Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0829 | 0.0829 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0884 | 0.0884 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.2513 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0884 | 0.0884 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0477 | 0.0477 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0884 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0884 | 0.1557 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0884 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0884 | 0.0884 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1544 | 0.1544 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0884 | 0.0884 |
Echinococcus multilocularis | musashi | 0.0054 | 0.1755 | 0.1755 |
Echinococcus granulosus | geminin | 0.0167 | 0.6963 | 0.6963 |
Echinococcus multilocularis | lamin dm0 | 0.0054 | 0.1755 | 0.1755 |
Echinococcus granulosus | intermediate filament protein | 0.0054 | 0.1755 | 0.1755 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0884 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0029 | 0.0608 | 0.0608 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.1471 | 0.2112 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.2037 | 0.2925 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.2865 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0029 | 0.0608 | 0.0608 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0222 | 0.95 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0182 | 0.7636 | 0.7636 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.7636 | 0.7636 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.6963 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 0.6963 | 0.6963 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0054 | 0.1755 | 0.1755 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0884 | 0.0884 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0051 | 0.1632 | 0.4744 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.2513 | 0.5 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.2865 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0884 | 0.0884 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0884 | 0.0884 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0884 | 0.1557 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0829 | 0.1191 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0432 | 0.0432 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0884 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0884 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0884 | 0.1557 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0026 | 0.0477 | 0.0477 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0051 | 0.1632 | 0.0868 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.2865 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.2865 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1544 | 0.1544 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1709 | 0.1709 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0026 | 0.0477 | 0.0477 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.2865 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0884 | 0.0884 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.1471 | 0.2112 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.2037 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.2037 | 0.6469 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.2865 | 0.2865 |
Brugia malayi | hypothetical protein | 0.007 | 0.2513 | 0.2513 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0884 | 0.1557 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0051 | 0.1632 | 0.1632 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0078 | 0.2865 | 0.4115 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.2865 | 0.5 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0078 | 0.2865 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.2865 | 1 |
Onchocerca volvulus | 0.0048 | 0.1471 | 0.0869 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0884 | 0.0884 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.6963 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.2513 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0884 | 0.0884 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.2037 | 0.2037 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0884 | 0.0884 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.2513 | 0.2513 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0884 | 0.0884 |
Brugia malayi | intermediate filament protein | 0.0054 | 0.1755 | 0.1755 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.2037 | 0.5818 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0051 | 0.1632 | 0.1632 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0182 | 0.7636 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0884 | 0.0884 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1755 | 0.1755 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.2037 | 0.2037 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0829 | 0.0829 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.2037 | 0.1338 |
Schistosoma mansoni | lamin | 0.0054 | 0.1755 | 0.252 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0884 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0054 | 0.1755 | 0.1755 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.2037 | 0.2925 |
Echinococcus multilocularis | lamin | 0.0054 | 0.1755 | 0.1755 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0884 | 0.127 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.1471 | 0.1471 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.2037 | 0.5818 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0884 | 0.127 |
Onchocerca volvulus | 0.0054 | 0.1755 | 0.1289 | |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.2513 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.2513 | 0.2513 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.2865 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.2865 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0054 | 0.1755 | 0.1755 |
Schistosoma mansoni | intermediate filament proteins | 0.0054 | 0.1755 | 0.252 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.2513 | 0.3609 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0884 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.2865 | 0.2865 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.2513 | 0.3609 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0054 | 0.1755 | 0.1755 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0432 | 0.0432 |
Schistosoma mansoni | lamin | 0.0054 | 0.1755 | 0.252 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1544 | 0.1544 |
Onchocerca volvulus | 0.0054 | 0.1755 | 0.1289 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0884 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0884 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1544 | 0.1544 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.2865 | 0.2865 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0051 | 0.1632 | 0.0868 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0078 | 0.2865 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0884 | 0.0884 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.2037 | 0.5818 |
Brugia malayi | Probable ClpP-like protease | 0.0078 | 0.2865 | 0.2865 |
Echinococcus granulosus | lamin | 0.0054 | 0.1755 | 0.1755 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.