Detailed information for compound 786664

Basic information

Technical information
  • TDR Targets ID: 786664
  • Name: (2-methoxyphenyl)-[4-(4-nitrophenyl)piperazin -1-yl]methanone
  • MW: 341.361 | Formula: C18H19N3O4
  • H donors: 0 H acceptors: 3 LogP: 2.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C(=O)N1CCN(CC1)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C18H19N3O4/c1-25-17-5-3-2-4-16(17)18(22)20-12-10-19(11-13-20)14-6-8-15(9-7-14)21(23)24/h2-9H,10-13H2,1H3
  • InChiKey: XMFFZHHWNRXFDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2-methoxyphenyl)-[4-(4-nitrophenyl)-1-piperazinyl]methanone
  • ZINC04359316
  • A0859/0040244
  • Oprea1_806745

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.054 0.1522
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.018 0.0639
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0113 0.051
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.009 0.005
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0151 0.1291
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0135 0.0135
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0151 0.0151
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0553 0.0794
Toxoplasma gondii ABC1 family protein 0.0037 0.0277 0.0277
Trichomonas vaginalis hypothetical protein 0.0978 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0277 0.0635
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.009 0.009
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.1338 0.1921
Mycobacterium tuberculosis Possible oxidoreductase 0.0066 0.0579 0.0311
Brugia malayi jmjC domain containing protein 0.0019 0.0088 0.0147
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.129 0.6556
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0579 0.0311
Brugia malayi RNA binding protein 0.0064 0.0553 0.2627
Schistosoma mansoni jumonji domain containing protein 0.0151 0.1452 0.2085
Echinococcus granulosus tumor protein p63 0.0335 0.3358 0.4819
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0151 0.1291
Schistosoma mansoni hypothetical protein 0.0019 0.009 0.0129
Loa Loa (eye worm) hypothetical protein 0.0058 0.0493 0.1364
Trichomonas vaginalis ran, putative 0.0021 0.0113 0.0113
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.1013 0.1453
Loa Loa (eye worm) retinol dehydrogenase 12 0.0066 0.0579 0.1652
Plasmodium falciparum phd finger protein, putative 0.0058 0.0493 0.0493
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0108 0.0108
Schistosoma mansoni cpg binding protein 0.0029 0.0189 0.0271
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0066 0.0579 0.0311
Brugia malayi jmjC domain containing protein 0.0072 0.0636 0.307
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0191 0.0233
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0978 1 1
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0066 0.0579 0.0311
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0277 0.0635
Echinococcus granulosus geminin 0.0165 0.1602 0.23
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.1935 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0493 0.0708
Schistosoma mansoni hypothetical protein 0.0165 0.1602 0.23
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.0579 0.1652
Loa Loa (eye worm) hypothetical protein 0.0049 0.0401 0.1055
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0579 0.0311
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.054 0.0775
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0978 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0066 0.0579 0.1652
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0065
Schistosoma mansoni hypothetical protein 0.0135 0.129 0.1851
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0088 0.0088
Entamoeba histolytica hypothetical protein 0.0108 0.1013 1
Trichomonas vaginalis esterase, putative 0.0037 0.0277 0.0277
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0105 0.0127
Schistosoma mansoni hypothetical protein 0.0063 0.054 0.0775
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.0579 0.0311
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0636 0.1844
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.0579 0.0311
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0493 0.1364
Entamoeba histolytica Ran family GTPase 0.0021 0.0113 0.1114
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0401 0.0576
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.0579 0.0311
Leishmania major importin beta-1 subunit, putative 0.0023 0.0135 0.0962
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0066 0.0579 0.0579
Brugia malayi PHD-finger family protein 0.0021 0.0107 0.0249
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0636 0.0913
Echinococcus multilocularis GPCR, family 2 0.0063 0.054 0.0658
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.019 0.1855 0.2261
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.0579 0.0311
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0105 0.015
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0066 0.0579 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0277 0.0277
Schistosoma mansoni hypothetical protein 0.0406 0.4087 0.5866
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0113 0.0281
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0277 0.0337
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0088 0.0088
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0553 0.1564
Entamoeba histolytica hypothetical protein 0.0108 0.1013 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.0579 0.2766
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0135 0.0135
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.1013 0.1453
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.009 0.009
Echinococcus multilocularis cpg binding protein 0.003 0.0206 0.0251
Plasmodium vivax JmjC domain containing protein 0.0019 0.0088 0.0088
Trypanosoma brucei pteridine reductase 1 0.0066 0.0579 1
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0978 1 1
Schistosoma mansoni ran 0.0021 0.0113 0.0162
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0135 0.0962
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0088 0.0126
Plasmodium vivax importin-beta 2, putative 0.0029 0.0191 0.0191
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0066 0.0579 0.0311
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.3061 1
Loa Loa (eye worm) beta-lactamase 0.0037 0.0277 0.0635
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0277 0.0277
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0066 0.0579 1
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.0014
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0553 0.1564
Brugia malayi Importin beta-1 subunit 0.0029 0.0191 0.0698
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0088 0.0126
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0331 0.0331
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0277 0.3847
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0066 0.0579 0.0311
Schistosoma mansoni hypothetical protein 0.0063 0.054 0.0775
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.138 0.7038
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0113 0.051
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0088 0.0107
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.019 0.1855 0.2663
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0088 0.0126
Onchocerca volvulus 0.0049 0.0401 0.545
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.1288 0.157
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0553 0.0794
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.0579 0.2766
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0088 0.0088
Brugia malayi beta-lactamase family protein 0.0037 0.0277 0.1154
Echinococcus granulosus cpg binding protein 0.003 0.0206 0.0295
Entamoeba histolytica hypothetical protein 0.0108 0.1013 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0277 0.0277
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0519 0.0745
Brugia malayi PHD-finger family protein 0.0058 0.0493 0.2309
Loa Loa (eye worm) hypothetical protein 0.0063 0.054 0.1522
Brugia malayi CXXC zinc finger family protein 0.0029 0.0189 0.0686
Echinococcus granulosus snurportin 1 0.0307 0.3061 0.4393
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.0579 0.0311
Leishmania major GTP-binding protein, putative 0.0021 0.0113 0.051
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0579 0.0311
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0553 0.2627
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0295 0.5981
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0728 0.1044
Loa Loa (eye worm) hypothetical protein 0.0025 0.0151 0.0213
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.0579 0.0311
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0579 0.0311
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0108 0.0108
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0295 0.2913
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0088 0.0107
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0066 0.0579 1
Schistosoma mansoni hypothetical protein 0.0307 0.3061 0.4393
Schistosoma mansoni hypothetical protein 0.0058 0.0493 0.0708
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0579 0.0311
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0088 0.0126
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0151 0.1291
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0113 0.0138
Schistosoma mansoni hypothetical protein 0.0125 0.1185 0.1701
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0636 0.0913
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.0579 0.0311
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0066 0.0579 0.0831
Schistosoma mansoni hypothetical protein 0.0165 0.1602 0.23
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0579 0.0311
Onchocerca volvulus 0.0037 0.0277 0.2252
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0579 0.0311
Entamoeba histolytica hypothetical protein 0.0108 0.1013 1
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.4087 0.498
Brugia malayi hypothetical protein 0.0025 0.0151 0.0485
Plasmodium falciparum importin beta, putative 0.0029 0.0191 0.0191
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0088 0.0126
Loa Loa (eye worm) hypothetical protein 0.0029 0.0191 0.0348
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0189 0.034
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0088 0.0107
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0489 0.0489
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0066 0.0579 0.0311
Brugia malayi Bromodomain containing protein 0.0061 0.053 0.2503
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0066 0.0579 0.0705
Brugia malayi RNA, U transporter 1 0.0082 0.0738 0.3614
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0088 0.0126
Loa Loa (eye worm) acetyltransferase 0.0144 0.138 0.4347
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0088 0.0126
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.0579 0.0311
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0277 0.0277
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0277 0.0277
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0277 0.3847
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0277 0.0277
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0579 0.0311
Schistosoma mansoni thyroid hormone receptor 0.0135 0.1288 0.1849
Schistosoma mansoni importin beta-1 0.0029 0.0191 0.0274
Echinococcus granulosus peregrin 0.0061 0.053 0.076
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0493 0.0493
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0066 0.0579 0.0579
Onchocerca volvulus 0.0066 0.0579 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0066 0.0579 0.0311
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0553 0.0794
Entamoeba histolytica hypothetical protein 0.0023 0.0135 0.1334
Echinococcus granulosus GPCR family 2 0.0063 0.054 0.0775
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0066 0.0579 0.0311
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0331 0.0476
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0066 0.0579 0.0831
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0066 0.0579 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0066 0.0579 0.0311
Echinococcus multilocularis snurportin 1 0.0307 0.3061 0.373
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.1935 0.6215
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0151 0.0151
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0135 0.129 0.4043
Leishmania major oxidoreductase-like protein 0.0066 0.0579 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.1013 0.1234
Brugia malayi jmjC domain containing protein 0.019 0.1855 0.9573
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0066 0.0579 0.0311
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0579 0.0311
Echinococcus multilocularis peregrin 0.0061 0.053 0.0645
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0066 0.0579 1
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0088 0.0126
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.138 0.1981
Brugia malayi jmjC domain containing protein 0.0019 0.0088 0.0147
Brugia malayi Latrophilin receptor protein 2 0.0063 0.054 0.256
Schistosoma mansoni cpg binding protein 0.003 0.0206 0.0295
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0331 0.0331
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0493 0.0601
Schistosoma mansoni hypothetical protein 0.0063 0.054 0.0775
Loa Loa (eye worm) oxidoreductase 0.0066 0.0579 0.1652
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0978 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.054 0.0658
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.0619 0.0755
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0113 0.2288
Loa Loa (eye worm) hypothetical protein 0.0037 0.0277 0.0635
Loa Loa (eye worm) jmjC domain-containing protein 0.012 0.1131 0.3508
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.0636 0.0913
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.001 0.0012
Echinococcus granulosus tar DNA binding protein 0.0064 0.0553 0.0794
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0553 0.0674
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0295 0.0295
Schistosoma mansoni microtubule-associated protein tau 0.0685 0.6968 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.138 0.1682
Trypanosoma brucei oxidoreductase-like protein 0.0066 0.0579 1
Brugia malayi hypothetical protein 0.0108 0.1013 0.5079
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.1935 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0066 0.0579 0.0579
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0579 0.0311
Schistosoma mansoni thyroid hormone receptor 0.0135 0.1288 0.1849
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.1185 0.1444
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0066 0.0579 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0066 0.0579 0.0311
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0113 0.0084
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0163 0.0234
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0135 0.0135
Brugia malayi TAR-binding protein 0.0064 0.0553 0.2627
Brugia malayi beta-lactamase family protein 0.0037 0.0277 0.1154
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0113 0.0113
Brugia malayi AF-10 protein 0.0019 0.009 0.016
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0066 0.0579 0.0311
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0978 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.0579 0.0311
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0277 0.1154
Leishmania major pteridine reductase 1 0.0066 0.0579 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0493 0.0708
Schistosoma mansoni dihydropteridine reductase 0.0066 0.0579 0.0831
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0066 0.0579 1
Echinococcus granulosus phd:f box containing protein 0.0019 0.0088 0.0126
Schistosoma mansoni hypothetical protein 0.0108 0.1013 0.1453
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0066 0.0579 0.0579
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0728 0.0887
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0066 0.0579 0.0311
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0113 0.051
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0805 0.8206 1
Echinococcus granulosus dnaJ subfamily B 0.0406 0.4087 0.5866
Loa Loa (eye worm) hypothetical protein 0.0198 0.1935 0.6215
Echinococcus multilocularis microtubule associated protein 2 0.0685 0.6968 0.8491
Loa Loa (eye worm) hypothetical protein 0.0037 0.0277 0.0635
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0277 0.0397
Brugia malayi beta-lactamase 0.0037 0.0277 0.1154
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0277 0.0397
Loa Loa (eye worm) RNA binding protein 0.0064 0.0553 0.1564
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0066 0.0579 0.0311
Onchocerca volvulus 0.0037 0.0277 0.2252
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.0579 0.0311
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0277 0.0397
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0553 0.0794
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0277 0.3847
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0493 0.0493
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.2336 0.2118
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0113 0.0113
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.0579 0.0311
Mycobacterium ulcerans short chain dehydrogenase 0.0066 0.0579 0.0311
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0978 1 1
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0066 0.0579 0.0311
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0066 0.0579 0.0579
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0191 0.2105
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0553 0.0794
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0088 0.0107
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0113 0.0162
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.054 0.0658
Loa Loa (eye worm) hypothetical protein 0.0099 0.0921 0.2802
Echinococcus multilocularis tumor protein p63 0.0335 0.3358 0.4092
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0579 0.0311
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0331 0.0331
Onchocerca volvulus 0.0037 0.0277 0.2252
Leishmania major hypothetical protein, conserved 0.0037 0.0277 0.3847
Loa Loa (eye worm) hypothetical protein 0.0037 0.0277 0.0635
Leishmania major hypothetical protein, conserved 0.0025 0.0151 0.1291
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.001 0.0014
Echinococcus granulosus microtubule associated protein 2 0.0685 0.6968 1
Schistosoma mansoni hypothetical protein 0.0063 0.054 0.0775
Onchocerca volvulus 0.0066 0.0579 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0331 0.0331
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0066 0.0579 0.0311
Schistosoma mansoni ran 0.0021 0.0113 0.0162
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.1185 0.1701
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0191 0.2105
Brugia malayi jmjC domain containing protein 0.0019 0.0088 0.0147
Mycobacterium ulcerans oxidoreductase 0.0066 0.0579 0.0311
Schistosoma mansoni cpg binding protein 0.003 0.0206 0.0295
Loa Loa (eye worm) hypothetical protein 0.0037 0.0277 0.0635
Onchocerca volvulus Alhambra homolog 0.0058 0.0493 0.7804
Mycobacterium tuberculosis Possible oxidoreductase 0.0066 0.0579 0.0311
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0493 0.0493
Plasmodium falciparum enoyl-acyl carrier reductase 0.0978 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0151 0.0151
Brugia malayi jmjC domain containing protein 0.0019 0.0088 0.0147
Loa Loa (eye worm) hypothetical protein 0.0037 0.0277 0.0635
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.054 0.256
Echinococcus multilocularis geminin 0.0165 0.1602 0.1953
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.0579 0.5717
Echinococcus granulosus importin subunit beta 1 0.0029 0.0191 0.0274
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0113 0.0113
Giardia lamblia PHD finger protein 15 0.0058 0.0493 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.009 0.005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.054 0.0775

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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