Detailed information for compound 786332

Basic information

Technical information
  • TDR Targets ID: 786332
  • Name: N-(3-methylbutyl)-3-oxo-2-propan-2-yl-2,4-dih ydro-1H-quinoxaline-6-carboxamide
  • MW: 303.399 | Formula: C17H25N3O2
  • H donors: 3 H acceptors: 2 LogP: 3.22 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CCNC(=O)c1ccc2c(c1)NC(=O)C(N2)C(C)C)C
  • InChi: 1S/C17H25N3O2/c1-10(2)7-8-18-16(21)12-5-6-13-14(9-12)20-17(22)15(19-13)11(3)4/h5-6,9-11,15,19H,7-8H2,1-4H3,(H,18,21)(H,20,22)
  • InChiKey: SQWYGHOODAPNTO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-isopentyl-2-isopropyl-3-oxo-2,4-dihydro-1H-quinoxaline-6-carboxamide
  • N-isoamyl-2-isopropyl-3-keto-2,4-dihydro-1H-quinoxaline-6-carboxamide
  • C209-0221
  • NCGC00105635-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0312 0.0629
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.1431 0.2182
Loa Loa (eye worm) hypothetical protein 0.0032 0.0312 0.0646
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0948 0.2145
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0214 0.1498
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1392 0.3279
Brugia malayi hypothetical protein 0.0023 0.0169 0.0343
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.262 0.4008
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0609 0.128
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1392 0.3279
Schistosoma mansoni nuclear receptor 0.002 0.0134 0.0205
Schistosoma mansoni DNA helicase recq1 0.0021 0.0153 0.0234
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0153 0.1691
Loa Loa (eye worm) hypothetical protein 0.0043 0.0463 0.0958
Echinococcus multilocularis thyroid hormone receptor alpha 0.0195 0.2682 0.4097
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0312 0.0423
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.056 0.113
Echinococcus multilocularis caspase 8 0.0045 0.05 0.0757
Brugia malayi nuclear hormone receptor 0.0043 0.0463 0.0951
Onchocerca volvulus 0.0043 0.0463 0.0844
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0389 0.0587
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0109
Schistosoma mansoni lamin 0.003 0.0284 0.0434
Brugia malayi hypothetical protein 0.0037 0.0376 0.0771
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0463 0.0844
Schistosoma mansoni ap endonuclease 0.0018 0.0107 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.05 0.1003
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0106 0.1392 0.2123
Echinococcus granulosus dnaJ subfamily B 0.0459 0.6536 1
Brugia malayi nuclear receptor NHR-88 0.0043 0.0463 0.0951
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0463 0.0951
Trypanosoma brucei glucosidase, putative 0.0076 0.0948 0.1735
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0463 0.0958
Schistosoma mansoni inositol monophosphatase 0.0038 0.0389 0.0595
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.056 0.113
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0377 0.0569
Loa Loa (eye worm) hypothetical protein 0.0043 0.0463 0.0958
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0463 0.0951
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.262 0.5422
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.0253 0.0301
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0153 0.031
Brugia malayi serine/threonine-protein kinase plk-2 0.0106 0.1392 0.2878
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1392 0.3279
Echinococcus multilocularis pyruvate kinase 0.0025 0.0213 0.0317
Brugia malayi RNA binding protein 0.0068 0.0839 0.1731
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0253 0.0373
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.1431 0.1338
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0119 0.1584 0.2417
Loa Loa (eye worm) hypothetical protein 0.0109 0.1431 0.2964
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.4953 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.05 0.1003
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0545 0.1122
Echinococcus granulosus tumor protein p63 0.0336 0.474 0.725
Brugia malayi Cytochrome P450 family protein 0.0024 0.0197 0.0401
Brugia malayi Glycosyl hydrolases family 31 protein 0.0342 0.4828 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0839 0.1738
Loa Loa (eye worm) hypothetical protein 0.0109 0.1431 0.2964
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0153 0.107
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0839 0.1284
Loa Loa (eye worm) hypothetical protein 0.0237 0.3293 0.682
Loa Loa (eye worm) RecQ helicase 0.0021 0.0153 0.0317
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0377 0.0569
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0153 0.11
Schistosoma mansoni kinase 0.0054 0.0629 0.0963
Schistosoma mansoni hypothetical protein 0.0459 0.6536 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0153 0.0226
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0751 0.5247
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0317
Trichomonas vaginalis esterase, putative 0.0109 0.1431 0.3378
Echinococcus granulosus pyruvate kinase 0.0032 0.0312 0.0469
Brugia malayi CXXC zinc finger family protein 0.0032 0.0311 0.0637
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0463 0.0951
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0569 0.1171
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0134 0.0197
Brugia malayi beta-lactamase family protein 0.0109 0.1431 0.2958
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0463 0.0958
Loa Loa (eye worm) beta-lactamase 0.0109 0.1431 0.2964
Loa Loa (eye worm) hypothetical protein 0.0109 0.1431 0.2964
Onchocerca volvulus Cell death protein 3 homolog 0.0087 0.1114 0.2519
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0006 0.0012
Trypanosoma brucei Metacaspase-4 0.0045 0.05 0.0812
Echinococcus granulosus lamin 0.003 0.0284 0.0426
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0134 0.0205
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0214 0.1498
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0463 0.07
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0071 0.01
Brugia malayi hypothetical protein 0.002 0.0134 0.027
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0389 0.0786
Schistosoma mansoni intermediate filament proteins 0.003 0.0284 0.0434
Loa Loa (eye worm) hypothetical protein 0.0087 0.1114 0.2308
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0377 0.0577
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0322 0.0651
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0463 0.07
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.1431 0.3378
Brugia malayi Inositol-1 0.0038 0.0389 0.0799
Leishmania major metacaspase, putative 0.0045 0.05 0.0812
Loa Loa (eye worm) intermediate filament protein 0.003 0.0284 0.0588
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.0524
Echinococcus multilocularis geminin 0.0184 0.2527 0.3861
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0312 0.0423
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.1431 0.2189
Plasmodium vivax hypothetical protein, conserved 0.0109 0.1431 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0463 0.07
Loa Loa (eye worm) hypothetical protein 0.0043 0.0463 0.0958
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.1431 0.2889
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.05 0.1003
Onchocerca volvulus 0.0109 0.1431 0.3332
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0948 0.1913
Brugia malayi Nuclear hormone receptor E75 0.002 0.0134 0.027
Echinococcus multilocularis lamin 0.003 0.0284 0.0426
Trypanosoma brucei metacaspase MCA2 0.0045 0.05 0.0812
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.1431 0.2189
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0134 0.027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0463 0.07
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0134 0.0197
Entamoeba histolytica hypothetical protein 0.0037 0.0376 0.2698
Brugia malayi beta-lactamase 0.0109 0.1431 0.2958
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0463 0.0958
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.1431 0.1338
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0134 0.0205
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0312 0.0646
Brugia malayi intermediate filament protein 0.003 0.0284 0.058
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1431 0.3378
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0214 0.0222
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0463 0.07
Trypanosoma brucei metacaspase MCA3 0.0045 0.05 0.0812
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0948 0.2145
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.1431 0.1338
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0351
Schistosoma mansoni alpha-glucosidase 0.0294 0.4134 0.6324
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0153 0.0226
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0312 0.0522
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0839 0.1284
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0463 0.0708
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.206 0.3145
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0076 0.0948 0.6622
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.05 0.1003
Leishmania major mitochondrial DNA polymerase beta 0.035 0.4953 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0253 0.0373
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0463 0.0958
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0134 0.0197
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.1431 0.2958
Schistosoma mansoni nuclear hormone receptor 0.002 0.0134 0.0205
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.056 0.0934
Trypanosoma cruzi metacaspase, putative 0.0045 0.05 0.101
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0096
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0312 0.0456
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0107 0.0216
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0857 0.1312
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0376 0.0566
Onchocerca volvulus 0.0109 0.1431 0.3332
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.05 0.1003
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0169 0.1216
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0463 0.07
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.226 0.4443
Giardia lamblia Kinase, PLK 0.0106 0.1392 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.05 0.3496
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0109
Schistosoma mansoni thyroid hormone receptor 0.0195 0.2682 0.4102
Entamoeba histolytica hypothetical protein 0.0037 0.0376 0.2698
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0278
Onchocerca volvulus 0.0109 0.1431 0.3332
Echinococcus granulosus pyruvate kinase 0.0017 0.0083 0.0118
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0045 0.05 0.0765
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0169 0.0343
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0463 0.0844
Onchocerca volvulus 0.0032 0.0311 0.0454
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0106 0.1392 0.2883
Leishmania major alpha glucosidase II subunit, putative 0.0076 0.0948 0.1735
Echinococcus granulosus caspase 8 0.0045 0.05 0.0757
Brugia malayi nuclear receptor NHR-88 0.002 0.0134 0.027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0351
Schistosoma mansoni cpg binding protein 0.0034 0.0338 0.0517
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.0455 0.0688
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0134 0.027
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0278
Mycobacterium ulcerans lipase LipD 0.0109 0.1431 0.5457
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.1431 0.2889
Loa Loa (eye worm) hypothetical protein 0.0037 0.0377 0.0781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.262 0.4008
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0334 0.0691
Schistosoma mansoni nuclear hormone receptor 0.002 0.0134 0.0205
Trichomonas vaginalis rotamase, putative 0.0033 0.0322 0.0549
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0389 0.0582
Chlamydia trachomatis pyruvate kinase 0.0032 0.0312 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0377 0.0569
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1392 0.3279
Schistosoma mansoni ap endonuclease 0.0018 0.0107 0.0164
Brugia malayi ecdysone receptor 0.002 0.0134 0.027
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0153 0.031
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0389 0.072
Mycobacterium tuberculosis Conserved hypothetical protein 0.0184 0.2533 0.2453
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.056 0.113
Plasmodium falciparum metacaspase-like protein 0.0045 0.05 1
Echinococcus granulosus GPCR family 2 0.0016 0.0071 0.01
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0134 0.0197
Echinococcus granulosus pyruvate kinase 0.0017 0.0083 0.0118
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0332 0.0227
Loa Loa (eye worm) hypothetical protein 0.0043 0.0463 0.0958
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0107 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0463 0.0951
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0463 0.0958
Leishmania major hypothetical protein, conserved 0.0109 0.1431 0.2732
Schistosoma mansoni lamin 0.003 0.0284 0.0434
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0389 0.2795
Schistosoma mansoni hypothetical protein 0.0034 0.0338 0.0518
Brugia malayi steroid hormone receptor 0.0043 0.0463 0.0951
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0376 0.0575
Loa Loa (eye worm) hypothetical protein 0.0109 0.1431 0.2964
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0839 0.1284
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0463 0.0951
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.1392 0.213
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.0253 0.0305
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0008 0.0004
Brugia malayi conserved hypotetical protein 0.002 0.0134 0.027
Schistosoma mansoni alpha-glucosidase 0.0294 0.4134 0.6324
Brugia malayi TAR-binding protein 0.0068 0.0839 0.1731
Echinococcus granulosus geminin 0.0184 0.2527 0.3861
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0311 0.0644
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0083 0.0577
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0076 0.0948 0.2145
Leishmania major hypothetical protein, conserved 0.0026 0.0214 0.0222
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0253 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0334 0.0579
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.05 0.1003
Schistosoma mansoni zinc finger protein 0.002 0.0134 0.0205
Trichomonas vaginalis set domain proteins, putative 0.0287 0.4026 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0342 0.4828 0.7385
Onchocerca volvulus 0.0048 0.0545 0.1055
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0463 0.0708
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0463 0.0951
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0214 0.3156
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0169 0.0351
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.05 0.1003
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0134 0.0205
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0342 0.4828 1
Echinococcus granulosus lamin dm0 0.003 0.0284 0.0426
Echinococcus multilocularis pyruvate kinase 0.0032 0.0312 0.0469
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.1431 0.2182
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0322 0.0444
Echinococcus multilocularis pyruvate kinase 0.0017 0.0083 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0609 0.128
Schistosoma mansoni caspase-7 (C14 family) 0.0119 0.1584 0.2424
Mycobacterium ulcerans beta-lactamase 0.0109 0.1431 0.5457
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0463 0.0708
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0134 0.0197
Loa Loa (eye worm) hypothetical protein 0.0026 0.0214 0.0444
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0134 0.0197
Schistosoma mansoni caspase-7 (C14 family) 0.0087 0.1114 0.1705
Loa Loa (eye worm) hypothetical protein 0.0109 0.1431 0.2964
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0253 0.0373
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0463 0.0951
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1392 0.3279
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.05 0.3496
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0071 0.014
Trypanosoma cruzi metacaspase, putative 0.0045 0.05 0.101
Echinococcus multilocularis pyruvate kinase 0.0017 0.0083 0.0118
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.1431 0.1338
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.1392 0.2811
Loa Loa (eye worm) hypothetical protein 0.0034 0.0338 0.0701
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.1431 0.5457
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0322 0.2314
Onchocerca volvulus 0.0287 0.4026 1
Brugia malayi hypothetical protein 0.0017 0.0082 0.0162
Schistosoma mansoni hypothetical protein 0.0152 0.206 0.3151
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0312 0.2179
Brugia malayi beta-lactamase family protein 0.0109 0.1431 0.2958
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.05 0.1003
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1431 0.3378
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0153 0.0118
Echinococcus multilocularis dnaJ subfamily B 0.0459 0.6536 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0253 0.0511
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0253 0.0517
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0312 0.0522
Loa Loa (eye worm) hypothetical protein 0.0011 0.00000000012878 0.00000000026672
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0278
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0169 0.0259
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0322 0.0444
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0278
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0463 0.0708
Echinococcus multilocularis musashi 0.003 0.0284 0.0426
Loa Loa (eye worm) hypothetical protein 0.0109 0.1431 0.2964
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.05 0.1003
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0134 0.0278
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.3293 0.5034
Onchocerca volvulus Serine\/threonine kinase homolog 0.0106 0.1392 0.3232
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0389 0.0582
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0055 0.0075
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0134 0.0197
Giardia lamblia Pyruvate kinase 0.0032 0.0312 0.175
Echinococcus granulosus intermediate filament protein 0.003 0.0284 0.0426
Trypanosoma cruzi metacaspase, putative 0.0045 0.05 0.101
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0107 0.0585
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0312 0.0629
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0278
Schistosoma mansoni rotamase 0.0034 0.0334 0.0511
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0107 0.0748
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0463 0.0951
Mycobacterium leprae Probable lipase LipE 0.0109 0.1431 1
Brugia malayi Nuclear hormone receptor E75 0.002 0.0134 0.027
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0134 0.0278
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0134 0.0197
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0717 0.1447
Schistosoma mansoni hypothetical protein 0.0042 0.0455 0.0696
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0214 0.3156
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0463 0.0951
Brugia malayi hypothetical protein 0.0026 0.0214 0.0436
Loa Loa (eye worm) hypothetical protein 0.0049 0.0558 0.1155
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0169 0.0251
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0389 0.0587
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0134 0.0197
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.3519 0.7289
Leishmania major pyruvate kinase 0.0032 0.0312 0.0423
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0463 0.07
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0107 0.0155
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0351
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0153 0.0317
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0948 0.2145
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0169 0.0259
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.1392 0.2811
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0463 0.0951
Plasmodium vivax hypothetical protein, conserved 0.0045 0.05 0.3496
Brugia malayi Pre-SET motif family protein 0.0252 0.3519 0.7286
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.05 0.1003
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0153 0.031
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0197 0.0409
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0096
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0312 0.0646
Loa Loa (eye worm) hypothetical protein 0.003 0.0284 0.0588
Loa Loa (eye worm) hypothetical protein 0.008 0.1007 0.2085
Toxoplasma gondii exonuclease III APE 0.0018 0.0107 0.0748
Schistosoma mansoni nuclear receptor 0.002 0.0134 0.0205
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0153 0.0118
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0076 0.0948 0.6806
Schistosoma mansoni coup transcription factor 0.0043 0.0463 0.0708
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0253 0.0373
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0463 0.07
Brugia malayi hypothetical protein 0.0023 0.0169 0.0343
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0389 0.072
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.1431 0.3378
Trypanosoma brucei polo-like protein kinase 0.0106 0.1392 0.2652
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.05 0.1003
Trypanosoma cruzi metacaspase, putative 0.0045 0.05 0.101
Brugia malayi Glycosyl hydrolases family 31 protein 0.0076 0.0948 0.1956
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0312 0.0207
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0389 0.1163
Loa Loa (eye worm) inositol-1 0.0038 0.0389 0.0806
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0147
Schistosoma mansoni thyroid hormone receptor 0.0195 0.2682 0.4102
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0113
Loa Loa (eye worm) hypothetical protein 0.0045 0.05 0.1036
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0312 0.0456
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.05 0.3496
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0253 0.1817
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.1007 0.7231
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0569 0.1171
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.1431 0.5457
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0312 0.2179
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0214 0.0433
Brugia malayi nuclear receptor RXR 0.0023 0.0169 0.0343
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0569 0.1178
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0839 0.1731
Schistosoma mansoni hypothetical protein 0.0048 0.0545 0.0834
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.1007 0.7231
Entamoeba histolytica serine/threonine protein kinase, putative 0.0106 0.1392 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0071 0.01
Onchocerca volvulus 0.0037 0.0377 0.0625
Loa Loa (eye worm) hypothetical protein 0.0042 0.0455 0.0942
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.262 0.5425
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0463 0.0951
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0463 0.0708
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0338 0.0693
Entamoeba histolytica hypothetical protein 0.0037 0.0376 0.2698
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.1431 0.2964
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0106 0.1392 0.2652
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0463 0.0958
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.262 0.4002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.262 0.4002
Echinococcus multilocularis caspase 2 0.0087 0.1114 0.1698
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0134 0.0197
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0169 0.0251
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0119 0.1584 0.2417
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0463 0.0708
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0312 0.0638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.262 0.4002
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0278
Schistosoma mansoni pyruvate kinase 0.0032 0.0312 0.0477
Trypanosoma brucei mitochondrial DNA polymerase beta 0.035 0.4953 1
Schistosoma mansoni hypothetical protein 0.0011 0.0008 0.0013
Brugia malayi nuclear receptor RXR 0.002 0.0134 0.027
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0153 0.0118
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0253 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0463 0.0951
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0377 0.0577
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1431 0.3378
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0134 0.0278
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0284 0.058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.262 0.4008
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0312 0.0844
Schistosoma mansoni hypothetical protein 0.0184 0.2527 0.3866
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0463 0.0708
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0948 0.1913
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0351
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0153 0.1691
Toxoplasma gondii hypothetical protein 0.0056 0.0665 0.4649
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0463 0.07
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0153 0.0226
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0312 0.0456
Loa Loa (eye worm) RNA binding protein 0.0068 0.0839 0.1738
Brugia malayi nuclear receptor NHR-67 0.002 0.0134 0.027
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0076 0.0948 0.6806
Loa Loa (eye worm) hypothetical protein 0.005 0.0569 0.1178
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0278
Brugia malayi tailless protein 0.002 0.0134 0.027
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0312 0.0638
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0839 0.1284
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0083 0.0577
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0558 0.0854
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0463 0.07
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0312 0.0646
Schistosoma mansoni alpha glucosidase 0.0076 0.0948 0.145
Entamoeba histolytica hypothetical protein 0.0037 0.0376 0.2698
Leishmania major pyruvate kinase 0.0032 0.0312 0.0423
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0278
Brugia malayi hypothetical protein 0.0237 0.3293 0.6817
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0153 0.0095
Echinococcus granulosus caspase 0.0119 0.1584 0.2417
Echinococcus granulosus bloom syndrome protein 0.0021 0.0153 0.0226
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0107 0.0155
Brugia malayi nuclear hormone receptor 0.002 0.0134 0.027
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0153 0.0095
Echinococcus multilocularis lysosomal alpha glucosidase 0.0342 0.4828 0.7385
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0571
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.1431 0.1338
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0153 0.0226
Echinococcus granulosus pyruvate kinase 0.0032 0.0312 0.0469
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0463 0.07
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0071 0.0147
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0348 0.0524
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0055 0.0075
Echinococcus granulosus cpg binding protein 0.0034 0.0338 0.0509
Schistosoma mansoni caspase-3 (C14 family) 0.0119 0.1584 0.2424
Loa Loa (eye worm) hypothetical protein 0.0043 0.0463 0.0958
Schistosoma mansoni cpg binding protein 0.0034 0.0338 0.0517
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0134 0.0197
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0278
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0839 0.1738
Echinococcus granulosus neutral alpha glucosidase AB 0.0076 0.0948 0.1442
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0948 0.2145
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0214 0.0433
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0334 0.0684
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0463 0.07
Schistosoma mansoni cpg binding protein 0.0032 0.0311 0.0476
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0071 0.01
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0389 0.072
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0377 0.2636
Brugia malayi ecdysteroid receptor 0.0043 0.0463 0.0951
Mycobacterium tuberculosis Conserved protein 0.0109 0.1431 0.1338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0463 0.0958
Schistosoma mansoni inositol monophosphatase 0.0038 0.0389 0.0595
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0463 0.07
Echinococcus granulosus caspase 2 0.0087 0.1114 0.1698
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0106 0.1392 0.2123
Onchocerca volvulus 0.003 0.0284 0.0384
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.206 0.3145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0463 0.0958
Loa Loa (eye worm) DR-78 0.002 0.0134 0.0278
Loa Loa (eye worm) hypothetical protein 0.0043 0.0463 0.0958
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0071 0.01
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0078 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0839 0.1284
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0389 0.0786
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.262 0.4002
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.05 0.1003
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.05 0.1003
Loa Loa (eye worm) hypothetical protein 0.0043 0.0463 0.0958
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0839 0.1276
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0351
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0376 0.0566
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0107 0.0768
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0278
Plasmodium vivax metacaspase 1, putative 0.0045 0.05 0.3496
Echinococcus multilocularis caspase 0.0119 0.1584 0.2417
Echinococcus multilocularis expressed protein 0.0034 0.0334 0.0503
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0076 0.0948 0.1962
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0332 0.0178
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0107 0.0214
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1392 0.3279
Onchocerca volvulus 0.0198 0.2726 0.6658
Plasmodium falciparum metacaspase 1 0.0045 0.05 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0253 0.0511
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0463 0.07
Mycobacterium leprae conserved hypothetical protein 0.0109 0.1431 1
Echinococcus multilocularis cpg binding protein 0.0034 0.0338 0.0509
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0107 0.0222
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0463 0.0708
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0078 0.0162
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0463 0.0951
Schistosoma mansoni pyruvate kinase 0.0017 0.0083 0.0126
Brugia malayi Cell death protein 3 precursor 0.0087 0.1114 0.2302
Echinococcus multilocularis GPCR, family 2 0.0016 0.0071 0.01
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0153 0.0539
Toxoplasma gondii ABC1 family protein 0.0109 0.1431 1
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0463 0.0708
Plasmodium falciparum pyruvate kinase 0.0032 0.0312 0.5487
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.05 0.101
Brugia malayi hypothetical protein 0.0042 0.0455 0.0935
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0107 0.0216
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0134 0.027
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.4953 1
Schistosoma mansoni hypothetical protein 0.0184 0.2527 0.3866
Echinococcus granulosus tar DNA binding protein 0.0068 0.0839 0.1276
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.05 0.1003
Echinococcus multilocularis neutral alpha glucosidase AB 0.0076 0.0948 0.1442
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0389 0.272
Onchocerca volvulus 0.0049 0.0558 0.1089
Onchocerca volvulus 0.003 0.0284 0.0384
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0389 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0153 0.0226
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0134 0.027
Echinococcus multilocularis caspase 3 0.0074 0.0925 0.1408
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0948 0.2145
Brugia malayi Pre-SET motif family protein 0.0037 0.0377 0.0774
Mycobacterium tuberculosis Conserved protein 0.0109 0.1431 0.1338
Trichomonas vaginalis rotamase, putative 0.0034 0.0334 0.0579
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0278
Echinococcus granulosus lysosomal alpha glucosidase 0.0342 0.4828 0.7385
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0166 0.226 0.4443
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0463 0.0951
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0463 0.0844
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.05 0.101
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0463 0.07
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0045 0.05 0.1029
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.226 0.4563
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0322 0.0651
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.1431 0.1338
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.1431 0.1338
Mycobacterium ulcerans hypothetical protein 0.0109 0.1431 0.5457
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0253 0.0373
Brugia malayi hypothetical protein 0.002 0.0134 0.027
Schistosoma mansoni DNA helicase recq5 0.0021 0.0153 0.0234
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0278
Leishmania major glycosyl hydrolase-like protein 0.0028 0.0253 0.0301
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0008 0.0004
Echinococcus granulosus expressed protein 0.0034 0.0334 0.0503
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0463 0.07
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0253 0.0373
Schistosoma mansoni hypothetical protein 0.0037 0.0376 0.0575
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.1431 0.2732
Trichomonas vaginalis sucrase-isomaltase, putative 0.0076 0.0948 0.2145
Echinococcus multilocularis pyruvate kinase 0.0017 0.0083 0.0118
Schistosoma mansoni pyruvate kinase 0.0032 0.0312 0.0477
Onchocerca volvulus 0.0042 0.0455 0.0824
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0463 0.0951
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0107 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0545 0.0834
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0153 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.05 0.1003
Trichomonas vaginalis maltase-glucoamylase, putative 0.0076 0.0948 0.2145
Echinococcus multilocularis lamin dm0 0.003 0.0284 0.0426
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0109
Mycobacterium tuberculosis Conserved protein 0.0109 0.1431 0.1338
Trypanosoma brucei metacaspase 0.0045 0.05 0.0812
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0322 0.2252
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0351
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0071 0.014
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.0455 0.0688
Plasmodium vivax SET domain protein, putative 0.0037 0.0377 0.2636
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0169 0.0351
Mycobacterium ulcerans hypothetical protein 0.0184 0.2533 1
Echinococcus multilocularis tumor protein p63 0.0336 0.474 0.725
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0076 0.0948 0.2145
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0284 0.0588
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1392 0.3279
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0169 0.0343
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0153 0.107
Echinococcus granulosus pyruvate kinase 0.0017 0.0083 0.0118
Loa Loa (eye worm) hypothetical protein 0.0043 0.0463 0.0958
Trypanosoma brucei metacaspase 5, putative 0.0045 0.05 0.0812
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0463 0.07
Echinococcus granulosus caspase 3 0.0074 0.0925 0.1408
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0463 0.0708
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0377 0.0577
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.3293 0.5034
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0134 0.0197
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0463 0.0951
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0377 0.0577
Echinococcus multilocularis pyruvate kinase 0.0032 0.0312 0.0469

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0028 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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