TDR Targets

Basic information

Technical information

TDR Targets ID: 785964
Name: 8-(5-bromo-2-methoxyphenyl)-3-(2-fluorophenyl )-6-oxo-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5 ]thiadiazine-9-carbonitrile
MW: 474.346 | Formula: C21H17BrFN3O2S
H donors: 0 H acceptors: 2 LogP: 4.28 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: N#CC1=C2SCN(CN2C(=O)CC1c1cc(Br)ccc1OC)c1ccccc1F
InChi: 1S/C21H17BrFN3O2S/c1-28-19-7-6-13(22)8-15(19)14-9-20(27)26-11-25(12-29-21(26)16(14)10-24)18-5-3-2-4-17(18)23/h2-8,14H,9,11-12H2,1H3
InChiKey: USTLXQGBOZCEPT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

8-(5-bromo-2-methoxy-phenyl)-3-(2-fluorophenyl)-6-oxo-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile
8-(5-bromo-2-methoxy-phenyl)-3-(2-fluorophenyl)-6-keto-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	jmjC domain-containing protein	0.0025	0.0048	0.0043
Onchocerca volvulus	Alhambra homolog	0.003	0.0075	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0451	0.2495	0.2491
Trichomonas vaginalis	glucosylceramidase, putative	0.027	0.1458	1
Plasmodium vivax	basic transcription factor 3b, putative	0.0037	0.0115	0.0293
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.016	0.0113
Brugia malayi	PHD-finger family protein	0.003	0.0075	0.0075
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.0924	0.6162
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0039	0.0034
Loa Loa (eye worm)	runx1	0.0057	0.023	0.0225
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0257	0.0252
Trichomonas vaginalis	glucosylceramidase, putative	0.0187	0.0979	0.6556
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0039	0.0039
Brugia malayi	hypothetical protein	0.0451	0.2495	0.2495
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0174	0.0174
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0244	0.0198
Brugia malayi	hypothetical protein	0.0026	0.0052	0.0052
Schistosoma mansoni	dihydrofolate reductase	0.1757	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0244	0.0239
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0142	0.0095
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.016	0.016
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0244	0.0198
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.0924	0.6162
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0262	0.0216
Schistosoma mansoni	hypothetical protein	0.003	0.0075	0.0028
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.023	0.1226	0.1222
Schistosoma mansoni	hypothetical protein	0.0033	0.0092	0.0045
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0244	0.0239
Trichomonas vaginalis	glucosylceramidase, putative	0.027	0.1458	1
Brugia malayi	Bromodomain containing protein	0.003	0.0075	0.0075
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0262	0.0258
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0075	0.0028
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0039	0.0034
Brugia malayi	jmjC domain containing protein	0.0093	0.044	0.044
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.0312	0.1766
Brugia malayi	hypothetical protein	0.012	0.0596	0.0596
Entamoeba histolytica	hypothetical protein	0.0072	0.0316	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0048	0.0043
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.0496	0.0492
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.016	0.0113
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0151	0.0604
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.016	0.0113
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0092	0.0045
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0244	0.0198
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0115	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0052	0.0047
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0244	0.0198
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.016	0.0113
Echinococcus granulosus	transcription factor btf3	0.0037	0.0115	0.0068
Echinococcus multilocularis	Protein lozenge	0.0057	0.023	0.0183
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.016	0.0113
Trichomonas vaginalis	glucosylceramidase, putative	0.027	0.1458	1
Loa Loa (eye worm)	heterochromatin protein 1	0.0071	0.0312	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0496	0.0492
Echinococcus granulosus	chromobox protein 1	0.0071	0.0312	0.0266
Loa Loa (eye worm)	hypothetical protein	0.012	0.0596	0.0592
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.016	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0039	0.0034
Brugia malayi	hypothetical protein	0.0072	0.0316	0.0316
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0039	0.0039
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0244	0.0529
Brugia malayi	jmjC domain containing protein	0.0025	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0451	0.2495	0.2491
Echinococcus multilocularis	dihydrofolate reductase	0.1757	1	1
Echinococcus granulosus	survival motor neuron protein 1	0.023	0.1226	0.1184
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0672	0.3765	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.0924	0.6162
Entamoeba histolytica	transcription factor BTF3, putative	0.0037	0.0115	0.2755
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0052	0.0013
Brugia malayi	hypothetical protein	0.023	0.1226	0.1226
Onchocerca volvulus		0.0047	0.0174	0.0553
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0093	0.044	0.0394
Loa Loa (eye worm)	dihydrofolate reductase	0.1757	1	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.016	0.0156
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0092	0.0045
Echinococcus multilocularis	lysine specific demethylase 5A	0.0093	0.044	0.0394
Trypanosoma brucei	transcription factor BTF3, putative	0.0037	0.0115	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0084	0.0079
Schistosoma mansoni	hypothetical protein	0.0033	0.0092	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0285	0.028
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0262	0.0216
Schistosoma mansoni	jumonji domain containing protein	0.0134	0.0677	0.0633
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0672	0.3765	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0092	0.0045
Onchocerca volvulus		0.0031	0.0084	0.0184
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0092	0.0045
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0075	0.0028
Brugia malayi	N-terminal motif family protein	0.0177	0.0924	0.0924
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0075	0.0075
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0154	0.0792	0.0748
Brugia malayi	jmjC domain containing protein	0.0025	0.0048	0.0048
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0154	0.0792	0.0748
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0052	0.0126
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.1757	1	1
Schistosoma mansoni	chromobox protein	0.0071	0.0312	0.0266
Entamoeba histolytica	hypothetical protein	0.0072	0.0316	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0039	0.0034
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0075	0.0028
Loa Loa (eye worm)	hypothetical protein	0.004	0.0133	0.0128
Plasmodium falciparum	phd finger protein, putative	0.003	0.0075	0.0187
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0672	0.3765	1
Toxoplasma gondii	NAC domain-containing protein	0.0037	0.0115	0.0182
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.027	0.1458	0.1454
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0672	0.3765	1
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0115	0.0182
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0262	0.0216
Entamoeba histolytica	hypothetical protein	0.0072	0.0316	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0052	0.0126
Trichomonas vaginalis	glucosylceramidase, putative	0.027	0.1458	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0052	0.0013
Echinococcus multilocularis	geminin	0.0334	0.1825	0.1786
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0115	0.0182
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0039	0.0034
Trichomonas vaginalis	glucosylceramidase, putative	0.027	0.1458	1
Giardia lamblia	PHD finger protein 15	0.003	0.0075	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0115	0.0349
Schistosoma mansoni	transcription factor btf3	0.0037	0.0115	0.0068
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0075	0.0075
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0092	0.0092
Brugia malayi	TAR-binding protein	0.0062	0.0262	0.0262
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0244	0.0239
Loa Loa (eye worm)	hypothetical protein	0.007	0.0309	0.0304
Schistosoma mansoni	chromobox protein	0.0071	0.0312	0.0266
Echinococcus granulosus	GPCR family 2	0.0033	0.0092	0.0045
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.0496	0.0496
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0092	0.0092
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0244	0.0239
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.0316	0.027
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0039	0.0039
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0262	0.0258
Brugia malayi	chromobox protein homolog 3	0.004	0.0133	0.0133
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0142	0.0095
Loa Loa (eye worm)	jmjC domain-containing protein	0.0025	0.0048	0.0043
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0262	0.0216
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0092	0.0087
Schistosoma mansoni	hypothetical protein	0.0047	0.0174	0.0127
Loa Loa (eye worm)	hypothetical protein	0.012	0.0596	0.0592
Schistosoma mansoni	hypothetical protein	0.0033	0.0092	0.0045
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0052	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0788	0.0784
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0262	0.0216
Brugia malayi	Heterochromatin protein 1	0.0071	0.0312	0.0312
Brugia malayi	beta-NAC-like protein	0.0037	0.0115	0.0115
Echinococcus multilocularis	survival motor neuron protein 1	0.023	0.1226	0.1184
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0039	0.0034
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0262	0.0262
Schistosoma mansoni	hypothetical protein	0.0072	0.0316	0.027
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0924	0.0919
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.016	0.0113
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0133	0.0479
Echinococcus multilocularis	chromobox protein 1	0.0071	0.0312	0.0266
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0849	0.4782	0.4757
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0025	0.0048	0.0114
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.1757	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.0924	0.6162
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0039	0.0034
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.0924	0.6162
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.0496	0.0496
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0262	0.0216
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0039	0.0034
Loa Loa (eye worm)	jmjC domain-containing protein	0.0093	0.044	0.0435
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.0924	0.6162
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0262	0.0216
Entamoeba histolytica	hypothetical protein	0.0072	0.0316	1
Echinococcus granulosus	chromobox protein 1	0.0071	0.0312	0.0266
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0133	0.0385
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0075	0.0187
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0075	0.0071
Brugia malayi	hypothetical protein	0.0154	0.0788	0.0788
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0052	0.0013
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0174	0.0127
Plasmodium falciparum	basic transcription factor 3b, putative	0.0037	0.0115	0.0293
Leishmania major	basic transcription factor 3a, putative	0.0037	0.0115	0.0205
Trichomonas vaginalis	glucosylceramidase, putative	0.027	0.1458	1
Schistosoma mansoni	hypothetical protein	0.007	0.0309	0.0263
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.1757	1	1
Leishmania major	hypothetical protein, conserved	0.0025	0.0048	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0048	0.0043
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0244	0.0552
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.0924	0.6162
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0115	0.0349
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0039	0.0034
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0039	0.0034
Onchocerca volvulus		0.0154	0.0788	0.3053
Schistosoma mansoni	hypothetical protein	0.0334	0.1825	0.1786
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.027	0.1458	0.1458
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0092	0.0087
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.0316	0.027
Echinococcus granulosus	dihydrofolate reductase	0.1757	1	1
Echinococcus multilocularis	peregrin	0.003	0.0075	0.0028
Echinococcus granulosus	lysine specific demethylase 5A	0.0093	0.044	0.0394
Plasmodium vivax	JmjC domain containing protein	0.0025	0.0048	0.0114
Trichomonas vaginalis	glucosylceramidase, putative	0.0187	0.0979	0.6556
Onchocerca volvulus	Huntingtin homolog	0.012	0.0596	0.227
Entamoeba histolytica	hypothetical protein	0.0037	0.0115	0.2755
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0672	0.3765	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0052	0.0036
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0151	0.0456
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0262	0.0258
Echinococcus granulosus	geminin	0.0334	0.1825	0.1786
Schistosoma mansoni	lozenge	0.0057	0.023	0.0183
Echinococcus multilocularis	chromobox protein 1	0.0071	0.0312	0.0266
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0092	0.0045
Brugia malayi	jmjC domain containing protein	0.0025	0.0048	0.0048
Onchocerca volvulus	Glucosylceramidase homolog	0.0177	0.0924	0.3605
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.0312	0.1766
Loa Loa (eye worm)	ICD-1 protein	0.0037	0.0115	0.011
Loa Loa (eye worm)	jmjC domain-containing protein	0.0025	0.0048	0.0043
Chlamydia trachomatis	dihydrofolate reductase	0.1757	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0039	0.0034
Onchocerca volvulus	Huntingtin homolog	0.012	0.0596	0.227
Schistosoma mansoni	hypothetical protein	0.0334	0.1825	0.1786
Brugia malayi	Dihydrofolate reductase	0.1757	1	1
Brugia malayi	jmjC domain containing protein	0.0154	0.0792	0.0792
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.0316	0.027
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.0309	0.0309
Onchocerca volvulus		0.0451	0.2495	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0092	0.0045
Brugia malayi	jmjC domain containing protein	0.0025	0.0048	0.0048
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0151	0.0604
Echinococcus granulosus	peregrin	0.003	0.0075	0.0028
Brugia malayi	RNA binding protein	0.0062	0.0262	0.0262
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0672	0.3765	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0075	0.0071
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0133	0.0479
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0052	0.0126
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0177	0.0924	0.3603
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0093	0.044	0.0394
Echinococcus multilocularis	transcription factor btf3	0.0037	0.0115	0.0068

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 785964