TDR Targets

Basic information

Technical information

TDR Targets ID: 786399
Name: N-ethyl-N-(4-fluorophenyl)-4-methyl-2,6-dioxo -3H-pyrimidine-5-sulfonamide
MW: 327.331 | Formula: C13H14FN3O4S
H donors: 2 H acceptors: 6 LogP: 2.28 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCN(S(=O)(=O)c1c(C)nc(nc1O)O)c1ccc(cc1)F
InChi: 1S/C13H14FN3O4S/c1-3-17(10-6-4-9(14)5-7-10)22(20,21)11-8(2)15-13(19)16-12(11)18/h4-7H,3H2,1-2H3,(H2,15,16,18,19)
InChiKey: VQLIIKZMSZOLLJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-ethyl-N-(4-fluorophenyl)-2,4-diketo-6-methyl-1H-pyrimidine-5-sulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.007	0.0371	0.0997
Echinococcus granulosus	lipoxygenase domain containing protein	0.004	0.0185	0.0204
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0188	0.1126	0.1126
Brugia malayi	photoreceptor-specific nuclear receptor	0.0148	0.0866	0.2081
Mycobacterium tuberculosis	Probable dehydrogenase	0.0093	0.0517	0.1738
Schistosoma mansoni	thyroid hormone receptor	0.1585	1	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.0671	0.1805
Schistosoma mansoni	nuclear receptor	0.007	0.0371	0.0353
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0392	1
Brugia malayi	nuclear receptor NHR-67	0.007	0.0371	0.0891
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0392	0.1055
Schistosoma mansoni	nuclear hormone receptor	0.007	0.0371	0.0353
Brugia malayi	hypothetical protein	0.007	0.0371	0.0891
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.007	0.0371	0.0891
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.007	0.0371	0.0409
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0392	0.0375
Schistosoma mansoni	hypothetical protein	0.0178	0.1058	0.1042
Schistosoma mansoni	nuclear receptor	0.007	0.0371	0.0353
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0466	0.2891	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0148	0.0866	0.2329
Onchocerca volvulus		0.0073	0.0392	0.3048
Echinococcus granulosus	thioredoxin glutathione reductase	0.0041	0.019	0.021
Echinococcus granulosus	transient receptor potential cation channel	0.0319	0.1957	0.216
Brugia malayi	Nuclear hormone receptor-like 1	0.0597	0.3719	0.8938
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0148	0.0866	0.2081
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0093	0.0517	0.1738
Echinococcus granulosus	GPCR family 2	0.0017	0.0034	0.0038
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0148	0.0866	0.0956
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.007	0.0371	0.2733
Brugia malayi	MH2 domain containing protein	0.0117	0.0671	0.1614
Brugia malayi	nuclear hormone receptor family member nhr-6	0.007	0.0371	0.0891
Onchocerca volvulus	Protein ultraspiracle homolog	0.0148	0.0866	1
Schistosoma mansoni	hypothetical protein	0.1437	0.9063	0.9061
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0424	0.114
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0392	1
Brugia malayi	mbt repeat family protein	0.0048	0.0232	0.0559
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0018	0.5
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0073	0.0392	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.007	0.0371	0.0371
Trypanosoma brucei	trypanothione reductase	0.0041	0.0187	0.4506
Schistosoma mansoni	hypothetical protein	0.004	0.0185	0.0167
Brugia malayi	nuclear hormone receptor	0.007	0.0371	0.0891
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0048	0.0232	0.0215
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0148	0.0866	0.0866
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0148	0.0866	0.0866
Plasmodium vivax	hypothetical protein, conserved	0.0073	0.0392	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.007	0.0371	0.0371
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0078	0.0424	0.0468
Brugia malayi	hypothetical protein	0.007	0.0371	0.0891
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.007	0.0371	0.0371
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.1437	0.9063	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0148	0.0866	0.0956
Echinococcus granulosus	RUN	0.004	0.0185	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0274	0.0738
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0148	0.0866	0.2081
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0054	0.0274	0.066
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0034	0.0034
Brugia malayi	beta-lactamase family protein	0.0073	0.0392	0.0943
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.0392	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0371	0.0997
Brugia malayi	hypothetical protein	0.0078	0.0424	0.1019
Loa Loa (eye worm)	hypothetical protein	0.007	0.0371	0.0997
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0148	0.0866	0.0956
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.007	0.0371	0.0353
Echinococcus granulosus	ankyrin repeat protein	0.0308	0.1888	0.2083
Brugia malayi	Nuclear hormone receptor-like 1	0.0597	0.3719	0.8938
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0018	0.5
Brugia malayi	nuclear hormone receptor family member odr-7	0.007	0.0371	0.0891
Brugia malayi	conserved hypotetical protein	0.007	0.0371	0.0891
Leishmania major	trypanothione reductase	0.0041	0.0187	0.4506
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0256	0.0689
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0073	0.0392	0.0943
Echinococcus granulosus	FTZ F1 alpha	0.0148	0.0866	0.0956
Schistosoma mansoni	polycystin 1-related	0.004	0.0185	0.0167
Mycobacterium tuberculosis	Probable hydrolase	0.0073	0.0392	0.1303
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0014	0.0018	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0078	0.0424	0.0406
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0093	0.0517	0.1738
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.0392	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0148	0.0866	0.0866
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0148	0.0866	0.2329
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0174	0.1032	0.1032
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0148	0.0866	0.0956
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0078	0.0424	0.0406
Brugia malayi	beta-lactamase family protein	0.0073	0.0392	0.0943
Echinococcus granulosus	geminin	0.0178	0.1058	0.1168
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0232	0.0215
Echinococcus granulosus	SAM and MBT domain containing protein	0.0048	0.0232	0.0256
Loa Loa (eye worm)	beta-lactamase	0.0073	0.0392	0.1055
Brugia malayi	nuclear receptor NHR-88	0.0148	0.0866	0.2081
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0103	0.0583	0.1966
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	0.0308	0.1888	0.1873
Brugia malayi	nuclear receptor RXR	0.0078	0.0424	0.1019
Plasmodium falciparum	glutathione reductase	0.0041	0.0187	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0073	0.0392	0.1303
Brugia malayi	beta-lactamase	0.0073	0.0392	0.0943
Onchocerca volvulus		0.007	0.0371	0.2733
Echinococcus granulosus	beta LACTamase domain containing family member	0.0073	0.0392	0.0433
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0093	0.0517	0.1738
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0093	0.0517	0.6554
Brugia malayi	steroid hormone receptor	0.0148	0.0866	0.2081
Loa Loa (eye worm)	hypothetical protein	0.007	0.0371	0.0997
Brugia malayi	Nuclear hormone receptor E75	0.007	0.0371	0.0891
Loa Loa (eye worm)	hypothetical protein	0.007	0.0371	0.0997
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0148	0.0866	0.0849
Loa Loa (eye worm)	mbt repeat family protein	0.0048	0.0232	0.0625
Onchocerca volvulus		0.0073	0.0392	0.3048
Loa Loa (eye worm)	nuclear receptor NHR-67	0.007	0.0371	0.0997
Echinococcus granulosus	thyroid hormone receptor alpha	0.007	0.0371	0.0409
Onchocerca volvulus		0.0148	0.0866	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.004	0.0185	0.0185
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0073	0.0392	0.1303
Echinococcus granulosus	Nuclear hormone receptor HR96	0.007	0.0371	0.0409
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0157	0.0376
Echinococcus multilocularis	RUN	0.004	0.0185	0.0185
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0048	0.0232	0.0701
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0041	0.0187	0.0587
Schistosoma mansoni	lipoxygenase	0.0101	0.0571	0.0554
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0392	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0148	0.0866	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0866	0.2329
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0148	0.0866	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0424	0.114
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0148	0.0866	0.0956
Schistosoma mansoni	hypothetical protein	0.0178	0.1058	0.1042
Mycobacterium ulcerans	lipase LipD	0.0073	0.0392	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0148	0.0866	0.0849
Treponema pallidum	NADH oxidase	0.0014	0.0018	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0392	1
Mycobacterium ulcerans	beta-lactamase	0.0073	0.0392	1
Loa Loa (eye worm)	hypothetical protein	0.0588	0.3666	0.9857
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.007	0.0371	0.0371
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0148	0.0866	0.0849
Schistosoma mansoni	coup transcription factor	0.0148	0.0866	0.0849
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0392	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0497
Brugia malayi	nuclear receptor RXR	0.007	0.0371	0.0891
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0148	0.0866	0.0956
Loa Loa (eye worm)	nuclear hormone receptor	0.007	0.0371	0.0997
Loa Loa (eye worm)	hypothetical protein	0.007	0.0371	0.0997
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0392	0.0375
Loa Loa (eye worm)	MBCTL1	0.0054	0.0274	0.0738
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.1437	0.9063	0.9063
Toxoplasma gondii	ABC1 family protein	0.0073	0.0392	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0148	0.0866	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0392	0.1055
Schistosoma mansoni	hypothetical protein	0.0017	0.0034	0.0016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0148	0.0866	0.2329
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0034	0.0092
Loa Loa (eye worm)	doublecortin family protein	0.004	0.0185	0.0497
Onchocerca volvulus		0.0073	0.0392	0.3048
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0148	0.0866	0.2081
Brugia malayi	mbt repeat family protein	0.0048	0.0232	0.0559
Loa Loa (eye worm)	hypothetical protein	0.007	0.0371	0.0997
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0866	0.2329
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0073	0.0392	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0262	0.0705
Loa Loa (eye worm)	hypothetical protein	0.007	0.0371	0.0997
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0103	0.0583	1
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0188	0.1126	0.1242
Echinococcus granulosus	Nuclear hormone receptor HR96	0.007	0.0371	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0866	0.2329
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0392	0.1055
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0054	0.0274	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0157	0.0421
Schistosoma mansoni	lipoxygenase	0.0174	0.1032	0.1016
Mycobacterium tuberculosis	Probable reductase	0.0093	0.0517	0.1738
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0014	0.0018	0.0018
Brugia malayi	Nuclear hormone receptor E75	0.007	0.0371	0.0891
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.007	0.0371	0.0371
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0148	0.0866	0.0866
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0392	0.1303
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0148	0.0866	1
Mycobacterium ulcerans	hypothetical protein	0.0073	0.0392	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0054	0.0274	0.0274
Loa Loa (eye worm)	hypothetical protein	0.007	0.0371	0.0997
Schistosoma mansoni	loxhd1	0.004	0.0185	0.0167
Plasmodium falciparum	LCCL domain-containing protein	0.004	0.0185	0.9878
Schistosoma mansoni	nuclear hormone receptor	0.0148	0.0866	0.0849
Schistosoma mansoni	hypothetical protein	0.0291	0.1775	0.176
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0034	0.0082
Echinococcus multilocularis	polycomb protein SCMH1	0.0048	0.0232	0.0232
Trypanosoma brucei	hypothetical protein, conserved	0.0073	0.0392	1
Brugia malayi	orphan nuclear receptor NR2E1	0.007	0.0371	0.0891
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0073	0.0392	0.1303
Brugia malayi	tailless protein	0.007	0.0371	0.0891
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0014	0.0018	0.002
Schistosoma mansoni	thyroid hormone receptor	0.1585	1	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.004	0.0185	0.0185
Schistosoma mansoni	cellular tumor antigen P53	0.0052	0.0256	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0424	0.114
Brugia malayi	Thioredoxin reductase	0.0041	0.0187	0.0449
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0034	0.0038
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0034	0.0038
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0148	0.0866	0.2329
Schistosoma mansoni	hypothetical protein	0.0017	0.0034	0.0016
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0392	0.1303
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0054	0.0274	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0866	0.2329
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0148	0.0866	0.2081
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0034	0.0034
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0148	0.0866	0.2081
Mycobacterium tuberculosis	Probable esterase LipL	0.0073	0.0392	0.1303
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0073	0.0392	0.1303
Schistosoma mansoni	hypothetical protein	0.0017	0.0034	0.0016
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0054	0.0274	0.0303
Schistosoma mansoni	hypothetical protein	0.0036	0.0157	0.0139
Onchocerca volvulus		0.007	0.0371	0.2733
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0262	0.0705
Plasmodium falciparum	thioredoxin reductase	0.0041	0.0187	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0262	0.063
Schistosoma mansoni	hypothetical protein	0.0017	0.0034	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0424	0.114
Brugia malayi	hypothetical protein	0.0078	0.0424	0.1019
Brugia malayi	ecdysone receptor	0.007	0.0371	0.0891
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0148	0.0866	0.2329
Echinococcus multilocularis	tumor protein p63	0.0352	0.2167	0.2167
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0866	0.2329
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0148	0.0866	0.0849
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0148	0.0866	0.2081
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0148	0.0866	0.0956
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0148	0.0866	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0034	0.0092
Loa Loa (eye worm)	hypothetical protein	0.004	0.0185	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0232	0.0625
Plasmodium vivax	multidomain scavenger receptor, putative	0.004	0.0185	0.4451
Schistosoma mansoni	nuclear receptor nhr-48	0.007	0.0371	0.0353
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.007	0.0371	0.0997
Echinococcus multilocularis	ankyrin repeat protein	0.0308	0.1888	0.1888
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0148	0.0866	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0392	0.1055
Brugia malayi	nuclear hormone receptor	0.0148	0.0866	0.2081
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0148	0.0866	0.2081
Plasmodium vivax	thioredoxin reductase, putative	0.0041	0.0187	0.4506
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0148	0.0866	0.0866
Brugia malayi	Nuclear hormone receptor-like 1	0.0666	0.4161	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0262	0.063
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0148	0.0866	0.0849
Echinococcus granulosus	nuclear receptor nhr 48	0.007	0.0371	0.0409
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0093	0.0517	0.1738
Schistosoma mansoni	retinoic acid receptor RXR	0.0148	0.0866	0.0849
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0148	0.0866	0.2081
Loa Loa (eye worm)	hypothetical protein	0.007	0.0371	0.0997
Brugia malayi	hypothetical protein	0.004	0.0185	0.0444
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0034	0.0082
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0048	0.0232	0.0232
Loa Loa (eye worm)	steroid hormone receptor	0.0148	0.0866	0.2329
Schistosoma mansoni	nuclear hormone receptor	0.007	0.0371	0.0353
Echinococcus granulosus	lipoxygenase domain containing protein	0.004	0.0185	0.0204
Onchocerca volvulus		0.0052	0.0256	0.1052
Echinococcus multilocularis	transient receptor potential cation channel	0.0319	0.1959	0.1959
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0148	0.0866	0.0849
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0148	0.0866	0.0866
Trichomonas vaginalis	esterase, putative	0.0073	0.0392	1
Echinococcus granulosus	Polycystic kidney disease protein	0.004	0.0185	0.0204
Brugia malayi	Steroid receptor seven-up type 2	0.0148	0.0866	0.2081
Schistosoma mansoni	zinc finger protein	0.007	0.0371	0.0353
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0014	0.0018	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0424	0.114
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0148	0.0866	0.0866
Toxoplasma gondii	thioredoxin reductase	0.0041	0.0187	0.4506
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.007	0.0371	0.0353
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0392	0.1303
Loa Loa (eye worm)	thioredoxin reductase	0.0041	0.0187	0.0502
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0813	0.5092	0.5092
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0073	0.0392	0.0392
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0041	0.019	0.019
Schistosoma mansoni	rab6-interacting	0.004	0.0185	0.0167
Echinococcus granulosus	polycomb protein SCMH1	0.0048	0.0232	0.0256
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0232	0.0215
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0014	0.0018	0.5
Brugia malayi	nuclear receptor NHR-88	0.007	0.0371	0.0891
Loa Loa (eye worm)	glutathione reductase	0.0041	0.0187	0.0502
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0148	0.0866	0.2329
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0078	0.0424	0.0424
Plasmodium vivax	glutathione reductase, putative	0.0041	0.0187	0.4506
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0392	0.1055
Echinococcus granulosus	tumor protein p63	0.0352	0.2167	0.2391
Schistosoma mansoni	rab6-interacting	0.004	0.0185	0.0167
Echinococcus multilocularis	FTZ F1 alpha	0.0148	0.0866	0.0866
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0148	0.0866	0.0956
Mycobacterium tuberculosis	Probable lipase LipD	0.0073	0.0392	0.1303
Trypanosoma cruzi	trypanothione reductase, putative	0.0041	0.0187	0.4506
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0866	0.2329
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0174	0.1032	0.1139
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.007	0.0371	0.0409
Leishmania major	hypothetical protein, conserved	0.0073	0.0392	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.0671	0.1805
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.007	0.0371	0.0371
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0148	0.0866	0.0849
Brugia malayi	glutathione reductase	0.0041	0.0187	0.0449
Mycobacterium tuberculosis	Probable oxidoreductase	0.0103	0.0583	0.1966
Brugia malayi	Doublecortin family protein	0.004	0.0185	0.0444
Loa Loa (eye worm)	hypothetical protein	0.007	0.0371	0.0997
Echinococcus granulosus	histone acetyltransferase MYST2	0.0054	0.0274	0.0303
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0148	0.0866	0.2329
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0392	0.1055
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0103	0.0583	0.1966
Echinococcus multilocularis	Polycystic kidney disease protein	0.004	0.0185	0.0185
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0034	0.0034
Onchocerca volvulus		0.0048	0.0232	0.0701
Brugia malayi	hypothetical protein	0.004	0.0185	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0866	0.2329
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0597	0.3719	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.007	0.0371	0.2733
Mycobacterium ulcerans	esterase/lipase LipP	0.0073	0.0392	1
Onchocerca volvulus	Bile acid receptor homolog	0.0148	0.0866	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0148	0.0866	0.0849
Loa Loa (eye worm)	hypothetical protein	0.007	0.0371	0.0997
Brugia malayi	ecdysteroid receptor	0.0148	0.0866	0.2081
Echinococcus multilocularis	geminin	0.0178	0.1058	0.1058
Loa Loa (eye worm)	DR-78	0.007	0.0371	0.0997
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0866	0.2329

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 786399