Detailed information for compound 788308

Basic information

Technical information
  • TDR Targets ID: 788308
  • Name: N-(3-chloro-4-methoxyphenyl)-5-(4-methylpheny l)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidi ne-3-carboxamide
  • MW: 460.836 | Formula: C22H16ClF3N4O2
  • H donors: 1 H acceptors: 3 LogP: 4.71 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Cl)NC(=O)c1cnn2c1nc(cc2C(F)(F)F)c1ccc(cc1)C
  • InChi: 1S/C22H16ClF3N4O2/c1-12-3-5-13(6-4-12)17-10-19(22(24,25)26)30-20(29-17)15(11-27-30)21(31)28-14-7-8-18(32-2)16(23)9-14/h3-11H,1-2H3,(H,28,31)
  • InChiKey: ACCLGDXEEBMFOK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chloro-4-methoxy-phenyl)-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
  • N-(3-chloro-4-methoxyphenyl)-5-(4-methylphenyl)-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor E75 0.001 0.0028 0.0004
Mycobacterium tuberculosis Conserved protein 0.0071 0.1407 0.1317
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.162 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.027 0.0353
Schistosoma mansoni hypothetical protein 0.0063 0.1235 0.1615
Schistosoma mansoni coup transcription factor 0.002 0.027 0.0353
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0028 0.0004
Schistosoma mansoni ets-related 0.001 0.0048 0.0063
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.1939 1
Schistosoma mansoni hypothetical protein 0.0063 0.1235 0.1615
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0054 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.027 0.0364
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0048 0.0063
Toxoplasma gondii thioredoxin reductase 0.0037 0.0651 0.3614
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.049 0.064
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.1726 0.164
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.023 0.0129
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0028 0.0004
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0435 0.2189
Onchocerca volvulus 0.0071 0.1407 0.2049
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0662 0.0866
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0028 0.0037
Brugia malayi tailless protein 0.001 0.0028 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.027 0.0364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.027 0.036
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.162 1
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0997 0.1304
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.027 0.0353
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0048 0.0063
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0997 0.0904
Toxoplasma gondii ABC1 family protein 0.0071 0.1407 0.8595
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.027 0.0353
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0103 0.0134
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0048 0.0063
Brugia malayi conserved hypotetical protein 0.001 0.0028 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0071 0.1407 0.8595
Onchocerca volvulus 0.0071 0.1407 0.2049
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0054 0.0071
Brugia malayi transcription factor E74 isoform 0.001 0.0048 0.0033
Schistosoma mansoni nuclear receptor 0.001 0.0028 0.0037
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.023 0.0255
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.4309 0.6364
Entamoeba histolytica hypothetical protein 0.0036 0.062 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.023 0.0839
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.1726 0.858
Plasmodium falciparum glutathione reductase 0.0037 0.0651 0.3614
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.027 0.0353
Brugia malayi hypothetical protein 0.0011 0.0054 0.0042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1407 0.1839
Loa Loa (eye worm) hypothetical protein 0.0071 0.1407 0.2049
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.162 1
Brugia malayi Nuclear hormone receptor E75 0.001 0.0028 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0039
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0028 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.027 0.036
Brugia malayi hypothetical protein 0.0307 0.6757 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.4309 0.6364
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.1726 0.164
Loa Loa (eye worm) fli-1 protein 0.0218 0.475 0.7018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.027 0.036
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0651 0.0926
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.027 0.0353
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0852 0.1115
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.1235 0.1797
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.027 0.0353
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.162 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.062 0.0811
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.027 0.0364
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.027 0.0353
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0048 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.027 0.0364
Loa Loa (eye worm) hypothetical protein 0.0136 0.2886 0.4248
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0435 0.2189
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0029
Schistosoma mansoni cpg binding protein 0.0029 0.0471 0.0616
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.027 0.0364
Loa Loa (eye worm) hypothetical protein 0.0071 0.1407 0.2049
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.004 0.0053
Schistosoma mansoni elf1 0.001 0.0048 0.0063
Onchocerca volvulus Bile acid receptor homolog 0.002 0.027 0.036
Loa Loa (eye worm) RNA binding protein 0.0194 0.4191 0.6187
Schistosoma mansoni nuclear receptor 0.001 0.0028 0.0037
Echinococcus granulosus FTZ F1 alpha 0.002 0.027 0.0353
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1407 1
Loa Loa (eye worm) hypothetical protein 0.002 0.027 0.036
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.162 0.2118
Plasmodium falciparum thioredoxin reductase 0.0037 0.0651 0.3614
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0028 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0039
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.1235 0.1615
Loa Loa (eye worm) hypothetical protein 0.0071 0.1407 0.2049
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.023 0.0255
Loa Loa (eye worm) hypothetical protein 0.008 0.162 0.2365
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.162 1
Schistosoma mansoni cpg binding protein 0.0031 0.0508 0.0665
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0852 0.1228
Brugia malayi nuclear receptor NHR-88 0.001 0.0028 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1407 0.2614
Loa Loa (eye worm) steroid hormone receptor 0.002 0.027 0.036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.1235 0.1615
Loa Loa (eye worm) hypothetical protein 0.002 0.027 0.036
Loa Loa (eye worm) hypothetical protein 0.0071 0.1407 0.2049
Toxoplasma gondii exonuclease III APE 0.0018 0.023 0.0839
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1407 0.2614
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0029
Brugia malayi beta-lactamase 0.0071 0.1407 0.2052
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.027 0.0353
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.027 0.0353
Brugia malayi nuclear receptor RXR 0.001 0.0028 0.0004
Mycobacterium tuberculosis Conserved protein 0.0071 0.1407 0.1317
Trichomonas vaginalis set domain proteins, putative 0.0234 0.509 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0028 0.0037
Brugia malayi glutathione reductase 0.0037 0.0651 0.0929
Leishmania major trypanothione reductase 0.0037 0.0651 0.4204
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0028 0.0037
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0852 0.1225
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.023 0.0304
Brugia malayi CXXC zinc finger family protein 0.0029 0.0471 0.0661
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0048 0.0063
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.049 0.064
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0103 0.0134
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.027 0.0353
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.027 0.0364
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.1407 0.1317
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.1407 0.8595
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.1439 0.1881
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.1726 0.164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.027 0.036
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0028 0.0037
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.004 0.0053
Brugia malayi Fli-1 protein 0.0218 0.475 0.7019
Mycobacterium tuberculosis Probable reductase 0.0085 0.1726 0.164
Brugia malayi nuclear hormone receptor 0.002 0.027 0.0364
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.023 0.0839
Loa Loa (eye worm) hypothetical protein 0.002 0.027 0.036
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.4451 0.6574
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0997 0.1304
Brugia malayi TAR-binding protein 0.0194 0.4191 0.6189
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0103 0.0134
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.1235 0.1793
Loa Loa (eye worm) beta-lactamase 0.0071 0.1407 0.2049
Brugia malayi nuclear receptor RXR 0.0011 0.0054 0.0042
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0054 0.0071
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.1939 0.1856
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.1407 0.2049
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0028 0.0037
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0048 0.0029
Brugia malayi steroid hormone receptor 0.002 0.027 0.0364
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0194 0.4191 0.6187
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0038 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.027 0.036
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0039
Trypanosoma brucei trypanothione reductase 0.0037 0.0651 0.4204
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.027 0.0364
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.023 0.0976
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0048 0.0063
Schistosoma mansoni thyroid hormone receptor 0.002 0.027 0.0353
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.162 1
Schistosoma mansoni zinc finger protein 0.001 0.0028 0.0037
Schistosoma mansoni gabp alpha 0.0072 0.1439 0.1881
Brugia malayi Pre-SET motif family protein 0.003 0.049 0.069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0852 0.1115
Loa Loa (eye worm) hypothetical protein 0.002 0.027 0.036
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0039
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0048 0.0029
Mycobacterium ulcerans lipase LipD 0.0071 0.1407 0.8595
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.027 0.0364
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0028 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.4309 0.6362
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0028 0.0037
Echinococcus multilocularis protein C ets 2 0.001 0.0048 0.0063
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1407 0.2614
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.027 0.036
Loa Loa (eye worm) hypothetical protein 0.002 0.027 0.036
Schistosoma mansoni hypothetical protein 0.0347 0.7648 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.162 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0852 0.1115
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0054 0.0042
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.027 0.0353
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.1407 0.1839
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0028 0.0037
Onchocerca volvulus 0.003 0.049 0.0686
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1084 0.6472
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0103 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0194 0.4191 0.548
Schistosoma mansoni nuclear hormone receptor 0.002 0.027 0.0353
Brugia malayi nuclear hormone receptor 0.001 0.0028 0.0004
Schistosoma mansoni hypothetical protein 0.001 0.0048 0.0063
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.027 0.0353
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.027 0.0353
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1234 0.1613
Brugia malayi nuclear receptor NHR-88 0.002 0.027 0.0364
Echinococcus granulosus geminin 0.0347 0.7648 1
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0048 0.0063
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0054 0.0042
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0451 0.059
Echinococcus granulosus tar DNA binding protein 0.0194 0.4191 0.548
Schistosoma mansoni hypothetical protein 0.0063 0.1235 0.1615
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.1407 0.1839
Schistosoma mansoni tar DNA-binding protein 0.0194 0.4191 0.548
Loa Loa (eye worm) hypothetical protein 0.0062 0.1203 0.1746
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.023 0.03
Brugia malayi hypothetical protein 0.001 0.0028 0.0004
Schistosoma mansoni thyroid hormone receptor 0.002 0.027 0.0353
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.027 0.036
Entamoeba histolytica hypothetical protein 0.0036 0.062 1
Brugia malayi hypothetical protein 0.0011 0.0054 0.0042
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.1407 0.1317
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.027 0.0364
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0054 0.0071
Brugia malayi hypothetical protein 0.001 0.0028 0.0004
Brugia malayi Ets-domain containing protein 0.0072 0.1439 0.2099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1407 0.1839
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0997 0.0904
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.049 0.064
Brugia malayi RNA recognition motif domain containing protein 0.0194 0.4191 0.6189
Brugia malayi ecdysteroid receptor 0.002 0.027 0.0364
Plasmodium vivax SET domain protein, putative 0.003 0.049 0.2551
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0048 0.0063
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.027 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.027 0.0364
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.2886 0.425
Echinococcus granulosus cpg binding protein 0.0031 0.0508 0.0665
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.1407 0.1317
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.049 0.064
Schistosoma mansoni ap endonuclease 0.0018 0.023 0.0301
Brugia malayi hypothetical protein 0.0036 0.062 0.0883
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.049 0.064
Onchocerca volvulus 0.0029 0.0471 0.0658
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.049 0.064
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.1407 0.2052
Echinococcus multilocularis ets variant gene 4 0.001 0.0048 0.0063
Schistosoma mansoni hypothetical protein 0.0036 0.062 0.0811
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0028 0.0037
Echinococcus multilocularis GPCR, family 2 0.0063 0.1235 0.1615
Schistosoma mansoni hypothetical protein 0.0347 0.7648 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0508 0.0665
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.1407 0.1317
Mycobacterium ulcerans hypothetical protein 0.0071 0.1407 0.8595
Brugia malayi nuclear receptor NHR-67 0.001 0.0028 0.0004
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.023 0.0839
Schistosoma mansoni nuclear hormone receptor 0.001 0.0028 0.0037
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.1939 0.1856
Schistosoma mansoni hypothetical protein 0.0136 0.2886 0.3774
Brugia malayi Latrophilin receptor protein 2 0.0063 0.1235 0.1797
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.1407 0.1317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.027 0.036
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.027 0.0353
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0048 0.0029
Echinococcus multilocularis tar DNA binding protein 0.0194 0.4191 0.548
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0054 0.0039
Loa Loa (eye worm) hypothetical protein 0.0063 0.1235 0.1793
Schistosoma mansoni hypothetical protein 0.0063 0.1235 0.1615
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.023 0.0839
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.1235 0.1615
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.1439 0.2096
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.023 0.0976
Loa Loa (eye worm) hypothetical protein 0.0071 0.1407 0.2049
Mycobacterium ulcerans beta-lactamase 0.0071 0.1407 0.8595
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.023 0.0839
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.1407 0.1317
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.1407 1
Brugia malayi beta-lactamase family protein 0.0071 0.1407 0.2052
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0028 0.0037
Brugia malayi Thioredoxin reductase 0.0037 0.0651 0.0929
Loa Loa (eye worm) glutathione reductase 0.0037 0.0651 0.0926
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.027 0.0364
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0651 0.3614
Mycobacterium leprae conserved hypothetical protein 0.0071 0.1407 0.646
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0435 0.2189
Loa Loa (eye worm) TAR-binding protein 0.0194 0.4191 0.6187
Schistosoma mansoni ets-related 0.0218 0.475 0.6211
Schistosoma mansoni tar DNA-binding protein 0.0194 0.4191 0.548
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.027 0.0353
Plasmodium vivax glutathione reductase, putative 0.0037 0.0651 0.3614
Mycobacterium leprae Probable lipase LipE 0.0071 0.1407 0.646
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.027 0.036
Onchocerca volvulus 0.0307 0.6757 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0852 0.1115
Toxoplasma gondii hypothetical protein 0.0028 0.0435 0.2189
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.162 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.027 0.036
Brugia malayi Pre-SET motif family protein 0.0205 0.4451 0.6575
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0028 0.0037
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0471 0.0658
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0048 0.0063
Mycobacterium tuberculosis Conserved protein 0.0071 0.1407 0.1317
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0039
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.1939 0.1856
Onchocerca volvulus 0.002 0.027 0.036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0852 0.1115
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.1726 0.164
Brugia malayi Steroid receptor seven-up type 2 0.002 0.027 0.0364
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0048 0.0063
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.027 0.0353
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.027 0.0353
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0651 0.0554
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0048 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1407 1
Trichomonas vaginalis esterase, putative 0.0071 0.1407 0.2614
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0852 0.1115
Brugia malayi beta-lactamase family protein 0.0071 0.1407 0.2052
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.049 0.2551
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0028 0.0004
Brugia malayi Ets-domain containing protein 0.0072 0.1439 0.2099
Schistosoma mansoni cpg binding protein 0.0031 0.0508 0.0665
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.023 0.0301
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.062 0.0811
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.027 0.0364
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.023 0.0301
Brugia malayi ecdysone receptor 0.001 0.0028 0.0004
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.162 0.2118
Echinococcus granulosus protein C ets 2 0.001 0.0048 0.0063
Schistosoma mansoni hypothetical protein 0.001 0.0048 0.0063
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.1235 0.1615
Schistosoma mansoni tar DNA-binding protein 0.0194 0.4191 0.548
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.027 0.0353
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1407 0.2614
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.027 0.0364
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.1726 0.164
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0028 0.0037
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.1439 0.1881
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.027 0.0364
Onchocerca volvulus 0.0071 0.1407 0.2049
Loa Loa (eye worm) hypothetical protein 0.002 0.027 0.036
Echinococcus multilocularis geminin 0.0347 0.7648 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.027 0.0353
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0048 0.0063
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0048 0.0063
Leishmania major hypothetical protein, conserved 0.0071 0.1407 1
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0651 0.4204
Loa Loa (eye worm) hypothetical protein 0.0071 0.1407 0.2049
Brugia malayi Ets-domain containing protein 0.001 0.0048 0.0033
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.027 0.0353
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.049 0.064
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.1407 0.8595
Onchocerca volvulus 0.0234 0.509 0.7523
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.162 0.2118
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.027 0.0353
Schistosoma mansoni tar DNA-binding protein 0.0194 0.4191 0.548
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.023 0.0976
Schistosoma mansoni ets 0.001 0.0048 0.0063
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0048 0.0033
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.062 0.0811
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.027 0.0364
Loa Loa (eye worm) histone methyltransferase 0.001 0.004 0.0018
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.162 1
Echinococcus granulosus GPCR family 2 0.0063 0.1235 0.1615
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.027 0.0353
Brugia malayi Probable ClpP-like protease 0.008 0.162 0.2368
Echinococcus multilocularis FTZ F1 alpha 0.002 0.027 0.0353
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0028 0.0037
Loa Loa (eye worm) hypothetical protein 0.0199 0.4309 0.6362
Loa Loa (eye worm) hypothetical protein 0.003 0.049 0.0686
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.1407 0.1317
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0997 0.3737
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0048 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0852 0.1115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.027 0.0353
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0028 0.0037
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1407 0.2614
Schistosoma mansoni ap endonuclease 0.0018 0.023 0.0301
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.027 0.036
Entamoeba histolytica hypothetical protein 0.0036 0.062 1
Brugia malayi RNA binding protein 0.0194 0.4191 0.6189
Loa Loa (eye worm) hypothetical protein 0.0307 0.6757 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.023 0.0976
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.162 0.7877
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.162 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0662 0.0866
Entamoeba histolytica hypothetical protein 0.0036 0.062 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.023 1
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0028 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.027 0.0353

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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