Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | 0.0082 | 0.0633 | 0.0789 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0116 | 0.1123 | 0.1123 |
Onchocerca volvulus | 0.0106 | 0.0981 | 0.17 | |
Schistosoma mansoni | single-minded | 0.006 | 0.0305 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1734 | 0.2163 |
Echinococcus multilocularis | Rac GTPase activating protein 1 | 0.0158 | 0.1734 | 0.1734 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0211 | 0.0211 |
Loa Loa (eye worm) | glutaminase | 0.0586 | 0.7982 | 0.9956 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0633 | 0.0789 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0043 | 0.0068 | 0.0085 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0082 | 0.0633 | 0.0633 |
Onchocerca volvulus | 0.0082 | 0.0633 | 0.1096 | |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.013 | 0.1324 | 0.1659 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0304 | 0.0304 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0554 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.5773 | 0.72 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0082 | 0.0633 | 0.0789 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0082 | 0.0633 | 0.0633 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0082 | 0.0633 | 0.0633 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0173 | 0.1958 | 0.2453 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0211 | 0.0211 |
Brugia malayi | PAS domain containing protein | 0.006 | 0.0305 | 0.038 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0082 | 0.0633 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1088 | 0.1357 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0082 | 0.0633 | 0.0633 |
Brugia malayi | small heat shock protein | 0.0589 | 0.8018 | 1 |
Schistosoma mansoni | glutaminase | 0.0586 | 0.7982 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0227 | 0.2749 | 0.3429 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0082 | 0.0633 | 0.0633 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0633 | 0.0789 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0082 | 0.0633 | 0.0793 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0252 | 0.3107 | 0.3107 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0211 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0554 | 0.0691 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0068 | 0.0085 |
Schistosoma mansoni | thyroid hormone receptor | 0.0334 | 0.4305 | 0.5393 |
Brugia malayi | steroid hormone receptor | 0.0082 | 0.0633 | 0.0789 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0072 | 0.0484 | 0.0484 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0068 | 0.0085 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0304 | 0.0285 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0082 | 0.0633 | 0.0633 |
Schistosoma mansoni | lipoxygenase | 0.0116 | 0.1123 | 0.1406 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0044 | 0.0079 | 0.0079 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0082 | 0.0633 | 0.0789 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0082 | 0.0633 | 0.1096 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0211 | 0.0211 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0082 | 0.0633 | 0.0633 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0082 | 0.0633 | 0.0789 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0082 | 0.0633 | 0.0789 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0072 | 0.0484 | 0.0484 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0554 | 0.0601 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0082 | 0.0633 | 0.0789 |
Brugia malayi | nuclear receptor RXR | 0.0043 | 0.0068 | 0.0085 |
Schistosoma mansoni | lipoxygenase | 0.0081 | 0.0615 | 0.077 |
Echinococcus granulosus | single minded 2 | 0.0044 | 0.0079 | 0.0079 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0082 | 0.0633 | 0.0633 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0981 | 0.1224 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0082 | 0.0633 | 0.0633 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0082 | 0.0633 | 0.0789 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0304 | 0.0381 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.013 | 0.1324 | 0.1324 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0082 | 0.0633 | 0.0793 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0082 | 0.0633 | 0.0789 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0484 | 0.0607 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.0554 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.013 | 0.1324 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0082 | 0.0633 | 0.0793 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0116 | 0.1123 | 0.1123 |
Loa Loa (eye worm) | glutaminase 2 | 0.0586 | 0.7982 | 0.9956 |
Brugia malayi | hypothetical protein | 0.0435 | 0.5773 | 0.72 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0082 | 0.0633 | 0.0633 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1307 | 0.163 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0082 | 0.0633 | 0.0793 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0082 | 0.0633 | 0.1096 |
Onchocerca volvulus | 0.0128 | 0.1307 | 0.2264 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0082 | 0.0633 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0633 | 0.0789 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0082 | 0.0633 | 0.0789 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0072 | 0.0484 | 0.0607 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0068 | 0.0085 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0113 | 0.1081 | 0.1348 |
Brugia malayi | RhoGAP domain containing protein | 0.0136 | 0.1419 | 0.177 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0304 | 0.0381 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0304 | 0.0304 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0554 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.0586 | 0.7982 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0082 | 0.0633 | 0.0793 |
Brugia malayi | hypothetical protein | 0.0072 | 0.0484 | 0.0604 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0082 | 0.0633 | 0.0789 |
Brugia malayi | Probable ClpP-like protease | 0.0077 | 0.0554 | 0.0691 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.0554 | 1 |
Giardia lamblia | Rho GAP, putative | 0.0136 | 0.1419 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0633 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0633 | 0.0789 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0082 | 0.0633 | 0.0633 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0082 | 0.0633 | 0.0633 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0554 | 0.0601 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0633 | 0.0789 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0082 | 0.0633 | 0.0793 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.013 | 0.1324 | 0.5 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0129 | 0.1314 | 0.1314 |
Onchocerca volvulus | 0.0435 | 0.5773 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0211 | 0.0264 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0077 | 0.0554 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0252 | 0.3107 | 0.3892 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.013 | 0.1324 | 0.1651 |
Brugia malayi | glutaminase DH11.1 | 0.0586 | 0.7982 | 0.9956 |
Brugia malayi | bHLH-PAS transcription factor | 0.0044 | 0.0079 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.0589 | 0.8018 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0077 | 0.0554 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0082 | 0.0633 | 0.0633 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.0168 | 0.0168 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0082 | 0.0633 | 0.0633 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0043 | 0.0068 | 0.0085 |
Echinococcus multilocularis | Protein lozenge | 0.0055 | 0.023 | 0.023 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0082 | 0.0633 | 0.0789 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0082 | 0.0633 | 0.0789 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0082 | 0.0633 | 0.0789 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.0168 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0068 | 0.0085 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0334 | 0.4305 | 0.4305 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0211 | 0.0263 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0043 | 0.0068 | 0.0068 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0129 | 0.1314 | 0.1314 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0043 | 0.0068 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0633 | 0.0789 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0106 | 0.0981 | 0.1229 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0075 | 0.0528 | 0.0528 |
Echinococcus granulosus | FTZ F1 alpha | 0.0082 | 0.0633 | 0.0633 |
Mycobacterium ulcerans | glutaminase | 0.0586 | 0.7982 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0082 | 0.0633 | 0.0789 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0043 | 0.0068 | 0.0085 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0304 | 0.0285 |
Schistosoma mansoni | thyroid hormone receptor | 0.0334 | 0.4305 | 0.5393 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.5773 | 0.72 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.1419 | 0.177 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0082 | 0.0633 | 0.0789 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0211 | 0.0211 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0082 | 0.0633 | 0.0789 |
Schistosoma mansoni | rac gtpase activating protein | 0.0158 | 0.1734 | 0.2173 |
Loa Loa (eye worm) | runx1 | 0.0055 | 0.023 | 0.0287 |
Brugia malayi | RhoGAP domain containing protein | 0.0158 | 0.1734 | 0.2163 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.013 | 0.1324 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0304 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0211 | 0.0264 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0211 | 0.0264 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0082 | 0.0633 | 0.0789 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0082 | 0.0633 | 0.0633 |
Schistosoma mansoni | nuclear hormone receptor | 0.0082 | 0.0633 | 0.0793 |
Brugia malayi | follicle stimulating hormone receptor | 0.0227 | 0.2749 | 0.3429 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0043 | 0.0068 | 0.0068 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.013 | 0.1324 | 0.1324 |
Schistosoma mansoni | lozenge | 0.0055 | 0.023 | 0.0288 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.013 | 0.1324 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0077 | 0.0554 | 0.0694 |
Brugia malayi | nuclear receptor NHR-88 | 0.0082 | 0.0633 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0633 | 0.0789 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.013 | 0.1324 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0252 | 0.3107 | 0.3107 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.0554 | 0.0554 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0082 | 0.0633 | 0.0793 |
Echinococcus multilocularis | tumor protein p63 | 0.0724 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0082 | 0.0633 | 0.0793 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0075 | 0.0528 | 0.0528 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0082 | 0.0633 | 0.0789 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.0554 | 0.0554 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0043 | 0.0068 | 0.0085 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0082 | 0.0633 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1081 | 0.1348 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0068 | 0.0085 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.013 | 0.1324 | 0.1651 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0082 | 0.0633 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0068 | 0.0085 |
Echinococcus granulosus | Rac GTPase activating protein 1 | 0.0158 | 0.1734 | 0.1734 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0068 | 0.0085 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0082 | 0.0633 | 0.0789 |
Brugia malayi | nuclear hormone receptor | 0.0082 | 0.0633 | 0.0789 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0082 | 0.0633 | 0.0789 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0082 | 0.0633 | 0.0789 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0082 | 0.0633 | 0.0633 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0082 | 0.0633 | 0.1096 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0554 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0554 | 0.5 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0554 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0304 | 0.0285 |
Onchocerca volvulus | 0.0045 | 0.0086 | 0.015 | |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0082 | 0.0633 | 0.0793 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0082 | 0.0633 | 0.0793 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.