Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0068 | 0.3565 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0068 | 0.3565 | 0.3565 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0068 | 0.3565 | 0.3565 |
Schistosoma mansoni | hypothetical protein | 0.017 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0068 | 0.3565 | 0.3565 |
Echinococcus granulosus | acetylcholinesterase | 0.0068 | 0.3565 | 0.3565 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3565 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.017 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0068 | 0.3565 | 0.3565 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0011 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0068 | 0.3565 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0068 | 0.3565 | 1 |
Echinococcus multilocularis | geminin | 0.017 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0068 | 0.3565 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3565 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0068 | 0.3565 | 0.3565 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0068 | 0.3565 | 0.3565 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.25 ug ml-1 | In vitro minimum inhibitory concentration against S. aureus UBMS 90-3 (sensitive). | ChEMBL. | 8289194 |
MIC (functional) | = 0.25 ug ml-1 | In vitro minimum inhibitory concentration against S. aureus smith (sensitive). | ChEMBL. | 8289194 |
MIC (functional) | = 0.25 ug ml-1 | In vitro minimum inhibitory concentration against Enterococcus faecalis ATCC 29212. | ChEMBL. | 8289194 |
MIC (functional) | = 1 ug ml-1 | In vitro minimum inhibitory concentration against S. aureus UBMS 90-1 (tet M ribosomal protection). | ChEMBL. | 8289194 |
MIC (functional) | = 4 ug ml-1 | In vitro minimum inhibitory concentration against E. coli UBMS 90-4 (tet M ribosomal protection). | ChEMBL. | 8289194 |
MIC (functional) | = 4 ug ml-1 | In vitro minimum inhibitory concentration against E. coli UBMS 90-4 (tet M ribosomal protection). | ChEMBL. | 8289194 |
MIC (functional) | = 8 ug ml-1 | In vitro minimum inhibitory concentration against E. coli UBMS 90-5 (sensitive). | ChEMBL. | 8289194 |
MIC (functional) | = 8 ug ml-1 | In vitro minimum inhibitory concentration against S. aureus UBMS 88-7 (tet K efflux). | ChEMBL. | 8289194 |
MIC (functional) | = 8 ug ml-1 | In vitro minimum inhibitory concentration against E. coli UBMS 90-5 (sensitive). | ChEMBL. | 8289194 |
MIC (functional) | > 32 ug ml-1 | In vitro minimum inhibitory concentration against E. coli UBMS 88-1 (tet B efflux). | ChEMBL. | 8289194 |
MIC (functional) | > 32 ug ml-1 | In vitro minimum inhibitory concentration against E. coli PRP-1 (tet A efflux). | ChEMBL. | 8289194 |
MIC (functional) | > 32 ug ml-1 | In vitro minimum inhibitory concentration against E. coli J3272 (tet C efflux). | ChEMBL. | 8289194 |
MIC (functional) | > 32 ug ml-1 | In vitro minimum inhibitory concentration against E. coli UBMS 88-1 (tet B efflux). | ChEMBL. | 8289194 |
MIC (functional) | > 32 ug ml-1 | In vitro minimum inhibitory concentration against E. coli PRP-1 (tet A efflux). | ChEMBL. | 8289194 |
MIC (functional) | > 32 ug ml-1 | In vitro minimum inhibitory concentration against E. coli J3272 (tet C efflux). | ChEMBL. | 8289194 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.