Detailed information for compound 786465

Basic information

Technical information
  • TDR Targets ID: 786465
  • Name: 2-[(3-bromophenyl)amino]-3-piperidin-1-ylnaph thalene-1,4-dione
  • MW: 411.292 | Formula: C21H19BrN2O2
  • H donors: 1 H acceptors: 2 LogP: 5.07 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cccc(c1)NC1=C(N2CCCCC2)C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C21H19BrN2O2/c22-14-7-6-8-15(13-14)23-18-19(24-11-4-1-5-12-24)21(26)17-10-3-2-9-16(17)20(18)25/h2-3,6-10,13,23H,1,4-5,11-12H2
  • InChiKey: NGSWPHJNQRQXNI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(3-bromophenyl)amino]-3-(1-piperidyl)naphthalene-1,4-dione
  • 2-[(3-bromophenyl)amino]-3-piperidino-1,4-naphthoquinone
  • 2-[(3-bromophenyl)amino]-3-piperidin-1-yl-naphthalene-1,4-dione
  • BIM-0022503.P001
  • CBMicro_022684
  • ZINC04008037

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0048 0.0712 0.1669
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0365 0.0856
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0416 0.9226 0.9226
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0365 0.0395
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0712 0.0712
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0365 0.0365
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0269 0.4274
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0365 0.0365
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0001 0.0002
Plasmodium falciparum thioredoxin reductase 0.0041 0.0543 1
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0476 0.1115
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.085 0.0922
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0104 0.2004 1
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0365 0.0395
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0269 0.4617
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0365 0.0856
Loa Loa (eye worm) hypothetical protein 0.0029 0.0269 0.063
Loa Loa (eye worm) hypothetical protein 0.0062 0.1025 0.2403
Brugia malayi hypothetical protein 0.0029 0.0269 0.063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0365 0.0856
Schistosoma mansoni coup transcription factor 0.0033 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0033 0.0365 0.0856
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0365 0.0856
Trichomonas vaginalis chromobox protein, putative 0.0069 0.1189 0.2369
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0543 0.1272
Onchocerca volvulus 0.0054 0.085 0.1206
Loa Loa (eye worm) glutathione reductase 0.0041 0.0543 0.1272
Loa Loa (eye worm) hypothetical protein 0.0033 0.0365 0.0856
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.085 0.1994
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0058 0.0135
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.054 0.0585
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0064 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0365 0.0856
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0034 0.0034
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0064 0.0597
Schistosoma mansoni chromobox protein 0.0069 0.1189 0.1189
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0416 0.9226 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0104 0.2004 1
Brugia malayi Pre-SET motif family protein 0.0202 0.4265 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0062 0.1025 0.1025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0365 0.0856
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.1189 0.2788
Onchocerca volvulus 0.0033 0.0365 0.0155
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0136 0.0319
Trichomonas vaginalis chromobox protein, putative 0.0069 0.1189 0.2369
Brugia malayi PHD-finger family protein 0.0028 0.0249 0.0584
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0365 0.0395
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0365 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0225 0.0393
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0365 0.0856
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0487 0.0929
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0365 0.0856
Toxoplasma gondii thioredoxin reductase 0.0041 0.0543 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0064 0.0151
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0885 0.2075
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.085 0.085
Echinococcus multilocularis zinc finger protein 0.0022 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0334 0.7341 0.7341
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0041 0.0041
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0543 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0044 0.0604 0.1417
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0365 0.0856
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0225 0.0393
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0269 0.4274
Brugia malayi hypothetical protein 0.0164 0.3391 0.7953
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0365 0.0365
Schistosoma mansoni bromodomain containing protein 0.0072 0.1262 0.1262
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.4265 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0365 0.0395
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0365 0.0365
Brugia malayi hypothetical protein 0.0019 0.0029 0.0067
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0555 0.1069
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0186 0.0186
Mycobacterium tuberculosis Probable dehydrogenase 0.0094 0.1761 0.8771
Schistosoma mansoni hypothetical protein 0.0023 0.0136 0.0136
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0094 0.1761 0.8771
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0365 0.0155
Echinococcus granulosus dna polymerase kappa 0.0019 0.0034 0.0037
Schistosoma mansoni chromobox protein 0.0069 0.1189 0.1189
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0001 0.0002
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0034 0.008
Mycobacterium tuberculosis Probable oxidoreductase 0.0104 0.2004 1
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0001 0.0002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0064 1
Schistosoma mansoni thyroid hormone receptor 0.0449 1 1
Brugia malayi steroid hormone receptor 0.0033 0.0365 0.0856
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0365 0.0856
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0365 0.0365
Echinococcus granulosus GPCR family 2 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0365 0.0856
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0365 0.0365
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0365 0.0856
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0062 0.1025 0.1111
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0365 0.0365
Echinococcus multilocularis dna polymerase eta 0.0019 0.0034 0.0034
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0262 0.0262
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0064 0.5
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0186 0.0186
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0094 0.1761 0.8771
Loa Loa (eye worm) hypothetical protein 0.0033 0.0365 0.0856
Echinococcus granulosus chromobox protein 1 0.0069 0.1189 0.1289
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0365 0.0365
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.1167 0.1265
Leishmania major hypothetical protein, conserved 0.0029 0.0269 0.4617
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0034 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0365 0.0856
Loa Loa (eye worm) hypothetical protein 0.0033 0.0365 0.0856
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0046 0.0667 0.1563
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0064 0.0064
Brugia malayi mbt repeat family protein 0.0054 0.085 0.1994
Loa Loa (eye worm) hypothetical protein 0.0033 0.0365 0.0856
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0365 0.0856
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0365 0.0856
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0365 0.0856
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0365 0.0856
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0365 0.0395
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0186 0.0202
Echinococcus granulosus dna polymerase eta 0.0019 0.0034 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0365 0.0856
Echinococcus multilocularis chromobox protein 1 0.0069 0.1189 0.1189
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0269 0.4617
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0365 0.0365
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0269 0.4274
Loa Loa (eye worm) hypothetical protein 0.0081 0.1458 0.3419
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0487 0.0419
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0034 0.0034
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0262 0.4125
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0034 0.008
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0712 0.0771
Brugia malayi glutathione reductase 0.0041 0.0543 0.1272
Brugia malayi Bromodomain containing protein 0.0044 0.0602 0.1412
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0218 0.4648 0.5038
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0269 0.4274
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0712 0.0712
Schistosoma mansoni ap endonuclease 0.002 0.0064 0.0064
Echinococcus granulosus chromobox protein 1 0.0069 0.1189 0.1289
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.085 0.085
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0164 0.3391 0.7953
Schistosoma mansoni zinc finger protein 0.0022 0.0108 0.0108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0365 0.0856
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0365 0.0856
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0001 0.0001
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0094 0.1761 0.8771
Plasmodium falciparum glutathione reductase 0.0041 0.0543 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0365 0.0856
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0064 0.0151
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0064 0.0597
Echinococcus multilocularis histone acetyltransferase MYST2 0.0062 0.1025 0.1025
Brugia malayi ecdysteroid receptor 0.0033 0.0365 0.0856
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0056 0.0885 0.2075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.008
Schistosoma mansoni ap endonuclease 0.002 0.0064 0.0064
Mycobacterium tuberculosis Probable reductase 0.0094 0.1761 0.8771
Brugia malayi Bromodomain containing protein 0.0085 0.1571 0.3684
Schistosoma mansoni DNA polymerase eta 0.0019 0.0034 0.0034
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0365 0.0395
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0555 0.0566
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0543 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0365 0.0856
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0104 0.2004 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0064 0.007
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0034 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0365 0.0856
Onchocerca volvulus 0.0164 0.3391 0.671
Brugia malayi Pre-SET motif family protein 0.0029 0.0262 0.0614
Brugia malayi chromobox protein homolog 3 0.0039 0.0487 0.1142
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0269 0.4617
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0365 0.0365
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0064 0.0597
Schistosoma mansoni myelin transcription factor 1 myt1 0.0062 0.1025 0.1025
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0049 0.0717 0.1681
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0365 0.0395
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0543 0.2583
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0064 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0885 0.2075
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0365 0.0395
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0064 0.0597
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0041 0.0045
Schistosoma mansoni thyroid hormone receptor 0.0449 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.085 0.1994
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0094 0.1761 0.8771
Onchocerca volvulus 0.0229 0.491 1
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.085 0.085
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.085 0.0922
Loa Loa (eye worm) hypothetical protein 0.003 0.0293 0.0688
Echinococcus granulosus zinc finger protein 0.0022 0.0108 0.0117
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.085 0.085
Plasmodium vivax glutathione reductase, putative 0.0041 0.0543 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0476 0.1115
Loa Loa (eye worm) hypothetical protein 0.0033 0.0365 0.0856
Echinococcus multilocularis chromobox protein 1 0.0069 0.1189 0.1189
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0041 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0523 0.0523
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0555 0.1069
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.1167 0.1167
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0365 0.0155
Brugia malayi nuclear hormone receptor 0.0033 0.0365 0.0856
Echinococcus multilocularis GPCR, family 2 0.0018 0.0001 0.0001
Leishmania major trypanothione reductase 0.0041 0.0543 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0365 0.0365
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.085 0.1206
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0001 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0365 0.0365
Brugia malayi nuclear receptor NHR-88 0.0033 0.0365 0.0856
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0555 0.0555
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0064 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0487 0.0929
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0365 0.0856
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0365 0.0365
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0064 0.0154
Schistosoma mansoni hypothetical protein 0.0038 0.0476 0.0476
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0365 0.0856
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0262 0.0262
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0365 0.0365
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0237 0.0257
Plasmodium vivax SET domain protein, putative 0.0029 0.0262 0.4125
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0885 0.2075
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0064 0.0062
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0365 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0365 0.0856
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0365 0.0365
Brugia malayi Heterochromatin protein 1 0.0069 0.1189 0.2788
Brugia malayi Thioredoxin reductase 0.0041 0.0543 0.1272
Trichomonas vaginalis set domain proteins, putative 0.0229 0.491 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0034 0.0037
Trypanosoma brucei trypanothione reductase 0.0041 0.0543 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0064 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0218 0.4648 0.4648
Loa Loa (eye worm) MBCTL1 0.0062 0.1025 0.2403
Schistosoma mansoni hypothetical protein 0.0416 0.9226 0.9226
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0034 0.0034
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0062 0.1025 0.2403
Brugia malayi mbt repeat family protein 0.0054 0.085 0.1994
Onchocerca volvulus 0.004 0.0523 0.0497
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0001 0.0001
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0041 0.0041
Echinococcus granulosus histone acetyltransferase MYST2 0.0062 0.1025 0.1111
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0039 0.0487 0.1142
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.054 0.054
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0555 0.0602

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 0.456 uM ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
EC50 (functional) = 0.46 uM Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
EC50 (functional) 1.149 uM ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
EC50 (functional) = 1.15 uM Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
Percent growth inhibition (functional) = 87.6 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye Saint Jude. 20485428
Percent growth inhibition (functional) = 111.4 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye Saint Jude. 20485428

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 20485428

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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