Detailed information for compound 785959

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 486.382 | Formula: C22H20BrN3O3S
  • H donors: 0 H acceptors: 2 LogP: 4.15 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C2SCN(CN2C(=O)CC1c1cccc(c1OC)OC)c1ccc(cc1)Br
  • InChi: 1S/C22H20BrN3O3S/c1-28-19-5-3-4-16(21(19)29-2)17-10-20(27)26-12-25(13-30-22(26)18(17)11-24)15-8-6-14(23)7-9-15/h3-9,17H,10,12-13H2,1-2H3
  • InChiKey: JLGXVBTYJWXZMB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0943 0.1036
Leishmania major metacaspase, putative 0.0026 0.0208 0.0297
Loa Loa (eye worm) hypoxia-induced factor 1 0.015 0.2838 0.4439
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0998 0.1426
Loa Loa (eye worm) hypothetical protein 0.0096 0.169 0.2644
Entamoeba histolytica Ran family GTPase 0.0022 0.011 0.0438
Brugia malayi Pre-SET motif family protein 0.0215 0.4207 0.6013
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0208 0.043
Onchocerca volvulus 0.002 0.0063 0.013
Plasmodium falciparum metacaspase 1 0.0026 0.0208 0.0297
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.0943 0.0943
Schistosoma mansoni prolyl-tRNA synthetase 0.0032 0.0328 0.0328
Echinococcus granulosus prolyl tRNA synthetase mitochondrial 0.0032 0.0328 0.0514
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0063 0.0099
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0299 0.0468
Schistosoma mansoni hypothetical protein 0.0096 0.169 0.169
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.169 0.2644
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.169 0.2644
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0157 0.0325
Schistosoma mansoni polycystin 1-related 0.002 0.0063 0.0063
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0933 0.1333
Brugia malayi Importin beta-1 subunit 0.003 0.0277 0.0396
Trypanosoma brucei metacaspase MCA2 0.0026 0.0208 0.0142
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.088 0.1258
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0208 0.043
Trichomonas vaginalis ran, putative 0.0022 0.011 0.0228
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0099
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0135 0.2516 0.3935
Trypanosoma cruzi metacaspase, putative 0.0026 0.0208 0.0297
Echinococcus multilocularis prolyl tRNA synthetase, mitochondrial 0.0032 0.0328 0.0514
Plasmodium vivax importin-beta 2, putative 0.003 0.0277 0.0396
Loa Loa (eye worm) hypothetical protein 0.0163 0.3106 0.4859
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0933 0.1459
Schistosoma mansoni single-minded 0.0049 0.0677 0.0677
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.011 0.0157
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0304 0.6108 0.8731
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0208 0.043
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.078 0.1219
Leishmania major dihydroorotate dehydrogenase 0.0346 0.6996 1
Chlamydia trachomatis proline--tRNA ligase 0.0038 0.0455 0.5
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0208 0.0297
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0063 0.0099
Loa Loa (eye worm) doublecortin family protein 0.002 0.0063 0.0099
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0135 0.2516 0.3935
Echinococcus multilocularis snurportin 1 0.0318 0.6392 1
Echinococcus multilocularis RUN 0.002 0.0063 0.0099
Plasmodium falciparum proline--tRNA ligase, putative 0.0032 0.0328 0.0469
Brugia malayi PAS domain containing protein 0.0049 0.0677 0.0967
Echinococcus granulosus caspase 8 0.0026 0.0208 0.0325
Schistosoma mansoni loxhd1 0.002 0.0063 0.0063
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0933 0.1459
Schistosoma mansoni lipoxygenase 0.0118 0.2146 0.2146
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0063 0.0099
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0943 0.1476
Plasmodium vivax SET domain protein, putative 0.0031 0.0299 0.0428
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0208 0.043
Schistosoma mansoni importin beta-1 0.003 0.0277 0.0277
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0346 0.6996 1
Schistosoma mansoni microsomal glutathione s-transferase 0.0112 0.2018 0.2018
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0208 0.0208
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.011 0.0172
Echinococcus granulosus microsomal glutathione S transferase 3 0.0112 0.2018 0.3157
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0208 0.043
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0299 0.0468
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0998 0.1426
Schistosoma mansoni hypothetical protein 0.0096 0.169 0.169
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.011 0.0157
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0063 0.009
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0346 0.6996 1
Trichomonas vaginalis set domain proteins, putative 0.0244 0.4837 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0208 0.043
Brugia malayi Met-10+ like-protein 0.0028 0.0244 0.0349
Brugia malayi Calcitonin receptor-like protein seb-1 0.0304 0.6108 0.8731
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.011 0.0157
Schistosoma mansoni dihydroorotate dehydrogenase 0.0346 0.6996 0.6996
Brugia malayi latrophilin 2 splice variant baaae 0.0208 0.4063 0.5808
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0208 0.0297
Brugia malayi RNA, U transporter 1 0.0085 0.1442 0.2061
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0208 0.043
Schistosoma mansoni hypothetical protein 0.002 0.0063 0.0063
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0943 0.0812
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0208 0.0297
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0208 0.043
Plasmodium falciparum importin beta, putative 0.003 0.0277 0.0396
Onchocerca volvulus Cell death protein 3 homolog 0.0026 0.0208 0.043
Brugia malayi hypothetical protein 0.0163 0.3106 0.4439
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0933 0.0796
Leishmania major cathepsin L-like protease 0.0064 0.0998 0.1426
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0933 0.1333
Trypanosoma cruzi metacaspase, putative 0.0026 0.0208 0.0297
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0998 0.1289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0998 0.1289
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.169 0.2644
Onchocerca volvulus 0.0036 0.0408 0.0844
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0099 0.175 0.2738
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0299 0.0299
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0038 0.0455 0.065
Echinococcus granulosus single minded 2 0.0036 0.0408 0.0639
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0408 0.0639
Schistosoma mansoni hypothetical protein 0.0208 0.4063 0.4063
Leishmania major importin beta-1 subunit, putative 0.0024 0.0157 0.0225
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0063 0.0099
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.011 0.0172
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0943 0.1476
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0346 0.6996 1
Brugia malayi hypoxia-induced factor 1 0.015 0.2838 0.4056
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0135 0.2516 0.52
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0208 0.043
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0038 0.0455 0.0071
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0026 0.0208 0.0208
Brugia malayi Zinc finger, C2H2 type family protein 0.0135 0.2516 0.3595
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0346 0.6996 1
Schistosoma mansoni hypothetical protein 0.0318 0.6392 0.6392
Schistosoma mansoni ran 0.0022 0.011 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0998 0.1289
Schistosoma mansoni caspase-3 (C14 family) 0.0099 0.175 0.175
Leishmania major cathepsin L-like protease 0.0064 0.0998 0.1426
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0933 0.0796
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0346 0.6996 1
Plasmodium vivax proline--tRNA ligase, putative 0.0032 0.0328 0.0469
Trypanosoma brucei metacaspase MCA3 0.0026 0.0208 0.0142
Schistosoma mansoni hypothetical protein 0.0096 0.169 0.169
Brugia malayi Doublecortin family protein 0.002 0.0063 0.009
Trypanosoma brucei metacaspase 5, putative 0.0026 0.0208 0.0142
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0275 0.0431
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0208 0.043
Brugia malayi Latrophilin receptor protein 2 0.0096 0.169 0.2415
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0135 0.2516 0.3595
Plasmodium vivax metacaspase 1, putative 0.0026 0.0208 0.0297
Echinococcus multilocularis caspase 2 0.0026 0.0208 0.0325
Trypanosoma brucei metacaspase 0.0026 0.0208 0.0142
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0318 0.6392 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0208 0.043
Trypanosoma cruzi metacaspase, putative 0.0026 0.0208 0.0297
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0998 0.1289
Onchocerca volvulus 0.002 0.0063 0.013
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0135 0.2516 0.3935
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0346 0.6996 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.011 0.0157
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0346 0.6996 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0135 0.2516 0.52
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.011 0.0157
Echinococcus granulosus GPCR family 2 0.0096 0.169 0.2644
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0998 0.1289
Schistosoma mansoni lipoxygenase 0.0082 0.1393 0.1393
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0933 0.102
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.169 0.2644
Schistosoma mansoni rab6-interacting 0.002 0.0063 0.0063
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0135 0.2516 1
Brugia malayi hypothetical protein 0.002 0.0063 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0998 0.1289
Trypanosoma brucei Metacaspase-4 0.0026 0.0208 0.0142
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0208 0.0297
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0208 0.4063 0.6356
Echinococcus granulosus importin subunit beta 1 0.003 0.0277 0.0433
Loa Loa (eye worm) hypothetical protein 0.0038 0.0455 0.0712
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0277 0.0242
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0346 0.6996 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0998 0.1289
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.2146 0.3357
Echinococcus granulosus caspase 2 0.0026 0.0208 0.0325
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0099
Loa Loa (eye worm) hypothetical protein 0.0026 0.0208 0.0325
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0933 0.0933
Echinococcus multilocularis caspase 8 0.0026 0.0208 0.0325
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0998 0.1426
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.169 0.2415
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0943 0.0812
Schistosoma mansoni ran 0.0022 0.011 0.011
Plasmodium falciparum metacaspase-like protein 0.0026 0.0208 0.0297
Treponema pallidum prolyl-tRNA synthetase 0.0038 0.0455 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0933 0.0933
Leishmania major GTP-binding protein, putative 0.0022 0.011 0.0157
Echinococcus multilocularis caspase 3 0.0073 0.1187 0.1857
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0299 0.0468
Brugia malayi Pre-SET motif family protein 0.0031 0.0299 0.0428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0998 0.1289
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0943 0.1348
Loa Loa (eye worm) hypothetical protein 0.003 0.0277 0.0433
Trypanosoma cruzi metacaspase, putative 0.0026 0.0208 0.0297
Echinococcus granulosus caspase 0.0099 0.175 0.2738
Toxoplasma gondii MAPEG family protein 0.0112 0.2018 0.2884
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0208 0.043
Echinococcus granulosus caspase 3 0.0073 0.1187 0.1857
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0408 0.0584
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0299 0.0299
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0135 0.2516 0.3935
Echinococcus granulosus RUN 0.002 0.0063 0.0099
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.011 0.5
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0135 0.2516 0.52
Leishmania major cathepsin L-like protease 0.0064 0.0998 0.1426
Entamoeba histolytica hypothetical protein 0.0024 0.0157 0.0626
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.011 0.0157
Schistosoma mansoni caspase-7 (C14 family) 0.0099 0.175 0.175
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0346 0.6996 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0208 0.0325
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0277 0.0396
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.2146 0.3357
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0157 0.0325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0998 0.1289
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0099 0.175 0.2738
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0346 0.6996 1
Loa Loa (eye worm) hypothetical protein 0.0304 0.6108 0.9556
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0157 0.0325
Echinococcus granulosus snurportin 1 0.0318 0.6392 1
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0208 0.0297
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0063 0.0099
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0998 0.1426
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0998 0.1289
Onchocerca volvulus 0.0031 0.0299 0.0619
Brugia malayi hypothetical protein 0.002 0.0063 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0208 0.043
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0208 0.043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0299 0.0299
Echinococcus multilocularis GPCR, family 2 0.0096 0.169 0.2644
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0135 0.2516 0.52
Loa Loa (eye worm) hypothetical protein 0.0031 0.0299 0.0468
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0346 0.6996 1
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0208 0.0297
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0943 0.1348
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0112 0.2018 0.3157
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.011 0.0172
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0063 0.0099
Echinococcus multilocularis importin subunit beta 1 0.003 0.0277 0.0433
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0157 0.0225
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0135 0.2516 0.52
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0708 0.1012
Brugia malayi Cytochrome P450 family protein 0.0023 0.0125 0.0178
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0208 0.043
Onchocerca volvulus 0.0244 0.4837 1
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0063 0.009
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.4207 0.6581
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0125 0.0195
Schistosoma mansoni hypothetical protein 0.0096 0.169 0.169
Echinococcus multilocularis caspase 0.0099 0.175 0.2738
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0135 0.2516 0.52
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0346 0.6996 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.169 0.2644
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0026 0.0208 0.0297
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0933 0.0796
Schistosoma mansoni rab6-interacting 0.002 0.0063 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0998 0.1289
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0677 0.0677
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0304 0.6108 0.9556
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0277 0.0242
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0299 0.0428
Brugia malayi Cell death protein 3 precursor 0.0026 0.0208 0.0297
Plasmodium falciparum dihydroorotate dehydrogenase 0.0346 0.6996 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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