Detailed information for compound 78734

Basic information

Technical information
  • TDR Targets ID: 78734
  • Name: 6-[(3,4,5-trichloro-N-methylanilino)methyl]py rido[3,2-d]pyrimidine-2,4-diamine
  • MW: 383.663 | Formula: C15H13Cl3N6
  • H donors: 2 H acceptors: 3 LogP: 3.4 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(N)c2c(n1)ccc(n2)CN(c1cc(Cl)c(c(c1)Cl)Cl)C
  • InChi: 1S/C15H13Cl3N6/c1-24(8-4-9(16)12(18)10(17)5-8)6-7-2-3-11-13(21-7)14(19)23-15(20)22-11/h2-5H,6H2,1H3,(H4,19,20,22,23)
  • InChiKey: FVRDUZOKYWZFLL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-[(3,4,5-trichloro-N-methyl-anilino)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
  • 6-[[methyl-(3,4,5-trichlorophenyl)amino]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
  • (2,4-diaminopyrido[3,2-d]pyrimidin-6-yl)methyl-methyl-(3,4,5-trichlorophenyl)amine
  • 6-[[methyl-(3,4,5-trichlorophenyl)amino]methyl]pyrido[2,3-e]pyrimidine-2,4-diamine
  • (2,4-diaminopyrido[6,5-e]pyrimidin-6-yl)methyl-methyl-(3,4,5-trichlorophenyl)amine
  • AIDS-031011
  • AIDS031011
  • Pyrido[3,2-d]pyrimidine-2,4-diamine, 6-[[methyl(3,4,5-trichlorophenyl)amino]methyl]-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Starlite/ChEMBL References
Saccharomyces cerevisiae dihydrofolate reductase Starlite/ChEMBL References
Rattus norvegicus Dihydrofolate reductase Starlite/ChEMBL References
Pneumocystis carinii Dihydrofolate reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127385 All targets in OG5_127385
Onchocerca volvulus Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium yoelii thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania donovani dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania major dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Get druggable targets OG5_128410 All targets in OG5_128410
Babesia bovis dihydrofolate reductase/thymidilate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00560 thymidylate synthase [EC2.1.1.45], putative Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania infantum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Loa Loa (eye worm) dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus granulosus thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi Dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus granulosus dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi dihydrofolate reductase family protein Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans hypothetical protein Get druggable targets OG5_128410 All targets in OG5_128410
Chlamydia trachomatis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium hominis chain A, crystal structure of Dhfr Get druggable targets OG5_127385 All targets in OG5_127385
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans dihydrofolate reductase DfrA Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus multilocularis thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 186 aa 37.1 %
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 33.7 %
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   206 aa 193 aa 29.5 %
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 210 aa 30.0 %
Babesia bovis dihydrofolate reductase/thymidilate synthase Dihydrofolate reductase   187 aa 191 aa 31.9 %
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 209 aa 29.2 %
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 211 aa 28.4 %
Leishmania major dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 34.3 %
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 202 aa 29.2 %
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Dihydrofolate reductase   187 aa 187 aa 35.8 %
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 182 aa 33.5 %
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 210 aa 30.0 %
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 193 aa 32.1 %
Cryptosporidium hominis chain A, crystal structure of Dhfr Dihydrofolate reductase   187 aa 182 aa 34.1 %
Plasmodium yoelii thymidylate synthase, putative Dihydrofolate reductase   187 aa 212 aa 27.8 %
Leishmania infantum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 209 aa 29.2 %
Leishmania donovani dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0046 0.0374 0.0404
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0099 0.1122 0.1214
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1227 0.1315
Schistosoma mansoni inositol monophosphatase 0.0036 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0159 0.1977 0.2138
Schistosoma mansoni cytochrome P450 0.0021 0.0031 0.0031
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0099 0.1122 0.1214
Onchocerca volvulus 0.0046 0.0374 0.1854
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0079 0.0118
Loa Loa (eye worm) hypothetical protein 0.0053 0.0481 0.0521
Brugia malayi Cytochrome P450 family protein 0.0039 0.0278 0.0301
Onchocerca volvulus 0.0099 0.1122 0.6993
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0053 0.0481 0.0521
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Onchocerca volvulus 0.0035 0.0219 0.0791
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0238 0.0926
Onchocerca volvulus 0.0036 0.0238 0.0926
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0238 0.0258
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0219 0.0219
Schistosoma mansoni biogenic amine receptor 0.0035 0.0219 0.0219
Brugia malayi Dopamine receptor 0.0035 0.0219 0.0237
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0046 0.0374 0.0404
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0104 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0238 0.0258
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0035 0.0219 0.0237
Schistosoma mansoni nAChR subunit 0.0099 0.1122 0.1122
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1227 0.1315
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0238 0.0258
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0035 0.0219 0.0219
Loa Loa (eye worm) acetylcholine receptor protein 0.0046 0.0374 0.0404
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0404
Echinococcus multilocularis glycine receptor subunit beta 0.0099 0.1122 0.1122
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0035 0.0219 0.0219
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0219 0.0219
Echinococcus granulosus nAChR subunit 0.0053 0.0481 0.0481
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0031 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0491 0.0531
Echinococcus granulosus nAChR subunit 0.0099 0.1122 0.1122
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0099 0.1122 0.1122
Onchocerca volvulus 0.0035 0.0219 0.0791
Echinococcus multilocularis dihydrofolate reductase 0.0676 0.9246 0.9246
Schistosoma mansoni neurotransmitter gated ion channel 0.0046 0.0374 0.0374
Echinococcus granulosus neuropeptide receptor A26 0.0035 0.0219 0.0219
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0035 0.0219 0.0219
Onchocerca volvulus 0.0099 0.1122 0.6993
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.013 0.156 0.1676
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0046 0.0374 0.0374
Onchocerca volvulus 0.0099 0.1122 0.6993
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0491 0.0847
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0099 0.1122 0.1122
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0421 0.5657 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0219 0.0219
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0219 0.0219
Brugia malayi Inositol-1 0.0036 0.0241 0.026
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0404
Onchocerca volvulus 0.0035 0.0219 0.0791
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0099 0.1122 0.1122
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0219 0.0237
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0491 1
Echinococcus granulosus synaptic vesicular amine transporter 0.0182 0.2296 0.2296
Echinococcus granulosus fmrfamide receptor 0.0035 0.0219 0.0219
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0079 0.0118
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0241 0.0404
Loa Loa (eye worm) hypothetical protein 0.0025 0.0079 0.0086
Brugia malayi hypoxia-induced factor 1 0.0147 0.1803 0.195
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Brugia malayi hypothetical protein 0.0046 0.0374 0.0404
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0219 0.0219
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0491 0.0847
Loa Loa (eye worm) hypothetical protein 0.0053 0.0481 0.0521
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0219 0.0219
Onchocerca volvulus 0.0099 0.1122 0.6993
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0035 0.0219 0.0237
Brugia malayi Cation transporter family protein 0.0099 0.1122 0.1214
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0219 0.0219
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0241 0.0404
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0681 0.0681
Brugia malayi sulfakinin receptor protein 0.0035 0.0219 0.0237
Schistosoma mansoni amine GPCR 0.0035 0.0219 0.0219
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0099 0.1122 0.1122
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0219 0.0219
Schistosoma mansoni coup transcription factor 0.0036 0.0238 0.0238
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0491 0.8116
Brugia malayi TAR-binding protein 0.0067 0.0681 0.0736
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0404
Brugia malayi Abnormal catecholamine distribution protein 1 0.0182 0.2296 0.2483
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0238 0.0238
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0046 0.0374 0.0374
Echinococcus multilocularis nAChR subunit 0.0053 0.0481 0.0481
Onchocerca volvulus 0.007 0.0714 0.4191
Echinococcus multilocularis dro:myosuppressin receptor 0.0035 0.0219 0.0219
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.2286 0.2462
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Brugia malayi G protein-coupled receptor F59B2.13 0.0035 0.0219 0.0237
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0031 0.002
Echinococcus multilocularis allatostatin A receptor 0.0035 0.0219 0.0219
Onchocerca volvulus 0.0099 0.1122 0.6993
Brugia malayi Melatonin receptor type 1A 0.0035 0.0219 0.0237
Brugia malayi steroid hormone receptor 0.0036 0.0238 0.0258
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0099 0.1122 0.1122
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0219 0.0219
Brugia malayi hypothetical protein 0.0046 0.0374 0.0404
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Brugia malayi Cation transporter family protein 0.0099 0.1122 0.1214
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0219 0.0219
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0035 0.0219 0.0219
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.2286 0.2462
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0258
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) glutathione reductase 0.0047 0.0388 0.042
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0099 0.1122 0.1214
Brugia malayi Thioredoxin reductase 0.0047 0.0388 0.042
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0031 0.002
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0404
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0031 0.002
Loa Loa (eye worm) RNA binding protein 0.0067 0.0681 0.0736
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0241 0.3868
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0031 0.002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0046 0.0374 0.0404
Brugia malayi Serotonin receptor 0.0035 0.0219 0.0237
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0258
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0099 0.1122 0.1122
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0491 0.0847
Echinococcus multilocularis microtubule associated protein 2 0.0729 1 1
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0388 0.042
Brugia malayi larval opioid receptor 0.0035 0.0219 0.0237
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0241 0.0404
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0219 0.0219
Schistosoma mansoni nAChR subunit 0.0099 0.1122 0.1122
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0099 0.1122 0.1122
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.0031 0.002
Loa Loa (eye worm) TYRA-2 protein 0.0035 0.0219 0.0237
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0676 0.9246 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0079 0.0118
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0099 0.1122 0.1122
Echinococcus multilocularis neuropeptide FF receptor 2 0.0035 0.0219 0.0219
Echinococcus multilocularis geminin 0.0346 0.4602 0.4602
Onchocerca volvulus 0.0035 0.0219 0.0791
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0491 0.0491
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0099 0.1122 0.1122
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0676 0.9246 1
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.156 0.156
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.0031 0.002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0502 0.6804 0.7358
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0602 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0035 0.0219 0.0219
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0031 0.002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0099 0.1122 0.1214
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0219 0.0219
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.0031 0.002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) melatonin receptor type 1A 0.0035 0.0219 0.0237
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0228 0.0246
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0219 0.0237
Loa Loa (eye worm) hypothetical protein 0.0053 0.0481 0.0521
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0099 0.1122 0.1214
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.0031 0.002
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0099 0.1122 0.1122
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.1394 0.1496
Schistosoma mansoni nAChR subunit 0.0046 0.0374 0.0374
Schistosoma mansoni opsin-like receptor 0.0035 0.0219 0.0219
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0681 0.0681
Schistosoma mansoni neurotransmitter gated ion channel 0.0046 0.0374 0.0374
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0238 0.0238
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0219 0.0219
Echinococcus multilocularis jun protein 0.0089 0.0982 0.0982
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0219 0.0219
Schistosoma mansoni jun-related protein 0.0072 0.0748 0.0748
Schistosoma mansoni dihydrofolate reductase 0.0676 0.9246 0.9246
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0238 0.0258
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0035 0.0219 0.0219
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0035 0.0219 0.0219
Echinococcus granulosus allatostatin A receptor 0.0035 0.0219 0.0219
Loa Loa (eye worm) ACC-1 protein 0.0099 0.1122 0.1214
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0241 0.0241
Brugia malayi neuropeptide F receptor 0.0035 0.0219 0.0237
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0238 0.0238
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1227 0.1315
Brugia malayi Dihydrofolate reductase 0.0676 0.9246 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0035 0.0219 0.0237
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Brugia malayi MAP kinase sur-1 0.0054 0.0491 0.0531
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0404
Brugia malayi hypothetical protein 0.0062 0.0602 0.0651
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.0031 0.002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0219 0.0219
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0031 0.002
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0187 0.0169
Brugia malayi hypothetical protein 0.0046 0.0374 0.0404
Brugia malayi G protein-coupled receptor 0.0035 0.0219 0.0237
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0053 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Echinococcus granulosus glycine receptor subunit alpha 1 0.0099 0.1122 0.1122
Brugia malayi hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0491 0.0847
Onchocerca volvulus 0.0035 0.0219 0.0791
Echinococcus granulosus lamin dm0 0.0026 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0404
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0031 0.002
Schistosoma mansoni nAChR subunit 0.0099 0.1122 0.1122
Onchocerca volvulus 0.0099 0.1122 0.6993
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.0031 0.002
Schistosoma mansoni amine GPCR 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0404
Loa Loa (eye worm) ACC-1 protein 0.0099 0.1122 0.1214
Schistosoma mansoni hypothetical protein 0.0035 0.0219 0.0219
Mycobacterium ulcerans thymidylate synthase 0.013 0.156 0.1676
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0219 0.0219
Brugia malayi hypothetical protein 0.007 0.0714 0.0772
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0035 0.0219 0.0219
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0031 0.002
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0035 0.0219 0.0237
Echinococcus granulosus sex peptide receptor 0.0035 0.0219 0.0219
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0238 0.0238
Onchocerca volvulus 0.0035 0.0219 0.0791
Echinococcus granulosus g protein coupled receptor 0.0035 0.0219 0.0219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0219 0.0219
Echinococcus multilocularis neuropeptide s receptor 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0099 0.1122 0.1214
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0491 0.8116
Schistosoma mansoni microtubule-associated protein tau 0.0729 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0035 0.0219 0.0219
Schistosoma mansoni growth hormone secretagogue receptor 0.0035 0.0219 0.0219
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1227 0.1315
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0238 0.0238
Echinococcus granulosus thymidylate synthase 0.013 0.156 0.156
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0099 0.1122 0.1214
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0421 0.5657 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0238 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0238 0.0258
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0031 0.002
Schistosoma mansoni histamine h1 receptor 0.0035 0.0219 0.0219
Brugia malayi hypothetical protein 0.0035 0.0219 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0238 0.0258
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.0031 0.002
Brugia malayi hypothetical protein 0.0035 0.0219 0.0237
Echinococcus granulosus neuropeptide s receptor 0.0035 0.0219 0.0219
Trypanosoma brucei cytochrome P450, putative 0.0039 0.0278 0.047
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0053 0.0481 0.0521
Onchocerca volvulus 0.0035 0.0219 0.0791
Echinococcus multilocularis G protein coupled receptor 139 0.0035 0.0219 0.0219
Echinococcus granulosus lamin 0.0026 0.0104 0.0104
Echinococcus granulosus 7tm_1 domain containing protein 0.0035 0.0219 0.0219
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.0031 0.002
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0491 0.0847
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0099 0.1122 0.1214
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0079 0.0118
Schistosoma mansoni hypothetical protein 0.0346 0.4602 0.4602
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0104 0.0112
Echinococcus granulosus g-protein coupled receptor 0.0035 0.0219 0.0219
Brugia malayi Cytochrome P450 family protein 0.004 0.0294 0.0318
Echinococcus multilocularis sex peptide receptor 0.0035 0.0219 0.0219
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0099 0.1122 0.1122
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0258
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0099 0.1122 0.1214
Schistosoma mansoni nAChR subunit 0.0099 0.1122 0.1122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0219 0.0219
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0294 0.0318
Leishmania major cytochrome p450-like protein 0.0021 0.0031 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0238 0.0258
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0491 0.0491
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0099 0.1122 0.1214
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.0031 0.002
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0099 0.1122 0.1122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0219 0.0219
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0187 0.0189
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0491 0.0847
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0219 0.0219
Brugia malayi hypothetical protein 0.0035 0.0219 0.0237
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.1394 0.1479
Schistosoma mansoni single-minded 0.0047 0.0402 0.0402
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0241 0.0404
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Brugia malayi hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) hypothetical protein 0.0053 0.0481 0.0521
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0181 0.2286 0.4027
Echinococcus granulosus tar DNA binding protein 0.0067 0.0681 0.0681
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0035 0.0219 0.0219
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0035 0.0219 0.0219
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0219 0.0219
Brugia malayi ecdysteroid receptor 0.0036 0.0238 0.0258
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0258
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0241 0.0247
Brugia malayi G-protein coupled receptor 0.0035 0.0219 0.0237
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.0031 0.002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0099 0.1122 0.1214
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0035 0.0219 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0238 0.0258
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0238 0.0238
Schistosoma mansoni aldehyde dehydrogenase 0.0181 0.2286 0.2286
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0039 0.0278 0.0287
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0258
Brugia malayi glutathione reductase 0.0047 0.0388 0.042
Loa Loa (eye worm) hypothetical protein 0.0026 0.0097 0.0105
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0219 0.0219
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0099 0.1122 0.1122
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0219 0.0219
Trypanosoma brucei trypanothione reductase 0.0047 0.0388 0.0665
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0031 0.0033
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0031 0.0033
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0241 0.0241
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0031 0.0033
Leishmania major cytochrome p450-like protein 0.0039 0.0278 0.047
Brugia malayi putative neuropeptide receptor 0.0035 0.0219 0.0237
Schistosoma mansoni acetylcholine receptor-related 0.0046 0.0374 0.0374
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0046 0.0374 0.0404
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0031 0.0033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0238 0.0238
Brugia malayi hypothetical protein 0.0035 0.0219 0.0237
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0219 0.0219
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0238 0.0238
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0219 0.0219
Echinococcus granulosus dihydrofolate reductase 0.0676 0.9246 0.9246
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0421 0.5657 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0035 0.0219 0.0219
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0491 0.8116
Echinococcus multilocularis serotonin receptor 0.0035 0.0219 0.0219
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0099 0.1122 0.1214
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0031 0.002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.0982 0.0982
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.0031 0.002
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0421 0.5657 1
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0219 0.0237
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0219 0.0219
Schistosoma mansoni thyroid hormone receptor 0.016 0.1983 0.1983
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0219 0.0219
Plasmodium falciparum thioredoxin reductase 0.0047 0.0388 0.0665
Loa Loa (eye worm) LGC-31 protein 0.0099 0.1122 0.1214
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1227 0.1298
Echinococcus granulosus g protein coupled receptor 0.0035 0.0219 0.0219
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0035 0.0219 0.0219
Echinococcus multilocularis serotonin receptor 0.0035 0.0219 0.0219
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0219 0.0219
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0099 0.1122 0.1122
Schistosoma mansoni amine GPCR 0.0035 0.0219 0.0219
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0219 0.0219
Loa Loa (eye worm) dihydrofolate reductase 0.0676 0.9246 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0241 0.0241
Echinococcus granulosus g protein coupled receptor 0.0035 0.0219 0.0219
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0031 0.0033
Echinococcus granulosus G protein coupled receptor 139 0.0035 0.0219 0.0219
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0031 0.002
Brugia malayi hypothetical protein 0.0046 0.0374 0.0404
Echinococcus multilocularis thymidylate synthase 0.013 0.156 0.156
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0079 0.0118
Onchocerca volvulus 0.0035 0.0219 0.0791
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.2286 0.2462
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0238 0.0238
Brugia malayi cytochrome P450 0.0021 0.0031 0.0034
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0219 0.0219
Echinococcus multilocularis lamin dm0 0.0026 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0099 0.1122 0.1122
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0031 0.002
Schistosoma mansoni neuropeptide receptor 0.0035 0.0219 0.0219
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0681 0.0736
Schistosoma mansoni hypothetical protein 0.0072 0.0748 0.0748
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0219 0.0219
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0031 0.002
Onchocerca volvulus 0.0035 0.0219 0.0791
Echinococcus multilocularis neuropeptide receptor A26 0.0035 0.0219 0.0219
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0238 0.0258
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0099 0.1122 0.1122
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0104 0.0112
Echinococcus multilocularis musashi 0.0026 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0404
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0181 0.2286 0.2286
Brugia malayi PAS domain containing protein 0.0047 0.0402 0.0434
Echinococcus multilocularis thyroid hormone receptor alpha 0.016 0.1983 0.1983
Echinococcus granulosus glycine receptor subunit beta 0.0099 0.1122 0.1122
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0238 0.0258
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0388 0.0406
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Schistosoma mansoni lamin 0.0026 0.0104 0.0104
Schistosoma mansoni biogenic amine receptor 0.0035 0.0219 0.0219
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0238 0.0238
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0228 0.0228
Echinococcus granulosus geminin 0.0346 0.4602 0.4602
Schistosoma mansoni neuropeptide receptor 0.0035 0.0219 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0238 0.0258
Schistosoma mansoni biogenic amine receptor 0.0035 0.0219 0.0219
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0035 0.0219 0.0219
Loa Loa (eye worm) thymidylate synthase 0.013 0.156 0.1687
Onchocerca volvulus 0.0035 0.0219 0.0791
Brugia malayi G-protein coupled receptor 0.0035 0.0219 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0238 0.0258
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0681 0.0681
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0219 0.0219
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0013 0.0014
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0035 0.0219 0.0237
Schistosoma mansoni intermediate filament proteins 0.0026 0.0104 0.0104
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0219 0.0219
Schistosoma mansoni nAChR subunit 0.0099 0.1122 0.1122
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0388 0.0665
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0238 0.0258
Schistosoma mansoni myosin xvIII 0.0035 0.0219 0.0219
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0219 0.0219
Schistosoma mansoni opsin-like receptor 0.0035 0.0219 0.0219
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.0982 0.0982
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0238 0.0238
Brugia malayi nuclear receptor NHR-88 0.0036 0.0238 0.0258
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0046 0.0374 0.0404
Schistosoma mansoni lamin 0.0026 0.0104 0.0104
Brugia malayi bZIP transcription factor family protein 0.0089 0.0982 0.1062
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0219 0.0219
Schistosoma mansoni hypothetical protein 0.0035 0.0219 0.0219
Brugia malayi putative neuropeptide receptor NPR1 0.0035 0.0219 0.0237
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0238 0.0238
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.0031 0.002
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.013 0.156 0.1659
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0238 0.0238
Echinococcus multilocularis 0.0021 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Onchocerca volvulus 0.0035 0.0219 0.0791
Onchocerca volvulus 0.0035 0.0219 0.0791
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.0031 0.002
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0388 0.0388
Loa Loa (eye worm) cytochrome P450 0.0021 0.0031 0.0034
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.0031 0.002
Brugia malayi dihydrofolate reductase family protein 0.0676 0.9246 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.1394 0.1496
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0219 0.0219
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0228 0.0233
Brugia malayi RNA binding protein 0.0067 0.0681 0.0736
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0219 0.0219
Loa Loa (eye worm) inositol-1 0.0036 0.0241 0.026
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0278 0.0301
Loa Loa (eye worm) hypothetical protein 0.0086 0.0948 0.1025
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0219 0.0219
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0031 0.002
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0035 0.0219 0.0219
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0402 0.0402
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1227 0.1315
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0046 0.0374 0.0404
Echinococcus granulosus intermediate filament protein 0.0026 0.0104 0.0104
Schistosoma mansoni ap endonuclease 0.002 0.0013 0.0013
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0031 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0219 0.0219
Schistosoma mansoni hypothetical protein 0.0035 0.0219 0.0219
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0219 0.0219
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0219 0.0219
Onchocerca volvulus 0.0035 0.0219 0.0791
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0238 0.0238
Onchocerca volvulus Neuropeptide F receptor homolog 0.0035 0.0219 0.0791
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0491 0.0491
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0421 0.5657 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0112
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0219 0.0219
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.0031 0.002
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.0031 0.002
Schistosoma mansoni neuropeptide receptor 0.0035 0.0219 0.0219
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0035 0.0219 0.0237
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0099 0.1122 0.1122
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0046 0.0374 0.0404
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0053 0.0481 0.0481
Schistosoma mansoni hypothetical protein 0.0021 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Schistosoma mansoni nAChR subunit 0.0099 0.1122 0.1122
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Onchocerca volvulus 0.0035 0.0219 0.0791
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0079 0.0118
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0421 0.5657 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Leishmania major trypanothione reductase 0.0047 0.0388 0.0665
Brugia malayi hypothetical protein 0.0035 0.0219 0.0237
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0238 0.0238
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0491 0.0847
Echinococcus granulosus neuropeptide receptor 0.0035 0.0219 0.0219
Brugia malayi ORL1-like opioid receptor 0.0035 0.0219 0.0237
Echinococcus multilocularis synaptic vesicular amine transporter 0.0182 0.2296 0.2296
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0219 0.0219
Onchocerca volvulus 0.0053 0.0481 0.2593
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.0031 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0219 0.0219
Brugia malayi excitatory GABA receptor EXP-1A 0.0099 0.1122 0.1214
Loa Loa (eye worm) hypothetical protein 0.0053 0.0481 0.0521
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0491 0.0847
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0013 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0238 0.0258
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0035 0.0219 0.0219
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0238 0.0258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0238 0.0258
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Echinococcus multilocularis orexin receptor type 2 0.0035 0.0219 0.0219
Brugia malayi hypothetical protein 0.0046 0.0374 0.0404
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0099 0.1122 0.1214
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0099 0.1122 0.1122
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0238 0.0926
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0046 0.0374 0.0374
Brugia malayi Cation transporter family protein 0.0099 0.1122 0.1214
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.0031 0.002
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0099 0.1122 0.1214
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0241 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0238 0.0258
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0404
Schistosoma mansoni aldehyde dehydrogenase 0.0181 0.2286 0.2286
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0099 0.1122 0.1214
Toxoplasma gondii aldehyde dehydrogenase 0.0181 0.2286 0.4027
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0388 0.0665
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0099 0.1122 0.1214
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0013 0.0013
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0182 0.2296 0.2483
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0278 0.047
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0241 0.4865
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0219 0.0219
Echinococcus granulosus tachykinin peptides receptor 99D 0.0035 0.0219 0.0219
Echinococcus granulosus glycine receptor subunit alpha 1 0.0099 0.1122 0.1122
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0099 0.1122 0.1122
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0404
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0099 0.1122 0.1122
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0681 0.0736
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0681 0.0681
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0238 0.0238
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0681 0.0681
Mycobacterium tuberculosis Probable reductase 0.0106 0.1227 0.1315
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0031 0.002
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Leishmania major cytochrome p450-like protein 0.0021 0.0031 0.0033
Onchocerca volvulus 0.0035 0.0219 0.0791
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Toxoplasma gondii thioredoxin reductase 0.0047 0.0388 0.0665
Loa Loa (eye worm) hypothetical protein 0.0053 0.0481 0.0521
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0099 0.1122 0.1122
Echinococcus multilocularis nAChR subunit 0.0099 0.1122 0.1122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0053 0.0481 0.0521
Brugia malayi hypothetical protein 0.0159 0.1977 0.2138
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.1803 0.195
Echinococcus granulosus orexin receptor type 2 0.0035 0.0219 0.0219
Onchocerca volvulus 0.0046 0.0374 0.1854
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0404
Schistosoma mansoni alpha-1 adrenergic receptor 0.0035 0.0219 0.0219
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0219 0.0219
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0238 0.0926
Schistosoma mansoni opsin-like receptor 0.0035 0.0219 0.0219
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0676 0.9246 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0238 0.0258
Echinococcus granulosus neuropeptide receptor 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0241 0.3868
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0099 0.1122 0.1214
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0219 0.0219
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0278 0.047
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0681 0.0736
Echinococcus granulosus peptide allatostatin:somatostatin 0.0035 0.0219 0.0219
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0099 0.1122 0.1122
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0099 0.1122 0.1214
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0258
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0238 0.0258
Brugia malayi Dopamine receptor protein 2 0.0035 0.0219 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0238 0.0258
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0035 0.0219 0.0219
Echinococcus multilocularis g-protein coupled receptor 0.0035 0.0219 0.0219
Plasmodium falciparum glutathione reductase 0.0047 0.0388 0.0665
Brugia malayi hypothetical protein 0.0025 0.0079 0.0086
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.1477 0.1477
Schistosoma mansoni hypothetical protein 0.0035 0.0219 0.0219
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0219 0.0219
Schistosoma mansoni neuropeptide f receptor 76f 0.0035 0.0219 0.0219
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0035 0.0219 0.0791
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0238 0.0238
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0219 0.0219
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.1477 0.1477
Schistosoma mansoni neurotransmitter gated ion channel 0.0053 0.0481 0.0481
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0219 0.0219
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0099 0.1122 0.1214
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0491 0.0491
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0079 0.0118
Brugia malayi RE15519p 0.0035 0.0219 0.0237
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0681 0.0681
Loa Loa (eye worm) CYP4Cod1 0.0039 0.0278 0.0301
Plasmodium vivax glutathione reductase, putative 0.0047 0.0388 0.0665
Schistosoma mansoni ap endonuclease 0.002 0.0013 0.0013
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0053 0.0481 0.0521
Schistosoma mansoni neuropeptide receptor 0.0035 0.0219 0.0219
Schistosoma mansoni hypothetical protein 0.0346 0.4602 0.4602
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0238 0.0258
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0238 0.0238
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0491 0.8116
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0241 0.3868
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0404
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0046 0.0374 0.0404
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Echinococcus granulosus glycine receptor subunit alpha 1 0.0099 0.1122 0.1122
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0035 0.0219 0.0219
Brugia malayi follicle stimulating hormone receptor 0.0502 0.6804 0.7358
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0219 0.0219
Schistosoma mansoni acetylcholine receptor subunit beta 0.0046 0.0374 0.0374
Schistosoma mansoni amine GPCR 0.0035 0.0219 0.0219
Echinococcus granulosus dro:myosuppressin receptor 0.0035 0.0219 0.0219
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0219 0.0219
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0219 0.0237
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0278 0.0301
Brugia malayi AKH receptor 0.0035 0.0219 0.0237
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0013 0.0013
Brugia malayi intermediate filament protein 0.0026 0.0104 0.0112
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0181 0.2286 0.2462
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0241 0.0404
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Onchocerca volvulus 0.0053 0.0481 0.2593
Echinococcus multilocularis glycine receptor subunit beta 0.0099 0.1122 0.1122
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0031 0.002
Onchocerca volvulus 0.0046 0.0374 0.1854
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0238 0.0238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0238 0.0258
Echinococcus granulosus serotonin receptor 0.0035 0.0219 0.0219
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0238 0.0238
Brugia malayi Tachykinin-like peptides receptor 99D 0.0035 0.0219 0.0237
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0053 0.0481 0.0521
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0258
Brugia malayi nuclear hormone receptor 0.0036 0.0238 0.0258
Loa Loa (eye worm) hypothetical protein 0.0099 0.1122 0.1214
Onchocerca volvulus 0.0035 0.0228 0.0853
Echinococcus granulosus glycine receptor subunit beta 0.0099 0.1122 0.1122
Echinococcus granulosus hypothetical protein 0.0035 0.0219 0.0219
Brugia malayi Dopamine receptor protein 1 0.0035 0.0219 0.0237
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0031 0.0031
Brugia malayi GnHR receptor homolog 0.0035 0.0219 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0238 0.0258
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0031 0.002
Brugia malayi Cytochrome P450 family protein 0.0021 0.0031 0.0034
Echinococcus granulosus somatostatin receptor 0.0035 0.0219 0.0219
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0099 0.1122 0.1214
Schistosoma mansoni adenoreceptor 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0404
Onchocerca volvulus 0.0035 0.0219 0.0791
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0099 0.1122 0.1122
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0053 0.0481 0.0521
Brugia malayi thymidylate synthase 0.013 0.156 0.1687
Echinococcus granulosus neuropeptide FF receptor 2 0.0035 0.0219 0.0219
Loa Loa (eye worm) GABA receptor subunit 0.0053 0.0481 0.0521
Onchocerca volvulus Putative nachr subunit 0.0099 0.1122 0.6993
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0099 0.1122 0.1214
Brugia malayi hypothetical protein 0.0035 0.0219 0.0237
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0238 0.0238
Onchocerca volvulus 0.0035 0.0219 0.0791
Trypanosoma brucei protein kinase, putative 0.0054 0.0491 0.0847
Schistosoma mansoni vesicular amine transporter 0.0182 0.2296 0.2296
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0238 0.0238
Onchocerca volvulus 0.013 0.156 1
Echinococcus multilocularis lamin 0.0026 0.0104 0.0104
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0035 0.0219 0.0237
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0219 0.0219
Entamoeba histolytica hypothetical protein 0.0053 0.0481 1
Schistosoma mansoni nAChR subunit 0.0099 0.1122 0.1122
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0035 0.0219 0.0237
Echinococcus granulosus jun protein 0.0089 0.0982 0.0982
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0046 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0258
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0181 0.2286 0.2286
Mycobacterium tuberculosis Hypothetical protein 0.0062 0.0602 0.0638
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0062 0.0602 0.1044
Brugia malayi hypothetical protein 0.0035 0.0219 0.0237
Brugia malayi Cytochrome P450 family protein 0.0039 0.0278 0.0301
Loa Loa (eye worm) hypothetical protein 0.0053 0.0481 0.0521
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0238 0.0238
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0099 0.1122 0.1214
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0035 0.0219 0.0237
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0491 0.0491
Schistosoma mansoni thyroid hormone receptor 0.016 0.1983 0.1983
Chlamydia trachomatis dihydrofolate reductase 0.0676 0.9246 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0219 0.0219
Brugia malayi hypothetical protein 0.0035 0.0219 0.0237
Echinococcus multilocularis somatostatin receptor 0.0035 0.0219 0.0219
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0099 0.1122 0.1122
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0404
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.1394 0.1496
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0031 0.002
Schistosoma mansoni amine GPCR 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0046 0.0374 0.0404
Brugia malayi Serotonin receptor 0.0035 0.0219 0.0237
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0046 0.0374 0.0374
Echinococcus granulosus single minded 2 0.0035 0.0228 0.0228
Brugia malayi neuropeptide F receptor 0.0035 0.0219 0.0237
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0219 0.0219
Leishmania major hypothetical protein, conserved 0.0025 0.0079 0.0118
Schistosoma mansoni nAChR subunit 0.0046 0.0374 0.0374
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.0031 0.002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0237
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0031 0.002
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.0031 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0238 0.0258
Schistosoma mansoni hypothetical protein 0.0124 0.1477 0.1477

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.602 Inhibition of Pneumocystis carinii dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 7.06 Inhibition of rat liver dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 7.4202 Inhibition of Toxoplasma gondii dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 0.038 uM Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. ChEMBL. 8627607
IC50 (binding) = 0.038 uM Inhibition of Toxoplasma gondii dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 0.038 uM Inhibitory activity against Toxoplasma gondii dihydrofolate reductase. ChEMBL. 8627607
IC50 (binding) = 0.038 uM Inhibition of Toxoplasma gondii dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 0.087 uM Inhibitory activity against rat liver dihydrofolate reductase. ChEMBL. 8627607
IC50 (binding) = 0.087 uM Inhibition of rat liver dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 0.087 uM Inhibitory activity against rat liver dihydrofolate reductase. ChEMBL. 8627607
IC50 (binding) = 0.087 uM Inhibition of rat liver dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 0.25 uM Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. ChEMBL. 8627607
IC50 (binding) = 0.25 uM Inhibition of Pneumocystis carinii dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 0.25 uM Inhibitory activity against Pneumocystis carinii dihydrofolate reductase. ChEMBL. 8627607
IC50 (binding) = 0.25 uM Inhibition of Pneumocystis carinii dihydrofolate reductase ChEMBL. 15743188
Log IC50 (binding) = 6.6021 Inhibition of Pneumocystis carinii dihydrofolate reductase ChEMBL. 15743188
Log IC50 (binding) = 7.0605 Inhibition of rat liver dihydrofolate reductase ChEMBL. 15743188
Log IC50 (binding) = 7.4202 Inhibition of Toxoplasma gondii dihydrofolate reductase ChEMBL. 15743188
Selectivity (binding) = 0.35 Ratio of inhibitory concentration of rat liver and Pneumocystis carinii DHFR. ChEMBL. 8627607
Selectivity (binding) = 2.29 Ratio of inhibitory concentration of rat liver and Toxoplasma gondii DHFR ChEMBL. 8627607

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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