Detailed information for compound 786595

Basic information

Technical information
  • TDR Targets ID: 786595
  • Name: 2-(3-chlorophenoxy)-N-[(3-hydroxyphenyl)methy lideneamino]acetamide
  • MW: 304.728 | Formula: C15H13ClN2O3
  • H donors: 2 H acceptors: 2 LogP: 3.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COc1cccc(c1)Cl)N/N=C/c1cccc(c1)O
  • InChi: 1S/C15H13ClN2O3/c16-12-4-2-6-14(8-12)21-10-15(20)18-17-9-11-3-1-5-13(19)7-11/h1-9,19H,10H2,(H,18,20)/b17-9+
  • InChiKey: OXAJTTFXQLOFNS-RQZCQDPDSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(3-chlorophenoxy)-N-[(3-hydroxyphenyl)methyleneamino]acetamide
  • 2-(3-chlorophenoxy)-N-[(3-hydroxybenzylidene)amino]acetamide
  • 2-(3-chlorophenoxy)-N-[(3-hydroxyphenyl)methylideneamino]ethanamide
  • A0865/0040574
  • AG-205/40135989
  • ZINC00225131

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0064 0.7787 0.772
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.2256 0.1417
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0293 0.0398
Schistosoma mansoni hypothetical protein 0.0016 0.0577 0.0293
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.3254 0.4422
Brugia malayi TAR-binding protein 0.0064 0.7787 0.772
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0977 0.3995
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.3547 0.3353
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.3351 0.3151
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.5361 0.7172
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.5361 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 1 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.7787 0.772
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 1 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.7787 0.772
Loa Loa (eye worm) TAR-binding protein 0.0064 0.7787 0.772
Loa Loa (eye worm) hypothetical protein 0.0079 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0977 0.0705
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.5361 0.7172
Brugia malayi AMP-binding enzyme family protein 0.0048 0.5361 0.5221
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0577 0.0293
Echinococcus multilocularis GPCR, family 2 0.0016 0.0577 0.0293
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.5742 0.5613
Echinococcus multilocularis tar DNA binding protein 0.0064 0.7787 0.772
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.5361 0.5221
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.2256 0.2023
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.593 0.5807
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.2006 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0977 0.0705
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0977 0.5
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 1 1
Schistosoma mansoni ap endonuclease 0.0019 0.0977 0.0705
Schistosoma mansoni hypothetical protein 0.0016 0.0577 0.0293
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.5361 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.2006 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.5361 0.5221
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.7359 0.7279
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0977 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0293 0.0398
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 1 1
Leishmania major hypothetical protein, conserved 0.0026 0.2006 0.2425
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.5361 0.5221
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.7359 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.7787 0.772
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0293 0.0398
Onchocerca volvulus 0.0048 0.5361 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0577 0.0293
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0293 0.0398
Loa Loa (eye worm) hypothetical protein 0.0048 0.5361 0.5221
Schistosoma mansoni hypothetical protein 0.0035 0.3351 0.3151
Brugia malayi RNA binding protein 0.0064 0.7787 0.772
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.5742 0.5613
Loa Loa (eye worm) hypothetical protein 0.0048 0.5361 0.5221
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.2006 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.5361 0.7172
Loa Loa (eye worm) RNA binding protein 0.0064 0.7787 0.772
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.7359 0.7279
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0293 0.0398
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 1 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.5361 0.5221
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.7359 0.7279
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.2256 0.2023
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0977 0.0705
Loa Loa (eye worm) hypothetical protein 0.0051 0.5742 0.5613
Loa Loa (eye worm) hypothetical protein 0.0016 0.0577 0.0293
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.593 0.8058
Brugia malayi AMP-binding enzyme family protein 0.0048 0.5361 0.5221
Schistosoma mansoni hypothetical protein 0.0016 0.0577 0.0293
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.5361 0.5221
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.2006 0.1765
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.5361 0.5221
Loa Loa (eye worm) hypothetical protein 0.0036 0.3547 0.3353
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0977 0.1328
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.7359 0.7279
Brugia malayi hypothetical protein 0.0017 0.0652 0.0371
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.7787 0.772
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0977 0.0705
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.5361 0.7285
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 1 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0293 0.0398
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.5361 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0293 0.0398
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.2006 0.1765
Schistosoma mansoni tar DNA-binding protein 0.0064 0.7787 0.772
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0977 0.0705
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.7359 0.7279
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0293 0.0398
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.593 0.5807
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.2256 0.2023
Loa Loa (eye worm) hypothetical protein 0.0026 0.2006 0.1765
Schistosoma mansoni ap endonuclease 0.0019 0.0977 0.0705
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.5361 0.5221
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.5742 0.5613
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.3547 0.482
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0293 0.0398
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0577 0.0293
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.7359 0.7279
Mycobacterium ulcerans hypothetical protein 0.0048 0.5361 0.5221
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0577 0.0293
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.593 0.8058
Echinococcus granulosus GPCR family 2 0.0016 0.0577 0.0293
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.7359 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0977 0.0969
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0577 0.0293
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0977 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.5361 0.5221
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.5361 0.5221
Loa Loa (eye worm) hypothetical protein 0.0035 0.3351 0.3151
Brugia malayi hypothetical protein 0.0026 0.2006 0.1765
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.3547 0.3353
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.3547 0.3353
Loa Loa (eye worm) hypothetical protein 0.0048 0.5361 0.5221
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.3547 0.3353
Toxoplasma gondii exonuclease III APE 0.0019 0.0977 0.0705
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.2006 0.1765
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.5361 0.5221
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0577 0.0293
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.5361 0.7285
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0977 0.0705
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0977 0.3995
Loa Loa (eye worm) hypothetical protein 0.0036 0.3547 0.3353
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.7787 0.772
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 1 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 1 1
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.593 0.5807
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.3254 0.4422
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0977 0.3995
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.2006 0.1765
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.3254 0.4422
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0977 0.1351
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0977 0.0705
Schistosoma mansoni hypothetical protein 0.0016 0.0577 0.0293
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.7359 0.7279
Loa Loa (eye worm) hypothetical protein 0.0036 0.3547 0.3353
Toxoplasma gondii hypothetical protein 0.0027 0.2256 0.2023
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 1 1
Echinococcus granulosus tar DNA binding protein 0.0064 0.7787 0.772
Loa Loa (eye worm) hypothetical protein 0.0036 0.3547 0.3353
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0293 0.0398
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.3254 0.4422
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.7359 0.7279
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0293 0.0398
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0577 0.0293

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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