Detailed information for compound 788488

Basic information

Technical information
  • TDR Targets ID: 788488
  • Name: N-butan-2-yl-5-(3-chlorophenyl)-1,2-oxazole-3 -carboxamide
  • MW: 278.734 | Formula: C14H15ClN2O2
  • H donors: 1 H acceptors: 2 LogP: 3.6 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(NC(=O)c1noc(c1)c1cccc(c1)Cl)C
  • InChi: 1S/C14H15ClN2O2/c1-3-9(2)16-14(18)12-8-13(19-17-12)10-5-4-6-11(15)7-10/h4-9H,3H2,1-2H3,(H,16,18)
  • InChiKey: GIMKBTXTVQZNOF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(3-chlorophenyl)-N-sec-butyl-isoxazole-3-carboxamide
  • 5-(3-chlorophenyl)-N-sec-butyl-3-isoxazolecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0069 0.5404 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.012 1 1
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.3801 0.6147
Brugia malayi hypothetical protein 0.0036 0.2503 0.2503
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.3801 0.6147
Leishmania major monoglyceride lipase, putative 0.0069 0.5404 0.5
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0069 0.5404 0.5
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.3801 0.4744
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.6183 1
Schistosoma mansoni hypothetical protein 0.0036 0.2503 0.4048
Trypanosoma cruzi monoglyceride lipase, putative 0.0069 0.5404 0.5
Trypanosoma brucei monoglyceride lipase, putative 0.0069 0.5404 0.5
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0069 0.5404 0.8281
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.6183 1
Plasmodium falciparum lysophospholipase, putative 0.0069 0.5404 0.8281
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.2503 0.4048
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.6183 1
Plasmodium falciparum lysophospholipase, putative 0.0069 0.5404 0.8281
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.6183 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.6183 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.6183 0.6183
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0069 0.5404 0.5
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0069 0.5404 1
Brugia malayi Probable ClpP-like protease 0.0077 0.6183 0.6183
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0069 0.5404 0.5
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0069 0.5404 0.5
Plasmodium falciparum lysophospholipase, putative 0.0069 0.5404 0.8281
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.6183 0.5
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.6183 1
Loa Loa (eye worm) transcription factor SMAD2 0.012 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.2503 0.4048
Plasmodium vivax PST-A protein 0.0069 0.5404 0.8281
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.6183 0.5
Mycobacterium tuberculosis Possible lysophospholipase 0.0069 0.5404 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.6183 1
Plasmodium falciparum esterase, putative 0.0069 0.5404 0.8281
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0069 0.5404 0.5
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.6183 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.6183 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0069 0.5404 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.2503 0.4048
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.6183 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.6183 1
Trypanosoma brucei monoglyceride lipase, putative 0.0069 0.5404 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.5404 0.5
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.6183 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.5404 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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