunit, putative 0.0025 0.0247 0.0888
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0153 0.023
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0643 0.0614
Schistosoma mansoni hypothetical protein 0.0067 0.1243 0.1109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0169 0.0066
Schistosoma mansoni alpha-glucosidase 0.0143 0.3022 0.2915
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0151 0.2772
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0169 0.0138
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.0248 0.0373
Schistosoma mansoni hypothetical protein 0.0186 0.402 0.3928
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.062 0.0591
Brugia malayi RNA recognition motif domain containing protein 0.0342 0.7659 1
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.038 0.0937
Schistosoma mansoni tar DNA-binding protein 0.0342 0.7659 0.7624
Schistosoma mansoni hypothetical protein 0.0323 0.7216 0.7173
Brugia malayi PHD-finger family protein 0.003 0.0371 0.0292
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0169 0.0018
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0194 0.0266
Schistosoma mansoni hypothetical protein 0.004 0.062 0.0476
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.2077 0.1956
Loa Loa (eye worm) hypothetical protein 0.0145 0.3064 0.3905
Echinococcus multilocularis dna polymerase eta 0.002 0.0151 0.012
Plasmodium falciparum histone acetyltransferase GCN5 0.0083 0.1623 0.963
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0169 0.0024
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0537 0.0807
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0169 0.0018
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.7216 0.9411
Echinococcus granulosus geminin 0.0186 0.402 0.4001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0151 0.2772
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.1679 0.5208
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0194 0.0163
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.3086 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0247 0.0371
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0151 0.2772
Entamoeba histolytica hypothetical protein 0.004 0.062 0.0721
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0169 0.0138
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0151 0.2772
Schistosoma mansoni jumonji domain containing protein 0.0078 0.1487 0.1356
Entamoeba histolytica hypothetical protein 0.0025 0.0247 0.0147
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0151 0.2772
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0365 0.0325
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.6658 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.6658 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0371 0.0223
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0151 0.0227
Schistosoma mansoni importin beta-1 0.003 0.038 0.0233
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0537 0.0807
Loa Loa (eye worm) hypothetical protein 0.0021 0.0169 0.0066
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0169 0.0138
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0194 0.3574
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0042
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0169 0.0138
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0153 0.0003
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.1679 0.6295
Loa Loa (eye worm) hypothetical protein 0.0067 0.1243 0.149
Trichomonas vaginalis ran, putative 0.0022 0.0194 0.0291
Brugia malayi CXXC zinc finger family protein 0.0062 0.1113 0.1281
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.0248 0.0149
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0086 0.1679 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0153 0.0007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.1243 0.1454
Entamoeba histolytica acetyltransferase, GNAT family 0.0083 0.1623 0.2262
Schistosoma mansoni hypothetical protein 0.003 0.0371 0.0223
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.3086 1
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0537 0.3582
Brugia malayi latrophilin 2 splice variant baaae 0.0145 0.3064 0.3879
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.1229 0.3672
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0169 0.0024
Onchocerca volvulus 0.0096 0.1924 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.3564 0.3544
Schistosoma mansoni tar DNA-binding protein 0.0342 0.7659 0.7624
Loa Loa (eye worm) hypothetical protein 0.0021 0.0169 0.0066
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0169 0.0138
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0194 0.1109
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.0248 0.0391
Brugia malayi jmjC domain containing protein 0.0098 0.1956 0.2404
Loa Loa (eye worm) hypothetical protein 0.0086 0.1679 0.2069
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0119 0.0088
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0153 0.0003
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.0248 0.0217
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.2077 0.2052
Echinococcus multilocularis geminin 0.0186 0.402 0.4001
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0371 0.0333
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0169 0.0024
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0989 0.2854
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0169 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0537 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0169 0.0018
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0365 0.1387
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0169 0.0024
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0151 0.012
Schistosoma mansoni tar DNA-binding protein 0.0342 0.7659 0.7624
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0086 0.1679 0.2346
Schistosoma mansoni ap endonuclease 0.002 0.0153 0.0002
Brugia malayi jmjC domain containing protein 0.004 0.0599 0.0597
Brugia malayi hypothetical protein 0.004 0.062 0.0625
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0371 0.034
Brugia malayi nuclear receptor NHR-88 0.0021 0.0169 0.0024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0153 0.0057
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.0248 0.4588
Entamoeba histolytica hypothetical protein 0.004 0.062 0.0721
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0169 0.0138
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0169 0.0138
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0247 0.0371
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0151 0.2772
Echinococcus granulosus histone acetyltransferase KAT2B 0.0301 0.6701 0.6691
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0153 0.2813
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0169 0.0018
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0169 0.0024
Loa Loa (eye worm) hypothetical protein 0.0212 0.4633 0.5986
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0151 0.2772
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0103 0.2077 0.2565
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.1113 0.1318
Loa Loa (eye worm) TAR-binding protein 0.0342 0.7659 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0371 0.0333
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0169 0.0018
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.1243 0.1215
Brugia malayi acetyltransferase, GNAT family protein 0.0309 0.6904 0.8994
Schistosoma mansoni hypothetical protein 0.0067 0.1243 0.1109
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.1679 0.6295
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0371 0.0897
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0247 0.248
Echinococcus multilocularis dnaJ subfamily B 0.0442 1 1
Schistosoma mansoni hypothetical protein 0.0145 0.3064 0.2957
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0169 0.0024
Echinococcus granulosus histone acetyltransferase KAT2B 0.0091 0.18 0.1774
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0153 0.0007
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.0248 0.0576
Echinococcus granulosus snurportin 1 0.0323 0.7216 0.7207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.2077 0.1956
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.3564 0.3544
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0989 0.2854
Brugia malayi Importin beta-1 subunit 0.003 0.038 0.0305
Onchocerca volvulus Alhambra homolog 0.003 0.0371 0.115

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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