Detailed information for compound 785515

Basic information

Technical information
  • TDR Targets ID: 785515
  • Name: N-(2,5-dimethoxyphenyl)-N-ethyl-1-oxoisochrom ene-4-carboxamide
  • MW: 353.369 | Formula: C20H19NO5
  • H donors: 0 H acceptors: 2 LogP: 2.95 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)c1coc(=O)c2c1cccc2)c1cc(OC)ccc1OC
  • InChi: 1S/C20H19NO5/c1-4-21(17-11-13(24-2)9-10-18(17)25-3)19(22)16-12-26-20(23)15-8-6-5-7-14(15)16/h5-12H,4H2,1-3H3
  • InChiKey: CCSNLENCXFCDNV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,5-dimethoxyphenyl)-N-ethyl-1-oxo-isochromene-4-carboxamide
  • N-(2,5-dimethoxyphenyl)-N-ethyl-1-oxo-4-isochromenecarboxamide
  • N-(2,5-dimethoxyphenyl)-N-ethyl-1-keto-isochromene-4-carboxamide
  • EU-0054162
  • MLS000086191
  • N-(2,5-dimethoxyphenyl)-N-ethyl-1-oxo-1H-isochromene-4-carboxamide
  • SMR000021700
  • IDI1_025621
  • ChemDiv3_007711

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0172 0.18 0.1782
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0119 0.0204
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0025 0.0125 0.0124
Plasmodium falciparum phd finger protein, putative 0.0033 0.0218 0.0521
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.005 0.0415 0.0831
Schistosoma mansoni hypothetical protein 0.0889 1 1
Onchocerca volvulus 0.0025 0.0119 0.0094
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.018 0.0357
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0073 0.0141
Schistosoma mansoni dihydropteridine reductase 0.0025 0.0125 0.0105
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0233
Trypanosoma brucei oxidoreductase-like protein 0.0025 0.0125 1
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0192
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0059 0.0113
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0025 0.0125 0.0131
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0021 0.0073 0.0062
Trichomonas vaginalis replication factor C large subunit, putative 0.0021 0.0073 0.0179
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0192
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.3034 0.611
Echinococcus multilocularis nibrin 0.0021 0.0073 0.0071
Schistosoma mansoni topbp1 0.0021 0.0073 0.0052
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0073 0.0179
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0073 0.0052
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0125 0.022
Loa Loa (eye worm) hypothetical protein 0.0057 0.0489 0.0979
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0048 0.0103
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0025 0.0125 1
Echinococcus granulosus geminin 0.0172 0.18 0.1798
Echinococcus multilocularis muscleblind protein 1 0.0155 0.1605 0.1604
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0141
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0233
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0371 0.4077 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0073 0.0179
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0025 0.0125 1
Entamoeba histolytica hypothetical protein 0.0075 0.0695 1
Leishmania major oxidoreductase-like protein 0.0025 0.0125 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0415 0.0831
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0119 0.0115
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0218 0.0362
Brugia malayi hypothetical protein 0.0021 0.0073 0.0141
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0059 0.0058
Mycobacterium ulcerans oxidoreductase 0.0025 0.0125 0.0192
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0371 0.4077 1
Loa Loa (eye worm) hypothetical protein 0.0449 0.4965 1
Schistosoma mansoni hypothetical protein 0.0075 0.0695 0.0676
Giardia lamblia PHD finger protein 15 0.0033 0.0218 1
Brugia malayi follicle stimulating hormone receptor 0.028 0.3034 0.611
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0192
Loa Loa (eye worm) runx1 0.0056 0.0481 0.0964
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0016 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0119 0.0233
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.0073 0.0165
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0025 0.0125 0.0192
Treponema pallidum DNA ligase (lig) 0.0021 0.0073 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0119 0.0204
Echinococcus multilocularis dnaJ subfamily B 0.0889 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0192
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.009
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0192
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0119 0.0176
Echinococcus granulosus nibrin 0.0021 0.0073 0.0071
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.943 0.943
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0192
Schistosoma mansoni cpg binding protein 0.0062 0.0552 0.0532
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0125 0.0192
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0192
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.009
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0109 0.1081 0.108
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0415 0.0831
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0021 0.0036
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0192
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0218 0.0216
Mycobacterium tuberculosis Probable oxidoreductase 0.0025 0.0125 0.022
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0025 0.0125 0.0131
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0025 0.0125 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0141
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.009
Echinococcus multilocularis GPCR, family 2 0.0016 0.0021 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0119 0.0115
Onchocerca volvulus 0.0025 0.0125 0.0107
Loa Loa (eye worm) hypothetical protein 0.0155 0.1605 0.3229
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0025 0.0125 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0125 0.0192
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.009
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0125 0.022
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0021 0.0073 0.0000052824
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0021 0.0019
Echinococcus granulosus microtubule associated protein 2 0.0786 0.882 0.882
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0025 0.0125 0.022
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0073 0.0179
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0695 0.0694
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0119 0.0176
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.009
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0371 0.4077 1
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0048 0.0103
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0218 0.0433
Onchocerca volvulus 0.0062 0.0552 0.0979
Brugia malayi jmjC domain containing protein 0.0044 0.0338 0.0676
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0622 0.1247
Mycobacterium ulcerans hypothetical protein 0.0025 0.0119 0.0176
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0073 0.0071
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0025 0.0125 0.0131
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.119 0.279
Loa Loa (eye worm) oxidoreductase 0.0025 0.0125 0.0247
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0338 0.0676
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0192
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0338 0.0337
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0073 0.0179
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.0073 0.0165
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0371 0.4077 1
Loa Loa (eye worm) hypothetical protein 0.0449 0.4965 1
Schistosoma mansoni topbp1 0.0021 0.0073 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0073 0.0179
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0016 0.0014
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0073 0.00000082115
Schistosoma mansoni lozenge 0.0056 0.0481 0.0461
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0218 0.0216
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0371 0.4077 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0119 0.0738
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0025 0.0125 0.0105
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0025 0.0125 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0125 0.0192
Brugia malayi Bromodomain containing protein 0.0033 0.0218 0.0433
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0192
Echinococcus multilocularis peregrin 0.0033 0.0218 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0233
Schistosoma mansoni cpg binding protein 0.0066 0.0593 0.0573
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0218 0.0197
Brugia malayi hypothetical protein 0.0449 0.4965 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0192
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0695 0.0676
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0036
Echinococcus granulosus muscleblind protein 0.0155 0.1605 0.1604
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0298 0.0296
Chlamydia trachomatis DNA ligase 0.0021 0.0073 0.0062
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0192
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0125 0.022
Loa Loa (eye worm) hypothetical protein 0.0155 0.1605 0.3229
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0366 0.0365
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0025 0.0125 0.0247
Brugia malayi Muscleblind-like protein 0.0155 0.1605 0.3229
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0125 0.0192
Echinococcus granulosus peregrin 0.0033 0.0218 0.0216
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0125 0.022
Brugia malayi CXXC zinc finger family protein 0.0062 0.0552 0.1106
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0025 0.0125 0.022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0021 0.0019
Schistosoma mansoni hypothetical protein 0.0033 0.0218 0.0197
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0119 0.0176
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0371 0.4077 1
Echinococcus granulosus GPCR family 2 0.0016 0.0021 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0119 0.0176
Plasmodium falciparum enoyl-acyl carrier reductase 0.0371 0.4077 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0119 0.0738
Brugia malayi jmjC domain containing protein 0.0109 0.1081 0.2173
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0119 0.0176
Brugia malayi topoisomerase 0.0021 0.0073 0.0141
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0192
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0025 0.0125 0.0192
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0119 0.0176
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.014 0.0119
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0025 0.0125 0.0192
Entamoeba histolytica hypothetical protein 0.0075 0.0695 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0073 0.0179
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0192
Schistosoma mansoni DNA ligase IV 0.0021 0.0073 0.0052
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0073 0.0071
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0125 0.022
Entamoeba histolytica hypothetical protein 0.0075 0.0695 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0021 0.0036
Trypanosoma brucei pteridine reductase 1 0.0025 0.0125 1
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0192
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0695 0.0694
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0141
Chlamydia trachomatis oxoacy-ACP reductase 0.0025 0.0125 0.0192
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0073 0.0179
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0141
Schistosoma mansoni microtubule-associated protein tau 0.0786 0.882 0.8818
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0025 0.0125 0.0294
Brugia malayi PHD-finger family protein 0.0033 0.0218 0.0433
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0141
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0119 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0073 0.0179
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0025 0.0125 0.0192
Echinococcus multilocularis cpg binding protein 0.0066 0.0593 0.0591
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0025 0.0125 0.0131
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0016 0.0014
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0371 0.4077 1
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0218 0.0521
Loa Loa (eye worm) hypothetical protein 0.0025 0.0125 0.0247
Echinococcus multilocularis muscleblind protein 0.0155 0.1605 0.1604
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0192
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0338 0.0318
Onchocerca volvulus Alhambra homolog 0.0033 0.0218 0.0296
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0119 0.0233
Entamoeba histolytica hypothetical protein 0.0075 0.0695 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0192
Loa Loa (eye worm) hypothetical protein 0.0033 0.0218 0.0433
Schistosoma mansoni cpg binding protein 0.0066 0.0593 0.0573
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0073 0.0179
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0125 0.0192
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0552 0.1106
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0025 0.0125 0.0294
Onchocerca volvulus 0.0025 0.0125 0.0107
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0415 0.0831
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0025 0.0125 0.0124
Echinococcus multilocularis geminin 0.0172 0.18 0.1798
Leishmania major pteridine reductase 1 0.0025 0.0125 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0025 0.0125 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0059 0.0058
Echinococcus multilocularis Protein lozenge 0.0056 0.0481 0.048
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0366 0.0365
Loa Loa (eye worm) retinol dehydrogenase 12 0.0025 0.0125 0.0247
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0125 0.0192
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0025 0.0125 0.0844
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0109 0.1081 0.108
Trichomonas vaginalis hypothetical protein 0.0371 0.4077 1
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0073 0.0141
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0025 0.0125 0.0247
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0141
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0338 0.0318
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0119 0.0233
Brugia malayi hypothetical protein 0.0075 0.0695 0.1395
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0021 0.0036
Echinococcus granulosus cpg binding protein 0.0066 0.0593 0.0591
Brugia malayi DKFZp564C0469 protein 0.0021 0.0073 0.0141
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0025 0.0125 1
Onchocerca volvulus 0.0449 0.4965 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0025 0.0125 0.0247
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0025 0.0125 0.0131
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0048 0.0028
Brugia malayi hypothetical protein 0.0021 0.0073 0.0141
Echinococcus multilocularis microtubule associated protein 2 0.0786 0.882 0.882
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0233 0.0463
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0218 0.0362
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0025 0.0125 0.0131
Loa Loa (eye worm) hypothetical protein 0.0035 0.0233 0.0463
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.1352 0.1334
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0025 0.0125 0.022
Schistosoma mansoni hypothetical protein 0.0172 0.18 0.1782
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0125 0.0192
Schistosoma mansoni jumonji domain containing protein 0.0086 0.0826 0.0806
Schistosoma mansoni hypothetical protein 0.0035 0.0233 0.0212
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0119 0.0738

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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