Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0429 | 0.0587 |
Echinococcus multilocularis | FTZ F1 alpha | 0.003 | 0.0936 | 0.0936 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.6736 | 0.9218 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0.0936 | 0.0936 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.003 | 0.0936 | 0.0936 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.1032 | 0.1032 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.003 | 0.0936 | 0.1281 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0633 | 0.2065 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.6939 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0633 | 0.0866 |
Schistosoma mansoni | nuclear hormone receptor | 0.003 | 0.0936 | 0.0936 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0037 | 0.0051 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1032 | 0.1032 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.5527 | 0.7564 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.3446 | 0.4717 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.1415 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.7307 | 0.7307 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.003 | 0.0936 | 0.0936 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.003 | 0.0936 | 0.1281 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.003 | 0.0936 | 0.0936 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1032 | 0.1032 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0.0936 | 0.0936 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1415 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.7307 | 0.7307 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.7307 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.003 | 0.0936 | 0.0936 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.6939 | 0.9497 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0936 | 0.1281 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0429 | 0.0587 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1032 | 0.1032 |
Echinococcus multilocularis | geminin | 0.0169 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.003 | 0.0936 | 0.1281 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.003 | 0.0936 | 0.0936 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.1032 | 0.1412 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.003 | 0.0936 | 0.0936 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.003 | 0.0936 | 0.0936 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.003 | 0.0936 | 0.1281 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0633 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.003 | 0.0936 | 0.1281 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0633 | 0.2065 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1032 | 0.1032 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.1415 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0936 | 0.1281 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.3446 | 0.4717 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.003 | 0.0936 | 0.0936 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.7307 | 0.7307 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.003 | 0.0936 | 0.0936 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.1415 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.003 | 0.0936 | 0.0936 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.003 | 0.0936 | 0.0936 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.1157 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.7307 | 0.7307 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.003 | 0.0936 | 0.0936 |
Brugia malayi | Inositol-1 | 0.0038 | 0.1415 | 0.1937 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.003 | 0.0936 | 0.1281 |
Schistosoma mansoni | thyroid hormone receptor | 0.003 | 0.0936 | 0.0936 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0936 | 0.1281 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.003 | 0.0936 | 0.1281 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0052 | 0.2325 | 0.3182 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.6939 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.003 | 0.0936 | 0.1281 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.7307 | 0.7307 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0633 | 0.2065 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.6939 | 0.9497 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.1032 | 0.1032 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.003 | 0.0936 | 0.1281 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.003 | 0.0936 | 0.0936 |
Loa Loa (eye worm) | steroid hormone receptor | 0.003 | 0.0936 | 0.1281 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.003 | 0.0936 | 0.0936 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.003 | 0.0936 | 0.1281 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1415 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.7307 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.003 | 0.0936 | 0.1281 |
Brugia malayi | ecdysteroid receptor | 0.003 | 0.0936 | 0.1281 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.1157 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.5527 | 0.7564 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0936 | 0.1281 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.003 | 0.0936 | 0.1281 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.3446 | 0.3446 |
Echinococcus granulosus | FTZ F1 alpha | 0.003 | 0.0936 | 0.0936 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1032 | 0.1032 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.5527 | 0.7564 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.003 | 0.0936 | 0.1281 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1032 | 0.1032 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0633 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.003 | 0.0936 | 0.1281 |
Brugia malayi | hypothetical protein | 0.0122 | 0.6939 | 0.9497 |
Schistosoma mansoni | thyroid hormone receptor | 0.003 | 0.0936 | 0.0936 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0429 | 0.0587 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1415 | 0.1415 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.003 | 0.0936 | 0.0936 |
Brugia malayi | RNA binding protein | 0.0128 | 0.7307 | 1 |
Schistosoma mansoni | coup transcription factor | 0.003 | 0.0936 | 0.0936 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0.0936 | 0.0936 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1415 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.003 | 0.0936 | 0.0936 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0.0936 | 0.0936 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0633 | 0.0866 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.003 | 0.0936 | 0.0936 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1415 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.003 | 0.0936 | 0.1281 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1415 | 0.1415 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0633 | 0.2065 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.7307 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.003 | 0.0936 | 0.0936 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0633 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0429 | 0.0587 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.1415 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.003 | 0.0936 | 0.0936 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.7307 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.1032 | 0.1412 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0936 | 0.1281 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.003 | 0.0936 | 0.1281 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.5527 | 0.7564 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.003 | 0.0936 | 0.0936 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.003 | 0.0936 | 0.1281 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.003 | 0.0936 | 0.1281 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.1415 | 0.1415 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.003 | 0.0936 | 0.1281 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.003 | 0.0936 | 0.1281 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.1415 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.1032 | 0.1412 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0936 | 0.1281 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1032 | 0.1412 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.6736 | 0.9218 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0936 | 0.1281 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1032 | 0.1032 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1032 | 0.1032 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0023 | 0.0429 | 0.0587 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.7307 | 0.7307 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.1415 | 0.1415 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.003 | 0.0936 | 0.0936 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0936 | 0.1281 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.1415 | 0.1937 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.003 | 0.0936 | 0.1281 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1415 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.7307 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.003 | 0.0936 | 0.1281 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.003 | 0.0936 | 0.1281 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.7307 | 0.7307 |
Brugia malayi | steroid hormone receptor | 0.003 | 0.0936 | 0.1281 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.6736 | 0.9218 |
Brugia malayi | Cytochrome P450 family protein | 0.0052 | 0.2325 | 0.3182 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.003 | 0.0936 | 0.1281 |
Brugia malayi | nuclear hormone receptor | 0.003 | 0.0936 | 0.1281 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1415 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.