TDR Targets

Basic information

Technical information

TDR Targets ID: 787017
Name: N-(2,2-dimethoxyethyl)quinoline-8-sulfonamide
MW: 296.342 | Formula: C13H16N2O4S
H donors: 1 H acceptors: 3 LogP: 1.02 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COC(CNS(=O)(=O)c1cccc2c1nccc2)OC
InChi: 1S/C13H16N2O4S/c1-18-12(19-2)9-15-20(16,17)11-7-3-5-10-6-4-8-14-13(10)11/h3-8,12,15H,9H2,1-2H3
InChiKey: HJXIJOBOKXQYJA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,2-dimethoxyethyl)-8-quinolinesulfonamide
ChemDiv3_008163

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0014	0.0092	0.0774
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0084	0.3002	0.3775
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0014	0.0092	0.0774
Plasmodium falciparum	glutathione reductase	0.004	0.1186	1
Toxoplasma gondii	thioredoxin reductase	0.004	0.1186	0.4877
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0833	0.0962
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.1749	0.215
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0833	0.0962
Mycobacterium tuberculosis	Probable oxidoreductase	0.0102	0.3759	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0092	0.3332	0.8837
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0014	0.0092	0.5
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0222	0.8727	1
Plasmodium vivax	glutathione reductase, putative	0.004	0.1186	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0151	0.0076
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0014	0.0092	0.0774
Trichomonas vaginalis	set domain proteins, putative	0.0252	1	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0151	0.0076
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0014	0.0092	0.0378
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0151	0.0076
Schistosoma mansoni	hypothetical protein	0.0084	0.3002	0.3775
Schistosoma mansoni	hypothetical protein	0.0015	0.0151	0.0076
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0833	0.0962
Schistosoma mansoni	transcription factor LCR-F1	0.0084	0.3002	0.3775
Brugia malayi	Thioredoxin reductase	0.004	0.1186	0.1268
Brugia malayi	Pre-SET motif family protein	0.0222	0.8727	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0092	0.0774
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0833	0.0962
Toxoplasma gondii	aldehyde dehydrogenase	0.007	0.2433	1
Brugia malayi	hypothetical protein	0.0084	0.3002	0.337
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.1749	0.215
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0014	0.0092	0.0774
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0092	0.3332	0.8837
Trypanosoma cruzi	trypanothione reductase, putative	0.004	0.1186	1
Mycobacterium tuberculosis	Probable reductase	0.0092	0.3332	0.8837
Trichomonas vaginalis	rotamase, putative	0.0039	0.1118	0.1036
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0102	0.3759	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0092	0.0774
Echinococcus multilocularis	expressed protein	0.0039	0.1118	0.1332
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.1532	0.1668
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0151	0.0068
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0092	0.0774
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0039	0.1118	0.1189
Schistosoma mansoni	aldehyde dehydrogenase	0.007	0.2433	0.3037
Treponema pallidum	NADH oxidase	0.0014	0.0092	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0893	0.0865
Trypanosoma cruzi	trypanothione reductase, putative	0.0014	0.0092	0.0774
Toxoplasma gondii	peptidylprolyl isomerase	0.0038	0.108	0.4442
Plasmodium vivax	thioredoxin reductase, putative	0.004	0.1186	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0038	0.108	0.9107
Entamoeba histolytica	hypothetical protein	0.0084	0.3002	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0151	0.0076
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.2433	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0893	0.1039
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.007	0.2433	0.3037
Trypanosoma brucei	trypanothione reductase	0.004	0.1186	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0092	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1532	0.1611
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0092	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0092	0.3332	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0833	0.0796
Leishmania major	trypanothione reductase	0.004	0.1186	0.4877
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0092	0.0774
Schistosoma mansoni	hypothetical protein	0.0199	0.7801	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0151	0.0076
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.1749	0.215
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0014	0.0092	0.0378
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.1749	0.215
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0014	0.0092	0.0774
Toxoplasma gondii	NADPH-glutathione reductase	0.0014	0.0092	0.0378
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0054	0.1749	0.1864
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0785	0.0899
Brugia malayi	Pre-SET motif family protein	0.0032	0.0833	0.0859
Echinococcus granulosus	geminin	0.0199	0.7801	1
Plasmodium falciparum	thioredoxin reductase	0.004	0.1186	1
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0014	0.0092	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0084	0.3002	0.3775
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0041	0.1209	0.1449
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.1749	0.215
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0833	0.0962
Schistosoma mansoni	hypothetical protein	0.0199	0.7801	1
Schistosoma mansoni	rotamase	0.0039	0.1118	0.1332
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0092	0.0774
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.007	0.2433	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.2433	1
Schistosoma mansoni	aldehyde dehydrogenase	0.007	0.2433	0.3037
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0092	0.3332	0.8837
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0014	0.0092	0.0378
Loa Loa (eye worm)	glutathione reductase	0.004	0.1186	0.1208
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0893	0.0927
Plasmodium vivax	SET domain protein, putative	0.0032	0.0833	0.6773
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0151	0.0076
Entamoeba histolytica	hypothetical protein	0.0084	0.3002	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0054	0.1749	0.1919
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0039	0.1118	0.1128
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.1532	0.1611
Brugia malayi	glutathione reductase	0.004	0.1186	0.1268
Echinococcus granulosus	expressed protein	0.0039	0.1118	0.1332
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.007	0.2433	0.6384
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0102	0.3759	1
Echinococcus granulosus	GPCR family 2	0.0015	0.0151	0.0076
Entamoeba histolytica	hypothetical protein	0.0084	0.3002	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0014	0.0092	0.0774
Trichomonas vaginalis	rotamase, putative	0.0038	0.108	0.0998
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.2433	1
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0038	0.108	0.9107
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.1749	0.215
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0102	0.3759	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0038	0.108	0.9107
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0038	0.108	0.4442
Echinococcus multilocularis	geminin	0.0199	0.7801	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0092	0.3332	0.8837
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0014	0.0092	0.0378
Echinococcus granulosus	thioredoxin glutathione reductase	0.0041	0.1209	0.1449
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.004	0.1186	0.2985
Loa Loa (eye worm)	thioredoxin reductase	0.004	0.1186	0.1208
Schistosoma mansoni	hypothetical protein	0.0015	0.0151	0.0076
Entamoeba histolytica	hypothetical protein	0.0084	0.3002	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0151	0.0076
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0014	0.0092	0.0378
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0151	0.0068
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.007	0.2433	0.3037
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0833	0.3425
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.1118	0.1036
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0833	0.0962
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.1749	0.215
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.1532	0.1668
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0833	0.0962
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0092	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 787017