Detailed information for compound 786038

Basic information

Technical information
  • TDR Targets ID: 786038
  • Name: 8-(2-chloro-6-fluorophenyl)-3-(4-fluorophenyl )-6-oxo-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5 ]thiadiazine-9-carbonitrile
  • MW: 417.859 | Formula: C20H14ClF2N3OS
  • H donors: 0 H acceptors: 2 LogP: 4.35 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C2SCN(CN2C(=O)CC1c1c(F)cccc1Cl)c1ccc(cc1)F
  • InChi: 1S/C20H14ClF2N3OS/c21-16-2-1-3-17(23)19(16)14-8-18(27)26-10-25(11-28-20(26)15(14)9-24)13-6-4-12(22)5-7-13/h1-7,14H,8,10-11H2
  • InChiKey: BUIJXJVAQMCVCE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 8-(2-chloro-6-fluoro-phenyl)-3-(4-fluorophenyl)-6-oxo-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile
  • 8-(2-chloro-6-fluoro-phenyl)-3-(4-fluorophenyl)-6-keto-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0103 0.0242
Schistosoma mansoni hypothetical protein 0.0175 0.1148 0.1148
Brugia malayi hypothetical protein 0.0029 0.0121 0.0121
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0072 0.006
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0349 0.0897
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1215 0.6407
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0183 1
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.002 0.0059 0.0059
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.1897 1
Onchocerca volvulus 0.0029 0.0121 0.0374
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.091 0.0909
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.0612 0.0612
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.1428 1 1
Echinococcus granulosus cpg binding protein 0.0034 0.0153 0.0152
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0098 0.0097
Brugia malayi hypothetical protein 0.0075 0.0441 0.0441
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0208 0.055
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0029 0.0121 0.0121
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0183 0.4153
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0051 0.0268
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1215 0.6407
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0207 0.1089
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0161 0.1049 0.1049
Loa Loa (eye worm) hypothetical protein 0.002 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0453 0.3114 0.3113
Schistosoma mansoni dihydrofolate reductase 0.1428 1 1
Leishmania major basic transcription factor 3a, putative 0.0038 0.0183 0.0455
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0122 0.064
Schistosoma mansoni chromobox protein 0.0074 0.0436 0.0435
Onchocerca volvulus Protein cycle homolog 0.002 0.0059 0.0182
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0098 0.0227
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0218 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0273 0.0273
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0546 0.3771 1
Schistosoma mansoni hypothetical protein 0.0065 0.0372 0.0372
Echinococcus multilocularis peregrin 0.0034 0.0157 0.0157
Leishmania major cytochrome p450-like protein 0.0022 0.0072 0.016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0051 0.0268
Entamoeba histolytica hypothetical protein 0.0038 0.0183 0.4153
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0183 0.0183
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.091 0.0909
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0183 0.0486
Echinococcus multilocularis lysine specific demethylase 5A 0.0097 0.0599 0.0599
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0229 0.1206
Entamoeba histolytica hypothetical protein 0.0075 0.0441 1
Echinococcus granulosus GPCR family 2 0.0065 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0041 0.0207 0.0207
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0133 0.0352
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0098 0.0097
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0098 0.0259
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.026 0.026
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.1285 0.6776
Brugia malayi hypothetical protein 0.024 0.1607 0.1606
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0103 0.0273
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0013 0.0013
Echinococcus multilocularis chromobox protein 1 0.0074 0.0436 0.0435
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0098 0.0097
Plasmodium vivax hypothetical protein, conserved 0.0012 0 0.0001
Schistosoma mansoni chromobox protein 0.0074 0.0436 0.0435
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0103 0.0242
Brugia malayi Dihydrofolate reductase 0.1428 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0072 0.016
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0441 0.0441
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1215 0.6407
Loa Loa (eye worm) hypothetical protein 0.014 0.0903 0.0902
Brugia malayi Heterochromatin protein 1 0.0074 0.0436 0.0435
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0072 0.0072
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0072 0.016
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0349 0.0349
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.1897 1
Echinococcus granulosus geminin 0.0175 0.1148 0.1148
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0051 0.0268
Entamoeba histolytica hypothetical protein 0.0075 0.0441 1
Brugia malayi aryl hydrocarbon receptor AHR-1 0.002 0.0059 0.0059
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.091 0.0909
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0441 0.0441
Loa Loa (eye worm) runx1 0.0059 0.033 0.033
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.002 0.0059 0.0059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0273 0.0273
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0349 0.0338
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.1897 1
Brugia malayi cytochrome P450 0.0014 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0065 0.0372 0.0372
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0103 0.0274
Leishmania major hypothetical protein, conserved 0.0026 0.0098 0.0227
Brugia malayi Calcitonin receptor-like protein seb-1 0.0205 0.136 0.136
Echinococcus multilocularis Protein lozenge 0.0059 0.033 0.033
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.1607 0.1606
Loa Loa (eye worm) hypothetical protein 0.002 0.0059 0.0059
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0441 0.0441
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0436 0.2295
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0273 0.0273
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0183 0.0486
Loa Loa (eye worm) dihydrofolate reductase 0.1428 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0882 0.0882
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0183 0.0486
Echinococcus granulosus transcription factor btf3 0.0038 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0032 0.0144 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0183 0.0965
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0183 0.0455
Brugia malayi hypothetical protein 0.0017 0.0037 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0183 0.0965
Onchocerca volvulus 0.0032 0.0144 0.0445
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0 0.0001
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0546 0.3771 1
Schistosoma mansoni hypothetical protein 0.0175 0.1148 0.1148
Plasmodium falciparum phd finger protein, putative 0.0031 0.0133 0.0352
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0103 0.0274
Chlamydia trachomatis dihydrofolate reductase 0.1428 1 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.0612 0.0612
Brugia malayi PHD-finger family protein 0.0031 0.0133 0.0133
Onchocerca volvulus 0.0049 0.026 0.0806
Brugia malayi chromobox protein homolog 3 0.0041 0.0207 0.0207
Echinococcus granulosus phd:f box containing protein 0.0026 0.0098 0.0097
Echinococcus multilocularis dnaJ subfamily B 0.0453 0.3114 0.3113
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.1897 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0546 0.3771 1
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0183 0.0455
Brugia malayi jmjC domain containing protein 0.0099 0.0612 0.0612
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0133 0.0352
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0208 0.055
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0183 0.0965
Brugia malayi Cytochrome P450 family protein 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0069 0.0401 0.04
Schistosoma mansoni hypothetical protein 0.0065 0.0372 0.0372
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0436 0.0435
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0051 0.0268
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0098 0.0097
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.011 0.011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0051 0.0268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0273 0.0273
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.1897 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0349 0.0338
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0372 0.0372
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0133 0.0352
Brugia malayi hypothetical protein 0.0469 0.3223 0.3223
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0012 0.0032
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0098 0.0227
Loa Loa (eye worm) hypothetical protein 0.0031 0.0133 0.0133
Echinococcus granulosus dihydrofolate reductase 0.1428 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0349 0.0349
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0098 0.0097
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0098 0.0227
Loa Loa (eye worm) hypothetical protein 0.0469 0.3223 0.3223
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0028 0.0144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0273 0.0273
Plasmodium falciparum heterochromatin protein 1 0.0012 0 0.0001
Echinococcus multilocularis GPCR, family 2 0.0065 0.0372 0.0372
Schistosoma mansoni cpg binding protein 0.0034 0.0153 0.0152
Schistosoma mansoni cytochrome P450 0.0014 0.0012 0.0012
Brugia malayi jmjC domain containing protein 0.0026 0.0098 0.0097
Schistosoma mansoni hypothetical protein 0.0049 0.026 0.026
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0365 0.0364
Echinococcus granulosus survival motor neuron protein 1 0.024 0.1607 0.1606
Echinococcus multilocularis transcription factor btf3 0.0038 0.0183 0.0183
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0103 0.0274
Loa Loa (eye worm) hypothetical protein 0.002 0.0059 0.0059
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0 0.0001
Brugia malayi Cytochrome P450 family protein 0.0022 0.0072 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.1897 1
Echinococcus granulosus peregrin 0.0034 0.0157 0.0157
Echinococcus multilocularis cpg binding protein 0.0034 0.0153 0.0152
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0273 0.0273
Echinococcus granulosus lysine specific demethylase 5A 0.0099 0.0612 0.0612
Schistosoma mansoni hypothetical protein 0.0014 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.014 0.0903 0.0902
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0098 0.0097
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0372 0.0372
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0183 0.0486
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0013 0.0013
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0072 0.016
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.002 0.0059 0.0059
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0208 0.0551
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0098 0.0097
Brugia malayi SET domain containing protein 0.0013 0.0005 0.0005
Echinococcus multilocularis aryl hydrocarbon receptor 0.0029 0.0121 0.0121
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0281 0.1897 0.1896
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0098 0.0097
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.0849 0.0848
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0205 0.136 0.136
Echinococcus multilocularis 0.0014 0.0012 0.0012
Loa Loa (eye worm) cytochrome P450 0.0014 0.0012 0.0012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0372 0.0372
Echinococcus granulosus dnaJ subfamily B 0.0453 0.3114 0.3113
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0012 0.0012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0349 0.0338
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0546 0.3771 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0133 0.0133
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0273 0.0273
Echinococcus multilocularis dihydrofolate reductase 0.1428 1 1
Onchocerca volvulus 0.016 0.1044 0.3237
Leishmania major hypothetical protein, conserved 0.0027 0.0103 0.0242
Echinococcus granulosus aryl hydrocarbon receptor 0.0029 0.0121 0.0121
Echinococcus granulosus chromobox protein 1 0.0074 0.0436 0.0435
Onchocerca volvulus 0.0469 0.3223 1
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0098 0.0097
Entamoeba histolytica hypothetical protein 0.0075 0.0441 1
Brugia malayi CHD4 protein 0.0014 0.0013 0.0013
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.014 0.0139
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0133 0.0133
Schistosoma mansoni survival motor neuron protein 0.0049 0.026 0.026
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1215 0.6407
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.0903 0.0902
Loa Loa (eye worm) hypothetical protein 0.0026 0.0098 0.0097
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0365 0.0967
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0436 0.2295
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0051 0.0268
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0065 0.0372 0.0372
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0349 0.0926
Loa Loa (eye worm) hypothetical protein 0.0027 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0065 0.0372 0.0372
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0273 0.0273
Brugia malayi hypothetical protein 0.016 0.1044 0.1044
Brugia malayi beta-NAC-like protein 0.0038 0.0183 0.0183
Echinococcus multilocularis geminin 0.0175 0.1148 0.1148
Entamoeba histolytica hypothetical protein 0.0075 0.0441 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0042 0.0042
Schistosoma mansoni lozenge 0.0059 0.033 0.033
Brugia malayi hypothetical protein 0.002 0.0059 0.0059
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.002 0.0059 0.0059
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0881 0.6137 0.6137
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1215 0.6407
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.0098 0.0258
Schistosoma mansoni jumonji domain containing protein 0.014 0.0902 0.0902
Onchocerca volvulus Glucosylceramidase homolog 0.0184 0.1215 0.377
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0391 0.0391
Loa Loa (eye worm) jmjC domain-containing protein 0.0099 0.0612 0.0612
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.0098 0.0258
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0098 0.0097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0024 0.0124
Schistosoma mansoni cpg binding protein 0.0034 0.0153 0.0152
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0 0.0001
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0229 0.071
Onchocerca volvulus 0.0032 0.014 0.0432
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0051 0.0268
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0208 0.1093
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0208 0.1093
Echinococcus multilocularis chromobox protein 1 0.0074 0.0436 0.0435
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.1428 1 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.016 0.1044 0.1044
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0072 0.0072
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0229 0.1206
Brugia malayi Cytochrome P450 family protein 0.0051 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0029 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0469 0.3223 0.3223
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.1428 1 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0546 0.3771 1
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0133 0.0133
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0183 0.0455
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1215 0.6407
Brugia malayi hypothetical protein 0.0027 0.0103 0.0103
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0013 0.0013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0372 0.0372
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0161 0.1049 0.1049
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.0849 0.0848
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0208 0.0207
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0098 0.0097
Brugia malayi Cytochrome P450 family protein 0.0014 0.0012 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.1285 0.6776
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0546 0.3771 1
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0055 0.0055
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0183 0.4149
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0051 0.0268
Onchocerca volvulus 0.0013 0.0005 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0207 0.1089
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0103 0.0242
Brugia malayi jmjC domain containing protein 0.0161 0.1049 0.1049
Brugia malayi jmjC domain containing protein 0.0026 0.0098 0.0097
Schistosoma mansoni hypothetical protein 0.0075 0.0441 0.0441
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0281 0.1897 0.1896
Schistosoma mansoni hypothetical protein 0.0031 0.0133 0.0133
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0372 0.0372
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0098 0.0097
Brugia malayi CXXC zinc finger family protein 0.0032 0.014 0.0139
Schistosoma mansoni cpg binding protein 0.0032 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.024 0.1607 0.1606
Loa Loa (eye worm) hypothetical protein 0.0026 0.0098 0.0097
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.002 0.0059 0.0059
Schistosoma mansoni transcription factor btf3 0.0038 0.0183 0.0183
Brugia malayi hypothetical protein 0.002 0.0059 0.0059
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0207 0.0641
Brugia malayi Bromodomain containing protein 0.0034 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0205 0.136 0.136
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0098 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.0005 0.0005
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0349 0.0349
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0205 0.136 0.136
Brugia malayi jmjC domain containing protein 0.0026 0.0098 0.0097
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0349 0.0349
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1215 0.6407
Plasmodium vivax JmjC domain containing protein 0.0026 0.0098 0.0259
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0372 0.0372
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0013 0.0013
Brugia malayi MH2 domain containing protein 0.0132 0.0849 0.0848
Plasmodium vivax hypothetical protein, conserved 0.0012 0 0.0001
Echinococcus granulosus chromobox protein 1 0.0074 0.0436 0.0435
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0028 0.0144
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0372 0.0372
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0098 0.0097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0273 0.0273
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0274 0.0274
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0098 0.0097
Loa Loa (eye worm) acetyltransferase 0.0141 0.091 0.0909
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0122 0.064
Brugia malayi jmjC domain containing protein 0.0026 0.0098 0.0097
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0349 0.0338
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0218 0.0218
Onchocerca volvulus Alhambra homolog 0.0031 0.0133 0.0411

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.