Detailed information for compound 785969

Basic information

Technical information
  • TDR Targets ID: 785969
  • Name: 3-(4-methoxyphenyl)-6-oxo-8-(3,4,5-trimethoxy phenyl)-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5 ]thiadiazine-9-carbonitrile
  • MW: 467.537 | Formula: C24H25N3O5S
  • H donors: 0 H acceptors: 2 LogP: 3.41 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N1CSC2=C(C#N)C(CC(=O)N2C1)c1cc(OC)c(c(c1)OC)OC
  • InChi: 1S/C24H25N3O5S/c1-29-17-7-5-16(6-8-17)26-13-27-22(28)11-18(19(12-25)24(27)33-14-26)15-9-20(30-2)23(32-4)21(10-15)31-3/h5-10,18H,11,13-14H2,1-4H3
  • InChiKey: WYAHTKHFOQYSFW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-keto-3-(4-methoxyphenyl)-8-(3,4,5-trimethoxyphenyl)-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0017 0.0002
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0123 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0217 0.0572
Brugia malayi nuclear receptor NHR-88 0.0034 0.0217 0.0572
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0217 0.3744
Loa Loa (eye worm) hypothetical protein 0.0226 0.2355 0.6674
Loa Loa (eye worm) hypothetical protein 0.0021 0.0068 0.0146
Brugia malayi beta-lactamase family protein 0.0039 0.0268 0.0715
Echinococcus granulosus geminin 0.017 0.1724 0.1711
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0473 0.931
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0055 0.0446 0.0431
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0027 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0217 0.0572
Schistosoma mansoni hypothetical protein 0.0226 0.2355 0.2343
Echinococcus multilocularis dnaJ subfamily B 0.0914 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.0473 0.931
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0217 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0217 0.0572
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0027 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0217 0.0202
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0217 0.0572
Loa Loa (eye worm) hypothetical protein 0.0021 0.0068 0.0146
Loa Loa (eye worm) hypothetical protein 0.0039 0.0268 0.0715
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0268 0.0943
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0068 0.0867
Trypanosoma cruzi ISWI complex protein 0.0035 0.0223 0.4088
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0061
Leishmania major hypothetical protein, conserved 0.0057 0.0473 0.931
Mycobacterium tuberculosis Conserved protein 0.0039 0.0268 0.0943
Echinococcus multilocularis geminin 0.017 0.1724 0.1711
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0473 0.931
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0198 0.2037 0.5768
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0572
Trypanosoma cruzi ISWI complex protein 0.0035 0.0223 0.4088
Mycobacterium ulcerans lipase LipD 0.0039 0.0268 0.4546
Mycobacterium ulcerans hypothetical protein 0.0028 0.0146 0.1775
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0217 0.0572
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0039 0.0061
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0594 0.0579
Schistosoma mansoni cpg binding protein 0.0072 0.0641 0.0626
Loa Loa (eye worm) hypothetical protein 0.0021 0.0068 0.0146
Onchocerca volvulus 0.0039 0.0268 0.4684
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0114
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0268 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0217 0.0572
Loa Loa (eye worm) hypothetical protein 0.0057 0.0473 0.1303
Schistosoma mansoni zinc finger protein 0.0048 0.0371 0.0356
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.004 0.0283 0.0267
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0198 0.2037 0.2025
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0059 0.0044
Schistosoma mansoni nuclear receptor 0.0016 0.0017 0.0002
Onchocerca volvulus 0.0064 0.0552 1
Brugia malayi CXXC zinc finger family protein 0.0064 0.0552 0.1527
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0146 0.0368
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0081 0.0742 0.0727
Loa Loa (eye worm) hypothetical protein 0.0028 0.0146 0.0368
Echinococcus granulosus histone lysine methyltransferase setb 0.004 0.0283 0.0267
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0017 0.0002
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0146 0.1775
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0594 0.0579
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0017 0.0002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0217 0.0202
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0217 0.0202
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0473 0.931
Loa Loa (eye worm) hypothetical protein 0.004 0.0283 0.0758
Schistosoma mansoni hypothetical protein 0.017 0.1724 0.1711
Schistosoma mansoni bromodomain containing protein 0.0147 0.147 0.1456
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0268 0.0252
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0869 0.9505 0.9505
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.004 0.0283 0.0267
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0017 0.0002
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0268 0.4546
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0039 0.0267 0.0252
Loa Loa (eye worm) RNA binding protein 0.0068 0.0594 0.1646
Toxoplasma gondii exonuclease III APE 0.006 0.0507 0.3924
Mycobacterium tuberculosis Conserved protein 0.0039 0.0268 0.0943
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0068 0.0867
Onchocerca volvulus 0.0039 0.0268 0.4684
Mycobacterium ulcerans hypothetical protein 0.0039 0.0268 0.4546
Schistosoma mansoni hypothetical protein 0.0035 0.0223 0.0208
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0217 0.0202
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0105 0.1003 0.0989
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0572
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0268 0.5282
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0217 0.0572
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0594 0.1646
Brugia malayi Calcitonin receptor-like protein seb-1 0.0331 0.352 1
Brugia malayi hypothetical protein 0.0018 0.0039 0.0061
Trypanosoma brucei ISWI complex protein 0.0035 0.0223 0.4088
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0039 0.0023
Schistosoma mansoni transcription factor LCR-F1 0.0275 0.2897 0.2886
Entamoeba histolytica hypothetical protein 0.0275 0.2897 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0198 0.2037 0.2025
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0217 0.0202
Brugia malayi TAR-binding protein 0.0068 0.0594 0.1646
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0268 0.5282
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.2037 0.2025
Brugia malayi beta-lactamase 0.0039 0.0268 0.0715
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0217 0.0202
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0217 0.0202
Loa Loa (eye worm) hypothetical protein 0.0039 0.0268 0.0715
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0268 0.0252
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0123 0.0108
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0027 0.0011
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.0507 1
Brugia malayi hypothetical protein 0.0057 0.0473 0.1303
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0507 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0039 0.0267 0.0252
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0081 0.0742 0.0727
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0027 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0217 0.0572
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0268 0.5019
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0146 0.2488
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0594 0.0579
Onchocerca volvulus 0.0039 0.0268 0.4684
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0268 0.0943
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0217 0.0572
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0217 0.0202
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0507 0.1398
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0507 1
Schistosoma mansoni zinc finger protein 0.0016 0.0017 0.0002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0268 0.0715
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0217 0.0572
Loa Loa (eye worm) hypothetical protein 0.016 0.1616 0.4565
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0114
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0507 1
Brugia malayi steroid hormone receptor 0.0034 0.0217 0.0572
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0268 0.0943
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.1371 0.3866
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0061
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.0507 0.1879
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0217 0.0202
Loa Loa (eye worm) hypothetical protein 0.0331 0.352 1
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0217 0.0572
Schistosoma mansoni cpg binding protein 0.0072 0.0641 0.0626
Toxoplasma gondii histone lysine methyltransferase SET1 0.0127 0.125 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0146 0.1775
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0507 0.1311
Schistosoma mansoni cpg binding protein 0.0064 0.0552 0.0537
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0217 0.0572
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0217 0.0202
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0105 0.1003 0.2815
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0027 0.0011
Schistosoma mansoni hypothetical protein 0.0026 0.0123 0.0108
Brugia malayi Bromodomain containing protein 0.0173 0.1764 0.4988
Schistosoma mansoni hypothetical protein 0.0047 0.0357 0.0342
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0027 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0217 0.0572
Schistosoma mansoni hypothetical protein 0.0105 0.1003 0.0989
Echinococcus granulosus fetal alzheimer antigen falz 0.0055 0.0446 0.0431
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0217 0.0202
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0017 0.0002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0217 0.0202
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0105 0.1003 0.0989
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0146 0.0468
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.2037 0.2025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0268 0.0252
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0017 0.0002
Brugia malayi hypothetical protein 0.0275 0.2897 0.8222
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0594 0.0579
Brugia malayi hypothetical protein 0.0037 0.0248 0.066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0217 0.0202
Brugia malayi Bromodomain containing protein 0.0087 0.0801 0.2238
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0268 0.0715
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0217 0.0572
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0017 0.0002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0552 0.1527
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0104 0.0249
Loa Loa (eye worm) hypothetical protein 0.0039 0.0268 0.0715
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0268 0.0943
Loa Loa (eye worm) hypothetical protein 0.0105 0.1003 0.2815
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0217 0.0202
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0017 0.0002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0331 0.352 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0198 0.2037 0.5768
Echinococcus granulosus GPCR family 2 0.0105 0.1003 0.0989
Onchocerca volvulus 0.0028 0.0146 0.2413
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0146 0.1775
Schistosoma mansoni ap endonuclease 0.006 0.0507 0.0492
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0268 0.4546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0217 0.0572
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0268 0.5282
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0507 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0275 0.2897 0.2886
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0268 0.0715
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0217 0.0202
Leishmania major hypothetical protein, conserved 0.0039 0.0268 0.5019
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0146 0.0368
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0039 0.0023
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.1371 0.3866
Brugia malayi beta-lactamase family protein 0.0039 0.0268 0.0715
Mycobacterium leprae Probable lipase LipE 0.0039 0.0268 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0027 0.0011
Brugia malayi ecdysteroid receptor 0.0034 0.0217 0.0572
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0139 0.138 0.1366
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0017 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0217 0.0572
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0039 0.0061
Loa Loa (eye worm) PHD-finger family protein 0.0047 0.0357 0.097
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.0473 0.931
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0017 0.0002
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0055 0.0446 0.0431
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0217 0.0572
Brugia malayi Latrophilin receptor protein 2 0.0105 0.1003 0.2815
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0017 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0114
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0068 0.0163
Brugia malayi nuclear hormone receptor 0.0034 0.0217 0.0572
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0507 1
Brugia malayi PHD-finger family protein 0.006 0.0505 0.1394
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0594 0.0579
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0039 0.0023
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0017 0.0002
Loa Loa (eye worm) hypothetical protein 0.0087 0.0803 0.2243
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0217 0.0202
Echinococcus granulosus methyl CpG binding domain protein 2 0.0039 0.0267 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0217 0.0572
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0268 0.5019
Mycobacterium tuberculosis Conserved protein 0.0039 0.0268 0.0943
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.0473 0.3654
Onchocerca volvulus 0.0034 0.0217 0.3744
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0217 0.0202
Brugia malayi hypothetical protein 0.0018 0.0039 0.0061
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0268 0.5282
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.004 0.0283 0.0267
Loa Loa (eye worm) hypothetical protein 0.0092 0.0862 0.2413
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0146 0.1775
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0217 0.0572
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0017 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0061
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0572
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0136 0.1352 0.1338
Loa Loa (eye worm) hypothetical protein 0.0039 0.0268 0.0715
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0217 0.3744
Schistosoma mansoni hypothetical protein 0.0275 0.2897 0.2886
Brugia malayi latrophilin 2 splice variant baaae 0.0226 0.2355 0.6674
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0331 0.352 1
Echinococcus granulosus tar DNA binding protein 0.0068 0.0594 0.0579
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0217 0.0202
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0059 0.0044
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0268 0.0252
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0105 0.1003 0.0989
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0507 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0146 0.0368
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0268 0.0943
Entamoeba histolytica hypothetical protein 0.0275 0.2897 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0146 0.2488
Brugia malayi MH2 domain containing protein 0.0138 0.1371 0.3866
Loa Loa (eye worm) latrophilin receptor protein 2 0.0105 0.1003 0.2815
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0572
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0507 0.0492
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0217 0.0202
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0268 0.5019
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0027 0.0011
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0507 1
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0217 0.0202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0198 0.2037 0.2025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0217 0.0202
Schistosoma mansoni hypothetical protein 0.017 0.1724 0.1711
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0217 0.3744
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0572
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0146 0.1775
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0146 0.1775
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0268 0.0943
Schistosoma mansoni nuclear receptor 0.0016 0.0017 0.0002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0217 0.0572
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0507 0.0492
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0146 0.2488
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0217 0.0572
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0473 0.931
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0217 0.0202
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0507 0.1398
Brugia malayi isocitrate dehydrogenase 0.0017 0.0027 0.0027
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0268 0.5282
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.006 0.0507 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0217 0.0202
Echinococcus granulosus zinc finger protein 0.0048 0.0371 0.0356
Mycobacterium ulcerans beta-lactamase 0.0039 0.0268 0.4546
Schistosoma mansoni hypothetical protein 0.0105 0.1003 0.0989
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0105 0.1003 0.0989
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0594 0.1646
Loa Loa (eye worm) hypothetical protein 0.0021 0.0068 0.0146
Loa Loa (eye worm) bromodomain containing protein 0.004 0.0282 0.0757
Echinococcus multilocularis GPCR, family 2 0.0105 0.1003 0.0989
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0275 0.2897 0.2886
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0146 0.0468
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0146 0.1775
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0217 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0217 0.0572
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0217 0.0202
Echinococcus multilocularis cpg binding protein 0.0072 0.0641 0.0626
Schistosoma mansoni hypothetical protein 0.0105 0.1003 0.0989
Brugia malayi RNA binding protein 0.0068 0.0594 0.1646
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.0507 0.5
Leishmania major hypothetical protein, conserved 0.0035 0.0223 0.4088
Loa Loa (eye worm) hypothetical protein 0.0028 0.0146 0.0368
Loa Loa (eye worm) beta-lactamase 0.0039 0.0268 0.0715
Loa Loa (eye worm) hypothetical protein 0.0021 0.0068 0.0146
Schistosoma mansoni methyl-cpg binding protein mbd 0.0039 0.0267 0.0252
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0039 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0039 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0217 0.0572
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0017 0.0002
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0268 0.0943
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0268 0.5019
Entamoeba histolytica hypothetical protein 0.0275 0.2897 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0017 0.0002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0507 1
Brugia malayi nuclear receptor RXR 0.0018 0.0039 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0217 0.0572
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0017 0.0002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0217 0.0202
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0146 0.0368
Loa Loa (eye worm) hypothetical protein 0.0039 0.0268 0.0715
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0217 0.0202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0198 0.2037 0.2025
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0217 0.0202
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0017 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0114
Loa Loa (eye worm) histone methyltransferase 0.002 0.0059 0.012
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0027 0.0027
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0594 0.1646
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0139 0.138 0.1366
Toxoplasma gondii ABC1 family protein 0.0039 0.0268 0.197
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0572
Entamoeba histolytica hypothetical protein 0.0275 0.2897 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0507 0.5
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0068 0.5
Echinococcus multilocularis zinc finger protein 0.0048 0.0371 0.0356
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.2037 0.2025
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0572
Schistosoma mansoni ap endonuclease 0.006 0.0507 0.0492
Loa Loa (eye worm) hypothetical protein 0.01 0.0951 0.2666
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0217 0.0202
Schistosoma mansoni hypothetical protein 0.0914 1 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0594 0.0579
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0061
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.2581 1
Schistosoma mansoni coup transcription factor 0.0034 0.0217 0.0202
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0572
Trichomonas vaginalis esterase, putative 0.0039 0.0268 0.5282
Schistosoma mansoni zinc finger protein 0.0035 0.0223 0.0208
Echinococcus granulosus cpg binding protein 0.0072 0.0641 0.0626
Schistosoma mansoni hypothetical protein 0.0105 0.1003 0.0989

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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