Detailed information for compound 787768

Basic information

Technical information
  • TDR Targets ID: 787768
  • Name: 1-[(3,5-dimethyl-1,2-oxazol-4-yl)sulfonyl]-N- (4-methylphenyl)piperidine-3-carboxamide
  • MW: 377.458 | Formula: C18H23N3O4S
  • H donors: 1 H acceptors: 4 LogP: 2.01 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)NC(=O)C1CCCN(C1)S(=O)(=O)c1c(C)noc1C
  • InChi: 1S/C18H23N3O4S/c1-12-6-8-16(9-7-12)19-18(22)15-5-4-10-21(11-15)26(23,24)17-13(2)20-25-14(17)3/h6-9,15H,4-5,10-11H2,1-3H3,(H,19,22)
  • InChiKey: ALKZUKNUVXJGIH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3,5-dimethylisoxazol-4-yl)sulfonyl-N-(4-methylphenyl)piperidine-3-carboxamide
  • 1-[(3,5-dimethyl-4-isoxazolyl)sulfonyl]-N-(4-methylphenyl)-3-piperidinecarboxamide
  • 1-(3,5-dimethylisoxazol-4-yl)sulfonyl-N-(4-methylphenyl)nipecotamide
  • C436-0789
  • NCGC00108306-01
  • 1-[(3,5-dimethylisoxazol-4-yl)sulfonyl]-N-(4-methylphenyl)piperidine-3-carboxamide
  • MLS000674607
  • SMR000314049

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.0134 0.0853 0.0895
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0203 0.1316
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0117 0.2895
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0116 0.0731
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0069 0.0462
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0116 0.0731
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0069 0.0462
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0203 0.1316
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0069 0.0065
Loa Loa (eye worm) hypothetical protein 0.0061 0.0343 0.072
Schistosoma mansoni myst-related protein 0.0017 0.0034 0.0036
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0343 0.0353
Echinococcus multilocularis zinc finger protein 0.0027 0.0104 0.0102
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0281 0.1741
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0177 0.0179
Schistosoma mansoni ferritin 0.0018 0.0045 0.0048
Entamoeba histolytica hypothetical protein 0.0115 0.0718 1
Mycobacterium leprae Probable lipase LipE 0.0227 0.1496 1
Trypanosoma brucei glucosidase, putative 0.0041 0.0203 0.1316
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0203 0.1316
Schistosoma mansoni bromodomain containing protein 0.0071 0.041 0.043
Brugia malayi CXXC zinc finger family protein 0.0125 0.079 0.1902
Brugia malayi ecdysteroid receptor 0.0022 0.0069 0.0166
Loa Loa (eye worm) RNA binding protein 0.0609 0.4156 0.9315
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0209 0.0212
Entamoeba histolytica hypothetical protein 0.0017 0.0034 0.0386
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0069 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0203 0.1316
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0227 0.1496 0.3318
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0281 0.1741
Leishmania major importin beta-1 subunit, putative 0.005 0.0263 0.172
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0024 0.0015
Toxoplasma gondii exonuclease III APE 0.0037 0.0177 0.0979
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0069 0.0166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.1597 0.1675
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0231 0.0235
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0231 0.1322
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0116 0.0731
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0069 0.0072
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0203 0.1141
Echinococcus multilocularis geminin 0.0714 0.4886 0.5121
Mycobacterium tuberculosis Probable esterase LipL 0.0227 0.1496 0.1488
Loa Loa (eye worm) hypothetical protein 0.0052 0.0281 0.0579
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0209 0.1359
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0024 0.0248
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0024 0.0118
Plasmodium vivax importin-beta 2, putative 0.0061 0.0343 0.2168
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0177 0.0427
Onchocerca volvulus 0.0227 0.1496 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0154 0.0293
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0154 0.0371
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0117 0.0738
Onchocerca volvulus 0.0227 0.1496 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0069 0.0166
Loa Loa (eye worm) hypothetical protein 0.0039 0.0189 0.0372
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0203 0.1316
Brugia malayi hypothetical protein 0.0152 0.0975 0.2345
Trichomonas vaginalis esterase, putative 0.0227 0.1496 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0203 0.1316
Trypanosoma cruzi hypothetical protein, conserved 0.0227 0.1496 1
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0069 0.0166
Brugia malayi beta-lactamase family protein 0.0227 0.1496 0.3599
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0177 0.0168
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0177 0.1146
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0024 0.0242
Trichomonas vaginalis helicase, putative 0.0028 0.0116 0.0731
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0024 0.0015
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.1201 0.1253
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0069 0.0065
Echinococcus granulosus geminin 0.0714 0.4886 0.5121
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0281 0.1741
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0281 0.1741
Loa Loa (eye worm) hypothetical protein 0.0022 0.0069 0.0102
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.0281 0.1741
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0116 0.0731
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0231 0.1506
Schistosoma mansoni apoferritin-2 0.0018 0.0045 0.0048
Schistosoma mansoni hypothetical protein 0.0058 0.0323 0.0339
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0084 0.052
Echinococcus granulosus cpg binding protein 0.0134 0.0853 0.0888
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0069 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0069 0.0102
Brugia malayi Bromodomain containing protein 0.0038 0.0186 0.0447
Schistosoma mansoni ferritin 0.0018 0.0045 0.0048
Schistosoma mansoni apoferritin-2 0.0018 0.0045 0.0048
Loa Loa (eye worm) hypothetical protein 0.0227 0.1496 0.3318
Echinococcus granulosus expressed protein 0.0018 0.0045 0.004
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0024 0.0118
Trypanosoma brucei ISWI complex protein 0.0015 0.0025 0.0122
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0024 0.0015
Brugia malayi nuclear hormone receptor 0.0022 0.0069 0.0166
Loa Loa (eye worm) hypothetical protein 0.0227 0.1496 0.3318
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0203 0.1316
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0056 0.0059
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0231 0.1404
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0209 0.1359
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0281 0.0675
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0024 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0116 0.0731
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0039 0.0188 0.019
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0203 0.1316
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0609 0.4156 0.9315
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0024 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0069 0.0102
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0069 0.0065
Loa Loa (eye worm) hypothetical protein 0.0042 0.0209 0.0418
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0177 0.1146
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0177 0.1146
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0281 0.1839
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0069 0.0102
Loa Loa (eye worm) TAR-binding protein 0.0609 0.4156 0.9315
Echinococcus granulosus importin subunit beta 1 0.0061 0.0343 0.0353
Brugia malayi hypothetical protein 0.0018 0.0046 0.0111
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0024 0.0059
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.003 0.0041
Leishmania major hypothetical protein, conserved 0.0029 0.0117 0.0738
Schistosoma mansoni cpg binding protein 0.0125 0.079 0.0829
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0116 0.0731
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0024 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.1597 0.1669
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0084 0.0203
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0007
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0231 0.0467
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0024 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0116 0.0731
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0028
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0024 0.0118
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0263 0.054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0116 0.0731
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0177 0.0179
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0029 0.003
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0117 0.0591
Mycobacterium tuberculosis Probable lipase LipD 0.0227 0.1496 0.1488
Trypanosoma cruzi ISWI complex protein 0.0015 0.0025 0.0122
Schistosoma mansoni ferritin light chain 0.0018 0.0045 0.0048
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0069 0.0072
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0027 0.0021
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0024 0.0015
Echinococcus granulosus tar DNA binding protein 0.0609 0.4156 0.4354
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0209 0.0219
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0001
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0343 0.226
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0135 0.0141
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0203 0.0488
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0024 0.0116
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0028
Loa Loa (eye worm) CXXC zinc finger family protein 0.0125 0.079 0.1728
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0343 0.226
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0024 0.0116
Brugia malayi RNA recognition motif domain containing protein 0.0609 0.4156 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0174 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0069 0.0166
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0209 0.0212
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1906 0.1993
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0203 0.1316
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0045 0.0143
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0069 0.0065
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0203 0.1316
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0323 0.0778
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0209 0.0212
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0116 0.0731
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0116 0.0731
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0069 0.0065
Onchocerca volvulus 0.0015 0.0024 0.0163
Echinococcus granulosus mixed lineage leukemia protein mll 0.0031 0.0135 0.0134
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0037 0.0032
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.1201 0.1253
Brugia malayi MH2 domain containing protein 0.0119 0.0745 0.1793
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0084 0.0081
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0281 0.1839
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0174 0.0165
Loa Loa (eye worm) hypothetical protein 0.0227 0.1496 0.3318
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0069 0.0102
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0169 0.017
Loa Loa (eye worm) hypothetical protein 0.0022 0.0069 0.0102
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.1597 0.1669
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0385 0.0397
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0241 0.1597 0.3842
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0745 0.1626
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0189 0.1118
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0069 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0116 0.0731
Brugia malayi hypothetical protein 0.0286 0.1906 0.4587
Schistosoma mansoni importin beta-1 0.0061 0.0343 0.036
Onchocerca volvulus 0.0107 0.066 0.4413
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0169 0.017
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0281 0.0675
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0231 0.1506
Leishmania major GTP-binding protein, putative 0.0045 0.0231 0.1506
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0227 0.1496 0.1569
Entamoeba histolytica hypothetical protein 0.005 0.0263 0.3601
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0069 0.0065
Plasmodium falciparum importin beta, putative 0.0061 0.0343 1
Leishmania major hypothetical protein, conserved 0.0015 0.0025 0.0122
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0027 0.0065
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0024 0.0116
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0919 0.6315 0.662
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0069 0.0072
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0031 0.0135 0.0134
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0024 0.016
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0227 0.1496 1
Schistosoma mansoni coup transcription factor 0.0022 0.0069 0.0072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0266 0.1768 0.1855
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0018
Onchocerca volvulus 0.0052 0.0281 0.1875
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0024 0.0059
Loa Loa (eye worm) hypothetical protein 0.005 0.0266 0.0545
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0024 0.0015
Echinococcus multilocularis GPCR, family 2 0.0016 0.0027 0.0021
Loa Loa (eye worm) hypothetical protein 0.005 0.0263 0.054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0069 0.0072
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0024 0.0015
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.0281 0.0271
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0177 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0241 0.1597 0.3546
Loa Loa (eye worm) hypothetical protein 0.0039 0.0189 0.0372
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.0281 0.1741
Toxoplasma gondii histone lysine methyltransferase SET1 0.024 0.1587 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0069 0.0065
Schistosoma mansoni ferritin 0.0018 0.0045 0.0048
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0177 0.0346
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0024 0.0116
Echinococcus granulosus ferritin 0.0018 0.0045 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0069 0.0166
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0024 0.0059
Schistosoma mansoni cpg binding protein 0.0134 0.0853 0.0895
Brugia malayi RNA binding protein 0.0609 0.4156 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0024 0.0001
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0069 0.0072
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0024 0.0118
Brugia malayi beta-lactamase family protein 0.0227 0.1496 0.3599
Onchocerca volvulus 0.0015 0.0024 0.0163
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0024 0.0118
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0069 0.0065
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0231 0.0235
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0281 0.385
Loa Loa (eye worm) hypothetical protein 0.0039 0.0189 0.0372
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0069 0.0065
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0024 0.0118
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0069 0.0102
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0263 0.172
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0177 0.4797
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0069 0.0166
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0024 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0052 0.0281 0.0579
Loa Loa (eye worm) hypothetical protein 0.0022 0.0069 0.0102
Onchocerca volvulus 0.0227 0.1496 1
Brugia malayi nuclear receptor NHR-88 0.0022 0.0069 0.0166
Schistosoma mansoni hypothetical protein 0.0021 0.0062 0.0065
Loa Loa (eye worm) oxidoreductase 0.0015 0.0024 0.0001
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0189 0.1118
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0652 0.446 1
Mycobacterium ulcerans lipase LipD 0.0227 0.1496 1
Schistosoma mansoni ferritin light chain 0.0018 0.0045 0.0048
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.0022 0.0069 0.0102
Mycobacterium tuberculosis Conserved protein 0.0227 0.1496 0.1488
Schistosoma mansoni zinc finger protein 0.0015 0.0025 0.0026
Leishmania major hypothetical protein, conserved 0.0227 0.1496 1
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0117 0.0738
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0024 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0069 0.0065
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0209 0.0212
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.0718 0.0746
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.0281 0.385
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0024 0.0118
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0209 0.5933
Echinococcus granulosus beta LACTamase domain containing family member 0.0227 0.1496 0.1563
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0069 0.0072
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0189 0.0179
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0024 0.0118
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0203 0.1316
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.1597 0.1669
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0231 0.0556
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0024 0.0118
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0024 0.0116
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0116 0.0731
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0069 0.0462
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0069 0.0065
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.0718 0.0746
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0069 0.0166
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0024 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0069 0.0166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.1597 0.1675
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0116 0.0731
Loa Loa (eye worm) hypothetical protein 0.0039 0.0189 0.0372
Echinococcus granulosus bloom syndrome protein 0.0024 0.0084 0.0081
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0189 0.5158
Trichomonas vaginalis D-aminoacylase, putative 0.0227 0.1496 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0073
Loa Loa (eye worm) hypothetical protein 0.0022 0.0069 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0116 0.0731
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0177 0.1146
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0177 0.104
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0069 0.0065
Schistosoma mansoni hypothetical protein 0.0013 0.0007 0.0007
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0069 0.0166
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0037 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0609 0.4156 0.4358
Echinococcus multilocularis snurportin 1 0.0652 0.446 0.4673
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0209 0.0212
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0028
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0281 0.385
Schistosoma mansoni tar DNA-binding protein 0.0609 0.4156 0.4358
Trichomonas vaginalis importin beta-1, putative 0.005 0.0263 0.172
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0062 0.0086
Mycobacterium ulcerans beta-lactamase 0.0227 0.1496 1
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0281 0.0675
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.0189 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0227 0.1496 1
Trichomonas vaginalis hypothetical protein 0.0015 0.0024 0.0115
Onchocerca volvulus 0.0125 0.079 0.5283
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0041 0.0039
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0069 0.0065
Trichomonas vaginalis penicillin-binding protein, putative 0.0227 0.1496 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0069 0.0166
Schistosoma mansoni hypothetical protein 0.0652 0.446 0.4677
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0049 0.0052
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0209 0.1359
Echinococcus granulosus GPCR family 2 0.0016 0.0027 0.0021
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0135 0.0134
Schistosoma mansoni ran 0.0045 0.0231 0.0242
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0037 0.0039
Brugia malayi hypothetical protein 0.0029 0.0117 0.0281
Loa Loa (eye worm) hypothetical protein 0.0041 0.0203 0.0403
Brugia malayi Bromodomain containing protein 0.0082 0.0492 0.1184
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0203 0.2755
Echinococcus multilocularis cpg binding protein 0.0134 0.0853 0.0888
Schistosoma mansoni hypothetical protein 0.0034 0.0154 0.0161
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0045 0.0036
Echinococcus multilocularis beta LACTamase domain containing family member 0.0227 0.1496 0.1563
Entamoeba histolytica hypothetical protein 0.0115 0.0718 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0024 0.0116
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0385 0.0397
Loa Loa (eye worm) hypothetical protein 0.0227 0.1496 0.3318
Echinococcus granulosus fetal alzheimer antigen falz 0.003 0.0125 0.0124
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0024 0.0018
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0028
Brugia malayi beta-lactamase 0.0227 0.1496 0.3599
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0263 0.0633
Trichomonas vaginalis ferritin, putative 0.0018 0.0045 0.026
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0045 0.0036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0069 0.0166
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0024 0.0118
Trypanosoma cruzi ISWI complex protein 0.0013 0.0009 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0069 0.0102
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0209 0.1359
Brugia malayi Glycosyl hydrolases family 31 protein 0.0184 0.1201 0.2891
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0024 0.0015
Echinococcus granulosus dnaJ subfamily B 0.1381 0.9535 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0227 0.1496 0.3599
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0069 0.0072
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0227 0.1496 0.1569
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0069 0.0166
Toxoplasma gondii ABC1 family protein 0.0227 0.1496 0.9415
Schistosoma mansoni tar DNA-binding protein 0.0609 0.4156 0.4358
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0069 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0069 0.0166
Loa Loa (eye worm) hypothetical protein 0.0022 0.0069 0.0102
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0024 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0116 0.0731
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0056 0.0052
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0203 0.1316
Trypanosoma brucei ISWI complex protein 0.0013 0.0009 0.0018
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0064 0.1243
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0209 0.1359
Schistosoma mansoni tar DNA-binding protein 0.0609 0.4156 0.4358
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.0718 0.0753
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0018
Echinococcus multilocularis ferritin 0.0018 0.0045 0.004
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0117 0.2895
Trichomonas vaginalis penicillin-binding protein, putative 0.0227 0.1496 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0231 0.6478
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0024 0.0059
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0024 0.0015
Loa Loa (eye worm) hypothetical protein 0.0286 0.1906 0.4243
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0177 0.2399
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0069 0.0072
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0203 0.0205
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0177 1
Onchocerca volvulus 0.0015 0.0024 0.0163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.1597 0.1675
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0263 0.0633
Brugia malayi hypothetical protein 0.0115 0.0718 0.1728
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0027 0.0021
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0745 0.1626
Loa Loa (eye worm) hypothetical protein 0.0022 0.0069 0.0102
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0069 0.0065
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0227 0.1496 0.1488
Brugia malayi Importin beta-1 subunit 0.0061 0.0343 0.0826
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0117 0.0628
Schistosoma mansoni hypothetical protein 0.0115 0.0718 0.0753
Loa Loa (eye worm) hypothetical protein 0.012 0.0755 0.1648
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.1597 0.1669
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0037 0.0032
Onchocerca volvulus 0.0015 0.0024 0.0163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0069 0.0102
Loa Loa (eye worm) histone methyltransferase 0.0039 0.0188 0.0369
Schistosoma mansoni survival motor neuron protein 0.0058 0.0323 0.0339
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0209
Loa Loa (eye worm) hypothetical protein 0.0039 0.0186 0.0366
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0116 0.0731
Entamoeba histolytica Ran family GTPase 0.0045 0.0231 0.3153
Echinococcus multilocularis fetal alzheimer antigen, falz 0.003 0.0125 0.0124
Schistosoma mansoni zinc finger protein 0.0027 0.0104 0.011
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0039 0.0188 0.019
Loa Loa (eye worm) hypothetical protein 0.0039 0.0189 0.0372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0069 0.0102
Echinococcus multilocularis dnaJ subfamily B 0.1381 0.9535 1
Entamoeba histolytica hypothetical protein 0.0115 0.0718 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0209 0.0219
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0056 0.0052
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0281 0.1741
Mycobacterium tuberculosis Probable hydrolase 0.0227 0.1496 0.1488
Echinococcus granulosus snurportin 1 0.0652 0.446 0.4673
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0027 0.0065
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0281 0.1741
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0024 0.0115
Brugia malayi TAR-binding protein 0.0609 0.4156 1
Schistosoma mansoni hypothetical protein 0.0015 0.0025 0.0026
Schistosoma mansoni hypothetical protein 0.0714 0.4886 0.5124
Trypanosoma brucei hypothetical protein, conserved 0.0227 0.1496 1
Schistosoma mansoni ran 0.0045 0.0231 0.0242
Loa Loa (eye worm) hypothetical protein 0.0227 0.1496 0.3318
Schistosoma mansoni tar DNA-binding protein 0.0609 0.4156 0.4358
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0231 1
Plasmodium falciparum zinc finger protein, putative 0.0017 0.0034 0.0307
Onchocerca volvulus 0.0152 0.0975 0.6516
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0027 0.0007
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.0281 0.1741
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0203 0.0205
Echinococcus multilocularis expressed protein 0.0018 0.0045 0.004
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0343 0.2041
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0177 0.104
Mycobacterium ulcerans esterase/lipase LipP 0.0227 0.1496 1
Plasmodium vivax hypothetical protein, conserved 0.0227 0.1496 1
Loa Loa (eye worm) beta-lactamase 0.0227 0.1496 0.3318
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.003 0.0125 0.0131
Trichomonas vaginalis ran, putative 0.0045 0.0231 0.1506
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0069 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0263 0.172
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0024 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0069 0.0102
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0024 0.0059
Schistosoma mansoni hypothetical protein 0.1381 0.9535 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.0263 0.172
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0069 0.0072
Brugia malayi RNA, U transporter 1 0.0174 0.1128 0.2714
Schistosoma mansoni alpha-glucosidase 0.0159 0.1023 0.1072
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0177 0.1146
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0069 0.0072
Mycobacterium ulcerans hypothetical protein 0.0227 0.1496 1
Trichomonas vaginalis D-aminoacylase, putative 0.0227 0.1496 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0174 0.0165
Mycobacterium tuberculosis Probable lipase LipE 0.0227 0.1496 0.1488
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0203 0.2755
Brugia malayi F/Y-rich N-terminus family protein 0.004 0.0198 0.0476
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0116 0.0731
Echinococcus granulosus lysosomal alpha glucosidase 0.0184 0.1201 0.1253
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0045 0.0143
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0043 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0056 0.0059
Echinococcus granulosus zinc finger protein 0.0027 0.0104 0.0102
Loa Loa (eye worm) RecQ helicase 0.0024 0.0084 0.0136
Brugia malayi steroid hormone receptor 0.0022 0.0069 0.0166
Loa Loa (eye worm) hypothetical protein 0.0071 0.0412 0.0876
Trypanosoma cruzi ISWI complex protein 0.0015 0.0025 0.0122
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0027 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0174 0.0165
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0069 0.0065
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0227 0.1496 0.1488
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0084 0.052
Trypanosoma cruzi hypothetical protein, conserved 0.0227 0.1496 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0024 0.0116
Brugia malayi PHD-finger family protein 0.0032 0.0142 0.0341
Schistosoma mansoni alpha-glucosidase 0.0159 0.1023 0.1072
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0117 0.0738
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0024 0.0058
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0024 0.0118
Schistosoma mansoni ferritin 0.0018 0.0045 0.0048
Schistosoma mansoni alpha glucosidase 0.0041 0.0203 0.0213
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0209 0.2846
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0281 0.0271
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0227 0.1496 0.1488
Schistosoma mansoni myst-related protein 0.0017 0.0034 0.0036
Schistosoma mansoni hypothetical protein 0.0714 0.4886 0.5124
Schistosoma mansoni ap endonuclease 0.0037 0.0177 0.0186
Loa Loa (eye worm) hypothetical protein 0.0227 0.1496 0.3318
Loa Loa (eye worm) hypothetical protein 0.0052 0.0281 0.0579
Mycobacterium ulcerans hypothetical protein 0.0052 0.0281 0.1741
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0135 0.0134
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0209 0.0212
Loa Loa (eye worm) hypothetical protein 0.0152 0.0975 0.2143
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0024 0.0116
Echinococcus multilocularis tar DNA binding protein 0.0609 0.4156 0.4354
Onchocerca volvulus 0.0058 0.0323 0.2162
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0024 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0069 0.0166
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0045 0.0143
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0184 0.1201 0.2654
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0027 0.0021
Schistosoma mansoni ap endonuclease 0.0037 0.0177 0.0186
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0209 0.1359
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1906 0.1993
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0069 0.0065
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0177 0.1146
Entamoeba histolytica hypothetical protein 0.0115 0.0718 1
Mycobacterium leprae conserved hypothetical protein 0.0227 0.1496 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0209 0.0503
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0024 0.0015
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0203 0.0403
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0281 0.1839
Mycobacterium tuberculosis Conserved protein 0.0227 0.1496 0.1488
Onchocerca volvulus 0.0022 0.0069 0.0462
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0231 0.1506
Mycobacterium tuberculosis Conserved protein 0.0227 0.1496 0.1488
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0069 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0209 0.1359

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1853 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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