Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0041 | 0.1076 | 0.1629 | |
Onchocerca volvulus | 0.0164 | 0.661 | 1 | |
Brugia malayi | hypothetical protein | 0.0041 | 0.1076 | 0.1076 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0239 | 1 | 0.5 |
Onchocerca volvulus | 0.0164 | 0.661 | 1 | |
Onchocerca volvulus | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog | 0.0128 | 0.5005 | 0.7573 |
Echinococcus multilocularis | NADH dehydrogenase (ubiquinone) flavoprotein 1 | 0.0239 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0053 | 0.1634 | 0.0625 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.661 | 0.661 |
Leishmania major | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0239 | 1 | 0.5 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0239 | 1 | 1 |
Treponema pallidum | nitrogen fixation protein (rnfC) | 0.0053 | 0.1634 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.6034 | 0.6034 |
Loa Loa (eye worm) | NADH dehydrogenase subunit 1 | 0.0041 | 0.1076 | 0.1076 |
Mycobacterium ulcerans | membrane protein ComEA | 0.0053 | 0.1634 | 0.0625 |
Onchocerca volvulus | 0.0164 | 0.661 | 1 | |
Loa Loa (eye worm) | NADH-ubiquinone oxidoreductase 51 kDa subunit | 0.0239 | 1 | 1 |
Brugia malayi | NADH dehydrogenase subunit 1, identical | 0.0041 | 0.1076 | 0.1076 |
Mycobacterium ulcerans | NADH dehydrogenase subunit H | 0.0152 | 0.6076 | 0.5603 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0164 | 0.661 | 0.5 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0164 | 0.661 | 0.5 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0164 | 0.661 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.6076 | 0.6076 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0239 | 1 | 1 |
Echinococcus granulosus | NADH dehydrogenase subunit 1 | 0.0152 | 0.6076 | 0.6076 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0164 | 0.661 | 0.661 |
Onchocerca volvulus | 0.0164 | 0.661 | 1 | |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) | 0.0152 | 0.6076 | 0.5603 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0164 | 0.661 | 0.661 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0164 | 0.661 | 0.661 |
Brugia malayi | NADH dehydrogenase subunit 1 | 0.0041 | 0.1076 | 0.1076 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative | 0.0239 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.661 | 0.661 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0164 | 0.661 | 0.661 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0239 | 1 | 0.5 |
Schistosoma mansoni | NADH dehydrogenase subunit 1 | 0.0041 | 0.1076 | 0.1076 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0164 | 0.661 | 0.661 |
Mycobacterium ulcerans | NADH dehydrogenase I subunit F | 0.0239 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase I subunit F | 0.0239 | 1 | 1 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0239 | 1 | 1 |
Onchocerca volvulus | 0.0041 | 0.1076 | 0.1629 | |
Echinococcus granulosus | NADH dehydrogenase ubiquinone flavoprotein 1 | 0.0239 | 1 | 1 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | 0.0239 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.6034 | 0.6034 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED25 (functional) | = 79 ug kg-1 | Compound was evaluated for its hypotensive activity (decrease in blood pressure) in normotensive rats. | ChEMBL. | No reference |
ED25 (functional) | = 93.3 ug kg-1 | Compound was evaluated for its hypotensive activity (decrease in blood pressure) in male guinea pigs. | ChEMBL. | No reference |
ED50 (functional) | = 91.2 ug kg-1 | Compound was evaluated in vivo for its ability to inhibit methacholine induced bronchospasm in male guinea pig. | ChEMBL. | No reference |
IC50 (functional) | = 0.21 uM | Concentration of the compound required to inhibit spontaneous tone of guinea pig isolated tracheal spirals | ChEMBL. | No reference |
IC50 (functional) | = 0.47 uM | Concentration required to inhibit NA-induced contractions in rat portal vein by 50% | ChEMBL. | No reference |
Max fall in blood pressure (functional) | = 74 mmHg | Changes in systolic blood pressure was measured at intervals of 1 hr for 4 hr after oral administration of 0.1 mg/kg in rats | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.