Detailed information for compound 787989

Basic information

Technical information
  • TDR Targets ID: 787989
  • Name: 5-(4-ethylphenyl)-1-[(3-methylphenyl)methyl]- 3a,6a-dihydropyrrolo[3,4-d]triazole-4,6-dione
  • MW: 348.398 | Formula: C20H20N4O2
  • H donors: 0 H acceptors: 2 LogP: 4.21 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)N1C(=O)C2C(C1=O)N=NN2Cc1cccc(c1)C
  • InChi: 1S/C20H20N4O2/c1-3-14-7-9-16(10-8-14)24-19(25)17-18(20(24)26)23(22-21-17)12-15-6-4-5-13(2)11-15/h4-11,17-18H,3,12H2,1-2H3
  • InChiKey: LQERDMJHYPOABJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-(4-ethylphenyl)-1-(3-methylbenzyl)-3a,6a-dihydropyrrolo[3,4-d]triazole-4,6-quinone
  • 5-(4-ethylphenyl)-1-[(3-methylphenyl)methyl]-3a,6a-dihydropyrrolo[3,4-d][1,2,3]triazole-4,6-dione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0199 0.0351
Schistosoma mansoni ap endonuclease 0.0039 0.0137 0.0241
Brugia malayi hypothetical protein 0.0025 0.0058 0.0126
Schistosoma mansoni ran 0.0046 0.0178 0.0314
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0112 0.0576 0.1255
Mycobacterium leprae conserved hypothetical protein 0.0181 0.099 1
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.099 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0231 0.1296 0.2283
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.1272 0.2241
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0032 0.0032
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0116 0.1139
Echinococcus granulosus snurportin 1 0.096 0.5677 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0032 0.0069
Echinococcus multilocularis GPCR, family 2 0.0033 0.01 0.01
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1678 0.5976
Giardia lamblia Fructose-bisphosphate aldolase 0.0295 0.1678 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1678 0.5976
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0032 0.0056
Loa Loa (eye worm) importin-beta domain-containing protein 0.0017 0.0007 0.0012
Echinococcus multilocularis dnaJ subfamily B 0.0831 0.4897 0.4897
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0262 0.0262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0032 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.099 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0032 0.0056
Plasmodium falciparum thioredoxin reductase 0.0039 0.0137 0.3075
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0058 0.0584
Echinococcus multilocularis beta LACTamase domain containing family member 0.0181 0.099 0.099
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.0533 0.0533
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0032 0.0056
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0181 0.099 0.2157
Plasmodium falciparum glutathione reductase 0.0039 0.0137 0.3075
Echinococcus multilocularis neutral amino acid transporter A 0.078 0.459 0.459
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0005 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0231 0.1296 0.1296
Brugia malayi jmjC domain containing protein 0.0059 0.0262 0.057
Loa Loa (eye worm) hypothetical protein 0.0181 0.099 0.1744
Brugia malayi MH2 domain containing protein 0.0116 0.0602 0.1312
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0116 0.1172
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0017 0.0007 0.0072
Schistosoma mansoni hypothetical protein 0.0043 0.0165 0.029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0032 0.0069
Trichomonas vaginalis set domain proteins, putative 0.0482 0.2804 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0116 0.0204
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0005 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0137 0.1383
Brugia malayi kap beta 3 protein 0.0017 0.0007 0.0015
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.014 0.014
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0277 0.0277
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0116 0.0652
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0032 0.0056
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0116 0.0652
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0231 0.1296 0.2283
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.0662 0.1166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0032 0.0056
Echinococcus granulosus tumor protein p63 0.0335 0.1916 0.3375
Loa Loa (eye worm) hypothetical protein 0.0239 0.134 0.236
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.078 0.459 0.8086
Toxoplasma gondii exonuclease III APE 0.0039 0.0137 0.1344
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.078 0.459 1
Echinococcus granulosus Excitatory amino acid transporter 0.078 0.459 0.8086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0277 0.0488
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0262 0.0461
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0434 0.0444
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0058 0.0584
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0178 0.1802
Echinococcus granulosus excitatory amino acid transporter 2 0.078 0.459 0.8086
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0116 0.039
Brugia malayi Importin beta-1 subunit 0.009 0.0446 0.0971
Brugia malayi beta-lactamase family protein 0.0181 0.099 0.2157
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.096 0.5677 1
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0017 0.0007 0.0072
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0112 0.0576 0.3406
Brugia malayi hypothetical protein 0.0239 0.134 0.2919
Schistosoma mansoni hypothetical protein 0.007 0.0328 0.0577
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0174 0.0307
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.0771 0.0947
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0178 0.1802
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.1019 1
Onchocerca volvulus Excitatory amino acid transporter homolog 0.078 0.459 1
Echinococcus multilocularis geminin 0.0343 0.1964 0.1964
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.039
Loa Loa (eye worm) hypothetical protein 0.0313 0.1787 0.3147
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0033 0.01 0.0177
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0116 0.039
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0032 0.0056
Echinococcus granulosus neutral amino acid transporter 0.078 0.459 0.8086
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0112 0.0576 0.1015
Echinococcus granulosus importin subunit beta 1 0.009 0.0446 0.0785
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0181 0.099 0.1744
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0056
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0005 0.0009
Loa Loa (eye worm) excitatory amino acid transporter 0.078 0.459 0.8086
Echinococcus multilocularis excitatory amino acid transporter 3 0.078 0.459 0.459
Onchocerca volvulus 0.0062 0.0277 0.0538
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0137 0.1384
Echinococcus granulosus dnaJ subfamily B 0.0831 0.4897 0.8627
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0032 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.099 0.3515
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0523 0.0922
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0282 0.0496
Loa Loa (eye worm) hypothetical protein 0.0049 0.0199 0.0351
Echinococcus granulosus expressed conserved protein 0.0098 0.0495 0.0872
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.01 0.01
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1678 0.5976
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0346 0.1982 0.1982
Mycobacterium tuberculosis Conserved protein 0.0181 0.099 0.1273
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0494 0.0532
Echinococcus granulosus muscleblind protein 0.0313 0.1787 0.3147
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0116 0.0253
Treponema pallidum glutamate/aspartate transporter 0.0346 0.1982 1
Plasmodium falciparum importin beta, putative 0.009 0.0446 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.0803 0.0803
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0032 0.0069
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0005 0.0005
Brugia malayi Excitatory amino acid transporter 0.078 0.459 1
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0116 0.1139
Schistosoma mansoni survival motor neuron protein 0.0049 0.0198 0.0348
Onchocerca volvulus 0.0058 0.0255 0.0491
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0116 0.039
Mycobacterium tuberculosis Probable esterase LipL 0.0181 0.099 0.1273
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0032 0.0069
Echinococcus multilocularis importin 5 0.0017 0.0007 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0523 0.114
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0174 0.0307
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0346 0.1982 0.3491
Echinococcus granulosus Excitatory amino acid transporter 0.078 0.459 0.8086
Schistosoma mansoni cpg binding protein 0.0062 0.0275 0.0485
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0231 0.1296 0.2823
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0032 0.0056
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0032 0.0032
Brugia malayi Muscleblind-like protein 0.0313 0.1787 0.3892
Echinococcus granulosus ubiquitin specific protease 41 0.0112 0.0576 0.1015
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.0533 0.3147
Schistosoma mansoni alpha-glucosidase 0.0136 0.0724 0.1276
Trypanosoma brucei glucosidase, putative 0.0035 0.0116 0.1172
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0007 0.007
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0282 0.0496
Echinococcus multilocularis microtubule associated protein 2 0.0712 0.4185 0.4185
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0328 0.0714
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0112 0.0576 0.0576
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.01 0.0177
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.1678 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.01 0.01
Brugia malayi jmjC domain containing protein 0.0063 0.0282 0.0614
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0137 0.3073
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0582 0.5717
Schistosoma mansoni hypothetical protein 0.0033 0.01 0.0177
Onchocerca volvulus 0.0092 0.0455 0.0929
Entamoeba histolytica Ran family GTPase 0.0046 0.0178 0.1025
Chlamydia trachomatis glutamate symporter 0.078 0.459 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0231 0.1296 0.1296
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.01 0.0219
Trypanosoma cruzi importin beta-1 subunit, putative 0.0073 0.0343 0.3467
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0282 0.0496
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0032 0.0056
Brugia malayi Pre-SET motif family protein 0.0062 0.0277 0.0603
Brugia malayi Thioredoxin reductase 0.0039 0.0137 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0032 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.099 0.3515
Mycobacterium tuberculosis Probable hydrolase 0.0181 0.099 0.1273
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.039
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0178 0.0389
Echinococcus granulosus sodium:dicarboxylate symporter 0.078 0.459 0.8086
Toxoplasma gondii ABC1 family protein 0.0181 0.099 0.9719
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0112 0.0576 0.5821
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0032 0.0056
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0032 0.0056
Echinococcus granulosus neuropeptide receptor A26 0.0468 0.272 0.4792
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1678 0.5976
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1678 0.5976
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0231 0.1296 0.2283
Mycobacterium ulcerans beta-lactamase 0.0181 0.099 0.9675
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0178 0.1752
Echinococcus multilocularis Excitatory amino acid transporter 0.078 0.459 0.459
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0277 0.0488
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0032 0.0056
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0178 0.0178
Mycobacterium tuberculosis Probable reductase 0.0088 0.0434 0.0444
Schistosoma mansoni hypothetical protein 0.0831 0.4897 0.8627
Echinococcus multilocularis excitatory amino acid transporter 2 0.078 0.459 0.459
Schistosoma mansoni hypothetical protein 0.0343 0.1964 0.346
Loa Loa (eye worm) hypothetical protein 0.0045 0.0174 0.0307
Plasmodium vivax hypothetical protein, conserved 0.0181 0.099 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.002 0.002
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0181 0.099 0.1273
Loa Loa (eye worm) kap beta 3 protein 0.0017 0.0007 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0032 0.0056
Mycobacterium ulcerans lipase LipD 0.0181 0.099 0.9675
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0181 0.099 0.1744
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0185 0.1019 0.1794
Onchocerca volvulus 0.0181 0.099 0.2102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0032 0.0056
Echinococcus multilocularis neutral amino acid transporter A 0.078 0.459 0.459
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.0494 0.0532
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0112 0.0576 0.0576
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.01 0.0177
Echinococcus multilocularis importin subunit beta 1 0.009 0.0446 0.0446
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0032 0.0056
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.0533 0.0939
Echinococcus granulosus GPCR family 2 0.0033 0.01 0.0177
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0032 0.0069
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.014 0.0247
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.1019 0.1794
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0137 0.0137
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0032 0.0056
Plasmodium vivax importin-beta 2, putative 0.009 0.0446 0.45
Loa Loa (eye worm) hypothetical protein 0.0112 0.0576 0.1015
Brugia malayi CHE-14 protein 0.0045 0.0174 0.038
Mycobacterium tuberculosis Conserved protein 0.0181 0.099 0.1273
Entamoeba histolytica hypothetical protein 0.0073 0.0343 0.2011
Plasmodium vivax transportin, putative 0.0017 0.0007 0.0072
Trypanosoma brucei importin beta-1 subunit, putative 0.009 0.0446 0.45
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0032 0.0056
Brugia malayi nuclear receptor NHR-88 0.0021 0.0032 0.0069
Loa Loa (eye worm) hypothetical protein 0.0313 0.1787 0.3147
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0058 0.1297
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0032 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0116 0.1172
Loa Loa (eye worm) hypothetical protein 0.009 0.0446 0.0785
Brugia malayi beta-lactamase 0.0181 0.099 0.2157
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0277 0.0488
Trichomonas vaginalis penicillin-binding protein, putative 0.0181 0.099 0.3515
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0137 0.0241
Echinococcus multilocularis excitatory amino acid transporter 2 0.078 0.459 0.459
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0255 0.045
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0178 0.0269
Toxoplasma gondii thioredoxin reductase 0.0039 0.0137 0.1345
Echinococcus granulosus excitatory amino acid transporter 2 0.078 0.459 0.8086
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0137 0.1383
Toxoplasma gondii aldehyde dehydrogenase 0.0185 0.1019 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0032 0.0056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1678 0.5976
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0032 0.0056
Echinococcus granulosus neutral amino acid transporter A 0.078 0.459 0.8086
Echinococcus granulosus transportin 1 0.0017 0.0007 0.0012
Leishmania major hypothetical protein, conserved 0.0181 0.099 0.9719
Echinococcus multilocularis neutral amino acid transporter A 0.078 0.459 0.459
Toxoplasma gondii HEAT repeat-containing protein 0.009 0.0446 0.4374
Trypanosoma brucei importin beta-1 subunit, putative 0.009 0.0446 0.45
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0137 0.0464
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0056
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0032 0.0069
Loa Loa (eye worm) hypothetical protein 0.0103 0.0523 0.0922
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.0857 0.1866
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0137 0.0241
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0112 0.0576 0.1015
Mycobacterium tuberculosis Conserved protein 0.0181 0.099 0.1273
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0112 0.0576 0.285
Schistosoma mansoni hypothetical protein 0.0033 0.01 0.0177
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0058 0.0584
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0032 0.0032
Trichomonas vaginalis importin beta-1, putative 0.0073 0.0343 0.1202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1678 0.5976
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0112 0.0576 0.2035
Loa Loa (eye worm) beta-lactamase 0.0181 0.099 0.1744
Echinococcus multilocularis neuropeptide s receptor 0.0468 0.272 0.272
Brugia malayi steroid hormone receptor 0.0021 0.0032 0.0069
Onchocerca volvulus 0.0482 0.2804 0.6081
Brugia malayi Latrophilin receptor protein 2 0.0033 0.01 0.0219
Schistosoma mansoni hypothetical protein 0.096 0.5677 1
Schistosoma mansoni alpha glucosidase 0.0035 0.0116 0.0204
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0007 0.007
Schistosoma mansoni cpg binding protein 0.0058 0.0255 0.045
Loa Loa (eye worm) hypothetical protein 0.0025 0.0058 0.0102
Loa Loa (eye worm) hypothetical protein 0.007 0.0328 0.0577
Echinococcus granulosus geminin 0.0343 0.1964 0.346
Trypanosoma brucei hypothetical protein, conserved 0.0181 0.099 1
Echinococcus multilocularis snurportin 1 0.096 0.5677 0.5677
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0602 0.1061
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0058 0.0584
Treponema pallidum fructose-bisphosphate aldolase 0.0295 0.1678 0.8356
Mycobacterium leprae Probable lipase LipE 0.0181 0.099 1
Echinococcus multilocularis transportin 1 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0056
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0343 0.1202
Echinococcus multilocularis translational activator gcn1 0.0017 0.0007 0.0007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0185 0.1019 0.1316
Brugia malayi Pre-SET motif family protein 0.0424 0.2453 0.5343
Brugia malayi CXXC zinc finger family protein 0.0058 0.0255 0.0556
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0005 0.0009
Schistosoma mansoni microtubule-associated protein tau 0.0712 0.4185 0.7372
Loa Loa (eye worm) hypothetical protein 0.0055 0.0235 0.0414
Echinococcus multilocularis protein dispatched 1 0.0051 0.0213 0.0213
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0602 0.1061
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0116 0.039
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0032 0.0069
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0027 0.0027
Brugia malayi hypothetical protein 0.0016 0.0004 0.0008
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0112 0.0576 0.1015
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0434 0.0444
Echinococcus multilocularis expressed conserved protein 0.0098 0.0495 0.0495
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.01 0.0177
Leishmania major trypanothione reductase 0.0039 0.0137 0.1345
Schistosoma mansoni importin-beta 2 0.0017 0.0007 0.0012
Schistosoma mansoni patched 1 0.0045 0.0174 0.0307
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0181 0.099 0.1744
Echinococcus multilocularis ubiquitin specific protease 41 0.0112 0.0576 0.0576
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.0771 0.7194
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0116 0.0204
Mycobacterium tuberculosis Probable lipase LipE 0.0181 0.099 0.1273
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0137 0.1383
Loa Loa (eye worm) hypothetical protein 0.0181 0.099 0.1744
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.0857 0.1509
Mycobacterium tuberculosis Probable lipase LipD 0.0181 0.099 0.1273
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.0543 0.0956
Onchocerca volvulus 0.0181 0.099 0.2102
Echinococcus multilocularis sodium:dicarboxylate symporter 0.078 0.459 0.459
Schistosoma mansoni ran 0.0046 0.0178 0.0314
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0178 0.0314
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0277 0.0488
Plasmodium vivax glutathione reductase, putative 0.0039 0.0137 0.1384
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0056
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0032 0.0056
Schistosoma mansoni alpha-glucosidase 0.0136 0.0724 0.1276
Leishmania major importin beta-1 subunit, putative 0.0073 0.0343 0.337
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0174 0.0598
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0277 0.0488
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0346 0.1982 0.3491
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0434 0.0444
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0032 0.0032
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0178 0.1802
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.1019 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.0857 0.1509
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0116 0.0116
Echinococcus multilocularis cpg binding protein 0.0062 0.0275 0.0275
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1154 0.6838 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0137 0.1383
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.1678 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0178 0.1802
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0032 0.0069
Leishmania major hypothetical protein, conserved 0.0017 0.0007 0.007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0231 0.1296 0.2283
Echinococcus multilocularis protein patched 0.0045 0.0174 0.0174
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0025 0.0055
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0032 0.0056
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0112 0.0576 0.1015
Plasmodium falciparum transportin 0.0017 0.0007 0.0159
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0262 0.0461
Echinococcus granulosus microtubule associated protein 2 0.0712 0.4185 0.7372
Loa Loa (eye worm) glutathione reductase 0.0039 0.0137 0.0241
Onchocerca volvulus 0.0049 0.0198 0.0364
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0027 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0032 0.0032
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.134 0.236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0032 0.0056
Echinococcus granulosus importin 5 0.0017 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0056
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0032 0.0056
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0174 0.0307
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.078 0.459 0.6646
Schistosoma mansoni hypothetical protein 0.0033 0.01 0.0177
Echinococcus granulosus excitatory amino acid transporter 3 0.078 0.459 0.8086
Brugia malayi beta-lactamase family protein 0.0181 0.099 0.2157
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1678 0.5976
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0181 0.099 0.1273
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0523 0.114
Loa Loa (eye worm) hypothetical protein 0.0033 0.01 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0032 0.0069
Onchocerca volvulus 0.0181 0.099 0.2102
Echinococcus multilocularis tumor protein p63 0.0335 0.1916 0.1916
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0032 0.0032
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0434 0.0444
Echinococcus multilocularis muscleblind protein 0.0313 0.1787 0.1787
Brugia malayi ecdysteroid receptor 0.0021 0.0032 0.0069
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0058 0.1297
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0032 0.0056
Plasmodium vivax SET domain protein, putative 0.0062 0.0277 0.2796
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0857 0.0857
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0032 0.0069
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0058 0.0567
Schistosoma mansoni importin beta-1 0.009 0.0446 0.0785
Leishmania major hypothetical protein, conserved 0.0025 0.0058 0.0567
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0056
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0112 0.0576 0.5657
Trichomonas vaginalis penicillin-binding protein, putative 0.0181 0.099 0.3515
Trypanosoma brucei trypanothione reductase 0.0039 0.0137 0.1384
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0424 0.2453 0.4321
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.0771 0.6062
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.039
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0032 0.0056
Loa Loa (eye worm) hypothetical protein 0.0181 0.099 0.1744
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0174 0.0174
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0112 0.0576 0.2035
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0857 0.0857
Schistosoma mansoni coup transcription factor 0.0021 0.0032 0.0056
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0178 0.4005
Schistosoma mansoni hypothetical protein 0.0049 0.0198 0.0348
Schistosoma mansoni cpg binding protein 0.0062 0.0275 0.0485
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.0533 0.1161
Echinococcus granulosus neuropeptide s receptor 0.0468 0.272 0.4792
Brugia malayi RNA, U transporter 1 0.0256 0.1442 0.3142
Loa Loa (eye worm) histone methyltransferase 0.002 0.0027 0.0047
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0434 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0576 0.2035
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.002 0.0035
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0032 0.0056
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0112 0.0576 0.5821
Echinococcus granulosus beta LACTamase domain containing family member 0.0181 0.099 0.1744
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0032 0.0056
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0137 0.0777
Loa Loa (eye worm) hypothetical protein 0.0181 0.099 0.1744
Trichomonas vaginalis ran, putative 0.0046 0.0178 0.0613
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0256 0.0451
Mycobacterium ulcerans esterase/lipase LipP 0.0181 0.099 0.9675
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0056
Schistosoma mansoni hypothetical protein 0.0043 0.0165 0.029
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0178 0.0314
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0277 0.2718
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0185 0.1019 0.1019
Brugia malayi glutathione reductase 0.0039 0.0137 0.0298
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0277 0.0277
Echinococcus granulosus cpg binding protein 0.0062 0.0275 0.0485
Echinococcus granulosus translational activator gcn1 0.0017 0.0007 0.0012
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0181 0.099 0.9675
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0032 0.0069
Trichomonas vaginalis esterase, putative 0.0181 0.099 0.3515
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0032 0.0032
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0137 0.1344
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.0803 0.1414
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0231 0.1296 0.2283
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.078 0.459 0.459
Schistosoma mansoni hypothetical protein 0.0043 0.0165 0.029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0282 0.0496
Echinococcus multilocularis muscleblind protein 1 0.0313 0.1787 0.1787
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0346 0.1982 0.1982
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.0494 0.1064
Brugia malayi nuclear hormone receptor 0.0021 0.0032 0.0069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.1019 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0533 0.0939
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.099 0.3515
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0181 0.099 0.1273
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0056
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0032 0.0069
Echinococcus multilocularis neuropeptide receptor A26 0.0468 0.272 0.272
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.134 0.134
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0343 0.1202
Loa Loa (eye worm) hypothetical protein 0.0062 0.0277 0.0488
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0137 0.0298
Schistosoma mansoni ap endonuclease 0.0039 0.0137 0.0241
Echinococcus granulosus neutral amino acid transporter A 0.078 0.459 0.8086
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0262 0.0262
Echinococcus multilocularis Excitatory amino acid transporter 0.078 0.459 0.459
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0198 0.043
Onchocerca volvulus 0.0049 0.0199 0.0367
Loa Loa (eye worm) hypothetical protein 0.0181 0.099 0.1744
Leishmania major GTP-binding protein, putative 0.0046 0.0178 0.1752
Schistosoma mansoni hypothetical protein 0.0343 0.1964 0.346
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0137 0.0241
Treponema pallidum glutamate transporter 0.0346 0.1982 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0032 0.0056
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.039
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0137 0.0464
Brugia malayi follicle stimulating hormone receptor 0.0228 0.1272 0.2772
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0032 0.0056
Loa Loa (eye worm) hypothetical protein 0.0181 0.099 0.1744
Mycobacterium ulcerans hypothetical protein 0.0181 0.099 0.9675
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0185 0.1019 1
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.1019 0.1794
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0032 0.0069
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0137 0.1384
Schistosoma mansoni hypothetical protein 0.0043 0.0165 0.029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0231 0.1296 0.2283
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.0494 0.0532
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0112 0.0576 0.5821

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.